先端モデル動物支援プラットフォーム

• Project/Area Number: 16H06276
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas ― Platforms for Advanced Technologies and Research Resources
• Allocation Type: Single-year Grants
• Research Institution: The University of Tokyo
• Principal Investigator: 井上 純一郎 (2019-2020) 東京大学, 医科学研究所, 特任研究員; 今井 浩三 (2016-2018) 東京大学, 医科学研究所, 客員教授 (60117603)
• Co-Investigator(Kenkyū-buntansha): 中村 卓郎 公益財団法人がん研究会, がん研究所, 副所長 (00180373) ; 井上 純一郎 東京大学, 医科学研究所, 教授 (70176428) ; 高田 昌彦 京都大学, 霊長類研究所, 教授 (00236233) ; 山田 泰広 東京大学, 医科学研究所, 教授 (70313872) ; 高橋 智 筑波大学, 医学医療系, 教授 (50271896) ; 伊川 正人 大阪大学, 微生物病研究所, 教授 (20304066) ; 﨑村 建司 新潟大学, 脳研究所, フェロー (40162325) ; 荒木 喜美 熊本大学, 生命資源研究・支援センター, 教授 (90211705) ; 八尾 良司 公益財団法人がん研究会, がん研究所・細胞生物部, 部長 (80291095) ; 真下 知士 大阪大学, 大学院医学系研究科, 准教授 (80397554) ; 小林 和人 福島県立医科大学, 医学部, 教授 (90211903) ; 豊國 伸哉 名古屋大学, 大学院医学系研究科, 教授 (90252460) ; 鰐渕 英機 大阪市立大学, 大学院医学研究科, 教授 (90220970) ; 今井田 克己 香川大学, 医学部, 教授 (90160043) ; 二口 充 長崎大学, 病院(医学系), 准教授 (60275120) ; 上野 正樹 香川大学, 医学部, 教授 (30322267) ; 宮崎 龍彦 岐阜大学, 医学部附属病院, 准教授 (80239384) ; 神田 浩明 埼玉県立がんセンター(臨床腫瘍研究所), 病理診断科, 部長 (90260067) ; 尾藤 晴彦 東京大学, 大学院医学系研究科, 教授 (00291964) ; 宮川 剛 藤田保健衛生大学, 総合医科学研究所, 教授 (10301780) ; 高雄 啓三 富山大学, 研究推進機構・研究推進総合支援センター, 教授 (80420397) ; 池田 和隆 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 分野長 (60281656) ; 虫明 元 東北大学, 大学院医学系研究科, 教授 (80219849) ; 清宮 啓之 公益財団法人がん研究会, がん化学療法センター・分子生物治療研究部, 部長 (50280623) ; 長田 裕之 国立研究開発法人理化学研究所, 環境資源科学研究センター, 副センター長 (80160836) ; 旦 慎吾 公益財団法人がん研究会, がん化学療法センター・分子薬理部, 部長 (70332202) ; 井本 正哉 慶應義塾大学, 理工学部, 教授 (60213253) ; 川田 学 公益財団法人微生物化学研究会, 微生物化学研究所・第1生物活性研究部, 部長 (20300808) ; 田原 栄俊 広島大学, 大学院医歯薬保健学研究科(薬), 教授 (00271065) ; 吉田 稔 国立研究開発法人理化学研究所, 環境資源科学研究センター, グループディレクター (80191617) ; 松浦 正明 帝京大学, 大学院公衆衛生学研究科, 教授 (40173794) ; 牛嶋 大 公益財団法人がん研究会, 有明病院・臨床研究・開発センター, 研究員 (60328565) ; 吉田 進昭 東京大学, 医科学研究所, 教授 (10250341)
• Project Period (FY): 2016 – 2021
• Project Status: Granted (Fiscal Year 2020)
• Budget Amount: ¥2,403,960,000 (Direct Cost: ¥1,849,200,000、Indirect Cost: ¥554,760,000); Fiscal Year 2018: ¥400,660,000 (Direct Cost: ¥308,200,000、Indirect Cost: ¥92,460,000); Fiscal Year 2017: ¥400,660,000 (Direct Cost: ¥308,200,000、Indirect Cost: ¥92,460,000); Fiscal Year 2016: ¥400,660,000 (Direct Cost: ¥308,200,000、Indirect Cost: ¥92,460,000)
• Keywords: モデル動物作製 / ゲノム編集 / 病理形態解析 / 生理機能解析 / 分子探索・プロファイリング / 分子プロファイリング / 分子探索・ブロファイリング / 行動解析

Outline of Annual Research Achievements

①総括支援活動 : 若手技術講習会を9月11日にオンラインにて開催した。108名の参加者があり、活発な討論が行われた。成果発表会は2月2日にハイブリッド形式で開催し、被支援者による研究成果の紹介を中心に行われ252名の参加者があった。支援拠点の研究者と被支援者が分担で執筆した本支援活動を紹介する「マウス・ラットモデル作製・解析プロフェッショナル」を出版した。
②モデル動物作製支援活動 : 前・後期2回の公募で申請のあった計116件について一次・二次審査を行い、学術的に優れた83件の申請を採択した。それぞれの採択者と個別に協議し、最適な遺伝子改変技術を用いて、遺伝子改変マウスおよびラットを迅速に作製し、研究リソースとして提供した。
③病理形態解析支援活動 : 55件の申請を受け、3回の審査の結果、35件に関して病理形態解析を実施した。研究の方向性を裏付ける多くの成果が得られた。論文の図の作成など、論文が受理されるまで支援を実施した。
④生理機能解析支援活動 : 行動学的解析では26件、薬理学的解析では16件、光技術による操作解析では9件、多機能電極・計測データ解析では13件の申請について支援し、コロナ禍にもかかわらず、4つの支援の全てで、昨年度よりも支援数を増やした。支援は、動物モデルにおける病態・生理学的基盤の解明推進などに寄与し、Nat Commun誌、iScience誌などに成果が発表された。
⑤分子プロファイリング支援活動 : 化合物の分子プロファイリング48件、阻害剤キット配付18件、RNA干渉キット配付・siRNAデザイン合成5件、shRNAライブラリー探索2件、分子間相互作用解析1件(計74件、支援提供回数として505回)に加え、高次情報解析、動物実験に向けた技術相談を行った。被支援者と全班員の意見交換を目的としたユーザー会議を開催した。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

①総括支援活動 : 今年度はコロナ禍にもかかわらず、若手技術講習会をオンライン開催で、成果発表会をハイブリッド開催で実施することができ、反響も大きかった。また、広報活動の一層の充実を目的として、支援拠点のメンバーによる出版企画を実施することができた。
②モデル動物作製支援活動 : 研究実施計画に沿った支援を行うことができている。コロナ禍にあっても、リモート会議を活用した綿密な打ち合わせを実施した。また、最新技術を導入するとともに、支援拠点で開発されたリソースおよび技術を活用し、効率的な遺伝子改変を行った。さらに、動物受け入れが困難な施設については、支援拠点で凍結胚を作製し、一時保管を行った。
③病理形態解析支援活動 : 申請数は増加しており、事前相談や再審査によりできるだけ多く若手研究者の支援を行うよう努力している。現在の予算ならびに班員のエフォートにおいてできる最大限の支援活動を実施しており、成果は確実に上がっている。今年度は、支援結果の議論にウェブ会議も使用した。
④生理機能解析支援活動 : 支援対象者のモデルマウスを対象にした「網羅的行動テストバッテリー」を用いた行動解析支援を26件、依存性薬物等の感受性に関連する行動解析および規制薬物作用ゲノム関連解析支援を16件、進展著しい光遺伝学に関する最新技術を活用した研究支援を9件、多機能集積化電極による最先端の技術提供を行う多元的生理機能計測操作支援を13件で実施した。
⑤分子プロファイリング支援活動 : コロナ禍の影響が危ぶまれたが、被支援者との事前打ち合わせや日程の弾力的調整により、円滑な支援体制を維持することができた。本年度は被支援者の研究室の若手も含めた技術指導、動物実験・論文構想・特許出願などに関する助言を強化し、多くの案件が共同研究に進展した。寄託化合物ライブラリー支援により、被支援者間の異分野共同研究斡旋にも成果があった。

Strategy for Future Research Activity

①総括支援活動 : WEBを利用した講習会や発表会の内容の向上を図る。特にディスカッションが一層推進されることを目指す。広報活動として、「マウス・ラットモデル作製・解析プロフェッショナル」の紹介に力をいれ、若手研究者に本支援活動をより理解してもらうよう努める。
②モデル動物作製支援活動 : 先端的な遺伝子改変技術の導入および開発とともに、支援拠点が持つ独自のリソース活用することにより、科研費により進められる学術研究を支援する。学術的な価値や成功時の波及効果の高い支援課題については、より高度なリソースの開発・提供を行う。作製された遺伝子改変動物は、公共リソースバンクに供出し、学術基盤としての研究リソースの整備を推進する。
③病理形態解析支援活動 : 現在、予算ならびに班員のエフォートに関して限界に近い状態となっている。今後は審査をより厳格に行うが、少額研究費の若手の申請に特に対応したいと考えている。基本姿勢が、一旦開始した病理形態支援は論文が受理されるまでサポートするという方針に変化はない。
④生理機能解析支援活動 : 5つの拠点への支援申請が何れも安定して多数であるとともに増加していることから、引き続きニーズに応えられるように拠点における技術力を維持・向上させ、公正に支援課題を選考し、支援実施体制をハイレベルに保つ。また、技術支援にとどまらず、支援該当部の論文分担執筆を積極的に進め、成果の公表にも貢献する。
⑤分子プロファイリング支援活動 : 前年度に引き続き、被支援者の要望に応じた解析条件のカスタマイズ対応・支援実施後のフォロー(科学的助言・技術指導、高次支援の勧奨)に努めるとともに、定例班会議とユーザーミーティングで課題を共有し、効果的な共同研究の提案・斡旋を行う。モデル動物研究の起点的役割を担う当班の6年間の実績を俯瞰し、次代の生命科学を牽引する新しい支援の枠組みを提案する。

Research Products

• [Int'l Joint Research] Johns Hopkins University/Medical University of South Crolina/Van Andel Resarch Institute(米国)
• [Int'l Joint Research] University of Western Ontario(カナダ)
• [Int'l Joint Research] Université Claude Bernard Lyonl(フランス)
• [Int'l Joint Research] Beijing University of Technology(シンガポール)
• [Int'l Joint Research] Beijing University of Technology/南通大学(中国)
• [Int'l Joint Research]
• [Int'l Joint Research] Yale University/Stanford University/Johns Hopkins University(アメリカ)
• [Int'l Joint Research] University of Ottawa/University of Toronto(カナダ)
• [Int'l Joint Research] Helmholtz Zentrum Muenchen/Technische Universitaet Muenchen(ドイツ)
• [Int'l Joint Research] Pohang University of Science and Technology(シンガポール)
• [Int'l Joint Research] 南通大学(中国)
• [Int'l Joint Research]
• [Int'l Joint Research] コロンピア大学/イリノイ大学/タフツ大学（米国）
• [Int'l Joint Research] ボルドー大学/マリーキューリー医科大学/グルノーブルアルプス大学（フランス）
• [Int'l Joint Research] 江蘇大学/Xi'an Jiaotong University（中国）
• [Int'l Joint Research] Seoul national University/韓南大学（韓国）
• [Int'l Joint Research] シンガポール国立大学（シンガポール）
• [Int'l Joint Research]
• [Int'l Joint Research] ベイラー医科大学/フロリダ大学/アラバマ大学(米国)
• [Int'l Joint Research] UCL Cancer Institute University College London/St. George's Medical School University of London(英国)
• [Int'l Joint Research] The Institute of Science and Technology Austria(オーストリア)
• [Int'l Joint Research] カルガリー大学(カナダ)
• [Int'l Joint Research] スプリト大学(クロアチア)
• [Int'l Joint Research]
• [Int'l Joint Research] ベイラー医科大学(米国)
• [Int'l Joint Research] Harvard Medical School, Boston(米国)
• [Int'l Joint Research] スタンフォード大学/エール大学(米国)
• [Int'l Joint Research] 南通大学(中国)
• [Journal Article] Genetic implications in quality palliative care and preventing opioid crisis in cancer-related pain management. (2022)
  • Author(s): Sumitani M, Nishizawa D, Hozumi J, Ikeda K.
  • Journal Title: J Neurosci Res Volume: 100 Pages: 362-372
  • DOI: 10.1002/jnr.24756
  • Description: in press
  • Peer Reviewed
• [Journal Article] Application of Optogenetics for Muscle Cells and Stem Cells. (2021)
  • Author(s): Asano T, Teh DBL, Yawo H.
  • Journal Title: Adv Exp Med Biol. Volume: 1293 Pages: 359-375
  • DOI: 10.1007/978-981-15-8763-4_23
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Arf1 and Arf6 Synergistically Maintain Survival of T Cells during Activation (2021)
  • Author(s): M. Sumiyoshi, Y. Kotani, Y. Ikuta, K. Suzue, M. Ozawa, T. Katakai, T. Yamada, T. Abe, K. Bando, S. Koyasu, Y. Kanaho, T. Watanabe and S. Matsuda
  • Journal Title: J Immunology Volume: 206 Pages: 366-375
  • DOI: 10.4049/jimmunol.2000971
  • Peer Reviewed / Open Access
• [Journal Article] Association of urinary free cortisol with bone formation in patients with mild autonomous cortisol secretion. (2021)
  • Author(s): Ishida A, Igarashi K, Ruike Y, Ishiwata K, Naito K, Kono S, Deguchi H, Fujimoto M, Shiga A, Suzuki S, Yoshida T, Tanaka T, Tatsuno I, Yokote K, Koide H.
  • Journal Title: Cl in Endocrinol (Oxf). Volume: 94 Pages: 544-550
  • DOI: 10.1111/cen.14385
  • Peer Reviewed / Open Access
• [Journal Article] Behavioral consequences of a combination of Gadl Haplodeficiency and adolescent exposure to NMDA receptor antagonist in Long-Evans rat. (2021)
  • Author(s): Fujihara K, Sato T, Higeta K, Miyasaka Y, Mashimo T, Yanagawa Y.
  • Journal Title: Front Pharmacol. Volume: 12 Pages: 1-10
  • DOI: 10.3389/fphar.2021.646088
  • Peer Reviewed / Open Access
• [Journal Article] Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice (2021)
  • Author(s): Yoshida T, Yamagata A, Imai A, Kim J, Izumi H, Maenaka K, Shimada T, Fukata M, Nishijo H, Takao K, Okabe S, Tabuchi K, Mishina M, Mori H, Fukai S.
  • Journal Title: Nature communications Volume: 12(1) Issue: 1 Pages: 1848-1848
  • DOI: 10.1038/s41467-021-22059-6
  • NAID: 120006996978
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Chondroitin Sulfate N-acetylgalactosaminyltransferase-2 Impacts Foam Cell Formation and Atherosclerosis by Altering Macrophage Glycosaminoglycan Chain (2021)
  • Author(s): Adhikara IM, Yagi K, Mayasari DS, Suzuki Y, Ikeda K, Ryanto GRT, Sasaki N, Rikitake Y, Nadanaka S, Kitagawa H, Miyata O, Igarashi M, Hirata K, Emoto N
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 41 Issue: 3 Pages: 1076-1091
  • DOI: 10.1161/atvbaha.120.315789
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Concise synthesis and in vitro anticancer activity of benzo[g][1]benzopyrano[4, 3-b]indol-6(13H)-ones (BBPIs), topoisomerase I inhibitors based on the marine alkaloid lamellarin (2021)
  • Author(s): Fumito Ishibashi, Tsutomu Fukuda, Shijiao Zha, Aya Hashirano, Shotaro Hirao, Masatomo Iwao
  • Journal Title: Bioscience, Biotechnology, and Biochemistry Volume: 85 Pages: 181-191
  • DOI: 10.1093/bbb/zbaa028
  • Peer Reviewed
• [Journal Article] Constitutive increase of IL-17A in serum affects microglial activity in the hippocampal dentate gyrus. (2021)
  • Author(s): Sasaki T, Takei Y.
  • Journal Title: Jap J Biol Psych. Volume: 32 Issue: 2
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Design and synthesis of 14 and 15-membered macrocyclic scaffolds exhibiting inhibitory activities of hypoxia-inducible factor 1α (2021)
  • Author(s): Shimizu T, Takahashi N, Huber VJ, Asawa Y, Ueda H, Yoshimori A, Muramatsu Y, Seimiya H, Kouji H, Nakamura H, Oguri H.
  • Journal Title: Bioorg Med Chem. Volume: 30 Pages: 115949-115949
  • DOI: 10.1016/j.bmc.2020.115949
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Development of a label-free ATP image sensor for analyzing spatiotemporal patterns of ATP release from biological tissues (2021)
  • Author(s): Doi H, Parajuli B, Horio T, Shigetomi E, Shinozaki Y, Noda T, Takahashi K, Hattori T, Koizumi S, Sawada K
  • Journal Title: Sensors and Actuators B : Chemical Volume: 335 Pages: 129686-129686
  • DOI: 10.1016/j.snb.2021.129686
  • Peer Reviewed / Open Access
• [Journal Article] Differences between a therosclerotic and non-atherosclerotic patients in expression levels of inflammatory mediators in the adipose tissue around the coronary artery. (2021)
  • Author(s): Suzuki T, Ogita H, Sato A, Minamidate N, Hachiro K.
  • Journal Title: Int. Heart J. Volume: 62 Issue: 2 Pages: 390-395
  • DOI: 10.1536/ihj.20-585
  • NAID: 130008007468
  • ISSN: 1349-2365, 1349-3299
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Distinct effects of chondroitin sulfate on hematopoietic cells and the stromal microenvironment in bone marrow hematopoiesis. (2021)
  • Author(s): Katagiri T, Ushiki T, Nakajima-Takagi Y, Oshima M, Mikami T, Kawasaki A, Ishiguro H, Tanaka T, Sone H, Kitagawa H, Igarashi M, Iwama A, Masuko M
  • Journal Title: Exp Hematol Volume: 96 Pages: 52-62
  • DOI: 10.1016/j.exphem.2021.02.003
  • Peer Reviewed
• [Journal Article] Divergent Total Synthesis of Azalamellarins D and N (2021)
  • Author(s): Tsutomu Fukuda, Seiya Okutani, Mayu Sumi, Kazuhito Miyagi, Gen Onodera, Masanari Kimura
  • Journal Title: Heterocycles Volume: 103
  • DOI: 10.3987/com-20-s(k)53
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons (2021)
  • Author(s): Kawahata I, Sekimori T, Wang H, Wang Y, Sasaoka T, Bousset L, Melki R, Mizobata T, Kawata Y, Fukunaga K.
  • Journal Title: Biomedicines Volume: 9 Issue: 1 Pages: 49-49
  • DOI: 10.3390/biomedicines9010049
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice. (2021)
  • Author(s): Ito, N., Riyadh, M., Ahmad, S., Hattori, S., Miyakawa, T. and Ohta, K., et al.
  • Journal Title: Science Translational Medicine Volume: 13 Issue: 587 Pages: 7896-7896
  • DOI: 10.1126/scitranslmed.aay7896
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of RORγt overexpression on the murine central nervous system. (2021)
  • Author(s): Sasaki T, Nagata R, Takahashi S, Takei Y
  • Journal Title: Neuropsychopharmacology Reports Pages: 1-9
  • NAID: 120007132525
  • Peer Reviewed / Open Access
• [Journal Article] Fhod3 Controls the Dendritic Spine Morphology of Specific Subpopulations of Pyramidal Neurons in the Mouse Cerebral Cortex (2021)
  • Author(s): Hikmawan Wahyu Sulistomo, Takayuki Nemoto, Yohko Kage, Hajime Fujii, Taku Uchida, Kogo Takamiya, Hideki Sumimoto, Hiroaki Kataoka, Haruhiko Bito, Ryu Takeya
  • Journal Title: Cerebral Cortex Volume: 31 Pages: 2205-2219
  • DOI: 10.1093/cercor/bhaa355
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Genetic deletion of the 67-kDa isoform of glutamate decarboxylase alters conditioned fear behavior in rats. (2021)
  • Author(s): Fujihara K, Sato T, Miyasaka Y, Mashimo T, Yanagawa Y.
  • Journal Title: FEBS Open Bio. Volume: 11 Pages: 340-353
  • DOI: 10.1002/2211-5463.13065
  • Description: in press
  • Peer Reviewed / Open Access
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• [Journal Article] Ni-catalyzed direct carboxylation of propargylic alcohols with carbon dioxide (2021)
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  • Peer Reviewed
• [Journal Article] Nickel-Catalyzed Carboxylation of Conjugated Dienes with Carbon Dioxide and DIBAL-H for the Synthesis of β,γ-Unsaturated Carboxylic Acids (2021)
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• [Journal Article] Phosphorylation of GAP-43 T172 is a molecular marker of growing axons in a wide range of mammals including primates. (2021)
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• [Journal Article] Potential role of astrocytes and Muller cells in the pathogenesis of glaucoma (2021)
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• [Journal Article] Stomatin-mediated inhibition of the Akt signaling axis suppresses tumor growth. (2021)
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• [Journal Article] Synthesis and evaluation of azalamellarin N and its A-ring-modified analogues as non-covalent inhibitors of the EGFR T790M/L858R mutant (2021)
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• [Journal Article] Total Synthesis and Biological Evaluation of Oscillatoxin D, E, and F (2021)
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• [Journal Article] Transnasal transplantation of human induced pluripotent stem cell-derived microglia to the brain of immunocompetent mice. (2021)
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• [Journal Article] TRIM28 Expression on Dendritic Cells Prevents Excessive T Cell Priming by Silencing Endogenous Retrovirus (2021)
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• [Journal Article] 環境応答・適応の分子機構 (2021)
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• [Journal Article] Dual targeting of DDX3 and eIF4A by the translation inhibitor rocaglamide A. (2021)
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• [Journal Article] Role of 5-HT1A receptor-mediated serotonergic transmission in the medial prefrontal cortex in acute restraint stress-induced augmentation of rewarding memory of cocaine in mice (2021)
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• [Journal Article] The synchronized gene expression of retrotransposons and type I interferon in dermatomyositis (2021)
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• [Journal Article] A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation (2020)
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• [Journal Article] ALDH1A3-mTOR axis as a therapeutic target for anticancer drug-tolerant persister cells in gastric cancer. (2020)
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• [Journal Article] Time-restricted G-protein signaling pathways via GPR176. Gz, and RGS16 set the pace of the master circadian clock in the suprachiasmatic nucleus. (2020)
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• [Journal Article] Vestigial-like family member 3 (VGLL3), a cofactor for TEAD transcription factors, promotes cancer cell proliferation by activating the Hippo pathway (2020)
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• [Journal Article] Molecular basis of the functions of the mammalian neuronal growth cone revealed using new methods. (2019)
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  • Author(s): 吾郷 由希夫、田邊 航、樋口 桃子、塚田 信司、田中 辰典、五十嵐 久人、横山 玲、勢力 薫、笠井 淳司、中澤 敬信、中川 晋作、橋本 謙二、橋本 均
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• [Journal Article] 5-Aza-2-deoxycytidine Enhances the Sensitivity of 5-Fluorouracil by Demethylation of the Thymidine Phosphorylase Promoter (2019)
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  • Author(s): Masami Ishido
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  • Journal Title: Neuroimage Volume: 印刷中 Pages: 243-251
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• [Journal Article] Enhanced emotional memory retrieval by chemogenetic activation of locus coeruleus norepinephrine neurons. (2019)
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• [Journal Article] IER5 Is a p53-Regulated Activator of HSF1 That Contributes to Promotion of Cancer. (2019)
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• [Journal Article] In Vitro and in Vivo antitumor activity and the mechanism of siphonodictyal B in human colon cancer cells (2019)
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• [Journal Article] KIF17-mediated transport of NMDA receptors and schizophrenia. (2019)
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• [Journal Article] Locomotor kinematics and EMG activity during quadrupedal versus bipedal gait in the Japanese macaque (2019)
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  • Journal Title: Pathobiology Volume: 86 Pages: 254-262
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• [Journal Article] Lineage-specific RUNX2 super-enhancer activates MYC via a chromosomal translocation and promotes the development of blastic plasmacytoid dendritic cell neoplasm (2019)
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• [Journal Article] Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-1 (2019)
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• [Journal Article] TFE3 Xpll. 2 translocation renal cell carcinoma mouse model reveals novel therapeutic targets and identifies GPNMB as a diagnostic marker for human disease (2019)
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• [Journal Article] Stereo-Divergent Synthesis of Bispyrrolidinoindoline Alkaloidal Scaffolds and Generation of a Lead Candidate with Stereospecific Anti-proliferative Activity (2019)
  • Author(s): Mitsuhiro Wada, Hiroyuki Suzuki, Mitsuyasu Kato, Hideaki Oikawa, Akira Tsubouchi, Hiroki Oguri
  • Journal Title: ChemBioChem Volume: 20 Pages: 1273-1281
  • DOI: 10.1002/cbic.201800815
  • Peer Reviewed
• [Journal Article] Forkhead box protein A1 confers resistance to transforming growth factor‐β‐induced apoptosis in breast cancer cells through inhibition of Smad3 nuclear translocation (2019)
  • Author(s): Hirata K, Takakura Y, Shibazaki M, Morii M, Honda T, Oshima M, Aoyama K, Iwama A, Nakayama Y, Takano H, Yamaguchi N, Yamaguchi N
  • Journal Title: J Cell Biochem. Volume: 120 Pages: 2259-2270
  • DOI: 10.1002/jcb.27551
  • Peer Reviewed
• [Journal Article] Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo [g] [1] benzopyrano [4, 3-b] indol-6 (13H)-one scaffold (2019)
  • Author(s): Tsutomu Fukuda, Yusuke Nanjo, Masahiro Fujimoto, Kenyu Yoshida, Yuko Natsui, Fumito Ishibashi, Fumiyasu Okazaki, Hideto To, Masatomo Iwao
  • Journal Title: Bioorganic and Medicinal Chemistry Volume: 27 Issue: 2 Pages: 265-277
  • DOI: 10.1016/j.bmc.2018.11.037
  • NAID: 120006987774
  • Peer Reviewed / Open Access
• [Journal Article] Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistance. (2019)
  • Author(s): Okada, K., Araki, M., Sakashita, T., Ma, B., Kanda, R., Yanagitani, N., Horiike, A., Koike, S., Oh-Hara, T., Watanabe, K., Tamai, K., Maemondo, M., Nishio, M., Ishikawa, T., Okuno, Y., Fujita, N. and *Katayama, R.
  • Journal Title: EBioMedicine Volume: 41 Pages: 105-119
  • DOI: 10.1016/j.ebiom.2019.01.019
  • NAID: 120006892063
  • Peer Reviewed / Open Access
• [Journal Article] High filamin-C expression predicts enhanced invasiveness and poor outcome in glioblastoma multiforme. (2019)
  • Author(s): Kamil M, Shinsato Y, Higa N, Hirano T, Idogawa M, Takajo T, Minami K, Shimokawa M, Yamamoto M, Kawahara K, Yonezawa H, Hirano H, Furukawa T, Yoshimoto K, Arita K.
  • Journal Title: British Journal of Cancer Volume: 120 Pages: 819-826
  • DOI: 10.1038/s41416-019-0413-x
  • Description: Epub ahead of print
  • Peer Reviewed / Open Access
• [Journal Article] Synthesis and evaluation of topoisomerase I inhibitors possessing the 5, 13-dihydro-6H-benzo [6, 7] indolo [3, 2-c] quinolin-6-one scaffold (2019)
  • Author(s): Tsutomu Fukuda, Yuri Matsuo, Fuyuki Matsuoka, Naoki Yoshioka, Gen Onodera, Masanari Kimura, Fumito Ishibashi, Masatomo Iwao
  • Journal Title: Heterocycles Volume: 99 Pages: 1032-1032
  • DOI: 10.3987/com-18-s(f)70
  • NAID: 120006988387
  • Peer Reviewed / Open Access
• [Journal Article] mS-11, a mimetic of the mSin3-binding helix in NRSF, ameliorates social interaction deficits in a prenatal valproic acid-induced autism mouse model. (2019)
  • Author(s): Kawase H, Ago Y, Naito M, Higuchi M, Hara Y, Hasebe S, Tsukada S, Kasai A, Nakazawa T, Mishina T, Kouji H, Takuma K, Hashimoto H.
  • Journal Title: Pharmacology Biochemistry and Behavior Volume: 176 Pages: 1-5
  • DOI: 10.1016/j.pbb.2018.11.003
  • Peer Reviewed / Open Access
• [Journal Article] Perturbed expression pattern of the immediate early gene Arc in the dentate gyrus of GluAl C-terminal palmitoylation deficient mice. (2019)
  • Author(s): Itoh M, Okuno H, Yamada D, Yamashita M, Abe M, Natsume R, Kaizuka T, Sakimura K, Hoshino M, Mishina M, Wada K, Sekiguchi M, Hayashi T
  • Journal Title: Neuropsychopharmacology Reports Volume: 39 Pages: 61-66
  • DOI: 10.1002/npr2.12044
  • Peer Reviewed / Open Access
• [Journal Article] Measuring Nonselective and Selective Autophagy in the Liver (2019)
  • Author(s): Ueno T, Kaomatsu M
  • Journal Title: Methods Mol Biol Volume: 1880 Pages: 535-540
  • DOI: 10.1007/978-1-4939-8873-0_34
  • Peer Reviewed
• [Journal Article] Reconsolidation/Destabilization, Extinction and Forgetting of Fear Memory as Therapeutic Targets for PTSD. (2019)
  • Author(s): Kida, S
  • Journal Title: Psychopharmacology Volume: 236 Pages: 49-57
  • DOI: 10.1007/s00213-018-5086-2
  • Peer Reviewed / Open Access
• [Journal Article] NSP-C contributes to the upregulation of CLOCK/BMALl-mediated transcription. (2019)
  • Author(s): Hosoda, H., *Kida, S
  • Journal Title: Cytotechnology Volume: 71 Pages: 453-460
  • DOI: 10.1007/s10616-018-0266-9
  • Peer Reviewed
• [Journal Article] CCN2/CTGF binds the small leucine rich proteoglycan protein Tsukushi. (2019)
  • Author(s): Ohta K, Aoyama E, Ahmad SAI, Ito N, Anam MB, Kubota S, Takigawa M.
  • Journal Title: J Cell Commun Signal. Volume: 13(1) Issue: 1 Pages: 113-118
  • DOI: 10.1007/s12079-018-0487-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Deregulated Polycomb functions in myeloproliferative neoplasms. (2019)
  • Author(s): Sashida G, Oshima M, Iwama A.
  • Journal Title: International Journal of Hematology Volume: 110 Pages: 170-178
  • DOI: 10.1007/s12185-019-02600-6
  • Peer Reviewed / Open Access
• [Journal Article] Chondroitin sulfate N-acetylgalactosaminyltransferase-2 deletion alleviates lipoprotein retention in early atherosclerosis and attenuates aortic smooth muscle cell migration. (2019)
  • Author(s): Adhikara IM, *Yagi K, Mayasari DS, Ikeda K, Kitagawa H, Miyata O, Igarashi M, Hatakeyama K, Asada Y, Hirata K, Emoto N
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 509 Pages: 89-95
  • DOI: 10.1016/j.bbrc.2018.12.068
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling (2019)
  • Author(s): Katsuya K, Oikawa D, Iio K, Obika S, Hori Y, Urashima T, Ayukawa K, Tokunaga F.
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 509 Issue: 3 Pages: 700-706
  • DOI: 10.1016/j.bbrc.2018.12.164
  • Peer Reviewed
• [Journal Article] Role for tyrosine phosphorylation of SUV39H1 histone methyltransferase in enhanced trimethylation of histone H3K9 via neuregulin-1/ErbB4 nuclear signaling. (2019)
  • Author(s): Nakajo H, Ishibashi K, Aoyama K, Kubota S, Hasegawa H, Yamaguchi N, Yamaguchi N
  • Journal Title: Biochem Biophys Res Commun. Volume: 511 Pages: 765-771
  • DOI: 10.1016/j.bbrc.2019.02.130
  • Peer Reviewed
• [Journal Article] Model studies for isolation of G-quadruplex-forming DNA sequences through a pull-down strategy with macrocyclic polyoxazole (2019)
  • Author(s): Keisuke Iida, Yamato Tsushima, Yue Ma, Shadi Sedghi Masoud, Mai Sakuma, Tomomi Yokoyama, Wataru Yoshida, Kazunari Ikebukuro, Kazuo Nagasawa
  • Journal Title: Bioorg. Med. Chem. Volume: 27 Issue: 8 Pages: 1742-1746
  • DOI: 10.1016/j.bmc.2019.02.056
  • Peer Reviewed
• [Journal Article] Analysis of the neuronal network of the medullary respiratory center in transgenic rats expressing archaerhodopsin-3 in Phox2b-expressing cells. (2019)
  • Author(s): Ikeda K, Kaneko R Yanagawa Y, Ogawa M, et al.
  • Journal Title: Brain Res Bull Volume: 144 Pages: 39-45
  • DOI: 10.1016/j.brainresbull.2018.11.005
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• [Journal Article] Dietary magnesium deficiency impairs hippocampus-dependent memories without changes in the spine density and morphology of hippocampal neurons in mice. (2019)
  • Author(s): Serita, T., Miyahara, M., Tanimizu, T., Takahashi, S., Oishi, S., Nagayoshi, T., Tsuji, R., Inoue, H., Uehara, M., Kida, S*.
  • Journal Title: Brain Res Bull. Volume: 144 Pages: 149-157
  • DOI: 10.1016/j.brainresbull.2018.11.019
  • Peer Reviewed / Open Access
• [Journal Article] Comparative evaluation of genetically encoded voltage indicators (2019)
  • Author(s): Bando Y*, Sakamoto M* (Co-first and corresponding author), Kim S, Ayzenshtat I, Yuste R.
  • Journal Title: Cell Reports Volume: 26 Issue: 3 Pages: 802-813
  • DOI: 10.1016/j.celrep.2018.12.088
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Large Timescale Interrogation of Neuronal Function by Fiberless Optogenetics Using Lanthanide Micro-particles. 26(4) : 1033-1043. e5. (2019)
  • Author(s): Miyazaki T, Chowdhury S, Yamashita T, Matsubara T, Yawo H, Yuasa H, Yamanaka A.
  • Journal Title: Cell Rep. Volume: 26 Issue: 4 Pages: 1033-1043
  • DOI: 10.1016/j.celrep.2019.01.001
  • Peer Reviewed / Open Access
• [Journal Article] Ras activation in retinal progenitor cells induces tumor formation in the eye (2019)
  • Author(s): Koso H, Tsuhako A, Matsubara D, Fujita Y, Watanabe S.
  • Journal Title: Exp, Eye Res. Volume: 180 Pages: 39-42
  • DOI: 10.1016/j.exer.2018.11.025
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Defecation initiates walking in the cricket Gryllus bimaculatus (2019)
  • Author(s): Naniwa K., Sugimoto Y., Osuka K. and Aonuma H.
  • Journal Title: Journal of Insect Physiology Volume: 112 Pages: 117-122
  • DOI: 10.1016/j.jinsphys.2018.11.004
  • Peer Reviewed
• [Journal Article] The translation inhibitor Rocaglamide targets a bimolecular cavity between eIF4A and polypurine RNA. (2019)
  • Author(s): Iwasaki S. *, Iwasaki W., Takahashi M., Sakamoto A., Watanabe C., Shichino Y., Floor SN., Fujiwara K., Mito M., Dodo K., Sodeoka M., Imataka H., Honma T., Fukuzawa K., Ito T. *, and Ingolia NT. *
  • Journal Title: Mol. Cell Volume: 73 Pages: 1-10
  • DOI: 10.1016/j.molcel.2018.11.026
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Administration of tetrahydrobiopterin restored the decline of dopamine in the striatum induced by an acute action of MPTP. (2019)
  • Author(s): Kurosaki H. Yamaguchi K, Man-Yoshi K, Muramatsu SI, Hara S, Ichinose H
  • Journal Title: Neurochemistry International Volume: 125 Pages: 16-24
  • DOI: 10.1016/j.neuint.2019.02.005
  • Peer Reviewed
• [Journal Article] Preproenkephalin-expressing ventral pallidal neurons control inhibitory avoidance learning. (2019)
  • Author(s): Macpherson T, Mizoguchi H, Yamanaka A, Hikida T.
  • Journal Title: Neurochem Int Volume: 126 Pages: 11-18
  • DOI: 10.1016/j.neuint.2019.02.011
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• [Journal Article] Carboxymethylation of CRMP2 is associated with decreased Schwann cell myelination efficiency. (2019)
  • Author(s): Saitoh F, Hagiwara H, Wakatsuki S, Araki T.
  • Journal Title: Neuroscience Resarch Volume: 139 Pages: 58-62
  • DOI: 10.1016/j.neures.2018.08.015
  • Peer Reviewed
• [Journal Article] Inhibition of collapsin response mediator protein-2 phosphorylation ameliorates motor phenotype of ALS model mice expressing SODIG93A. (2019)
  • Author(s): Numata-Uematsu Y, Wakatsuki S, Nagano S, Shibata M, Sakai K, Ichinohe N, Mikoshiba K, Ohshima T, Yamashita N, Goshima Y, Araki T.
  • Journal Title: Neuroscience Resarch Volume: 139 Pages: 63-68
  • DOI: 10.1016/j.neures.2018.08.016
  • Peer Reviewed
• [Journal Article] Different types of suppression-burst patterns in patients with epilepsy of infancy with migrating focal seizures (EIMFS). (2019)
  • Author(s): Yoshitomi S, Takahashi Y, Imai K, Koshimizu E, Miyatake S, Nakashima M, Saitsu H, Matsumoto N, Kato M, Fujita T, Ishii A, Hirose S, Inoue Y.
  • Journal Title: Seizure Volume: 65 Pages: 118-123
  • DOI: 10.1016/j.seizure.2019.01.009
  • Peer Reviewed
• [Journal Article] Desuppression of TGF-β signaling via nuclear c-Abl-mediated phosphorylation of TIF1γ/TRIM33 at Tyr-524, -610, and -1048. (2019)
  • Author(s): Yuki R, Tatewaki T, Yamaguchi N, Aoyama K, Honda T, Kubota S, Morii M, Manabe I, Kuga T, Tomonaga T, Yamaguchi N
  • Journal Title: Oncogene Volume: 38 Pages: 635-655
  • DOI: 10.1038/s41388-018-0481-z
  • Peer Reviewed
• [Journal Article] Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway. (2019)
  • Author(s): Nam SA, Kim WY, Kim JW, Park SH, Kim Hl, Lee MS, Komatsu M, Ha H, Lim JH, Park CW, Yang CW, Kim J, Kim YK.
  • Journal Title: Cell Death Dis. Volume: 10 Issue: 2 Pages: 535-540
  • DOI: 10.1038/s41419-019-1356-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Autophagy regulates lipid metabolism through selective turnover of NCoRl (2019)
  • Author(s): Saito Tetsuya、Kuma Akiko、Sugiura Yuki、Ichimura Yoshinobu、Obata Miki、Kitamura Hiroshi、Okuda Shujiro、Lee Hyeon-Cheol、Ikeda Kazutaka、Kanegae Yumi、Saito Izumu、Auwerx Johan、Motohashi Hozumi、Suematsu Makoto、Soga Tomoyoshi、Yokomizo Takehiko、Waguri Satoshi、Mizushima Noboru、Komatsu Masaaki
  • Journal Title: Nature Communication Volume: 10 Issue: 1 Pages: 1567-1567
  • DOI: 10.1038/s41467-019-08829-3
  • NAID: 120006884308
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cdkl-mediated DIAPHI phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase. (2019)
  • Author(s): Nishimura K, Johmura Y, Deguchi K, Jiang Z, Uchida KSK, Suzuki N, Shimada M, Chiba Y, Hirota T, Yoshimura SH, Kono K, Nakanishi M.
  • Journal Title: Nat commun. Volume: 10 Issue: 1 Pages: 1-10
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Upconversion Amplification through Dielectric Superlensing Modulation. (2019)
  • Author(s): Liang L, Teb D, Dinh ND, Chen W, Chen Q, Wu Y, Chowdhury S, Yamanaka A, Sum TC, Chen CH, Thakor N, All A, Liu X
  • Journal Title: Nat Commun Volume: 10(1) Issue: 1 Pages: 1391-1391
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Reversible S-glutathionylation of human 6-pyruvoyl tetrahydropterin synthase protects its enzymatic activity. (2019)
  • Author(s): Hara S, Fukumura S, Ichinose H
  • Journal Title: J Biol Chem Volume: 294 Pages: 1420-1427
  • DOI: 10.1074/jbc.ra118.005280
  • Peer Reviewed
• [Journal Article] Markerless visual servo control of a servosphere for behavior observation of a variety of wandering animals (2019)
  • Author(s): Iwatani Y, Ogawa, H, Shidara H, Sakura M, Sato T. Hojo MK, Honma A, Tsurui K
  • Journal Title: Advanced Robotics Volume: 33 Pages: 183-194
  • DOI: 10.1080/01691864.2019.1570334
  • Peer Reviewed / Open Access
• [Journal Article] Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non-small cell lung cancer. (2019)
  • Author(s): Gong B., Kiyotani K., Sakata S., Nagano S., Kumehara S., Baba S., Besse B., Yanagitani N., Friboulet L., Nishio M., Takeuchi K., Kawamoto H., Fujita N., *Katayama R.
  • Journal Title: Journal of Experimental Medicine Volume: 216 Pages: 982-1000
  • DOI: 10.1084/jem.20180870
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis. (2019)
  • Author(s): Muto Y., Moroishi T., Ichihara K., Nishiyama M., Shimizu H., Eguchi H., Moriya K., Koike K., Mimori K., Mori M., Katayama Y., Nakayama KI.
  • Journal Title: J. Exp. Med. Volume: 216 Issue: 4 Pages: 950-965
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  • Peer Reviewed / Open Access
• [Journal Article] Prefrontal-Enriched SLITI Expression in Primate Cortex and its Alteration during Cortical Development (2019)
  • Author(s): Tetsuya Sasaki (Corresponding Author), Yusuke Komatsu, Tetsuo Yamamori (Corresponding Author)
  • Journal Title: Japanese Journal of Biological Psychiatry Volume: 20(10) Issue: 10 Pages: 2496-2510
  • DOI: 10.1093/cercor/bhp319
  • Peer Reviewed
• [Journal Article] NPY deficiency prevents postmenopausal adiposity by augmenting estradiol-mediated browning. (2019)
  • Author(s): Park S, Nayantai E, Komatsu T, Hayashi H, Mori R, Shimokawa I
  • Journal Title: J Gerontol A Biol Sci Med Sci. Volume: -
  • DOI: 10.1093/gerona/gly282
  • NAID: 120006988174
  • Description: in press