Introduction of lysophospholipids into clinical laboratory medicine, focusing on lipoproteins
Project/Area Number |
16H06236
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Laboratory medicine
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Research Institution | The University of Tokyo |
Principal Investigator |
Kurano Makoto 東京大学, 医学部附属病院, 講師 (60621745)
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2018: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
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Keywords | リポ蛋白 / リゾリン脂質 / HDL / 生理活性脂質 / 臨床検査 |
Outline of Final Research Achievements |
Lipoproteins carry lipids in blood. In addition to a classical role of lipoproteins as a carrier of cholesterol, lipoproteins, especially HDL, possess pleiotorpic effects, such as anti-apoptosis and anti-inflammatory properties. In this study, I elucidated that lysophospholipids, potent lipid mediators, exist on lipoproteins and that the metabolism of lipoproteins influenced on the dynamism and physiological properties of lysophospholipids, Moreover, I have demonstrated that lysophospholipids could be introduced into clinical laboratory medicien as a novel biomarer for pleiotropic effects of lipoproteins. These results sugest that lysophospholipids might make it possible to apply pleiotropic effects of lipoproteins to clinical practice.
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Academic Significance and Societal Importance of the Research Achievements |
現在の脂質関連の臨床検査では、LDLコレステロールやHDLコレステロールが広く使われているが、これらの検査のみでは、動脈硬化性疾患の発症を完全には予測できない。また、LDLコレステロールを標的とする内服薬のみでは、動脈硬化性疾患の発症を高々40%程度しか抑制できない。 このような、現在の脂質異常症の診療の限界点を、本研究は、リゾリン脂質に着目することにより、克服できるのではないか、という可能性を初めて示した。
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Serum autotaxin levels are associated with Graves’ disease2019
Author(s)
Nojiri Takahiro、Kurano Makoto、Araki Osamu、Nakawatari Kazuki、Nishikawa Masako、Shimamoto Satoshi、Igarashi Koji、Kano Kuniyuki、Aoki Junken、Kihara Shinji、Murakami Masami、Yatomi Yutaka
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Journal Title
Endocrine Journal
Volume: 66
Issue: 5
Pages: 409-422
DOI
NAID
ISSN
0918-8959, 1348-4540
Related Report
Peer Reviewed / Open Access
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[Journal Article] Analysis of glycero-lysophospholipids in gastric cancerous ascites.2017
Author(s)
Emoto, S., Kurano, M., Kano, K., Matsusaki, K., Yamashita, H., Nishikawa, M., Igarashi, K., Ikeda, H., Aoki, J., Kitayama, J., and Yatomi, Y.
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Journal Title
J. Lipid Res
Volume: 58
Issue: 4
Pages: 763-771
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Vehicle-dependent Effects of Sphingosine 1-phosphate on Plasminogen Activator Inhibitor-1 Expression2017
Author(s)
Takahashi, C., Kurano, M., Nishikawa, M., Kano, K., Dohi, T., Miyauchi, K., Daida, H., Shimizu, T., Aoki, J., and Yatomi, Y.
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Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 24
Issue: 9
Pages: 954-969
DOI
NAID
ISSN
1340-3478, 1880-3873
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Different Origins of Lysophospholipid Mediators between Coronary and Peripheral Arteries in Acute Coronary Syndrome.2017
Author(s)
Kurano, M., Kano, K., Dohi, T., Matsumoto, H., Igarashi, K., Nishikawa, M., Ohkawa, R., Ikeda, H., Miyauchi, K., Daida, H., Aoki, J., and Yatomi, Y.
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Journal Title
J. Lipid Res.
Volume: 58
Issue: 2
Pages: 433-442
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Glycation of Apolipoprotein M attenuated its capacity to bind Sphingosine-1 Phosphate2017
Author(s)
Kobayashi, T., Kurano, M., Mishima, Y., Nojiri, T., Ohkawa, R., Tozuka, M., and Yatomi, Y
Organizer
The 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine (WASPaLM)
Related Report
Int'l Joint Research
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[Presentation] Possible involvement of glycero-lysophopholipids in the pathogenesis of ACS, revealed by an LC/MS technique2017
Author(s)
Kurano, M., Kano, K., Dohi, T., Ikeda, H., Aoki, J., and Yatomi Y
Organizer
The 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine (WASPaLM)
Related Report
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[Presentation] Difference between sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in their preference to HDL or albumin2017
Author(s)
Mishima,Y., Kurano,M., Kobayahsi,T., Nishikawa,M., Ohkawa,R., Tozuka,M.,Yatomi,Y
Organizer
The 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine (WASPaLM)
Related Report
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[Presentation] Sphingosine 1-Phosphate Possesses the Carrier-dependent Effects on the Plasminogen Activator Inhibitor 1 Expression in Adipocytes.2016
Author(s)
Takahashi, C., Kurano, M., Nishikawa, M., Kano, K., Dohi, T., Miyauchi, K., Daida, H., Shimizu, T., Aoki, J., and Yatomi, Y.
Organizer
AHA Scientific Sessions 2016.
Place of Presentation
New Orleans, Louisiana, USA.
Year and Date
2016-11-12
Related Report
Int'l Joint Research
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[Presentation] Detection and Regulation of Apolipoprotein M in Central Nervous System.2016
Author(s)
Hisasue, N., Kurano, M., Morimoto, Y., Tsuneyama, K., Kubota, T., Yatomi, Y.
Organizer
The 32nd World Congress of Biomedical Laboratory Science 2016 IFBLS.
Place of Presentation
Kobe, Japan
Year and Date
2016-08-31
Related Report
Int'l Joint Research
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[Presentation] Oxidation and Glycation Modulate HDL Capacity to Carry Sphingosine 1-Phosphate, an Anti-Atherosclerotic Bioactive Lipid.2016
Author(s)
Kobayashi, T., Kurano, M., Nojiri, T., Ohkawa, R., Tozuka, M., Okubo, S., and Yatomi, Y.
Organizer
The 32nd World Congress of Biomedical Laboratory Science 2016 IFBLS.
Place of Presentation
Kobe, Japan
Year and Date
2016-08-31
Related Report
Int'l Joint Research
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