Study of disorder-specific macrophage involved in fibrosis
| Project/Area Number |
16H06234
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Osaka University |
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Principal Investigator |
Satoh Takashi 大阪大学, 微生物病研究所, 助教 (60619716)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2017: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2016: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
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| Keywords | 疾患特異的マクロファージ / 線維症 / アレルギー / メタボリックシンドローム / 自然免疫 / 疾患 / 創薬 / 細胞分化 / 疾患特異的マクロファージサブタイプ |
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| Outline of Final Research Achievements |
The purpose of this research project is to investigate the character of disorder-specific M2 macrophages, which acts an important role in development and exacerbation of various corresponding diseases.
Recent our studies have revealed that various macrophage subtypes were existed in our body. Next, we focused on fibrosis as a pathological model and studied M2 macrophages. As a result, we found a M2 macrophage-like cell population that proliferates in the diseased part as the disease state progresses. In this research, we identify critical molecule of the cells and clarify the differentiation mechanism of the pro-fibrotic cells. Also, we examine how this cell type contributes to the onset of fibrosis.
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Report
(3 results)
Research Products
(24 results)
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[Journal Article] Identification of an atypical monocyte and committed progenitor involved in fibrosis.2017
Author(s)
Kozaki T, Komano J, Kanbayashi D, Takahama M, Misawa T, Satoh T, Takeuchi O, Kawai T, Shimizu S, Matsuura Y, Akira S, Saitoh T
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Journal Title
PNAS
Volume: 114
Pages: 96-101
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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