| Budget Amount *help |
¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
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| Outline of Final Research Achievements |
There are abundant proteins in extracellular spaces including blood and body fluid in mammals. On the other hand, the stress induce protein denature. It is well known that intracellular protein degradation systems degrade aberrant intracellular proteins to maintain proteostasis. However, degradation system for aberrant extracellular proteins remained unclear. We identified Chaperone and Receptor mediated Extracellular protein degradation (CRED) pathway which leads to selective degradation of aberrant extracellular protein via an extracellular chaperone. These data indicate that the extracellular protein degradation pathway has important role for extracellular proteostasis.
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