| Budget Amount *help |
¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2018: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2017: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Outline of Final Research Achievements |
In this study, we focused on the molecular mechanisms of centriole formation, which is an important process in centrosome duplication, and analyzed the functions of molecules working in nanospace during the initial process. The results clarify the significance of the formation of the cartwheel, which is a foundation structure constructed in the initial process. In addition, we have identified a molecular complex that is required for the formation of the matrix structure around the centriole and for the binding between mother and daughter centrioles during mitosis.
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