| Budget Amount *help |
¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
Fiscal Year 2018: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2017: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2016: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Outline of Final Research Achievements |
In this study, we examined the protective role of the carbohydrate moieties expressed on intestinal epithelial cells against infection by Salmonella typhimurium and Candida albicans. As a result, we identified that alpha1,2-fucose expressed on intestinal epithelial cells inhibits adhesion of S. typhimurium to the epithelial cells while colonization of C. albicans was not affected by epithelial alpha1,2-fucose. Commensal bacteria inhibit colonization of C. albicans in the gut. Mice treated with beta-lactam antibiotics harbor significant numbers of C. albicans in the gut. Administration of commensal bacteria effectively excluded C. albicans colonized in the gut.
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