Genetic mechanisms that regulate stress responses in Drosophila

• Project/Area Number: 16H06220
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: General physiology
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Yoo Sa Kan 国立研究開発法人理化学研究所, 開拓研究本部, 主任研究員 (30768213)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000); Fiscal Year 2019: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2018: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2017: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2016: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: ストレス応答 / 傷 / 癌 / 老化 / 栄養 / 組織修復

Outline of Final Research Achievements

The original purpose of this research proposal was to investigate the mechanisms of wound responses and tissue repair, which animals possess innately. We tackled this problem using genetics of Drosophila melanogaster. We revealed the mechanisms of the following events: wound response, systemic effects of wounding to different organs and responses to stresses other than wounding, such as cancer, aging, abnormal nutrition and oxidative stress.

Academic Significance and Societal Importance of the Research Achievements

ヒトなど哺乳類において、組織修復は生存に必須である。 咳や腸の蠕動運動、摩擦、感染など、物理的・化学的刺激による小さな傷は日常的に起こり、修復される。熱傷瘢痕、ケロイド、褥瘡、糖尿病性壊疽、心筋梗塞などは、組織修復異常がその病態の根本である。現代人類の敵、癌は、「治らない傷」と呼ばれ、癌と傷は、病理学、生化学、生理学的に非常に共通点が多く、癌は、慢性損傷として捉えなおすことができる。このように、損傷応答・組織修復は、医学、生物学的観点から非常に大事であるが、そのメカニズムの多くは未だに謎に包まれている。私たちの研究は、このように非常に重要な損傷応答・組織修復メカニズムの一端を解明した。

Research Products

• [Journal Article] Plexins function in epithelial repair in both Drosophila and zebrafish (2016)
  • Author(s): Sa Kan Yoo, Heath G. Pascoe, Telmo Pereira, Shu Kondo, Antonio Jacinto, Xuewu Zhang, Iswar Hariharan
  • Journal Title: Nature Communications Volume: - Issue: 1
  • DOI: 10.1038/ncomms12282
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] The role of hydroxyproline in cancer-induced organismal death (2019)
  • Author(s): Lynna Yang, 兪史幹
  • Organizer: Drosophila as a cancer model (Spain)
  • Int'l Joint Research
• [Presentation] Discovery of the first drosophila BH3-only protein Sayonara (2019)
  • Author(s): 池川優子、兪史幹
  • Organizer: International cell death society 25th anniversary meeting
  • Int'l Joint Research
• [Presentation] ショウジョウバエにおける細胞死の新しい制御機構 (2019)
  • Author(s): 兪史幹
  • Organizer: 第28回日本Cell Death学会 学術集会
  • Invited
• [Presentation] How do organisms cope with disruption of homeostasis (2019)
  • Author(s): 兪史幹
  • Organizer: 第78回日本癌学 会学術総会
  • Invited
• [Presentation] An ABC transporter regulates aging-induced intestinal stem cell dysplasia (2019)
  • Author(s): 兪史幹
  • Organizer: 第42回日本分子生物学会年会
  • Invited
• [Presentation] 生物はどのようにして組織恒常性破綻に対応するか? (2018)
  • Author(s): 兪 史幹
  • Organizer: 第39回日本炎症・再生医学会
  • Invited
• [Presentation] A phenotypic landscape of mechanisms underlying resistance to multiple stressors (2018)
  • Author(s): 西田弘、兪史幹
  • Organizer: 59th Annual Drosophila Conference
  • Int'l Joint Research
• [Presentation] An ABC transporter regulates aging-induced intestinal stem cell dysplasia in the midgut of Drosophila (2018)
  • Author(s): 佐々木彩伽、西村隆史、兪史幹
  • Organizer: 59th Annual Drosophila Conference
  • Int'l Joint Research
• [Presentation] An ABC transporter regulates aging-induced intestinal stem cell dysplasia in the midgut of Drosophila (2018)
  • Author(s): 佐々木彩伽、西村隆史、兪史幹
  • Organizer: JDRC13
• [Presentation] Developmental origin of aging-induced drift in stem cell dynamics in Drosopphila (2018)
  • Author(s): 福原彩、兪史幹
  • Organizer: JDRC13
• [Presentation] Genetic screening to identify factors that regulate lifespan and homeostasis of intestinel stem cells during aging in Drosophila (2018)
  • Author(s): 内藤早紀、西田弘、兪史幹
  • Organizer: 60th Annual Drosophila Conference
  • Int'l Joint Research
• [Presentation] An evolutionarily ancient role for Plexins during epithelial repair in Drosophila and zebrafish (2016)
  • Author(s): Sa Kan Yoo
  • Organizer: JDRC12
  • Place of Presentation: 立教大学