| Budget Amount *help |
¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2017: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2016: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Outline of Final Research Achievements |
Control of inflammatory responses as well as promotion of mucosal repair are required for the adequate treatment and cure of intestinal bowel diseases, such as Crohn's diseases and Ulcerative colitis. Mucosal mesenchymal cell populations function as a central source of extra cellular matrix and are required for the development and maintenance of stem cell niches in the colon. However, the precise mechanisms and subsets within the mucosal mesenchymal cells, involved in the process of mucosal repair, have not been well elucidated.
In this project, we first comprehensively analyzed the functional characteristics of those mesenchymal cells and found the unique and novel subsets are increased upon inflammatory responses. We further regulated the mesenchymal cellular population and found the disruption of its function resulted in the delay of mucosal repair. These results indicated the novel target of mesenchymal cells for promotion of mucosal repair was elucidated.
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