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The role of Gas6/Axl signal in the immune response associated with RSV infection

Research Project

Project/Area Number 16H06246
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

Shibata Takehiko  国立感染症研究所, 免疫部, 主任研究官 (00739196)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2018: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2017: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2016: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
KeywordsAxl / RSV / タイプ2免疫 / ワクチン / Gas6 / アレルギー / 感染症 / 免疫学 / ウィルス / アレルギー・ぜんそく
Outline of Final Research Achievements

Respiratory syncytial virus (RSV) vaccine is currently not available. In this study, we examined the induction mechanism of allergic responses after vaccination with RSV and type 2 immune response with RSV infection. First, it was revealed that growth arrest specific 6 produced by formalin fixed RSV induces type 2 immune response (allergic airway inflammation) via its receptor Axl. We also found that Axl inhibitor shift the immune response from type 2 to 1 and can be an adjuvant and also useful for the elimination of RSV.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は、安全性と有効性を担保した新しいrespiratory syncytial virus (RSV) ワクチン接種方法となる可能性がある。また、Axlシグナル阻害により免疫応答をシフトさせるという新しい概念は、抗ウイルス薬の開発につながる可能性がある。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • Research Products

    (6 results)

All 2018 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] A critical role of Gas6/Axl signal in allergic airway responses during RSV vaccine-enhanced disease2017

    • Author(s)
      Shibata Takehiko、Ato Manabu
    • Journal Title

      Immunology & Cell Biology

      Volume: 95 Issue: 10 Pages: 906-915

    • DOI

      10.1038/icb.2017.61

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] RSV induces suppressive Gas6/Axl signaling in macrophages increasing susceptibility to secondary S. pneumoniae infection.2018

    • Author(s)
      Takehiko Shibata, Toshihiro Ito, Yoshimasa Takahashi, Manabu Ato
    • Organizer
      The 47th Annual Meeting of The Japanese Society for Immunology
    • Related Report
      2018 Annual Research Report
  • [Presentation] RSV-induced Gas6/Axl signal ultimately leads to severer bacterial pneumonia2017

    • Author(s)
      Takehiko Shibata
    • Organizer
      the 5th Annual Meeting of the International Cytokine and Interferon Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The role of RSV-induced Gas6/Axl signaling in secondary bacterial infection.2017

    • Author(s)
      Takehiko Shibata
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Gas6/Axl signal causes the failure of RSV vaccine development in mice.2016

    • Author(s)
      Takehiko Shibata, Manabu Ato
    • Organizer
      The 24th International Symposium on Molecular Cell Biology of Macrophages
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gas6/Axl signal plays critical roles in allergic responses and insufficient protection by formalin-inactivated RSV vaccine in mice2016

    • Author(s)
      Takehiko Shibata, Manabu Ato
    • Organizer
      第45回日本免疫学会学術集会46回日本免疫学会学術集会
    • Related Report
      2016 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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