| Budget Amount *help |
¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2018: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Outline of Final Research Achievements |
The purpose of this study is to explore and analyze a new epigenetic factor that can modulate differentiation and function of brown adipocytes and beige adipocytes. We identified methionine adenosyltransferase II α(MATIIα), a synthetase of methyl donor S-adenosylmethionine, as a newly binding partner of a PRDM16/EHMT1 transcriptional complex. Genetic ablation of MATIIαcauses a loss of brown adipose tissue in vivo. Depletion of MATIIα in brown adipocytes or beige adipocytes induced demethylation of H3K9 at a promoter region of white adipocyte specific genes and caused reductions of thermogenic genes such as ucp1. These findings revealed a novel mechanism that MATIIα modulate differentiation of brown adipocytes through chromatin modification.
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