Genetic basis of cancer progression by dying tumor cells
| Project/Area Number |
16H06222
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
Enomoto Masato 京都大学, 生命科学研究科, 助教 (00596174)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
Fiscal Year 2018: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2017: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2016: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | がん / 死細胞 / シグナル伝達 / ショウジョウバエ / 細胞間相互作用 / 腫瘍内不均一性 / 代償性増殖 / 細胞死 / 細胞間コミュニケーション / 癌 |
|---|
| Outline of Final Research Achievements |
Although it has been recently shown that distinct oncogenic cell clones heterogeneously exist in cancer tissues, it is still poorly understood how tumor-microenvironment causes cancer progression. To elucidate the underlying mechanism, I recapitulated tumor heterogeneity in Drosophila epithelium and genetically analyzed cell-cell interaction of distinct oncogenic cell populations in vivo. In this research, I found that dying Src-activating cells transform surrounding Ras-activating cells to malignant tumors via cell-cell interaction. Furthermore, I also found that malignant Ras-activating cell clones provide metastatic behaviors to surviving Src-activating cells, thereby two oncogenic cell populations mutually invade the adjacent tissues. These findings suggest that two distinct oncogenic cells mutually develop into malignant tumors via cellular cooperation triggered by dying oncogenic cells.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の成果は、死にゆく腫瘍細胞がその死と引き換えに周囲の腫瘍細胞に悪性化能を誘発するという新しいがん制御メカニズムを明らかにした。このような細胞死を起点とした細胞間コミュニケーションによるがん制御システムの理解は、新たながん治療戦略や抗がん剤開発の基盤になることが期待できる。
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Drosophila As a Cancer Model2018
Author(s)
Masato Enomoto, Carmen Siow, Tatsushi Igaki
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Journal Title
Advances in Experimental Medicine and Biology
Volume: 1076
Pages: 173-194
DOI
ISBN
9789811305283, 9789811305290
Related Report
Peer Reviewed
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[Presentation] 細胞間コミュニケーションによるがん進展2017
Author(s)
榎本将人, 本田直樹, 武本花奈美, 竹本大策, 井垣達吏
Organizer
生命動態の分子メカニズムと数理
Place of Presentation
理化学研究所 生命システム研究センター（大阪府吹田市）
Year and Date
2017-03-17
Related Report
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