| Budget Amount *help |
¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2018: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2017: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2016: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Outline of Final Research Achievements |
Del-1 has currently emerged as an important factor for homeostatic immunity by regulating neutrophil infiltration and resolution of inflammation. Del-1 is a versatile, multidomain protein that can interact with phospholipids and distinct integrins, thereby regulating the host inflammatory response at different stages. Intriguingly, Del-1 expression progressively declined with aging. Specifically, we have done that ① Analysis of the control mechanism of inflammatory bone destruction by Del-1 and to expand the field of osteoimmunology by Del-1 ② Elucidation of pathological condition of rheumatoid arthritis by balance control of IL-17 and Del-1 and novel bone destruction control mechanism of Del-1 for osteoclasts ③ Select compounds that induce Del-1 in vivo.
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