| Budget Amount *help |
¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000)
Fiscal Year 2018: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2017: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2016: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Outline of Final Research Achievements |
Mammalian sleep architecture consists of REM sleep, non-REM sleep, and short arousals. How the pattern of the sleep architecture is determined and how it affects the individual’s health remains largely unknown. Previously, we identified neurons in the brainstem that negatively regulate REM sleep. DREADD-activation of these neurons resulted in a sleep architecture in which REM sleep is skipped. To further elucidate how the sleep architecture is regulated, we aimed to elucidate how these neurons convey these effects by analyzing the downstream targets. Moreover, we identified neurons in the brainstem that play an essential role in the positive regulation of REM sleep. Genetic ablation of these neurons resulted in a severely deteriorated sleep architecture. These results reveal the neural mechanism underlying the regulation of the mammalian sleep architecture.
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