Identification of new itch transmitter in spinal cord under chronic itch conditions
| Project/Area Number |
16H06237
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (A)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Pain science
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2017: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2016: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
|
|---|
| Keywords | 痒み / 脊髄 / 慢性掻痒 / GRPR / 慢性的な痒み / アトピー性皮膚炎 / ＧＲＰＲ |
|---|
| Outline of Final Research Achievements |
Chronic itch is a debilitating symptom of skin diseases including atopic dermatitis; however, antihistamines are mostly ineffective and underlying mechanisms are poorly understood. Previous studies have suggested that spinal GRPR signaling plays an impoetant role in development and maintenance of chronic itch. However, using GRPR mutant mice, we have shown that GRPR signaling makes a partial contribution to the development and maintenance of chronic itch and little contribution to initiation of it. In this study, we focused on GRPR-independent mechanisms of itch transmission in the spinal cord under chronic itch conditions and found that X-positive neurons as candidates for mediating GRPR-independent itch.
|
| Academic Significance and Societal Importance of the Research Achievements |
慢性掻痒の初期から進行・維持期にわたって関与する脊髄における痒み伝達メカニズムの発見に繋がり、慢性掻痒メカニズムの全容解明に大きく貢献し、有効な新規治療標的の創出につながる。さらに新たな脊髄痒みシグナル及び神経回路の解明にもつながるため、‘慢性的な痒み’のみならず、‘痒み’さらには‘感覚’研究全般において、日本が世界をリードすることにも貢献すると期待される。
|
Report
(4 results)
Research Products
(15 results)
-
[Journal Article] Role of P2X3 receptors in scratching behavior in mouse models2019
Author(s)
Shiratori-Hayashi Miho、Hasegawa Ayumi、Toyonaga Honami、Andoh Tsugunobu、Nakahara Takeshi、Kido-Nakahara Makiko、Furue Masutaka、Kuraishi Yasushi、Inoue Kazuhide、Dong Xinzhong、Tsuda Makoto
-
Journal Title
Journal of Allergy and Clinical Immunology
Volume: 143
Issue: 3
Pages: 1252-1254
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
