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Understanding molecular dynamics underlying behavioral plasticity

Research Project

Project/Area Number 16H06175
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Genetics/Chromosome dynamics
Research InstitutionShiga University of Medical Science

Principal Investigator

Sugi Takuma  滋賀医科大学, 神経難病研究センター, 助教 (70571305)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2017: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2016: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Keywords線虫 / 行動 / 記憶 / 記憶・学習 / 行動遺伝学 / ナノテクノロジー / 力学刺激応答行動 / 遺伝学 / 生物物理学 / 神経科学 / デバイス開発 / 顕微鏡開発 / 生物物理
Outline of Final Research Achievements

Animals cope with environmental stimuli through its own behavioral plasticity. In this study, I investigated the mechanism underlying the behavioral plasticity in C. elegans. I first found that an activity of a MAP kinase oscillates in vivo. Therefore, I analyzed this oscillation using biochemical and imaging techniques. As a result, I showed that the oscillation of MAP kinase activity underlies plasticity of C. elegans mechanosensory behavior. I further analyzed the coding and decoding mechanism of the oscillation during establishment of behavioral plasticity. I summarized these results and am now submitting manuscript in a journal.

Academic Significance and Societal Importance of the Research Achievements

p38は別名ストレス応答性キナーゼと呼ばれ, ストレス応答を制御するマスターレギュレーターである. 本研究で注目した力学刺激は1つの物理的ストレスともみなすことができ, その処理機構の一端を示したこととも同義である. 現在, 他のストレス刺激下における動的変化の時間パターンの違いからのストレス刺激識別機構の解明しつつある.

Report

(3 results)
  • 2018 Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (5 results)

All 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (3 results) (of which Invited: 2 results)

  • [Journal Article] Genome Editing of C. elegans.2017

    • Author(s)
      Takuma Sugi
    • Journal Title

      Methods Mol Biol.

      Volume: 1630 Pages: 247-254

    • DOI

      10.1007/978-1-4939-7128-2_20

    • ISBN
      9781493971275, 9781493971282
    • Related Report
      2017 Annual Research Report
  • [Journal Article] Nanoscale Mechanical Stimulation Method for Quantifying <i>C. elegans</i> Mechanosensory Behavior and Memory2016

    • Author(s)
      Sugi T, Okumura E, Kiso K, Igarashi R
    • Journal Title

      Analytical Sciences

      Volume: 32 Issue: 11 Pages: 1159-1164

    • DOI

      10.2116/analsci.32.1159

    • NAID

      130005278002

    • ISSN
      0910-6340, 1348-2246
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Presentation] In vivo における細胞特異的機能解析から明らかにする 記憶の仕組みとその応用2017

    • Author(s)
      杉拓磨
    • Organizer
      2016年度 第7回 SENRIの会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ナノスケール力学刺激による動物個体の応答行動と記憶の解析2016

    • Author(s)
      杉拓磨
    • Organizer
      ナノ学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 動物1個体と集団レベルの行動を規定する力学的制御機構2016

    • Author(s)
      杉拓磨
    • Organizer
      野村ERATO-さきがけ細胞構成joint work shop
    • Related Report
      2016 Annual Research Report
    • Invited

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Published: 2016-04-21   Modified: 2021-01-27  

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