Study of novel mechanisms of transcriptional regulation and lipid metabolism by FGF21

Research Project

Project/Area Number	16H06195
Research Category	Grant-in-Aid for Young Scientists (A)
Allocation Type	Single-year Grants
Research Field	Food science
Research Institution	The University of Tokyo
Principal Investigator	Shimizu Makoto 東京大学, 大学院農学生命科学研究科(農学部), 助教 (40409008)
Co-Investigator(Renkei-kenkyūsha)	SATO Ryuichiro 東京大学, 大学院農学生命科学研究科(農学部), 教授 (50187259)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥24,700,000 (Direct Cost: ¥19,000,000、Indirect Cost: ¥5,700,000) Fiscal Year 2017: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000) Fiscal Year 2016: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Keywords	FGF21 / 脂肪肝 / PPARg / 転写因子
Outline of Final Research Achievements	FGF21 is an anti-obese hormone which is synthesized and secreted from the liver. In this study, mechanisms of regulation of fatty liver by FGF21, and transcriptional regulation of FGF21 gene by a novel transcription factor were analyzed. I found that FGF21 prevents fatty liver through a nuclear hormone receptor PPARg. I also found a resnpose element of a novel transcription factor on the FGF21 promoter, and induction of FGF21 gene by fatty liver is significantly decresed by its knockout mouse.

Report

(3 results)