| Budget Amount *help |
¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
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| Outline of Final Research Achievements |
This study was conducted to elucidate trans-organ metabolic network that induces muscle protein degradation in broiler chickens exposed to heat stress (HS). In the study, corticosterone (CORT), mitochondrial reactive oxygen species generation (mitROS), intestinal barrier function, inflammatory response, amino acid metabolism were evaluated. As a result, the study revealed that i) HS-induced muscle proteolysis could be attributed to mitROS rather than CORT, and that ii) LPS influx evoked by intestinal barrier dysfunction may stimulate 3-MH and CORT secretion, and iii) Arg generated by the muscle proteolysis might contribute to the amelioration of inflammation in HS-exposed broiler chickens. These findings suggest that HS-induced muscle proteolysis may occur in the systemic inflammation in broiler chickens.
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