| Budget Amount *help |
¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
In this study, we investigated the pathophysiology of polyPR peptide, produced from ALS-causative C9orf72 gene, and the treatment methods through comprehensive analysis of proteome and cytotoxic pathways. As a result, we found that polyPR accumulated in nucleoli and inhibited protein translation, and caused phase separation to inhibit the function of many proteins. In addition, we have identified a compound that suppresses the production of polyPR and we are continuing the experiments for future clinical application.
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