| Budget Amount *help |
¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2018: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
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| Outline of Final Research Achievements |
Lipoproteins carry lipids in blood. In addition to a classical role of lipoproteins as a carrier of cholesterol, lipoproteins, especially HDL, possess pleiotorpic effects, such as anti-apoptosis and anti-inflammatory properties. In this study, I elucidated that lysophospholipids, potent lipid mediators, exist on lipoproteins and that the metabolism of lipoproteins influenced on the dynamism and physiological properties of lysophospholipids, Moreover, I have demonstrated that lysophospholipids could be introduced into clinical laboratory medicien as a novel biomarer for pleiotropic effects of lipoproteins. These results sugest that lysophospholipids might make it possible to apply pleiotropic effects of lipoproteins to clinical practice.
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