Roles of a circadian photopigment melanopsin in mammals
| Project/Area Number |
16H06174
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Keio University |
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Principal Investigator |
Hatori Megumi 慶應義塾大学, 医学部(信濃町), 特任准教授 (90590472)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2017: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2016: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
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| Keywords | 概日時計 / 目 / メラノプシン / 非視覚応答 / 光受容体 / 光受容 / オプシン / 遺伝子 / 蛋白質 / 細胞・組織 / 神経科学 / 脳・神経 |
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| Outline of Final Research Achievements |
In mammalian retinas, there are three photoreceptors: rods, cones and melanopsin-expressing retinal ganglion cells. Rods and cones are responsible for image forming vision. In contrast, melanopsin-expressing retinal ganglion cells contribute to non-image forming visions, such as circadian photoentrainment and pupil constriction. Melanopsin is a GPCR which can be activated by 460-480 nm light, and its light response properties are different from those of rods and cones. We had revealed phosphorylation of and Arrestin binding to the C-terminus cytosolic region of melanopsin is responsible for the shut-off mechanism after light pulse.
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| Academic Significance and Societal Importance of the Research Achievements |
わたしたちの睡眠・覚醒やホルモン分泌など、様々な生理機能は一日を周期として変化し、日々繰り返されます。このリズムを制御しているのが概日時計です。概日時計の周期は２４時間ぴったりではないため、光を浴びることや食事を摂取することにより、時間のずれを毎日補正しています。地球上には昼行性生物と夜行性生物が存在するため、両者のモデル生物を使用することにより、概日時計の機能の理解に近づくことができます。その一例として、目に発現して青色光を感じるタンパク質メラノプシンの機能解析を行いました。今後はメラノプシンの機能を調節する薬剤などの解析が進み、生体機能の維持および健康の増進の一助となると期待されます。
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies.2017
Author(s)
Hatori,M., Gronfier, C., Van Gelder, R.N., Bernstein, P.S., Carreras, J., Panda, S., Marks, F., Sliney, D., Hunt, C.E., Hirota, T., Furukawa, T. and Tsubota, K.
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Journal Title
NPJ Aging Mech. Dis.
Volume: 3
Issue: 1
Pages: 9-9
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression.2017
Author(s)
Torii H, Kurihara T, Seko Y, Negishi K, Ohnuma K, Inaba T, Kawashima M, Jiang X, Kondo S, Miyauchi M, Miwa Y, Katada Y, Mori K, Kato K, Tsubota K, Goto H, Oda M, Hatori M, Tsubota K.
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Journal Title
EBioMedicine
Volume: 15
Pages: 210-219
DOI
Related Report
Peer Reviewed / Open Access
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