| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
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| Outline of Final Research Achievements |
Protease-activated receptor-2 (PAR-2) is a receptor that activated by several proteases such as trypsin and tryptase. However, the role of PAR-2 in tumor microenvironment is unclear. In the present project, we have revealed that endothelial PAR-2 activation induces angiogenesis and tumor growth using murine models. In addition, we showed the importance of mast cell-derived tryptase as a ligand of PAR-2 in the tumor tissue.
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