| Budget Amount *help |
¥24,700,000 (Direct Cost: ¥19,000,000、Indirect Cost: ¥5,700,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2017: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2016: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Outline of Final Research Achievements |
This research objective is to develop a microfilter for specifically capturing the cancer cells in the blood. To achieve this goal, a 3D deformable microfilters were fabricated using photolithography technique and precisely electro forming technique. The surface of this microfilter was modified the nucleic acid aptamer for selectively capture the cancer cell. The cancer cell capturing test was carried out using the fabricated microfilter. The cancer cells were significantly captured compared with the normal cells by the fabricated microfilter. Also, we carried out the cancer cell capturing test using the cancer cell spiked whole blood. As a results, we succeeded in the small amount of cancer cells in the whole blood can be captured by the fabricated microfilter. This result was also good performance compared with CellSearch System that is already commercially available apparatus.
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