| Budget Amount *help |
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2018: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2017: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2016: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Outline of Final Research Achievements |
Neural tube dysplasia, such as spina bifida, is a relatively common neurological disorder. Understanding the pathogenesis of the disease at the molecular level is expected to lead to the development of diagnostic techniques and treatment methods. Cells change their morphology and gene expression status in response to various extracellular stimuli, and this is called signal transduction. In this study, we investigated the molecular mechanism of signal transduction that regulates neural tube formation by focusing on the G protein, which is responsible for turning on and off signal transduction. We found that one of the G proteins, called R-Ras, may regulate neural tube formation in response to the ON/OFF of information transmission through Vangl2, which is involved in the development of neural tube dysplasia.
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