| Budget Amount *help |
¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2017: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2016: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
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| Outline of Final Research Achievements |
The purpose of this research project is to investigate the character of disorder-specific M2 macrophages, which acts an important role in development and exacerbation of various corresponding diseases.
Recent our studies have revealed that various macrophage subtypes were existed in our body. Next, we focused on fibrosis as a pathological model and studied M2 macrophages. As a result, we found a M2 macrophage-like cell population that proliferates in the diseased part as the disease state progresses. In this research, we identify critical molecule of the cells and clarify the differentiation mechanism of the pro-fibrotic cells. Also, we examine how this cell type contributes to the onset of fibrosis.
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