| Budget Amount *help |
¥27,430,000 (Direct Cost: ¥21,100,000、Indirect Cost: ¥6,330,000)
Fiscal Year 2018: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2017: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2016: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Outline of Final Research Achievements |
The technology to directly manipulate arbitrary intracellular DNA molecules has made great progress with the advent of genome editing technologies such as CRISPR and TALEN. On the other hand, there are no technology that manipulate or modify cellular RNA molecules except the antisense technology.
PPR (pentatricopeptide repeat) is a RNA binding protein that can be designed for the sequence specificity. In this study, I developed a technology that can control the expression level of endogenous protein specifically and precisely by fusing translation related domain to designed PPR protein.
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