Development of the molecular detector for the imaging mass spectrometry of proteins in a cell

• Project/Area Number: 16H06092
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Measurement engineering
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: Zen Nobuyuki 国立研究開発法人産業技術総合研究所, エレクトロニクス・製造領域, 主任研究員 (20455439)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000); Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2017: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 超伝導検出器 / 超伝導ストリップ / SSPD / 単一磁束量子回路 / SFQ / 質量分析 / 分子検出 / 光子検出 / イオン検出 / 計測工学 / 超伝導材料・素子 / 量子細線 / 生体分子 / 細胞・組織 / イメージング質量分析 / 電子デバイス・機器 / 細胞イメージング

Outline of Final Research Achievements

The aim of this study is the development of the ultra-high sensitive molecular detector for the imaging mass spectrometry, which enables to determine the position on which an irradiated molecule lands. The superconducting strip particle detector (SSPD) is a high-sensitive molecular detector which consists of a superconducting strip line. This study has successfully demonstrated that the irradiated bio-molecule triggers the emission of the positive and negative current pulses from the both ends of the superconducting strip line, respectively; that is, the position-sensitive SSPD is possible.

Academic Significance and Societal Importance of the Research Achievements

SSPDが分子撮像可能であることの証明は世界初の成果であるが、分子イメージングを取得するまでには至らなかった。その理由を突き詰めれば、分子が衝突したときに超伝導体内部で起きている、電子やフォノンを巻き込んだ微視的な相互作用が十分に解明されていない現状にある。本研究で得たその認識の下、フォノンを自在に改変できるフォノン工学の手法を用いて、SSPDの素材である金属ニオブ中の電子-フォノン相互作用を垣間見ようとしたところ、通常の金属ニオブでは有り得ない電子間相互作用が起きていることを発見した。この新発見は、ドーパントを必要とせずに材料を改変できる新事実を顕に示しており、新たな学術分野を切り拓く。

Research Products

• [Int'l Joint Research] University of Glasgow(英国)
• [Int'l Joint Research] CNR-Istituto SPIN Pozzuoli(イタリア)
• [Journal Article] Phonon-engineered Nb film as a Mott-insulating tunnel-junction network (2019)
  • Author(s): Zen Nobuyuki
  • Journal Title: AIP Advances Volume: 9 Issue: 9 Pages: 095023-095023
  • DOI: 10.1063/1.5126616
  • Peer Reviewed / Open Access
• [Journal Article] Development of Superconducting Nanostrip X-Ray Detector for High-Resolution Resonant Inelastic Soft X-Ray Scattering (RIXS) (2019)
  • Author(s): Watanabe Chiharu、Ukibe Masahiro、Zen Nobuyuki、Fujii Go、Makise Kazumasa、Ohkubo Masataka、Lee Te-Hui、Huang Di-Jing
  • Journal Title: IEEE Transactions on Applied Superconductivity Volume: 29 Issue: 5 Pages: 1-4
  • DOI: 10.1109/tasc.2019.2903419
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Demonstration of Picosecond Time Resolution in Double-Oscillator Time-to-Digital Converter Using Single-Flux-Quantum Circuits (2019)
  • Author(s): Tomitsuka Yuma、Yamanashi Yuki、Zen Nobuyuki、Ohkubo Masataka、Yoshikawa Nobuyuki
  • Journal Title: IEEE Transactions on Applied Superconductivity Volume: 29 Issue: 5 Pages: 1-5
  • DOI: 10.1109/tasc.2019.2902478
  • Peer Reviewed / Open Access
• [Journal Article] Integrated Joule switches for the control of current dynamics in parallel superconducting strips (2018)
  • Author(s): Casaburi A、Heath R M、Cristiano R、Ejrnaes M、Zen N、Ohkubo M、Hadfield R H
  • Journal Title: Superconductor Science and Technology Volume: 31 Issue: 6 Pages: 06LT01-06LT01
  • DOI: 10.1088/1361-6668/aabcfd
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] High-Operating-Temperature Superconducting Nanowire Single Photon Detectors based on Magnesium Diboride (2017)
  • Author(s): Velasco Angel E.、Cunnane Daniel P.、Frasca Simone、Melbourne Thomas、Acharya Narendra、Briggs Ryan、Beyer Andrew D.、Shaw Matthew D.、Karasik Boris S.、Wolak Matth?us A.、Verma Varun B.、Lita Adriana E.、Shibata Hiroyuki、Ohkubo Masataka、Zen Nobuyuki、Ukibe Masahiro、Xi Xiaoxing、Marsili Francesco
  • Journal Title: OSA CLEO: QELS_Fundamental Science Volume: - Pages: FF1E.7-FF1E.7
  • DOI: 10.1364/cleo_qels.2017.ff1e.7
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Superconducting Time-of-flight Mass Spectrometry Systems for Biomolecules using Superconducting Digital Circuits (2017)
  • Author(s): 吉川 信行、佐野 京佑、山梨 裕希、全 伸幸、大久保 雅隆
  • Journal Title: TEION KOGAKU (Journal of Cryogenics and Superconductivity Society of Japan) Volume: 52 Issue: 5 Pages: 349-354
  • DOI: 10.2221/jcsj.52.349
  • NAID: 130006183702
  • ISSN: 0389-2441, 1880-0408
  • Peer Reviewed / Open Access
• [Presentation] Gbps級の量子鍵生成率を目指した超伝導ストリップ光子検出器の開発 (2018)
  • Author(s): 全 伸幸
  • Organizer: 超伝導エレクトロニクス研究会
  • Invited
• [Presentation] Superconductor detectors overcoming the limits in conventional analytical instruments (2018)
  • Author(s): 大久保 雅隆、志岐 成友、藤井 剛、渡邉 千春、全 伸幸、浮辺 雅宏
  • Organizer: International Workshop for Superconducting Sensors and Detectors 2018
  • Int'l Joint Research
• [Presentation] Development of superconducting nanostripline X-ray detector for high-resolution resonant inelastic soft X-ray scattering (RIXS) (2018)
  • Author(s): 浮辺 雅宏、渡邉 千春、全 伸幸、藤井 剛、牧瀬 圭正、大久保 雅隆
  • Organizer: Applied Superconductivity Conference 2018
  • Int'l Joint Research
• [Presentation] 1D-時間遅延線型超伝導ナノストリップX線イメージング検出器 の開発 (2017)
  • Author(s): 渡邉千春、全伸幸、藤井剛、牧瀬圭正、浮辺雅宏、大久保雅隆
  • Organizer: 第78回応用物理学会秋季学術講演会
• [Presentation] Demonstration of picosecond time resolution of double-oscillator time-to-digital converters using single-flux-quantum circuits (2017)
  • Author(s): Yuma Tomitsuka, Yutaka Abe, Yuki Yamanashi, Nobuyuki Zen, Masataka Ohkubo, Nobuyuki Yoshikawa
  • Organizer: 30th International Symposium on Superconductivity
  • Int'l Joint Research
• [Presentation] 1D-時間遅延線型超伝導ナノストリップX線イメージング検出器 の開発 (2017)
  • Author(s): 渡邉千春、全伸幸、藤井剛、牧瀬圭正、浮辺雅宏、大久保雅隆
  • Organizer: 第65回応用物理学会春季学術講演会
• [Patent(Industrial Property Rights)] PHOTON DETECTION DEVICE AND PHOTON DETECTION METHOD (2016)
  • Inventor(s): Zen Nobuyuki
  • Industrial Property Rights Holder: 国立研究開発法人産業技術総合研究所
  • Industrial Property Rights Type: 特許
  • Filing Date: 2016
  • Acquisition Date: 2020
  • Overseas