| Budget Amount *help |
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2016: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
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| Outline of Final Research Achievements |
Microbiome analysis is widely performed in recent years in the intestinal tract, skin, etc., and the contribution of microbiome to the diseases is becoming clearer. When we analysis the microbe-immune response in the skin, we have to analyze not only the host immune responses and bacterial community, but also fungal and viral community. However, there was no good model for microbial immune response analysis targeting whole symbiotic microorganisms. Therefore, we aim to establish a new model for analyzing the microbe-immune response in the skin. In this study, we found that IL-17-producing cells in our S. aureus infection model were ILC3 and gdT cells. In addition, a phenotypic differences were obvious in keratinocyte-specific MyD88knockout and IL-1/36 deficient mice.We also established a new inflammatory skin model with pathogenic fungi such as C. albicans and M. furfur.
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