| Project/Area Number |
16H06175
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Genetics/Chromosome dynamics
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
Sugi Takuma 滋賀医科大学, 神経難病研究センター, 助教 (70571305)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2017: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2016: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Keywords | 線虫 / 行動 / 記憶 / 記憶・学習 / 行動遺伝学 / ナノテクノロジー / 力学刺激応答行動 / 遺伝学 / 生物物理学 / 神経科学 / デバイス開発 / 顕微鏡開発 / 生物物理 |
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| Outline of Final Research Achievements |
Animals cope with environmental stimuli through its own behavioral plasticity. In this study, I investigated the mechanism underlying the behavioral plasticity in C. elegans. I first found that an activity of a MAP kinase oscillates in vivo. Therefore, I analyzed this oscillation using biochemical and imaging techniques. As a result, I showed that the oscillation of MAP kinase activity underlies plasticity of C. elegans mechanosensory behavior. I further analyzed the coding and decoding mechanism of the oscillation during establishment of behavioral plasticity. I summarized these results and am now submitting manuscript in a journal.
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| Academic Significance and Societal Importance of the Research Achievements |
p38は別名ストレス応答性キナーゼと呼ばれ, ストレス応答を制御するマスターレギュレーターである. 本研究で注目した力学刺激は１つの物理的ストレスともみなすことができ, その処理機構の一端を示したこととも同義である. 現在, 他のストレス刺激下における動的変化の時間パターンの違いからのストレス刺激識別機構の解明しつつある.
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