| Budget Amount *help |
¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥21,190,000 (Direct Cost: ¥16,300,000、Indirect Cost: ¥4,890,000)
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| Outline of Final Research Achievements |
During the development of an ascidian, Halocynthia roretzi, the mesendoderm cell divides and forms daughter cells which are fated to produce mesoderm and endoderm cells. Asymmetric partitioning of mRNA encoding Not to the mesoderm daughter is central to this fate segregation. In order to understand the mechanism that partitions Not mRNA, I analyzed the movement of the nucleus which is coupled to the localization of Not mRNA. Results of the 4D characterization of nuclear position within the mesendoderm has been obtained and should provide basis for further analysis of the mechanism that regulates nuclear movement. I found that the morphological change of the mesendoderm cell that accompanies nuclear migration is also important for Not mRNA partitioning. The deformation of the mesendoderm cell was caused by cell cycle differences between the animal- and vegetal-hemispheres.
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