Repairing incurable meniscal tears using a novel nanofibrous scaffold
| Project/Area Number |
16H06264
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2019: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2018: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 半月板 / 再生医療 / スキャフォールド / エレクトロスピニング / 間葉系幹細胞 / 半月板損傷 / 整形外科 / エレクトロスピニング法 / ミニブタ / 家兎 / 膝関節 |
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| Outline of Final Research Achievements |
In this study, we investigated the applicability of cell-seeded nanofibrous scaffolds to repair the meniscal injury along with the prevention of subsequent cartilage degeneration using an animal model. The cell-seeded nanofibrous scaffolds contributed significantly to the reinforcement of meniscal torn site and exerted a chondroprotective effect, compared with the untreated control groups. Thus, we have demonstrated the feasibility of our technique to repair the meniscal injury, and prevent the progression to osteoarthritis, as a potential tissue engineering method.
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| Academic Significance and Societal Importance of the Research Achievements |
半月板は膝関節内において重要な機能を有するが、半月板は大部分が無血管野であり、一旦損傷すると自然修復が期待されず、これまで有効な治療法が無かった。また多くの場合、切除を余儀なくされ、変形性関節症の要因となっていた。本治療法は、これまで難治性であった半月板損傷に対する新たな治療法として期待され、今後、変形性関節症発症予防へ繋がる可能性がある。
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Report
(5 results)
Research Products
(15 results)
