Nanoparticle Therapy Targeting Activated Monocytes/Macrophages for Retinits Pigmentosa
Project/Area Number |
16H06268
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Ophthalmology
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Research Institution | Kyushu University |
Principal Investigator |
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Research Collaborator |
Sonoda Koh-hei
Ikeda Yasuhro
Egashira Kensuke
Vavvas Demetrios
Paschalis Eleftherios
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2016: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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Keywords | 網膜色素変性 / 神経炎症 / マクロファージ / マイクログリア / ナノ粒子 / 網膜変性 / ナノ材料 / 脳・神経 / 単球 / ナノバイオ |
Outline of Final Research Achievements |
Although retinal degeneration in retinitis pigmentosa (RP) is initiated by genetic mutations, recent evidence indicate that chronic inflammation modulates the disease progression of RP. Microglia and monocyte/macrophage are key players in neuroinflammation; however, their phenotype changes and functions in RP are still elusive. In the present study, we showed that monocyte/macrophage promoted photoreceptor cell death, while microglia exhibited protective effect in rd10 mice, a model of RP. Novel nanoparticles (NP) efficiently transduced the encapsulated contents into the monocyte/macrophage, and may serve as a potential anti-inflammatory therapy for RP.
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Academic Significance and Societal Importance of the Research Achievements |
過去の研究では、慢性炎症がRPに対して保護的に働くとの報告と、逆に網膜変性を促進するとの報告があり、RPにおけるマイクログリアならびに単球/マクロファージの役割は混沌としている。本研究は、マイクログリアと単球/マクロファージの新しい表面マーカーの解析や、特異的な抑制/除去実験を行い、それぞれの分画の役割を明確にすることができた。 また我々が開発しているナノ粒子は国産の新規技術を用いて作製しており、本研究結果をもとに単球/マクロファージを標的とした新規ナノ粒子治療薬の開発を、産学連携のもとに進めている。
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Discovery of a Cynomolgus Monkey Family With Retinitis Pigmentosa2018
Author(s)
Ikeda Yasuhiro、Nishiguchi Koji M.、Miya Fuyuki、Shimozawa Nobuhiro、Funatsu Jun、Nakatake Shunji、Fujiwara Kohta、Tachibana Takashi、Murakami Yusuke、Hisatomi Toshio、Yoshida Shigeo、Yasutomi Yasuhiro、Tsunoda Tatsuhiko、Nakazawa Toru、Ishibashi Tatsuro、Sonoda Koh-Hei
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Journal Title
Investigative Opthalmology & Visual Science
Volume: 59
Issue: 2
Pages: 826-826
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Risk Factors for Posterior Subcapsular Cataract in Retinitis Pigmentosa.2017
Author(s)
Fujiwara K, Ikeda Y, Murakami Y, Funatsu J, Nakatake S, Tachibana T, Yoshida N, Nakao S, Hisatomi T, Yoshida S,Yoshitomi T, Ishibashi T, Sonoda KH:
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 58(5)
Issue: 5
Pages: 2534-2537
DOI
Related Report
Peer Reviewed
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[Journal Article] C-Reactive protein and progression of vision loss in retinitis pigmentosa.2017
Author(s)
Murakami Y, Ikeda Y, Nakatake S, Fujiwara K, Tachibana T, Yoshida N, Notomi S, Hisatomi T, Yoshida S, Ishibashi T, Sonoda KH:
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Journal Title
Acta Ophthalmol
Volume: 96(2)
Issue: 2
DOI
Related Report
Peer Reviewed
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[Journal Article] Optical coherence tomography angiography of the macular microvasculature changes in retinitis pigmentosa.2017
Author(s)
Koyanagi Y, Murakami Y, Funatsu J, Akiyama M, Nakatake S, Fujiwara K, Tachibana T, Nakao S, Hisatomi T, Yoshida S,Ishibashi T, Sonoda KH, Ikeda Y:
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Journal Title
Acta Ophthalmol
Volume: 96(1)
Issue: 1
DOI
Related Report
Peer Reviewed
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[Journal Article] MUTYH promotes oxidative microglial activation and inherited retinal degeneration.2016
Author(s)
Nakatake S, Murakami Y, Ikeda Y, Morioka N, Tachibana T, Fujiwara K, Yoshida N, Notomi S, Hisatomi T, Yoshida S, Ishibashi T, Nakabeppu Y, Sonoda KH.
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Journal Title
JCI Insight
Volume: 1
Issue: 15
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Association Between Aqueous Flare and Epiretinal Membrane in Retinitis Pigmentosa.2016
Author(s)
Fujiwara K, Ikeda Y, Murakami Y, Nakatake S, Tachibana T, Yoshida N, Nakao S, Hisatomi T, Yoshida S, Yoshitomi T, Sonoda KH, Ishibashi T.
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Journal Title
Invest Ophthalmol Vis Sci.
Volume: 57
Issue: 10
Pages: 4282-6
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] 村上祐介2017
Author(s)
網膜色素変性における錐体細胞死と炎症の関連
Organizer
日本眼科学会
Place of Presentation
東京
Year and Date
2017-04-08
Related Report
Invited
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[Presentation] 網膜色素変性における前房内フレア値と黄斑上膜の関連2016
Author(s)
藤原康太, 池田康博, 村上祐介, 中武俊二, 立花崇, 中尾新太郎, 久冨智朗, 吉田茂生, 吉冨健志, 石橋達朗, 園田康平
Organizer
日本眼科学会
Place of Presentation
仙台
Year and Date
2016-04-10
Related Report
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