| Budget Amount *help |
¥26,910,000 (Direct Cost: ¥20,700,000、Indirect Cost: ¥6,210,000)
Fiscal Year 2019: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2016: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
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| Outline of Final Research Achievements |
Correlated spontaneous neuronal activity is involved in the development of nervous systems; however, the nature of correlated activity during the circuit formation is still obscure in living animals. In this study, we used the thalamocortical circuit formation in mouse barrel cortex layer 4 as a model. By in vivo two-photon calcium imaging of the barrel cortex during the first postnatal week, we found that layer 4 neurons within the same barrel fire synchronously in the absence of peripheral stimulation, creating a ‘patchwork’ pattern of spontaneous activity corresponding to the barrel map. The patchwork activity pattern largely disappeared during postnatal week 2, and layer 4 neurons within the same barrel tended to fire asynchronously. This spontaneous layer 4 activity pattern has features suitable for the thalamocortical circuit formation in neonatal barrel cortex.
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