先端モデル動物支援プラットフォーム

• Project/Area Number: 16H06276
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas ― Platforms for Advanced Technologies and Research Resources
• Allocation Type: Single-year Grants
• Research Institution: The University of Tokyo
• Principal Investigator(Support): 今井 浩三 東京大学, 医科学研究所, 客員教授 (60117603)
• Co-Investigator(Kenkyū-buntansha)(Support): 中村 卓郎 公益財団法人がん研究会, がん研究所, 副所長 (00180373) ; 井上 純一郎 東京大学, 医科学研究所, 教授 (70176428) ; 高田 昌彦 京都大学, 霊長類研究所, 教授 (00236233) ; 山田 泰広 東京大学, 医科学研究所, 教授 (70313872) ; 高橋 智 筑波大学, 医学医療系, 教授 (50271896) ; 伊川 正人 大阪大学, 微生物病研究所, 教授 (20304066) ; 﨑村 建司 新潟大学, 脳研究所, フェロー (40162325) ; 荒木 喜美 熊本大学, 生命資源研究・支援センター, 教授 (90211705) ; 八尾 良司 公益財団法人がん研究会, がん研究所・細胞生物部, 部長 (80291095) ; 真下 知士 大阪大学, 大学院医学系研究科, 准教授 (80397554) ; 小林 和人 福島県立医科大学, 医学部, 教授 (90211903) ; 豊國 伸哉 名古屋大学, 大学院医学系研究科, 教授 (90252460) ; 鰐渕 英機 大阪市立大学, 大学院医学研究科, 教授 (90220970) ; 今井田 克己 香川大学, 医学部, 教授 (90160043) ; 二口 充 長崎大学, 病院(医学系), 准教授 (60275120) ; 上野 正樹 香川大学, 医学部, 教授 (30322267) ; 宮崎 龍彦 岐阜大学, 医学部附属病院, 准教授 (80239384) ; 神田 浩明 埼玉県立がんセンター(臨床腫瘍研究所), 病理診断科, 部長 (90260067) ; 尾藤 晴彦 東京大学, 大学院医学系研究科, 教授 (00291964) ; 宮川 剛 藤田保健衛生大学, 総合医科学研究所, 教授 (10301780) ; 高雄 啓三 富山大学, 研究推進機構・研究推進総合支援センター, 教授 (80420397) ; 池田 和隆 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 分野長 (60281656) ; 虫明 元 東北大学, 大学院医学系研究科, 教授 (80219849) ; 清宮 啓之 公益財団法人がん研究会, がん化学療法センター・分子生物治療研究部, 部長 (50280623) ; 長田 裕之 国立研究開発法人理化学研究所, 環境資源科学研究センター, 副センター長 (80160836) ; 旦 慎吾 公益財団法人がん研究会, がん化学療法センター・分子薬理部, 部長 (70332202) ; 井本 正哉 慶應義塾大学, 理工学部, 教授 (60213253) ; 川田 学 公益財団法人微生物化学研究会, 微生物化学研究所・第1生物活性研究部, 部長 (20300808) ; 田原 栄俊 広島大学, 大学院医歯薬保健学研究科(薬), 教授 (00271065) ; 吉田 稔 国立研究開発法人理化学研究所, 環境資源科学研究センター, グループディレクター (80191617) ; 松浦 正明 帝京大学, 大学院公衆衛生学研究科, 教授 (40173794) ; 牛嶋 大 公益財団法人がん研究会, 有明病院・臨床研究・開発センター, 研究員 (60328565) ; 吉田 進昭 東京大学, 医科学研究所, 教授 (10250341)
• Project Period (FY): 2016 – 2021
• Project Status: Granted (Fiscal Year 2018)
• Budget Amount: ¥2,403,960,000 (Direct Cost: ¥1,849,200,000、Indirect Cost: ¥554,760,000); Fiscal Year 2018: ¥400,660,000 (Direct Cost: ¥308,200,000、Indirect Cost: ¥92,460,000); Fiscal Year 2017: ¥400,660,000 (Direct Cost: ¥308,200,000、Indirect Cost: ¥92,460,000); Fiscal Year 2016: ¥400,660,000 (Direct Cost: ¥308,200,000、Indirect Cost: ¥92,460,000)
• Keywords: モデル動物作製 / ゲノム編集 / 病理形態解析 / 生理機能解析 / 分子プロファイリング / 分子探索・プロファイリング / 分子探索・ブロファイリング / 行動解析

Outline of Annual Research Achievements

①総括支援活動 : 前年度立ち上げたホームページ(HP)に改良を加えて公募の円滑化を進めた。モデル動物作製解析の講習や若手研究者の交流促進を推進する技術講習会を開催した。成果ワークショップを開催し本活動の支援成果をアピールした。
②モデル動物作製支援活動 : 相同組換えやゲノム編集など支援課題に応じた最適な胚操作技術を用いて、様々な遺伝子改変マウスおよびラットを的確かつ迅速に作製し、学術性の高い個体レベルの研究推進に資する研究リソースとして提供した。件数は昨年度より大幅に増加した。
③病理形態解析支援活動 : 昨年より多い35件の病理形態解析支援を7名の班員で実施した。研究の方向性を決定づける多くの成果が得られた。論文の図の作成にもかかわり、論文が受理されるまで支援を行った。その結果、より高いレベルの科学誌にも受理された。
④生理機能解析支援活動 : 疾患モデルマウスの行動解析支援を実施するとともに、諸動物モデルでの規制薬物感受性解析、光遺伝学的in vivo細胞操作、意志決定に関与する脳深部機能解析、等の支援を展開した。
⑤分子プロファイリング支援活動 : 依頼化合物の分子プロファイリング316件、阻害剤キット配付86枚、RNA干渉キット配付・siRNAデザイン合成83件、バーコードshRNAライブラリーによる化合物の標的経路探索15件、を実施し、より多くの研究者の利便性を図った。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

①総括支援活動 : HPの改良により公募申請と選考作業の効率化が促進された。技術講習会と成果発表会も多くの参加者を得て好評裡に開催することができた。特に、参加者の研究分野の多様性が顕著になったことと、支援の成果がより可視化出来るようになった。成果発表会等の機会に幹事・班長が意見交換して、より良い支援のあり方を検討してきた。
②モデル動物作製支援活動 : 毎年、増加している応募に対し、効率的に遺伝子改変動物を作製することにより、予算が許す範囲で可能な限りの課題数を採択している。特に、学術性の高い課題については、新規技術の導入・開発を行い対応している。
③病理形態解析支援活動 : 年を追うごとに病理形態支援希望数が増加している。現在の予算と人員においてできる最大限のことを実施しており、確実に成果は上がっていると認識している。
④生理機能解析支援活動 : 生理機能解析支援拠点としては、当初設定した支援件数を概ね達成するとともに、被支援研究者からの要望にも適切に対応できており、着実に支援が進展していると考える。
⑤分子プロファイリング支援活動 : 支援内容の性質上、萌芽的な課題であっても最大限に採択する方針を維持し、フル稼働で支援を実施した。但し、昨年度と比べて応募数が増加したため、マンパワーと予算が許容範囲を超えた部分に関しては、年度の途中で公募を中断する措置が必要であった。一部の採択課題において、評価依頼化合物の在庫不足など、被支援者側の都合により支援の実施が遅延したケースもあったが、おおむね想定内の事態として対応することが出来た。

Strategy for Future Research Activity

①総括支援活動 : HPを利用した広報は順調に進んでいるので、今後は支援により得られた成果の広報にも力を入れたい。さらに学会とのネットワークを作成しつつある。技術講習会では生命科学連携推進協議会や他のプラットフォームとの連携を推進し、H30年度はコホート・生体試料支援プラットフォームから参加者を受け入れる。
②モデル動物作製支援活動 : 予算限度を越える応募があり、採択することができる支援課題数に限りがある。今後は、先端的なゲノム編集技術や研究リソースを積極的に導入・開発することにより、さらなる効率化と迅速化による支援活動の拡充を図る。
③病理形態解析支援活動 : 現在、予算ならびに実施人員に関してもほぼ限界となっている。これまで一次審査ならびに二次審査を実施していたが、ほとんどの課題を最終的に採択していた。今後は年数回に分けて審査をもう少し厳格に行い、実施数を少し制限することを考慮している。ただし、一度始めた病理解析支援は論文が受理されるまでサポートするという方針に変化はない。
④生理機能解析支援活動 : これまで2年間の支援活動における推進方策を今後も引き続き堅持するとともに、被支援研究者からのフィードバックに対応し、より多くの要望実現できるよう、解析技術の向上と支援活動の益々の発展に努める。
⑤分子プロファイリング支援活動 : 広報活動により被支援者層の拡大を図るとともに、支援実施後も適宜、科学的助言や共同研究斡旋などのフォローを行う。細胞パネル・細胞表現型解析支援で特に興味深い結果が得られた課題については、オミクス解析支援への再応募を勧奨する。高度な統計解析などの要望も出てきているので、適宜共同研究に移行しながら、高い成果を上げるために柔軟に対応する。年2回の定例班会議で問題点を洗い出し、常に最善の運用体制で支援を実施する。

Research Products

• [Int'l Joint Research] ベイラー医科大学/フロリダ大学/アラバマ大学(アメリカ合衆国)
• [Int'l Joint Research] UCL Cancer Institute University College London/St. George's Medical School University of London(イギリス)
• [Int'l Joint Research] The Institute of Science and Technology Austria(オーストリア)
• [Int'l Joint Research] カルガリー大学(カナダ)
• [Int'l Joint Research] スプリト大学(クロアチア共和国)
• [Int'l Joint Research]
• [Int'l Joint Research] ベイラー医科大学(アメリカ合衆国)
• [Int'l Joint Research] Harvard Medical School, Boston(アメリカ合衆国)
• [Int'l Joint Research] スタンフォード大学/エール大学(アメリカ合衆国)
• [Int'l Joint Research] 南通大学(中国)
• [Journal Article] Opioid and non-dopamine reward circuitry and state-dcpendent mechanisms. (2019)
  • Author(s): Fujita M, Ide S, Ikeda K
  • Journal Title: Aun NY Acad Sci Volume: 印刷中
  • DOI: 10.1111/nyas.13605
  • Description: in press
  • Peer Reviewed
• [Journal Article] TUFTI interacts with RABGAP1 and regulates mTORCI signaling. (2018)
  • Author(s): Kawasaki N, Isogaya K, Dan S, Yamori T, Takano H, Yao R, Morishita Y, Taguchi L, Morikawa M, Heldin CH, Noda T, Ehata S, Miyazono K, Koinuma D.
  • Journal Title: Cell Discov. Volume: 4 Pages: 1-1
  • DOI: 10.1038/s41421-017-0001-2
  • NAID: 120006707418
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mechanistic insight into the suppression of microglial ROS production by voltage-gated proton channels(VSOP/Hv1) (2018)
  • Author(s): Kawai T, Tatsumi S, Kihara S, Sakimura K, Okamura Y.
  • Journal Title: Channels Volume: 12 Issue: 1 Pages: 43108-43108
  • DOI: 10.1080/19336950.2017.1385684
  • Peer Reviewed / Open Access
• [Journal Article] PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptie transmission in cerebellum. (2018)
  • Author(s): Tan GH, Liu YY, Wang L, Li K, Zhang ZQ, Li HF, Yang ZF, Li Y, Li D, Wu MY, Yu CI, Long JJ, Liu JW, Cheng XW, Shen Q, Shu YS, Sakimura K, Liao LJ, Wu ZY, Xiong ZQ, et al.
  • Journal Title: Cell Res. Volume: 28 Issue: 1 Pages: 90-110
  • DOI: 10.1038/cr.2017.128
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] CDC42EP4, a perisynaptic scaffold protein in bergmann glia, is rcquired for glutamatergic tripartite synapse configuration. (2018)
  • Author(s): Ageta-Ishihara N, Konno K, Yamazaki M, Abe M, Sakimura K, Watanabe M, Kinoshita M.
  • Journal Title: Neurochem Int. Volume: S0197-0186 Issue: 17 Pages: 190-198
  • DOI: 10.1016/j.neuint.2018.01.003
  • NAID: 120006554471
  • Peer Reviewed / Open Access
• [Journal Article] Input-specific NMDAR-Dcpendent potentiation of dendritic GABAergic inhibition. (2018)
  • Author(s): Chiu CQ, Martenson JS, Yamazaki M, Natsume R, Sakimura K, Tomita S, Tavalin SJ, Higley MJ.
  • Journal Title: Neuron Volume: 97 Issue: 2 Pages: 368-377
  • DOI: 10.1016/j.neuron.2017.12.032
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Targeting the SphK1/SIP/S1PR1 axis that links obesity, chronic inflammation and breast cancer metastasis. (2018)
  • Author(s): Nagahashi M, Yamada A, Katsuta E, Aoyagi T, Huang WC, Terracina KP, Hait NC, Allegood JC, Tsuchida J, Yuza K, Nakajima M, Abe M, Sakimura K, Milstien S, Wakai T, Spiegel S, Takabe K.
  • Journal Title: Cancer Res. Volume: 78 Pages: 1713-1725
  • DOI: 10.1158/0008-5472.can-17-1423
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Rctrograde signaling from progranulin to sortl counteracts synapse climination in the developing cerebellum. (2018)
  • Author(s): Ucsaka X, Abe M, Konno K, Yamazaki M, Sakoori K, Watanabe T, Kao TH, Mikuni T, Watanabe M, Sakimura K, Kano M.
  • Journal Title: Ncuron Volume: 97 Issue: 4
  • Peer Reviewed
• [Journal Article] Keratan Sulfate Phenotype in the β-1, 3-N-Acetylglucosaminyltransferase-7-Null Mouse Cornea. (2018)
  • Author(s): Littlechild SL, Young RD, Caterson B, Yoshida H, Yamazaki M, Sakimura K, Quantock AJ, Akama TO.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 59 Pages: 1641-1641
  • DOI: 10.1167/iovs.17-22716
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Deletion of GIRK2 subunit containing GIRK channcls of neurons expressing dopamine transporter decrease immobility time on forced swimming in mice. (2018)
  • Author(s): Honda, I., Araki, K., Honda S., Soeda, F., Shin, M. C., Misumi, S., Yamamura, K. I. and Takahama, K.
  • Journal Title: Ncurosci. Lett. Volume: 665 Pages: 140-146
  • DOI: 10.1016/j.neulet.2017.11.028
  • Peer Reviewed
• [Journal Article] WDRll-modiated Hedgchog signalling defects underlie a new ciliopathy related to kallmann syndrome. (2018)
  • Author(s): Kim, Y. J., Osborn, D. P., Lee, J. Y., Araki, M., Araki, K., Mohun, T., Kansakoski, J., Brandstack, N., Kim, H. T., Miralles, F., Kim, C. H., Brown, N. A., Kim, H. G., Martinez-Barbera, J. P., Ataliotis, P., Raivio, T., Layaman, L, C. and Kim, S. H.
  • Journal Title: EMBO Rep. Volume: 19 Pages: 269-289
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Defective mitochondrial tRNA taurine modification activates global protcostress and leads to mitochondrial disease. (2018)
  • Author(s): Fakruddin, M., Wei, F. Y., Suzuki, T., Asano, K., Kaieda, T., Omori, A., Izumi, R., Fujimura, A., Kaitsuka, T., Miyata, K., Araki, K., Oike, Y., Scorrano, L., Suzuki, T. and Tomizawa, K.
  • Journal Title: Cell Rep Volume: 22 Pages: 482-496
  • DOI: 10.1016/j.celrep.2017.12.051
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Amyloid deposition in a mouse model humanized at the transthyretin and retinol-binding protein 4 loci. (2018)
  • Author(s): Li, X., Lyu, Y., Shon, J., Mu, Y., Qiang, L., Liu, L., Araki, K., Imbimbo, B. P., Yamamura, K., Jin, S. and Li, Z.
  • Journal Title: Lab Invest. Volume: 98 Pages: 512-524
  • DOI: 10.1038/s41374-017-0019-y
  • Description: in press
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Incomplete Clearance of apoptotic cells by core I-derived O-glycan-deficient resident peritoncal macrophages. (2018)
  • Author(s): Wakui H, Fuseya S, Suzuki R, Shimbo M, Okada R, Hamada M, Kuno A, Hagiwara K, Sato T, Narimatsu H, Kudo T, Takahashi S.
  • Journal Title: Biochem Biophys Res Commun. Volume: 495 Pages: 2017-2023
  • Peer Reviewed
• [Journal Article] Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acctylgalactosaminyltransferase-l and -2. (2018)
  • Author(s): Shimbo M, Suzuki R, Fuseya S, Sato T, Kiyohara K, Hagiwara K, Okada R, Wakui H, Tsunakawa Y, Watanabe H, Kimate K, Narimatsu H, Kudo T, Takahashi S.
  • Journal Title: PLoS One. Volume: 12
  • DOI: 10.1371/journal.pone.0190333
  • NAID: 120006454805
  • Peer Reviewed / Open Access
• [Journal Article] Transcription factor MafB may play an important role in secondary hyperparathyroidism. (2018)
  • Author(s): Morito N, Yoh K, Usui T, Oishi H, Ojima M, Fujita A, Koshida R, Shawki HH, Hamada M, Muratani M, Yamagata K, Takahashi S.
  • Journal Title: Kidney Int Volume: 93 Pages: 54-68
  • DOI: 10.1016/j.kint.2017.06.023
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Enhanced antibody responses in a novel NOG transgenic mouse with rostored lymph node organogenesis. (2018)
  • Author(s): Takahashi T, Katano I, Ito R, Goto M, Abe H, Mizuno S, Kawai K, Sugiyama F, Ito M.
  • Journal Title: Front Immunol Volume: 8 Pages: 2017-2017
  • DOI: 10.3389/fimmu.2017.02017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Targeted expression of step-function opsins in transgcnic rats for optogenetic studies. (2018)
  • Author(s): Igarashi H, Ikeda K, Onimaru H, Kaneko R, Koizumi K, Beppu K, Nishizawa K, Takahashi Y, Kato F, Matsui K, Kobayashi K, Yanagawa Y, Muramatsu SI, Ishizuka T, Yawo H.
  • Journal Title: Sci Rep. Volume: 8 Pages: 5435-5435
  • DOI: 10.1038/s41598-018-23810-8
  • Peer Reviewed / Open Access
• [Journal Article] Application of genome editing technologies in rats for human discase models. (2018)
  • Author(s): Yoshimi K, Mashimo T.
  • Journal Title: Journal of Human Gonetics Volume: 63 Pages: 115-123
  • DOI: 10.1038/s10038-017-0346-2
  • Peer Reviewed
• [Journal Article] Differential behavioral phenotypes of dopamine D1 receptor knockdown mice at the embryonic, postnatal, and adult stages. (2018)
  • Author(s): Okubo T, Sato A, Okamoto H, Sato T, Sasaoka T
  • Journal Title: Int J Dev Neurosci. Volume: 66 Pages: 1-8
  • DOI: 10.1016/j.ijdevneu.2017.11.004
  • Peer Reviewed / Open Access
• [Journal Article] Redundancy of matrix metalloprotcinases cloaving beta-dystroglycan : Implications for the pathogenesis of sarcoglycanopathy (2018)
  • Author(s): Fukai Y, Ohsawa Y, Ohtsubo H, Nishimatsu S, Hagiwara H, Noda M, Sasaoka T, Murakami T, Sunada Y
  • Journal Title: Biochcmical Biophysical Research Communications Volume: 30(1) Issue: 2 Pages: 199-205
  • DOI: 10.1016/j.bbrc.2017.08.048
  • Peer Reviewed / Open Access
• [Journal Article] Comprehensive behavioral analysis of tryptophan 2,3-dioxygenaso (Tdo2) knockout mice (2018)
  • Author(s): Hattori S, Takao K, Funakoshi H, *Miyakawa T
  • Journal Title: Neuropsychopharmacology Reports Volume: 38 Pages: 52-60
  • DOI: 10.1002/npr2.12006
  • NAID: 120006496928
  • Peer Reviewed / Open Access
• [Journal Article] Decroased brain pH as a shared endophenotype of psychiatric disorders (2018)
  • Author(s): Hagihara H, Catts VS, Katayama Y, Shoji H, Takagi T, Huang FL, Nakao A, Mori Y, Huang KP, Ishii S, Graef IA, Nakayama KI, Shannon Weickert C, *Miyakawa T
  • Journal Title: Neuropsychopharmacology Volume: 43 Pages: 459-468
  • DOI: 10.1038/npp.2017.167
  • NAID: 120006537072
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Bchavioral effccts of long-term oral administration of aluminum ammonium sulfate in male and female C57BL/6J mice (2018)
  • Author(s): Shoji H, Irino Y, Yoshida M, Miyakawa T
  • Journal Title: Neuropsychopharmacology Reports Volume: 38 Pages: 18-36
  • DOI: 10.1002/npr2.12002
  • Peer Reviewed / Open Access
• [Journal Article] Initial scverity of major depression and efficacy of new generation antidepressants : Individual-participant data meta-analysis. (2018)
  • Author(s): Furukawa TA, Maruo K, Noma H, Tanaka S, Imai H, Shinohara K, Ikeda K, Yamawaki S, Levine SZ, Goldberg Y, Leucht S, Cipriani A
  • Journal Title: Acta Psychiatr Scand Volume: 印刷中 Pages: 450-458
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  • Description: in press
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  • Description: in press
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• [Journal Article] Early manifestation of dopressivc-like behavior in transgenic mico that express demcntia with Lcwy bodies-linked mutant beta-synuclein. (2018)
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• [Journal Article] Association between the rs7583431 single-nucleotide polymorphism close to the activating transeription factor 2 (ATF2) gene and the analgesic effect of fentanyl in the cold pain test. (2018)
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  • Journal Title: East Asian Arch Psychiatry
  • Description: in press
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• [Journal Article] A randomized controlled study of the offoct of ifenprodil on alcohol use in patients with alcohol dependence. (2018)
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• [Journal Article] Genome-wide association study identifies polymorphisms associated with the analgcsic offoct of fentanyl in the prooporative cold pressor-induced pain test. (2018)
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• [Journal Article] Association between polymorphisms in the purinergic P2Y12 receptor gone and severity of both cancer pain and postoperative pain. (2018)
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• [Journal Article] A pharmacogenetics approach to pain management. (2018)
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  • Journal Title: 臨床精神医学 Volume: 47 Pages: 315-319
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  • Author(s): 中込和幸, 森尾保徳, 小居秀紀, 池田和隆, 山脇成人
  • Journal Title: 臨床精神薬理 Volume: 21 Pages: 155-161
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• [Journal Article] Delayed Degradation and Impaired Dondritic Delivery of Intron-Lacking EGFP-Arc/Arg3.1 mRNA in EGFP-Arc Transgenic Mice. (2018)
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• [Journal Article] Abnormalities in perineuronal nots and behavior in mice lacking CSGalNAcT1, a key cnzymc in chondroitin sulfate synthesis (2018)
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  • Description: Epub ahead of print
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  • Journal Title: Nat Commun. Volume: 8 Pages: 1700-1700
  • DOI: 10.1038/s41467-017-01711-0
  • NAID: 120006370809
  • Peer Reviewed / Open Access
• [Journal Article] MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1. (2017)
  • Author(s): Shichita T, Ito M, Morita R, Komai K, Noguchi Y, Ooboshi H, Koshida R, Takahashi S, Kodama T, Yoshimura A.
  • Journal Title: Nat Med Volume: in press Pages: 723-732
  • DOI: 10.1038/nm.4312
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Simple generation of hairless mice for in vivo imaging. (2017)
  • Author(s): Hoshino Y, Mizuno S, Kato K, Mizuno-Iijima S, Tanimoto Y, Ishida M, Kajiwara N, Sakasai T, Miwa Y, Takahashi S, Yagami KI, Sugiyama F
  • Journal Title: Exp. Anim. Volume: 66(4) Issue: 4 Pages: 437-445
  • DOI: 10.1538/expanim.17-0049
  • NAID: 130006187194
  • Peer Reviewed / Open Access
• [Journal Article] WNT rogulation of embryonic development likely involves pathways independent of nuclear CTNNBI. (2017)
  • Author(s): Tribulo P, Moss JI, Ozawa M, Jiang Z, Tian C, Hansen PJ.
  • Journal Title: Reproduction Volume: 153 Pages: 405-419
  • DOI: 10.1530/rep-16-0610
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Using a novel PV-Cre rat model to characterize pallidonigral cells and their terminations (2017)
  • Author(s): Oh, Y. -M., Karube, F., Takahashi, S., Kobayashi, K., Takada, M., Uchigashima, M., Watanabe, M., Nishizawa, K., Kobayashi, K., and Fujiyama, F.
  • Journal Title: Brain Str. Funct. Volume: 印刷中 Pages: 2359-2378
  • DOI: 10.1007/s00429-016-1346-2
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] From engineering to editing the rat genome. (2017)
  • Author(s): Meek S, Mashimo T, Burdon T.
  • Journal Title: Mammalian Genome Volume: 28 Pages: 302-314
  • DOI: 10.1007/s00335-017-9705-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Endocytosis following dopamine D2 recoptor activation is critical for nouronal activity and dendritic spine formation via Rabex-5/PDGFRβ signaling in striatopallidal medium spiny neurons. (2017)
  • Author(s): Shioda N, Yabuki Y, Wang Y, Uchigashima M, Hikida T, Sasaoka T, Mori H, Watanabc M, Sasahara M, Fukunaga K
  • Journal Title: Molecular Psychiatry Volume: 印刷中 Issue: 8 Pages: 1205-1222
  • DOI: 10.1038/mp.2016.200
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Striatal hypodopamine phenotypes found in transgenic mice that overexpress glial cell line-derived neurotrophic factor. (2017)
  • Author(s): Sotoyama H, Iwakura Y, Oda K, Sasaoka T, Takei N, Kakita A, Enomoto H, Nawa H
  • Journal Title: Xeuroscience Letters Volume: 654 Pages: 99-106
  • DOI: 10.1016/j.neulet.2017.06.005
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] BRAG2a, a guanine nucleotide exchange factor for Arf6, is a component of the dystrophin-associated glycoprotein complex at the photoreceptor terminal. (2017)
  • Author(s): Sakagami H, Katsumata O, Hara Y, Sasaoka T, Fukaya M
  • Journal Title: Investigative Ophthalmology and Visual Science(IOVS) Volume: 58 Issue: 9 Pages: 3795-3795
  • DOI: 10.1167/iovs.17-21746
  • Peer Reviewed / Open Access
• [Journal Article] Forroptosis : a regulated cell death nexus linking metabolism, redox biology, and disease. (2017)
  • Author(s): Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon S, Fulda S, Gascon S, Hatzios SK, Kagan V, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat G, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti F, Torti
  • Journal Title: Cell Volume: 171 Pages: 273-285
  • DOI: 10.1016/j.cell.2017.09.021
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Iron and thiol redox signaling in cancer : an exquisite balance to escape ferroptosis. (2017)
  • Author(s): Toyokuni S, Ito F, Yamashita K, Okazaki Y, Akatsuka S.
  • Journal Title: Free Radic Biol Med Volume: 108 Pages: 610-616
  • DOI: 10.1016/j.freeradbiomed.2017.04.024
  • NAID: 120006343681
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Gut microbiota promotes obcsity-associatcd liver cancer through PGE2-mediated suppression of antitumor immunity (2017)
  • Author(s): Loo TM, Kamachi F, Watanabe Y, Yoshimoto S, Kanda H, Arai Y, Nakajima-Takagi Y, Koga T, Sugimoto Y, Ozawa T, Nakamura M, Kumagai M, Watashi K, Taketo MM, Aoki T, Narumiya S, Oshima M, Arita M, Hara E, Ohtani N, et al.
  • Journal Title: Cancer Discovery Volume: 7 Pages: 522-538
  • DOI: 10.1158/2159-8290.cd-16-0932
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Cireulating fibronectin contributes to mesangial expansion in a murine model of type 1 diabetes (2017)
  • Author(s): Klcmis, V., Ghura, H., Federico, G., Wurfel, C., Bontmann, A., Gretz, N., Miyazaki, T., Grone, H. J., Nakchbandi, I. A.
  • Journal Title: Kidney Int Volume: 91 Pages: 1374-1385
  • DOI: 10.1016/j.kint.2016.12.006
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] p53 expression as a diagnostic biomarker in ulcerative colitis-associated cancer (2017)
  • Author(s): Kobayashi, K., Tomita, H., Shimizu, M., Tanaka, T., Suzui, N., Miyazaki, T., Hara, A.
  • Journal Title: Int J Mol Sci Volume: 18
  • Peer Reviewed / Open Access
• [Journal Article] A novel monoclonal antibody targeting coxsackie virus and adenovirus receptor inhibits tumor growth in vivo (2017)
  • Author(s): M. Kawada, H. Inoue, M. Kajikawa, M. Sugiura, S. Sakamoto, S. Urano, C. Karasawa, I. Usami, M. Futakuchi, T. Masuda.
  • Journal Title: Sci Rep Volume: 7 Pages: 40400-40400
  • DOI: 10.1038/srep40400
  • Peer Reviewed / Open Access
• [Journal Article] Association between N-methyl-D-aspartate receptor subunit 2B gone polymorphisms and alcohol dependence in a Japanese population. (2017)
  • Author(s): Narita S, Yoshihara E, Nishizawa D, Kawai A, Ikeda K, Iwahashi K
  • Journal Title: 日本アルコール薬物医学会雑誌 Volume: 52 Issue: 5 Pages: 156-167
  • Peer Reviewed
• [Journal Article] Rolc of NMDA receptor GluN2D subunit in the antideprossant effects of onantiomers of ketamine. (2017)
  • Author(s): Idc S, Ikokubo Y, Mishina M, Hashimoto K, Ikeda K
  • Journal Title: J Pharmacol Sci Volume: 135(3) Issue: 3 Pages: 138-140
  • DOI: 10.1016/j.jphs.2017.11.001
  • Peer Reviewed / Open Access
• [Journal Article] Paclitaxel-induced sensory peripheral neuropathy is associated with an ABCB1 single nuclcotide polymorphism and older age in Japanese. (2017)
  • Author(s): Tanabe Y, Shimizu C, Hamada A, Hashimoto K, Ikeda K, Nishizawa D, Hasegawa J, Shimomura A, Ozaki Y, Tamura N, Yamamoto H, Yunokawa M, Yonemori K, Takano T, Kawabata H, Tamura K, Fujiwara Y
  • Journal Title: Cancer Chemother Pharmacol Volume: 79(6) Issue: 6 Pages: 1179-1186
  • DOI: 10.1007/s00280-017-3314-9
  • Peer Reviewed / Open Access
• [Journal Article] Light/dark phase-dopendent spontancous activity is maintained in dopamine-doficient mice. (2017)
  • Author(s): Fujita M, Hagino Y, Takeda T, Kasai S, Tanaka M, Takamatsu Y, Kobayashi K, Ikcda K
  • Journal Title: Mol Brain Volume: 10 Issue: 1 Pages: 49-49
  • DOI: 10.1186/s13041-017-0329-4
  • Peer Reviewed / Open Access
• [Journal Article] No association between the polymorphism rs6943555 in the AUTS2 gene and personality traits in Japanese university students. (2017)
  • Author(s): Narita S, Ikeda K, Nishizawa D, Yoshihara E, Numajiri M, Onozawa Y, Ohtani N, Iwahashi K
  • Journal Title: Psychiatry Investigation Volume: 14(5) Issue: 5 Pages: 681-686
  • DOI: 10.4306/pi.2017.14.5.681
  • Peer Reviewed / Open Access
• [Journal Article] Opioid dose and neuropathic pain before-and-after electroconvulsive therapy. (2017)
  • Author(s): Iwata K, Kobayashi Y, Mera H, Doi N, Suwa H, Ikeda K
  • Journal Title: JJSPC Volume: 24(2) Issue: 2 Pages: 116-120
  • DOI: 10.11321/jjspc.16-0024
  • NAID: 130006832066
  • Peer Reviewed / Open Access
• [Journal Article] ゲノムワイド関連解析を利用したオピオイドのデーラーメイド医療への試み。 (2017)
  • Author(s): 三枝勉, 西澤大輔, 福田謙一, 池田和隆, 北村晶, 林田眞和
  • Journal Title: 麻酔・集中治療とテクノロジー2017 Pages: 16-21
  • Open Access
• [Journal Article] JSNP Excellent Presentation Award for CINP2016 : Association between autism susceptibility candidate 2 haplotypes and alcohol dependence in a Japanese population. (2017)
  • Author(s): Narita S, Iwahashi K, Yoshihara E, Kawai A, Nishizawa D, Ikeda K
  • Journal Title: 日本神経精神薬理学雑誌 Volume: 37 Issue: 3 Pages: 97-98
• [Journal Article] JSNP Excollent Prosentation Award for CINP2016 : 注意欠如/多動性障害モデルマウスにおけるメチルフェニデートの報酬効果の変化。 (2017)
  • Author(s): 井手聡一郎, 高松幸雄, 池窪結子, Takeda TC, Nagasawa S, Hua J, Uhl GR, 曽良一郎, 池田和隆
  • Journal Title: 日本神経精神薬理学雑誌 Volume: 37 Issue: 2 Pages: 49-50
  • Int'l Joint Research
• [Journal Article] JSNP Excellent Presentation Award for CINP2016 : ゲノムワイド関連解析(GWAS)による腹腔鏡補助下大腸切除術後フェンタニル必要量に影響する遺伝子多型の同定。 (2017)
  • Author(s): 西澤大輔, 三枝勉, 辻田美紀, 天野功二郎, 田代浄, 石井利昌, 山口茂樹, 笠井慎也, 長谷川準子, 池田和隆, 北村晶, 林田眞和
  • Journal Title: 日本神経精神薬理学雑誌 Volume: 37 Issue: 2 Pages: 53-54
• [Journal Article] 遺伝子多型に基づいた個別鎮痛法の開発 (2017)
  • Author(s): 西澤大輔, 福田謙一, 林田眞和, 池田和隆
  • Journal Title: ペインクリニック Volume: 38
• [Journal Article] ペインクリニックにおける精密医療 (2017)
  • Author(s): 池田和隆
  • Journal Title: ペインクリニック Volume: 38 Pages: 557-558
  • Peer Reviewed
• [Journal Article] Higher Arc Nucleus-to-Cytoplasm Ration during Sleep in the Superficial Layers of the Mouse Cortex. (2017)
  • Author(s): Honjoh S, de Vivo L, Okuno H, Bito H, Tononi G, Cirelli C.
  • Journal Title: Front Neural Circuits. Volume: 11 Pages: 60-60
  • DOI: 10.3389/fncir.2017.00060
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Are restores juvenile plasticity in adult mouse visual cortex. (2017)
  • Author(s): Jenks KR, Kim T, Pastuzyn ED, Okuno H, Taibi AV, Bito H, Bear MF, Shephord JD.
  • Journal Title: Proc Natl Acad Sci USA. Volume: 114 Pages: 9182-9187
  • DOI: 10.1073/pnas.1700866114
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Histaminc modulation of the basal ganglia circuitry in the dovelopment of pathological grooming. (2017)
  • Author(s): Rapanclli M, Frick L, Bito H, Pittenger C
  • Journal Title: Proc Natl Aead Sci USA. Volume: 114 Pages: 6599-6604
  • DOI: 10.1073/pnas.1704547114
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Calmodulin kinases : essential regulators in health and disease. (2017)
  • Author(s): Takemoto-Kimura S, Suzuki K, Horigane SI, Kamijo S, Inoue M, Sakamoto M, Fujii H, Bito H.
  • Journal Title: J Neurochem. Volume: - Pages: 808-818
  • DOI: 10.1111/jnc.14020
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Optogenctic activation of the sensorimotor cortex reveals "local inhibitory and global excitatory" inputs to the basal ganglia. (2017)
  • Author(s): Ozaki M, Sano H, Sato S, Ogura M, Mushiake H, Chiken S, Nakao N, Nambu A.
  • Journal Title: Cereb Cortex. Volume: 27 Pages: 5716-5726
  • DOI: 10.1093/cercor/bhx234
  • Peer Reviewed / Open Access
• [Journal Article] Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease : analysis of Osaka mutation-knockin mice (2017)
  • Author(s): Umcda T, Kimura T, Yoshida K, Takao K, Fujita Y, Matsuyama S, Sakai A, Yamashita M, Yamashita Y, Ohnishi K, Suzuki M, Takuma H, Miyakawa T, Takashima A, Morita T, Mori H, Tomiyama T
  • Journal Title: Acta Neuropathol Commun Volume: 5 Pages: 59-59
  • DOI: 10.1186/s40478-017-0461-5
  • NAID: 120006371271
  • Peer Reviewed / Open Access
• [Journal Article] Comprehensive behavioral analysis of activating transcription factor 5-deficient mice (2017)
  • Author(s): Umemura M ; Ogura T, Matsuzaki A, Nakano H, Takao K, Miyakawa T, Takahashi Y
  • Journal Title: Frontiers in Behavioral Neuroscience Volume: 11 Pages: 125-125
  • DOI: 10.3389/fnbeh.2017.00125
  • Peer Reviewed / Open Access
• [Journal Article] Decreased cohesin in the brain leads to defective synapse devclopmont and anxicty-related behavior. (2017)
  • Author(s): Fujita Y, Masuda K, Bando M, Nakato R, Katou Y, Tanaka T, Nakayama M, Takao K, Miyakawa T, Tanaka T, Ago Y, Hashimoto H, Shirahige K, Yamashita T
  • Journal Title: The Journal of Experiment Medicine Volume: 印刷中 Issue: 5 Pages: 1431-1452
  • DOI: 10.1084/jem.20161517
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Comprehensive behavioral analysis of activating transcription factor 5-deficient mice (2017)
  • Author(s): Umemura M, Ogura T, Matsuzaki A, Nakano H, Takao K, Miyakawa T, Takahashi Y
  • Journal Title: Frontiers in Behavioral Neuroscience Volume: 8 Pages: 125-125
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Prothymosin alpha-deficiency enhances anxiety-like behaviors and impairs learning/memory-functions and neurogenesis (2017)
  • Author(s): Ueda H, Sasaki K, Halder SK, Deguchi Y, Takao K, Miyakawa T, Tajima A
  • Journal Title: Journal of Neurochemistry Volume: 141 Issue: 1 Pages: 124-136
  • DOI: 10.1111/jnc.13963
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Loss of the phenolic hydroxyl group and aromaticity from the side chain of anti-proliferative 10-methyl-aplog-1, a simplified analog of aplysiatoxin, enhances its tumor-promoting and proinflammatory activities. (2017)
  • Author(s): Hanaki Y, Kikumori M, Tokuda H, Okamura M, Dan S, Adachi N, Saito N, Yanagita RC, Irie K.
  • Journal Title: Molecules Volume: 22 Issue: 4 Pages: 631-631
  • DOI: 10.3390/molecules22040631
  • NAID: 120006363289
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Convergent synthesis of stereoisomers of THF ring moiety of acetogenin thiopheno analogue and thoir antiproliferative activities against human cancer cell lines. (2017)
  • Author(s): Matsumoto T, Kojima N, Akatsuka A, Yamori T, Dan S, Iwasaki H, Yamashita M.
  • Journal Title: Tetrahedron Volume: 73 Issue: 17 Pages: 2359-2366
  • DOI: 10.1016/j.tet.2017.03.011
  • Peer Reviewed
• [Journal Article] Allantopyrone a activates Keapl-Nrf2 pathway and protects PC12 cells from oxidative stress-induced cell death. (2017)
  • Author(s): Uesugi S, Muroi M, Kondoh Y, Shiono Y, Osada H, Kimura KI
  • Journal Title: Journal of Antibiotics Volume: 70 Issue: 4 Pages: 429-434
  • DOI: 10.1038/ja.2016.99
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Phenotypic identification of a novel autophagy inhibitor chemotype targeting lipid kinase VPS34. (2017)
  • Author(s): Robke I., Laraia L, Carnero Corrales MA, Konstantinidis G, Muroi M, Richters A, Winzker M, Engbring T, Tomassi S, Watanabe N, Osada H, Rauh D, Waldmann H, Wu YW, Engel J
  • Journal Title: Angewandte Chemie International Edition Volume: 56 Issue: 28 Pages: 8153-8157
  • DOI: 10.1002/anie.201703738
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Development of a terpenoid-production platform in streptomyces reveromyceticus SN-593. (2017)
  • Author(s): Khalid A, Takagi H, Panthee S, Muroi M, Chappell J, Osada H, Takahashi S
  • Journal Title: ACS Synthctic Biology Volume: 6 Issue: 12 Pages: 233-2349
  • DOI: 10.1021/acssynbio.7b00249
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Protein kinase A inhibition facilitates the antitumor activity of xanthohumol, a valosin-containing protein inhibitor. (2017)
  • Author(s): Shikata Y, Yoshimaru T, Komatsu M, Katoh H, Sato R, Kanagaki S, Okazaki Y, Toyokuni S, Tashiro E, Ishikawa S, Katagiri T, Imoto M.
  • Journal Title: Cancer Science Volume: 108 Pages: 785-794
  • DOI: 10.1111/cas.13175
  • Description: Epub ahead of print
  • Peer Reviewed / Open Access
• [Journal Article] Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells. (2017)
  • Author(s): Shikata Y, Kiga M, Futamura Y, Aono H, Inoue H, Kawada M, Osada H, and Imoto M.
  • Journal Title: Cancer Science Volume: 108 Pages: 772-784
  • DOI: 10.1111/cas.13172
  • Peer Reviewed / Open Access
• [Journal Article] Antarlides F-H, new members of the antarlide family produced by Streptomyces sp. BB47. (2017)
  • Author(s): Saito S, Fujimaki T, Panbangred W, Sawa R, Igarashi Y, Imoto M
  • Journal Title: Journal of Antibiotics Volume: 印刷中 Pages: 595-600
  • DOI: 10.1038/ja.2017.6
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Arabilin overcomes resistance to AR-targeted therapy. (2017)
  • Author(s): Fujimaki T, Saito S, and Imoto M.
  • Journal Title: Journal of Antibiotics Volume: 70 Pages: 328-330
  • DOI: 10.1038/ja.2016.162
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Metacycloprodigiosin (mcPG) induced cell death selectively in beta-catenin mutated tumor colls. (2017)
  • Author(s): Ikeda H, Shikata Y, Watanapokasin R, Tashiro E, Imoto M
  • Journal Title: Journal of Antibiotics Volume: 70 Pages: 109-112
  • DOI: 10.1038/ja.2016.75
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Targeting glioma stem cells in vivo by a G-quadruplex-stabilizing synthetic macrocylic hexaoxazole (2017)
  • Author(s): Nakamura T, Okabe S, Yoshida H, Iida K, Ma Y, Sasaki S, Yamori T, Shin-Ya K, Nakano I, Nagasawa K, Seimiya H.
  • Journal Title: Sci Rep Volume: 7 Pages: 3605-3605
  • DOI: 10.1038/s41598-017-03785-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Forward genetic analysis of sleep in randomly mutagenized mice. (2017)
  • Author(s): Funato H, et al.
  • Journal Title: Nature. Volume: 539(7629) Issue: 46 Pages: 378-383
  • DOI: 10.1038/nature20142
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice. (2017)
  • Author(s): Naruse C, Shibata S, Tamura M, Kawaguchi T, Abe K, Sugihara K, Kato T, Nishiuchi T, Wakana S, Ikawa M, Asano M.
  • Journal Title: FASEB J. Volume: in press Pages: 2252-2266
  • DOI: 10.1096/fj.201600642r
  • Description: Epub ahead of print
  • Peer Reviewed / Open Access
• [Journal Article] The mechanics clarifying counterclockwise rotation in most IVF eggs in mice. (2017)
  • Author(s): Ishimoto K, Ikawa M, Okabe M.
  • Journal Title: Sci Rep. Volume: 7 Pages: 43456-43456
  • Peer Reviewed / Open Access
• [Journal Article] SHISA6 confers resistance to differentiation-promoting Wnt/6-catenin aignaling in mouse spermatogenic stem cells. (2017)
  • Author(s): Tokue M, Jkami K, Mizuno S, Takagi C, Miyagi A, Takada R, Noda C, Kitadate Y, Hara K, Mizuguchi H, Sato T, Taketo MM, Sugiyama F, Ogawa T, Kobayashi S, Ueno N, Takahashi S, Takada S, Yoshida S.
  • Journal Title: Stem Cell Reports Volume: 8 Pages: 561-575
  • DOI: 10.1016/j.stemcr.2017.01.006
  • NAID: 120006224053
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Pharmacological targeting of plasmin prevents lethality in a murine mode of macrophage activation syndrome. (2017)
  • Author(s): Shimazu H, Munakata S, Tashiro Y, Salama Y, Dhahri D, Eiamboonsert S, Ota Y, Onoda H, Tsuda Y, Okada Y, Nakauchi H, Heissig B, Hattori K.
  • Journal Title: Blood Volume: 印刷中 Pages: 59-72
  • DOI: 10.1182/blood-2016-09-738096
  • Description: Epub ahead of print
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia (2017)
  • Author(s): Matsumoto J, Nakanishi H, Kunii Y, Sugiura Y, Yuki D, Wada A, Hino M, Niwa SI, Kondo T, Waki M, Hayasaka T, Masaki N, Akatsu H, Hashizume Y, Yamamoto S, Sato S, Sasaki T, Setou M, Yabe H
  • Journal Title: Sci Rep Volume: 7 Issue: 7 Pages: 1-11
  • DOI: 10.1038/srep45050
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Loss of NDRG2 expression confers oral squamous cell carcinoma with enhanced metastatic potential (2017)
  • Author(s): T. Tamura, T. Ichikawa, S. Nakahata, Y. Kondo, Y. Tagawa, K. Yamamoto, K. Nagai, T. Baba, R. Yamaguchi, M. Futakuchi, Y. Yamashita, K. Morishita
  • Journal Title: Cancer Research Volume: 印刷中 Pages: 2363-2374
  • DOI: 10.1158/0008-5472.can-16-2114
  • Description: Epub ahead of print
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Stapled BIG3 helical peptide ERAP potentiates antitumour activity for breast cancer therapeutics. (2017)
  • Author(s): Yoshimaru T, Aihara K, Komatsu M, Matsushita Y, Okazaki Y, Toyokuni S, Honda J, Sasa M, Miyoshi Y, Otaka A, Katagiri T.
  • Journal Title: Sci Rep.
  • NAID: 120006535017
  • Description: In press
  • Peer Reviewed / Open Access
• [Journal Article] Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism. (2017)
  • Author(s): Shimohata A, Ishihara K, Hattori S, Miyamoto H, Morishita H, Ornthanalai G, Raveau M, Ebrahim AS, Amano K, Yamada K, Sago H, Akiba S, Mataga N, Murphy NP, Miyakawa T, Yamakawa K.
  • Journal Title: Exp Neurol Volume: S0014-4886(17) Pages: 1-12
  • DOI: 10.1016/j.expneurol.2017.03.009
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Combination treatment with naftopidil increases the efficacy of radiotherapy in PC-3 human prostate cancer cells (2017)
  • Author(s): Iwamoto Y, Ishii K, Kanda H, Kato M, Miki M, Kajiwara S, Arima K, Shiraishi T, Sugimura Y.
  • Journal Title: J Cancer Res Clin Oncol Volume: 印刷中 Pages: 933-939
  • DOI: 10.1007/s00432-017-2367-9
  • Description: Epub ahead of print
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A quantitative shRNA screen identifies ATP1A1 as a gene that regulates cytotoxicity by aurilide B (2017)
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  • Journal Title: Sci Rep
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Down-regulation of Forkhead Box Protein A1 (FOXA1) Leads Cancer-stem Cell-like Properties in Tamoxifen-resistant Breast Cancer Cells through Induction of Interleukin-6 (2017)
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• [Journal Article] The relationship between EZH2 expression and microRNA-31 in colorectal cancer and the role in evolution of the serrated pathway. (2016)
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• [Journal Article] Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer. (2016)
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• [Journal Article] Seasonal allergies and serial changes of serum levels of IgG4 in cases treated with maintenance therapy for IgG4-related disease. (2016)
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• [Journal Article] Report of the Japan diabetes society/Japanese cancer association joint committee on diabetes and cancer, Second report. (2016)
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• [Journal Article] Fertilization defects in sperm from Cysteine-rich secretory protein 2(Crisp2) knockout mice : Implications for fertility disorders. (2016)
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• [Journal Article] GPI-AP release in cellular, developmental, and reproductive biology. (2016)
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• [Journal Article] Generation of Hprt-disrupted rat through mouse <- rat ES chimeras (2016)
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• [Journal Article] The Histone Demethylase FBXL10 Regulates the Proliferation of Spermatogonia and Ensures Long-Term Sustainable Spermatogenesis in Mice. (2016)
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• [Journal Article] TARP γ-2 and γ-8 differentially control AMPAR density across Schaffer collateral/commissural synapsee in the hippocampal CA1 area. (2016)
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• [Journal Article] Kidney-specific knockout of Savl in the mouse promotes hyper-proliferation of renal tubular epithelium through suppression of the Hippo pathway. (2016)
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• [Journal Article] The Mg2+ transporter CNNM4 regulates sperm Ca2+ homeostasis and it is essential for reproduction. (2016)
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• [Journal Article] The importance of basonuclin 2 in adult mice and its relation to basonuclinl. (2016)
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  • Journal Title: Mech. Dev. Volume: Feb 29 Pages: 1-21
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• [Journal Article] Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies. (2016)
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• [Journal Article] Transsynaptic modulation of kainate receptor functions by Clq-like proteins. (2016)
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  • Journal Title: Neuron Volume: 90 Pages: 752-67
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  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Biogenesis of sperm acrosome is regulated by pre-mRNA alternative splicing of Acrbp in the mouse. (2016)
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• [Journal Article] Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout micegenerated using a one-step CRISPR/Cas9 system. (2016)
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  • NAID: 120005819540
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Aberrant PD-L1 expression via 3'-UTR disruption in multiple cancers. (2016)
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  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. (2016)
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  • Journal Title: Proc Natl Acad Sci USA. Volume: 113 Issue: 28 Pages: 7704-10
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  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Essential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis. (2016)
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  • Journal Title: Nat Commun. Volume: 7 Pages: 12059-12059
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  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization. (2016)
  • Author(s): Kato K, Satouh Y, Nishimasu H, Kurabayashi A, Morita J, Fujihara Y, Oji A, Ishitani R, Ikawa M, Nureki O.
  • Journal Title: Nat. Commun. Volume: 7 Pages: 12198-12198
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  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator. (2016)
  • Author(s): Akiyama N, Takizawa N, Miyauchi M, Yanai H, Tateishi R, Shinzawa M, Yoshinaga R, Kurihara M, Demizu Y, Yasuda H, Yagi S, Wu G, Matsumoto M, Sakamoto R, Yoshida N, Penninger JM, Kobayashi Y, Inoue J, Akiyama T.
  • Journal Title: J Exp Med Volume: 213 Pages: 1441-1458
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  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells. (2016)
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  • Journal Title: Nat Commun. Volume: 7 Pages: 12135-12135
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  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Ionic basis for membrane potential resonance in neurons of the inferiorolive. (2016)
  • Author(s): Matsumoto-Makidono Y, Nakayama H, Yamasaki M, Miyazaki T, Kobayashi K, Watanabe M, Kano M, Sakimura K, Hashimoto K.
  • Journal Title: Cell Rep Volume: 16 Pages: 994-1004
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  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Fibrinolytic crosstalk with endothelial cells expands murine mesenchymal stromal cells. (2016)
  • Author(s): Dhahri D, Sato-Kusubata K, Ohki-Koizumi M, Nishida C, Tashiro Y, Munakata S, Shimazu H, Salama Y, Eiamboonsert S, Nakauchi H, Hattori K, Heissig B.
  • Journal Title: Blood Volume: 128 Issue: 8 Pages: 1063-1075
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• [Journal Article] Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. (2016)
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  • Journal Title: Cell Volume: 166 Pages: 1147-1162
  • DOI: 10.1016/j.cell.2016.07.025
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1. (2016)
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  • Journal Title: Nat. Commun. Volume: 7 Pages: 12756-12756
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  • NAID: 120006535062
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] ANGPTL2 activity in cardiac pathologies accelerates heart failure by perturbing cardiac function and energy metabolism. (2016)
  • Author(s): Tian, Z., Miyata, K., Kadomatsu, T., Horiguchi, H., Takeda, N., Araki, K., Manabe, I., Fukuda, K., Otsu, K., Wada, J., Murohara, T., Mohri, S., Yamashita, J. K., Sano, M., Oike, Y., et al.
  • Journal Title: Nat. Commun. Volume: 7 Pages: 13016-13016
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  • NAID: 120006345014
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] SAD-B phosphorylation of CAST controls active zone vesicle recycling for synaptic depression. (2016)
  • Author(s): Mochida S, Hida Y, Tanifuji S, Hagiwara A, Hamada S, Abe M, Ma H, Yasumura M, Kitajima I, Sakimura K, Ohtsuka T
  • Journal Title: Cell Rep. Volume: 16 Issue: 11 Pages: 2901-13
  • DOI: 10.1016/j.celrep.2016.08.020
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Spatiotemporal dynamics of lesion-induced axonal sprouting and its relationto functional architecture of the cerebellum. (2016)
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  • Journal Title: Nat Commun Volume: 7 Pages: 12938-12938
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] SCOP/PHLPP16 mediates circadian regulation of long-term recognition memory. (2016)
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  • Journal Title: Nat Commun. Volume: 7 Pages: 12926-12926
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  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Suppression of intestinal tumors by targeting the mitotic spindle of intestinal stem cells. (2016)
  • Author(s): Yao R, Oyanagi J, Natsume Y, Kusama D, Kato Y, Nagayama S, Noda T.
  • Journal Title: Oncogene Volume: Epub ahead of print Issue: 47 Pages: 1-11
  • DOI: 10.1038/onc.2016.148
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTO. (2016)
  • Author(s): Lee GH, Fujita M, Takaoka K, Murakami Y, Fujihara Y, Kanzawa N, Murakami KI, Kajikawa E, Takada Y, Saito K, Ikawa M, Hamada H, Maeda Y, Kinoshita T.
  • Journal Title: J Cell Biol. Volume: 215 Pages: 705-718
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  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Novel working hypothesis for pathogenesis of hematological malignancies : combination of mutations-induced cellular phenotypes determines the disease (cMIP-DD). (2016)
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  • DOI: 10.1093/jb/mvv114
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A Diarylpentanoid Curcumin Analog Exhibits Improved Radioprotective Potential in the Intestinal Mucosa (2016)
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  • Journal Title: International Journal of Radiation Biology Volume: in press Pages: 388-394
  • DOI: 10.3109/09553002.2016.1164910
  • Peer Reviewed
• [Journal Article] CHD8 haploinsufficiency results in autistic-like phenotypes in mice. (2016)
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  • Journal Title: Nature Volume: 537 Issue: 7622 Pages: 28636-28636
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  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Mice that lack the C-terminal region of Reelin exhibit behaviora abnormalities related to neuropsychiatric disorders. (2016)
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  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Disruption of the Sjögren-Larsson Syndrome Gene Aldh3a2 in Mice Increases Keratinocyte Growth and Retards Skin Barrier Recovery. (2016)
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  • Journal Title: J Biol Chem Volume: 印刷中 Issue: 22 Pages: 11676-11688
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  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Simultaneous fast measurement of circuit dynamics at multiple sites across the mammalian brain. (2016)
  • Author(s): Kim CK, Yang SJ, Pichamoorthy N, Young NP, Kauvar I, Jennings JH, Lerner TN, Berndt A, Lee SY, Ramakrishnan C, Davidson TJ, Inoue M, Bito H, Deisseroth K.
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  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Total Synthesis of the Depsipeptide FR901375 and Preliminary Evaluation of Its Biological Activity. (2016)
  • Author(s): Narita K, Katoh Y, Ojima K, Dan S, Yamori T, Ito A, Yoshida M, Katoh T.
  • Journal Title: European Journal of Organic Chemistry Volume: 2016 Pages: 5667-5677
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  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Synthesis and biological evaluation of novel FK228 analogues as potential isoform selective HDAC inhibitors. (2016)
  • Author(s): Narita K, Matsuhara K, Itoh J, Akiyama Y, Dan S, Yamori T, Ito A, Yoshida M, Katoh T.
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  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Synthesis and in vitro cancer cell growth inhibition evaluation of 11-amino-modified 5-Me-indolo[2,3-b]quinolines and their COMPARE analyses. (2016)
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  • Journal Title: Med Chem Res Volume: 25(5) Issue: 5 Pages: 879-892
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  • Peer Reviewed
• [Journal Article] Inhibition of the PI3K-Akt and mTORC1 signaling pathways promotes the elongation of vascular endothelial cells (2016)
  • Author(s): Tamura K, Ogawa M
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  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] α-Amanitin Restrains Cancer Relapse from Drug-Tolerant Cell Subpopulations via TAF15. (2016)
  • Author(s): Kume K, Ikeda M, Miura S, Ito K, Sato KA, Ohmori Y, Endo F, Katagiri H, Ishida K, Ito C, Iwaya T, Nishizuka SS.
  • Journal Title: Sci Rep Volume: - Pages: 25895-25895
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  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Proteomic profiling reveals that collismycin A is an iron chelator. (2016)
  • Author(s): Kawatani M, Muroi M, Wada A, Inoue G, Futamura Y, Aono H, Shimizu K, Shimizu T, Igarashi Y, Takahashi-Ando N, Osada H.
  • Journal Title: Sci Rep Volume: 6 Pages: 38385-38385
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  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival. (2016)
  • Author(s): Kawamura T, Kawatani M, Muroi M, Kondoh Y, Futamura Y, Aono H, Tanaka M, Honda K, Osada H.
  • Journal Title: Sci Rep Volume: 6 Pages: 26521-26521
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  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Integrated profiling methods for identifying the targets of bioactive compounds : MorphoBase and ChemProteoBase. (2016)
  • Author(s): Muroi M, Futamura Y, Osada H.
  • Journal Title: Nat Prod Rep Volume: 33 Pages: 621-625
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  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Storkhead box 2 and melanoma inhibitory activity promote oral squamou cell carcinoma progression. (2016)
  • Author(s): Sasahira T, Nishiguchi Y, Fujiwara R, Kurihara M, Kirita T, Bosserhoff AK, Kuniyasu H.
  • Journal Title: Oncotarget Volume: vol.7 Pages: 26751-26764
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  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] HEGI is a novel mucin-like membrane protein that is useful for the diagnosis of malignant mesothelioma. (2018)
  • Author(s): Hiroshima K, Miyagi Y, Tsuji S, Imai K.
  • Organizer: USCAP 2018 Annual Meeting
  • Int'l Joint Research
• [Presentation] The development of gene-manipulated animal models : aiming to generate better suited mouse, rat and marmosct for the analysis brain function (2018)
  • Author(s): Kenji Sakimura
  • Organizer: The 8th BRI International Symposium
  • Int'l Joint Research / Invited
• [Presentation] ゲノム編集を利用した精巣特異的遺伝子の網羅的機能解析 (2018)
  • Author(s): 伊川正人
  • Organizer: 先端酵素学研究所講演会
  • Invited
• [Presentation] CRISPR/Cas9 mcdiated genome editing in mice and its application for the study of reproduction (2018)
  • Author(s): 伊川正人
  • Organizer: Bridging Biomedical Worlds (BBW) 2018
  • Int'l Joint Research / Invited
• [Presentation] CRISPR/Cas9システムを用いた遺伝子改変マウス作製の現状 (2018)
  • Author(s): 野田 大地、櫻井 伸行、伊川 正人
  • Organizer: 平成29年度新学術領域研究学術研究支援基盤形成【先端モデル動物支援プラットフォーム】成果発表会
• [Presentation] 背内側線条体コリン作動性介在神経細胞の行動柔軟性における双方向的制御 (2018)
  • Author(s): 岡田佳奈、西澤佳代、瀬戸川将、橋本浩一、小林和人
  • Organizer: 先端モデル動物支援プラットフォーム成果発表会
• [Presentation] ゲノム編集技術と新規モデル動物 (2018)
  • Author(s): 真下知士
  • Organizer: 先導的学際研究機構創薬サイエンス部門シンポジウム
  • Invited
• [Presentation] ゲノム編集技術によるモデル動物の作製 (2018)
  • Author(s): 真下知士
  • Organizer: 日本実験動物技術者協会関西支部平成29年度春季大会
  • Invited
• [Presentation] D1/D2ドーパミン受容体コンディショナル発現マウスによる運動制御機構の解明 (2018)
  • Author(s): 笹岡俊邦, 佐藤朝子, 知見聡美, 大久保直, 阿部学, 川村名子, 中尾聡宏, 小田佳奈子, 齊藤奈英, 酒井清子, 神保幸弘, 佐藤俊哉, 藤澤信義, 崎村建司, 南部篤
  • Organizer: 平成29年度先端モデル動物支援プラットフォーム 成果発表会
• [Presentation] Cancer as iron addiction with ferroptosis-resistance. (2018)
  • Author(s): Toyokuni S.
  • Organizer: Gordon Research Conforence : Oxygen Radicals
  • Int'l Joint Research / Invited
• [Presentation] マウスの大規模網羅的行動解析データの二次利用によるメタ解析 (2018)
  • Author(s): 服部聡子、昌子浩孝、高雄啓三、宮川剛
  • Organizer: 先端モデル動物支援プラットフォーム 成果発表会2017
• [Presentation] Altered spatial representation in the dentate gyrus of alpha-CaMKII hKO mice, a model for schizophrenia and bipolar disorder (2018)
  • Author(s): Akito Nakao, Tomoyuki Murano, Nao Hirata, Akira Murakami, Satoko Amemori, Yuki Sugaya, Hiroyuki Okuno, Masanobu Kano, Yukiyasu Kamitani, Jun Yamamoto, Tsuyoshi Miyakawa
  • Organizer: 第8回新潟大学脳研究所共同研究拠点国際シンポジウム
• [Presentation] Ketamine and NMDA receptor channels. (2018)
  • Author(s): Ikeda K
  • Organizer: TSBPN 2018 Spring Meeting
  • Int'l Joint Research / Invited
• [Presentation] Rapamycin treatment ameliorates impairment of social interaction in the mice treated prenatally with valproic acid. (2018)
  • Author(s): Kotajima H, Kobayashi T, Kashii H, Sato A, Hagino Y, Tanaka M, Nishito Y, Takamatsu Y, Uchino S, Ikeda K
  • Organizer: 第8回 新潟大学脳研究所共同研究拠点国際シンポジウム
• [Presentation] Gene expression profile corresponding to autism-like behaviors in mouse models of tuberous sclerosis complex. (2018)
  • Author(s): Kashii H, Kasai S, Hagino Y, Sato A, Kotajima H, Tanaka M, Kobayashi T, Hino O, Oka A, Mizuguchi M, Ikeda K
  • Organizer: 第8回 新潟大学脳研究所共同研究拠点国際シンポジウム
• [Presentation] Development and imaging of new color indicators for Ca2+ signaling in living neurons (2018)
  • Author(s): Fujii H
  • Organizer: UK-Japan Neuroscience Symposium, Royal Society
  • Int'l Joint Research / Invited
• [Presentation] マウス・ヴァーチャルリアリティ順応システムの開発 (2018)
  • Author(s): 坂本一寛, 洞口学志, Janos Negyesi, 片山統裕, 虫明元
  • Organizer: 文部科学省 新学術領域研究 学術研究支援基盤形成 先端モデル動物支援プラットフォーム成果発表会
• [Presentation] development of 3d-stacked multi-shank si neural probe array (1) -fabrication of embcdded multiple optical fibcrs in multi-shank (2018)
  • Author(s): Bowen Zhang, Takuya Harashima, Takumi Morikawa, Chidai Shima, Hisashi Kino, Takafumi Fukushima, Tetsu Tanaka
  • Organizer: 第65回応用物理学会春季学術講演会
• [Presentation] 三次元積層シリコン神経プローブアレイの開発(2) -低侵襲刺入を目的としたシャンク配置の検討- (2018)
  • Author(s): 島 智大, 原島 卓也, 張 博文, 森川 拓実, 木野 久志, 福島 誉史, 田中 徹
  • Organizer: 第65回応用物理学会春季学術講演会
• [Presentation] 脳深部機能解析のための極微細蛍光内視鏡イメージングシステム (2018)
  • Author(s): 小山内 実, 大川 宜昭, 神谷 厚範, 稲波 千尋, 佐藤 正晃, 大倉 正道, 小島 太郎, 幸村 裕治, 林 康紀, 柳川 右千夫, 大澤 匡弘, 中井 淳一, 井ノ口 馨, 本間 経康, 虫明 元
  • Organizer: 平成29年度文部科学省新学術領域研究 学術研究支援基盤形成 先端モデル動物支援プラットフォーム成果発表会
• [Presentation] マウス大脳皮質におけるアグリカン陽性ペリニューロナルネットの発現 (2018)
  • Author(s): 上野 浩司, 高雄 啓三, 藤井 一希, 末光 俊介, 岡本 基, 石原 武士
  • Organizer: 第95回日本生理学会大会
• [Presentation] Behavioral physiological approach to the pathology and treatment of psychiatric disorders (2018)
  • Author(s): 高雄 啓三
  • Organizer: 第8回新潟大学脳研究所共同研究拠点国際シンポジウム
• [Presentation] Bchavioral physiological approach to the pathology and trcatment of psychiatric disorders (2018)
  • Author(s): 高雄 啓三
  • Organizer: 第8回新潟大学脳研究所共同研究拠点国際シンポジウム
• [Presentation] テロメアの長さによって発現変動する遺伝子群が腫瘍形態に及ぼす影響 (2018)
  • Author(s): 藤原理恵、岡本啓治、吉田喜香、右田敏郎、清宮啓之
  • Organizer: 先端モデル動物支援プラットフォーム平成29年度成果発表会
• [Presentation] ケミカルゲノミクスによるオートファジー制御機構の解析 (2018)
  • Author(s): 片浦哲志、井本正哉
  • Organizer: 先端モデル動物支援プラットフォーム成果発表会
• [Presentation] エストロゲン依存性乳癌細胞のタモキシフェン耐性獲得におけるNF-κB経路の役割 (2017)
  • Author(s): 山口憲孝, 中山祐治, 山口直人
  • Organizer: 第137回日本薬学会年会
  • Place of Presentation: 東北大学川内キャンパス(宮城県、仙台市)
  • Year and Date: 2017-03-25
• [Presentation] Genome-wide association study of pain sensitivity in cold pressor test. (2017)
  • Author(s): Takahashi K, Fukuda K, Nishizawa D, Kasai S, Kokita Y, Ichinohe T, Ikeda K
  • Organizer: 2017 LADR(International Association for Dental Research) General Session & Exhibition
  • Place of Presentation: San Francisco, California, USA
  • Year and Date: 2017-03-23
  • Int'l Joint Research
• [Presentation] Aplysiatoxin単純化アナログ・10-Me-aplog-1のフェノール性側鎖が各種生物活性に与える影響 (2017)
  • Author(s): 花木祐輔、菊森将之、徳田春邦、岡村睦美、旦 慎吾、柳田 亮、入江一浩
  • Organizer: 2017年度日本農芸化学会大会
  • Place of Presentation: 京都女子大学(京都府京都市)
  • Year and Date: 2017-03-17
• [Presentation] The rewarding effect of methylphenidate on attention deficit/hyperactivity disorder model mice. (2017)
  • Author(s): Ikekubo Y, Ide S, Takamatsu Y, Takeda TC, Nagasawa S, Hua J, Ikeda K
  • Organizer: 第90回日本薬理学会年会
  • Place of Presentation: 長崎ブリックホール・長崎新聞文化ホール(長崎県長崎市)
  • Year and Date: 2017-03-16
• [Presentation] CRISPR/Cas9 Mediated Genome Editing and its Application for the Study of Reproduction (2017)
  • Author(s): 伊川 正人
  • Organizer: The 20th US-Japan Cellular and Gene Therapy Conference
  • Place of Presentation: FDA White Oak Campus (Silver Spring, Maryland, USA)
  • Year and Date: 2017-03-09
  • Int'l Joint Research / Invited
• [Presentation] The molecular function of ASPSCRI-TFE3 in alveolar soft part sarcoma (2017)
  • Author(s): Tanaka M, Nakamura T
  • Organizer: AACR Special Conference on Advances in Sarcomas : From basic science to clinical
• [Presentation] 骨軟部肉腫のGDAモデル : がんの生物学と治療法評価系としての重要性 (2017)
  • Author(s): 中村卓郎
  • Organizer: 第76回日本癌学会学術総会
  • Invited
• [Presentation] 家族性大腸線腫症オルガノイドを用いた発がん機構解明 (2017)
  • Author(s): 八尾 良司、小柳 潤、長山 聡、野田 哲生
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 発がん過程におけるストレス獲得耐性 (2017)
  • Author(s): 石川 冬木、八尾 良司、若林 雄一
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] TUFT1-RABAP1を介した小胞輸送制御によるmTORC1シグナルの新規活性化機構の解析 (2017)
  • Author(s): 川崎 夏実、磯谷 一暢、旦 慎吾、矢守 隆夫、高野 洋志、八尾 良司、田口 瑠奈、森川 真大、野田 哲生、江幡 正悟、宮園 浩平、鯉沼 代造
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] CARD HypcrOvaを用いたBNラットの過剰排卵誘起処置の有用性 (2017)
  • Author(s): 中務胞、夏目里恵、崎村建司
  • Organizer: 第64回日本実験動物学会総会
• [Presentation] GluDI・Cbln1複合体は分界条床核GABA作動性神経と結合腕傍核由来の神経終末との接着に関与する (2017)
  • Author(s): 今野幸太郎、森さくら、崎村建司、柚崎通介、渡辺雅彦
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] GABAニューロン前駆細胞の一部はグリア細胞に分化する (2017)
  • Author(s): 江角重行、柳川右千夫、崎村建司、鹿川哲史、石龍徳、竹林浩秀、玉巻伸章
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] D1/D2ドーパミン受容体コンディショナル発現マウスによる運動制御機構の解明 (2017)
  • Author(s): 笹岡俊邦、佐藤朝子、知見聡美、大久保直、阿部学、川村名子、中尾聡宏、小田佳奈子、酒井清子、前田宜俊、神保幸弘、田中稔、山本美丘、藤俊哉、藤沢信義、崎村建司、南部篤
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] 目的指向性行動における小脳モジュールの機能 (2017)
  • Author(s): 喜多村和郎、堤信一郎、日高直樹、磯村宜和、松崎正紀、崎村建司、狩野方伸
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] 大脳皮質Arc経路活性化による遠隔記憶セルアンサンブルの制御 (2017)
  • Author(s): 金亮、酒井一輝、川島尚之、近藤弥生、井上昌俊、野中美応、坂本雅行、岡本理子、阿部学、崎村建司、今吉格、奥野浩行、尾藤晴彦
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Loss of autism susceptibility gene, Auts2 induces the excessive synaptic formation in mouse forebrains. (2017)
  • Author(s): 山田 光代、堀 啓、坂本 亜沙美、阿部 学、崎村建司、曽根 雅紀、星野 幹雄
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Microglia dependent development of neuronal circuits in the cerebellum (2017)
  • Author(s): 中山 寿子、阿部 学、森本 千恵、﨑村 建司、橋本 浩一
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Functional analyses of SRF coactivator MKL2 including a novel isoform SOLOIST (2017)
  • Author(s): 田邉 広樹、石橋 悠太、庄司 しずく、久保 友喜美、袴田 知之、田中 拓郎、森 寿、和泉 宏謙、崎村 健司、福地 守、津田 正明、田渕 明子
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] CAST/ELKS doletion from photoreceptor causes blindness by synaptic and neural remodeling during retinal maturation (2017)
  • Author(s): 萩原 明、北原 陽介、Vogl Christian, 阿部 学、橘田 涼、太田 啓介、中村 桂一郎、崎村 建司、Moser Tobias、西 昭徳、大塚 稔久
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Sex specific changes in mEPSC of CRH neurons in the lateral BST in CRF-Venus ΔNeo mice in association with formalin test (2017)
  • Author(s): 萩原 裕子、崎村 建司、井樋 慶一、舩橋 利也
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] プルキンエ細胞に発現するカルシニューリンBIサブユニットは抑制性シナブス形成過程において適切なプレ-ポストシナプスの接着に関わってる (2017)
  • Author(s): 宮﨑太輔、崎村建司、渡辺雅彦
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] ドレブリンはmGluR5およびNMDA受容体依存性LTD誘導に関わる (2017)
  • Author(s): 児島伸彦、安田浩樹、崎村建司、白尾智明
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] 内因性カンナビノイド、2-アラキドノイルグリセロールはマウスのパレル皮質の視床皮質投射、4層-2/3層投射において重要な役割を果たす (2017)
  • Author(s): 木村文隆、伊丹千晶、崎村建司、狩野方伸
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Key roles of cannabinoid CB1 rcceptor and 2-arachidonoylglycerol in the regulation of excitatory synaptic transmission in the bednuclcus of the stria terminalis and neuropathic pain (2017)
  • Author(s): Ako Kato, Kazuto Sakoori, Kenji Sakimura, Yuki Sugaya, Masanobu Kano
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] BDXF to TrkB signaling promotes climbing fiber synapse elimination in the developing cerebellum (2017)
  • Author(s): 秋 明貞、宮崎 太輔、山崎 真弥、川村 名子、中澤 敬信、谷村 あさみ、上阪 直史、渡辺 雅彦、崎村 健司、狩野 方伸
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Generation and analysis of cerebellar granule cell-specific neurexins triple knockout mice (2017)
  • Author(s): 植村 健、鈴木 絵美、小池 梨絵、川瀨 詩織、栗原 大河、崎村 建司、三品 昌美、田渕 克彦
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] A role of actin remodeling in cortical interneuron for critical period plasticity (2017)
  • Author(s): 侯 旭濱、國見 順子、崎村 建司、杉山 清佳
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Disruption of AMPA receptor-palmitoylation leads excitatory/inhibitory imbalance and elevated seizure susceptibility (2017)
  • Author(s): 伊藤 政之、山下 真梨子、山田 大輔、奥野 浩行、阿部 学、山崎 真弥、夏目 里恵、金子 雅規、貝塚 利恵、崎村 建司、関口 正幸、和田 司、星野 幹雄、三品 昌美、林 崇
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Behavioral analyses of forebrain specific knock-out mice of an orphan metabotropic receptor Prrt3 and screening of small moloc library toward identification of its ligand (2017)
  • Author(s): 陳 以珊、山本 友美、周 麗、夏目 里恵、今野 幸太郎、上杉 志成、渡辺 雅彦、高雄 啓三、宮川 剛、崎村建司、久保 義弘
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Depression-like behavior in the GluD1 deficient mice was remedied by antidepressants (2017)
  • Author(s): 中本千尋、夏目 里恵、阿部 学、川村 名子、内田 仁司、渡辺 雅彦、崎村建司
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Biochemical analysis of phosphorylated CAST/ELKS in mice brain (2017)
  • Author(s): 浜田 駿、阿部 学、崎村 建司、大塚 稔久
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Gene expression and behavior analysis of microglial voltage-gated proton channels in mouse (2017)
  • Author(s): 河合 喬文、高雄 啓三、崎村建司、宮川 剛、岡村 康司
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Classification of corticotropin-releasing factor neurons in the hypothalamic paraventricular nucleus according to their difforential neural projections (2017)
  • Author(s): 堀尾 修平、山形 聡、小林 憲太、加藤 成樹、崎村 建司、上山 敬司、小林 和人、井樋 慶一
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Generation of corticotropin-releasing factor neuron-selective vasopressin knockout mouse : unravelling the physiological role vasopressin expressed in the parvocellular neurons in th (2017)
  • Author(s): 山形 聡、Talukder Hossain Ashraf、渡辺 真秀、周 麗、夏目 里恵、阿部 学、蔭山 和則、大門 眞、崎村 建司、井樋 慶一
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Oroxin modulates behavioral fear expression through noradrenergic neurons in the locus cooruleus (2017)
  • Author(s): 高橋 徹、征矢 晋吾、Thomas J Mchugh、前島 隆、阿部 学、崎村 建司、櫻井 武
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Identification and characterization of brain-enriched guanylatc kinase-associated protein as a neuropathic pain-related prote the spinal dorsal horn (2017)
  • Author(s): 片野 泰代、福田 正史、山崎 真弥、、阿部 学、渡辺 雅彦、矢尾 育子、奥村 宣明、中澤 敬信、山本 雅、崎村 建司、高尾 敏文、伊藤 二
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Purkinje cells are more vulnerable to the specific depletion of cathepsin D than to that of Atg7 (2017)
  • Author(s): 小池 正人、柴田 昌宏、砂堀 毅彦、山口 隼司、崎村 建司、小松 雅明、田中 啓二、内山 安男
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Maturation of cerebellar climbing fiber and Purkinje cell population activities during postnatal development (2017)
  • Author(s): Michael Mahoney、Jean-Marc Good、Taisuke Miyazaki、Kenji F Tanaka、Kenji Sakimura、Masahiko Watanabe、Kazuo Kitamura、Masanobu Kano
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] The role of Auts2 in the dentate gyrus development (2017)
  • Author(s): 江草 早紀、堀 啓、坂本 亜沙美、阿部 学、崎村 建司、郷 康広、星野 幹雄
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Visualizing single-neuron identity specified by Pcdh-b cluster (2017)
  • Author(s): 金子 涼輔、阿部 学、高鶴 裕介、渡辺 雅彦、崎村 建司、柳川 右千夫、八木 健
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Phosphorylation of GAP-43 by JNK regulates axonal growth (2017)
  • Author(s): 河嵜 麻実、岡田 正康、小林 大紀、野住 素広、崎村 建司、仁科 博史、武内 恒成、五十嵐 道弘
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Sleep/wakefulness behavior after ablation of central serotonergic neuron (2017)
  • Author(s): 岩崎 加奈子、柿崎 美代、阿部 学、崎村 建司、船戸 弘正、柳沢 正史
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] RNA editing enzymc ADAR2 contributos to neuropathic pain (2017)
  • Author(s): 内田 仁司、崎村 建司、伊藤 誠二
  • Organizer: 第40回日本神経科学大会
  • Int'l Joint Research
• [Presentation] Depression-like behavior in the GluD1 deficient mice was remedied by antidepressants. (2017)
  • Author(s): Chihiro Nakamoto、Rie Natsumo, Manabu Abe, Meiko Kawamura, Hitoshi Uchida, Masahiko Watanabe, Kenji Sakimura
  • Organizer: 26th Meeting of the Intcrnational Society for Neurochemistry
  • Int'l Joint Research
• [Presentation] Roles of Arc/arg3.1 on surface expression dynamics of AMPA rcceptors during structural plasticity and on cognitive refinement processes (2017)
  • Author(s): H. OKUNO、Y. ISHII, T. ENDO, M. UEHARA, Y. SUZUKI, K. MINATOHARA, A. ARAKI, M. ABE, I. IMAYOSHI, M. KAKEYAMA, K. SAKIMURA, H.
  • Organizer: Neuroscience2017
  • Int'l Joint Research
• [Presentation] Aifl-iCre knock-in mouse line : A tool for conditional gene manipulation in microglia (2017)
  • Author(s): M. ABE、F. PENG, K. SAKIMURA
  • Organizer: Neuroscience2017
  • Int'l Joint Research
• [Presentation] A Flp-dependent G-CaMP9a transgenic mouse for neuronal imaging In vivo (2017)
  • Author(s): M. SAKANOTO、M. INOUE、K. SAKAI、S. KOBARI、S. TAKEMOTO-KIMURA, M. ABE, K. SAKIMURA, R. BITO
  • Organizer: Neuroscience2017
  • Int'l Joint Research
• [Presentation] Rational engineering of XCaMPs, a. multicolor GECI suite for In vivo imaging of brain circuit dynamics (2017)
  • Author(s): M. INOUE, A. TAKEUCHI, S. MANJTA, I. HORIGANEI, R. KAWAKAMI, K. YAMAGUCHI, M. SAKAMOTO, H. YOKOYAMA, R. KIM, S. TAKEMOTO-KIMURA, M. ABE, K, SAKIMURA T. NEMOTO, M. KANO, H. FUJII, K. KITAMURA, H. BITO
  • Organizer: Neuroscience2017
  • Int'l Joint Research
• [Presentation] ラット卵巣卵胞内卵子の成熟培養なしでの体外受精 (2017)
  • Author(s): 中務 胞、夏目里恵、崎村建司
  • Organizer: 第40回日本分子生物学会年会
  • Int'l Joint Research
• [Presentation] 発生および慢性疼痛下の一次知覚神経におけるRNA編集の変動 (2017)
  • Author(s): 内田 仁司、松村伸治、崎村建司、伊藤 誠二
  • Organizer: 第40回日本分子生物学会年会
  • Int'l Joint Research
• [Presentation] ニューロンIDの可視化～クラスター型プロトカドヘリンの発現解析～ (2017)
  • Author(s): 金子 涼輔、阿部学、高鶴裕介、渡辺雅彦、崎村建司、柳川 右千夫、八木 健
  • Organizer: 第40回日本分子生物学会年会
  • Int'l Joint Research
• [Presentation] PKNIはリンパ球の細胞運動・トラフィッキングを制御する (2017)
  • Author(s): 窪内 康二、團野紗莉、野町昭、平田多佳子、松尾一彦、中山隆志、佐藤亮介、杉浦麗子、阿部学、崎村建司、若菜茂晴、大崎博之、鴨志田吾、向井 秀幸
  • Organizer: 第40回日本分子生物学会年会
  • Int'l Joint Research
• [Presentation] CRISPR/Cas9 mediated genome editing in mice and its application for the study of reproduction (2017)
  • Author(s): 伊川正人
  • Organizer: 第9回武田科学振興財団薬科学シンポジウム
  • Invited
• [Presentation] CRISPR/Cas9システムによるゲノム編集マウスの作製と受精研究への応用 (2017)
  • Author(s): 伊川正人
  • Organizer: 生化学若い研究者の会 九州支部 夏のセミナー
  • Invited
• [Presentation] CRISPR/Cas9 mediated genome editing and its application for the study of roproduction (2017)
  • Author(s): 伊川正人
  • Organizer: 4th World Congress of Reproductive Biology(WCRB 2017)
  • Int'l Joint Research / Invited
• [Presentation] ゲノム編集を利用した精巣特異的遺伝子の網羅的機能解析 (2017)
  • Author(s): 伊川正人
  • Organizer: 第3回生体調節研究所 内分泌代謝シンポジウム
  • Invited
• [Presentation] ゲノム編集技術の進歩と課題 (2017)
  • Author(s): 伊川正人
  • Organizer: 日本動物実験代替法学会 第30回大会
  • Invited
• [Presentation] ゲノム編集マウス作製と受精研究への応用 (2017)
  • Author(s): 伊川正人
  • Organizer: 第40回日本分子生物学会年会
  • Invited
• [Presentation] CRISPR/Cas9 mediated genome editing and its application for the study of sperm functions (2017)
  • Author(s): 伊川正人
  • Organizer: 11th International Congross of Andrology
  • Int'l Joint Research / Invited
• [Presentation] CRISPR/Cas9 Modiated Genome Editing and its Application for the Study of Reproduction (2017)
  • Author(s): 伊川正人
  • Organizer: JST戦略的国際共同研究プログラム
  • Invited
• [Presentation] ゲノム編集技術の進歩と課題 (2017)
  • Author(s): 伊川正人
  • Organizer: 第12回関西ライフサイエンスリーディングサイエンティストセミナー
  • Invited
• [Presentation] Fertilization and Oocyte Activation : New Insights Using Genome Editing (2017)
  • Author(s): 伊川正人
  • Organizer: Fertilization & Aetivation of Development(Gordon Research Conference)
  • Int'l Joint Research / Invited
• [Presentation] TCTEI is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatoz (2017)
  • Author(s): Julio Castaneda, Rong Hua, Haruhiko Miyata, Asami Oji, Yueshuai Guo, Yiwei Cheng, Tao Zhou, Xuejiang Guo, Yiqiang Cui, Bin She Zibin Wang, Zhibin Hu, Zuomin Zhou, Jiahao Sha, Renata Prunskaite-Hyyrylainen, Zhifeng Yu, Ramiro Ramirez-Solis, Masahito Ikaw
  • Organizer: 50th Annual Mceting of the Society for the Study of Reproduction
  • Int'l Joint Research
• [Presentation] マウス初期発生過程におけるGARP complexの役割 (2017)
  • Author(s): 杉本道彦、牟田真由美、村上久美子、峯陽子、荒木喜美
  • Organizer: 第50回日本発生生物学会大会
• [Presentation] エレクトロボレーションを用いた簡便・高効率マウスゲノム操作技術 (2017)
  • Author(s): 杉本道彦、有安大典、石黒啓一郎、伊藤慎悟、荒木喜美
  • Organizer: 日本遺伝学会第89回大会
• [Presentation] An easy and high efficient technique for mouse genome manipulation by electroporation. (2017)
  • Author(s): Michihiko Sugimoto, Daisuke Ariyasu, Kei-ichiro Ishiguro, Shingo Ito, Kimi Araki.
  • Organizer: 2017 ASMRA & AMPC meeting.
  • Int'l Joint Research
• [Presentation] 染色体特異的にクラスターを形成しているトラップ領域 : CSCT13は、マウス初期発生過程において重要な役割を演じていることが示唆された (2017)
  • Author(s): 荒木 正健、武田 伊世、中原 舞、吉信 公美子、荒木 喜美
  • Organizer: 日本遺伝学会第89回大会
• [Presentation] 常染色体優性遺伝性GH1遺伝子異常症モデルマウスのGH分泌不全は、Ghrhr mRNAの低下による (2017)
  • Author(s): 有安 大典、久保 英美香、芝田 晋介、長谷川 行洋、長谷川 奉延、荒木 喜美
  • Organizer: 第51回日本小児内分泌学会学術集会
• [Presentation] 可変型遺伝子トラップ法を用いた効率的な新規骨代謝関連遺伝子の探索 (2017)
  • Author(s): 関本朝久、黒木修司、舩元太郎、大田智美、中村志保子、永井琢哉、中原舞、吉信公美子、荒木喜美、荒木正健、帖佐悦男
  • Organizer: 第32回日本整形外科学会基礎学術集会
• [Presentation] 骨表現型スクリーニングで選別したTmem161a欠損トラップマウスは明らかな骨量増加を呈する (2017)
  • Author(s): 永井琢哉、関本朝久、黒木修司、舩元太郎、大田智美、中村志保子、中原舞、吉信公美子、荒木喜美、荒木正健、帖佐悦男
  • Organizer: 第32回日本整形外科学会基礎学術集会
• [Presentation] 可変型遺伝子トラップ法を用いたlamin B receptor変異マウスの解析 (2017)
  • Author(s): 舩元太郎、関本朝久、黒木修司、大田智美、中村志保子、永井琢哉、中原舞、吉信公美子、荒木喜美、荒木正健、帖佐悦男
  • Organizer: 第32回日本整形外科学会基礎学術集会
• [Presentation] エレクトロポレーション法によるCRISPR/Cas9ゲノム編集マウス作製時における高効率化と生存率向上の試み (2017)
  • Author(s): 杉本道彦、有安大典、石黒啓一郎、伊藤慎悟、荒木喜美
  • Organizer: 2017年度生命科学系学会合同年次大会・第40回日本分子生物学会年会・第90回日本生化学会大会
• [Presentation] 生体内におけるLincRNA-p21の発現解析 (2017)
  • Author(s): 古畑 理樹, 今坂 舞, 伊東 春香, 荒木 正健, 吉信 公美子, 山村 研一, 荒木 喜美
  • Organizer: 2017年度生命科学系学会合同年次大会・第40回日本分子生物学会年会・第90回日本生化学会大会
• [Presentation] 常染色体優性遺伝性GH1遺伝子異常症の発症機序の解明～モデルマウスのGH分泌不全は、Ghrhr mRNAの低下による (2017)
  • Author(s): 有安 大典、久保 英美香、芝田 晋、荒木 喜美
  • Organizer: 2017年度生命科学系学会合同年次大会・第40回日本分子生物学会年会・第90回日本生化学会大会
• [Presentation] 常染色体優性遺伝性GH1遺伝子異常症の発症機序に関する検討-遺伝子置換システムを用いたヒト化GHマウスの作出と解析- (2017)
  • Author(s): 久保 英実香、有安 大典、芝田 晋介、荒木 喜美
  • Organizer: 2017年度生命科学系学会合同年次大会・第40回日本分子生物学会年会・第90回日本生化学会大会
• [Presentation] 可変型遺伝子トラップ法による新規lincRNAの生体内機能解析 (2017)
  • Author(s): 吉信公美子, 吉住友希, 林田隆成, 今坂舞, 荒木喜美, 荒木正健
  • Organizer: 2017年度生命科学系学会合同年次大会・第40回日本分子生物学会年会・第90回日本生化学会大会
• [Presentation] 染色体特異的にクラスターを形成しているトラップ領域 : CSCT13は、マウス初期発生過程において重要な役割を演じていることが示唆された (2017)
  • Author(s): 荒木正健, 武田伊世, 山口友輔, 高田幸基, 今坂舞, 吉信公美子, 荒木喜美
  • Organizer: 2017年度生命科学系学会合同年次大会・第40回日本分子生物学会年会・第90回日本生化学会大会
• [Presentation] CRISPR/Cas9による遺伝子改変マウス作製の実際 (2017)
  • Author(s): 高橋 智、水野聖哉、杉山文博
  • Organizer: 第2回日本ゲノム編集学会総会
  • Invited
• [Presentation] The histone demethylase KDM2A regulates differentiation of spormatogonia in mice. (2017)
  • Author(s): Ozawa M, Kawakami E, Tokunaga A, Sakamoto R, Yoshida N
  • Organizer: 4th World Congress of Reproductive Biology
  • Int'l Joint Research
• [Presentation] Ptbpl deficiency induces a decrease of spermatogonia in neonatal mice. (2017)
  • Author(s): Manami Senoo, Takashi Takijiri, Manabu Ozawa, Nobuaki Yoshida
  • Organizer: 4th World Congress of Roproductive Biology
  • Int'l Joint Research
• [Presentation] 精子形成におけるPtbplの機能解析 (2017)
  • Author(s): 妹尾真奈美、瀧尻崇史、小沢学、吉田進昭
  • Organizer: 第29回高遠分子細胞生物学シンポジウム
• [Presentation] ヒストン脱メチル化酵素Fbx111は精原細胞の自己複製と分化のバランスを調整する (2017)
  • Author(s): 小沢学、川上絵里、徳永暁憲、坂本怜子、吉田進昭
  • Organizer: 第29回高遠分子細胞生物学シンポジウム
• [Presentation] 精子形成におけるPtbp1の機能解析 (2017)
  • Author(s): 妹尾真奈美、瀧尻崇史、小沢学、吉田進昭
  • Organizer: 先端モデル動物支援プラットフォーム 若手支援技術講習会
• [Presentation] The histone demethylase Fbx111 regulates differentiation of spermatogonia in mice. (2017)
  • Author(s): 小沢学、川上絵里、徳永暁憲、坂本怜子、吉田進昭
  • Organizer: 先端モデル動物支援プラットフォーム 若手支援技術講習会
• [Presentation] Action-specific reinforcement and update by direct- and indirect- pathway striatal projection neurons (2017)
  • Author(s): Nonomura, S., Nishizawa, K., Kobayashi, K., Sakai, Y., Kawaguchi, Y., Nambu, A., Yamanaka, K., Enomoto, K., Isomura, Y., Kimura, M.
  • Organizer: Neuroscience2017
  • Int'l Joint Research
• [Presentation] Activity of direct- and indirect-pathway striatal projection neurons identified by optogenctics during adaptive choice task probabilistics reward (2017)
  • Author(s): Nonomura, S., Yamanaka, K., Nishizawa, K., Kobayashi, K., Sakai, Y., Kawaguchi, Y., Nambu, A., Isomura, Y., Kimura, M.
  • Organizer: The 40th Annual Meeting of the Japan Neuroscience Society
• [Presentation] Using a novel PV-Cro rat model to characterize pallidal cells and their terminations (2017)
  • Author(s): Oh, Y. M., Karube, F., Takahashi, S., Kobayashi, K., Kobayashi, K., Fujiyama, F.
  • Organizer: 40th Annual Meeting of the Japan Neuroscience Society
• [Presentation] Optogenetic analysis of neuronal network of medullary respiratory center in transgenic rats expressing channelrhodopsin in Phox2b expressing cells (2017)
  • Author(s): Onimura, H., Ikeda, K., Igarashi, H., Yao, H., Kobayashi, K., Kawakami, K.
  • Organizer: 40th Annual Meeting of the Japan Neuroscience Society
• [Presentation] Differential involvement of direct- and indirect-pathway spiny projection neuron in action valuation and update in the dorsomedial striatum (2017)
  • Author(s): Kimura, M., Nonomura, S., Nishizawa, K., Kobayashi, K., Sakai, Y., Kawaguchi, Y., Nambu, A., Yamanaka, K., Isomura, Y
  • Organizer: 40th Annual Meeting of the Japan Neuroscience Society
  • Invited
• [Presentation] Controlling stimulus-response learning through striatal direct and indirect pathways (2017)
  • Author(s): Kobayashi, K.
  • Organizer: 40th Annual Meeting of the Japan Neuroscience Society
  • Invited
• [Presentation] 動物実験施設におけるゲノム編集技術の活用 (2017)
  • Author(s): 真下知士
  • Organizer: 第43回国立大学法人動物実験施設協議会総会技術職員懇談会
  • Invited
• [Presentation] ゲノム編集による疾患モデル動物の開発 (2017)
  • Author(s): 真下知士
  • Organizer: 第57回日本先天異常学会第6回日本DOHaD学会 合同学術集会
  • Invited
• [Presentation] 動物実験施設におけるゲノム編集技術の活用 (2017)
  • Author(s): 真下知士
  • Organizer: 第60回日本神経化学会大会
  • Invited
• [Presentation] Highly efficient genomo editing in embryos using the super electroporator NEPA21. (2017)
  • Author(s): 真下知士
  • Organizer: The 4th World Congress of Reproductive Biology
  • Int'l Joint Research / Invited
• [Presentation] CRISPR-mediated genome ongineering in zygotes. (2017)
  • Author(s): 真下知士
  • Organizer: 14th Transgenic Technology Meeting, The International Society for Transgenic Technologies
  • Int'l Joint Research / Invited
• [Presentation] CRISPR-mediated genome engineering in animals. (2017)
  • Author(s): 真下知士
  • Organizer: International Conference of the Genetics Society of Korea
  • Int'l Joint Research / Invited
• [Presentation] CRISPR-mediated genome engineering in rats. (2017)
  • Author(s): 真下知士
  • Organizer: Edinburgh Rat Meeting
  • Int'l Joint Research / Invited
• [Presentation] ゲノム編集技術によるモデル動物開発研究 (2017)
  • Author(s): 真下知士
  • Organizer: 先端医療技術開発センターシンポジウム
  • Invited
• [Presentation] ラットの遺伝子改変 (2017)
  • Author(s): 真下知士
  • Organizer: 2017年度遺伝研研究会
  • Invited
• [Presentation] Elucidation of motor control mechanism using gonetically mice harboring tetracycline-regulated expression of D1/D2 dopamine receptors (2017)
  • Author(s): Toshikuni Sasaoka, Asako Sato, Satomi Chikon, Tadashi Okubo, Manabu Abe, Meiko Kawamura, Satohiro Nakao, Kanako Oda, Seiko Sakai, Yoshitaka Maeda, Yukihiro Jinbo, Toshiya Sato, Nobuyoshi Fujisawa, Kenji Sakimura, Atsushi Nambu
  • Organizer: Elucidation of motor control mechanism using genotically mice harboring tetracycline-regulated expression of D1/D2 dopamine receptors
• [Presentation] D1/D2ドーパミン受容体コンディショナル発現マウスによる運動制御機構の解明 (2017)
  • Author(s): 笹岡 俊邦, 佐藤 朝子, 知見 聡美, 大久保 直, 阿部 学, 川村 名子, 中尾 聡宏, 小田 佳奈子, 酒井 清子, 前田 宜俊, 神保 幸弘, 佐藤 俊哉, 藤澤 信義, 崎村 建司, 南部 篤
  • Organizer: 第32回 日本大脳基底核研究会
• [Presentation] D1/D2ドーパミン受容体コンディショナル発現マウスによる運動制御機構の解明 (2017)
  • Author(s): 笹岡 俊邦, 佐藤 朝子, 知見 聡美, 大久保 直, 阿部学, 川村名子, 中尾 聡宏, 小田 佳奈子, 酒井 清子, 前田 宜俊, 神保 幸弘, 田中 本美丘, 佐藤 俊哉, 藤澤 信義, 崎村建司, 南部 篤
  • Organizer: 第40回日本神経科学大会
• [Presentation] ドーパミン受容体及びNMDA受容体変異マウスを用いた大脳基底核回路の機能解析 (2017)
  • Author(s): 笹岡俊邦, 佐藤 朝子, 知見 聡美, 大久保 直, 阿部学, 川村名子, 中尾 聡宏, 小田 佳奈子, 酒井 清子, 前田 宜俊, 神保 幸弘, 田中稔, 山本美丘, 佐藤 俊哉, 藤澤 信義, 崎村建司, 南部 篤
  • Organizer: 科学研究費補助金「新学術領域研究(研究領域提案型)」非線形発振現象を基盤としたヒューマンネイチャーの理解「オシロロジー」 2017 年度第1回領域会議
• [Presentation] Elucidation of motor control mechanism using genetically modified mice harboring tetracycline-regulated expression of D1/D2 dopamine roceptors (2017)
  • Author(s): Toshikuni Sasaoka, Asako Sato, Satomi Chiken, Tadashi Okubo, Manabu Abe, Meiko Kawamura, Satohiro Nakao, Nae Saito, Seiko Sakai, Kanako Oda, Yoshitaka Maeda, Yukihiro Jimbo, Minoru Tanaka, Yoshitaka Yamamoto, Toshiya Sato, Nobuyoshi Fujisawa, Kenji Sakimu
  • Organizer: 2017年度 生命科学系学会合同年次大会 第40回日本分子生物学会 第90回日本生化学会大会
• [Presentation] D1/D2ドーパミン受容体コンディショナル発現マウスによる運動制御機構の解明 (2017)
  • Author(s): 笹岡俊邦, 佐藤朝子, 知見聡美, 大久保直, 阿部学, 川村名子, 中尾聡宏, 小田佳奈子, 齊藤奈英, 酒井清子, 神保幸弘, 佐藤俊哉, 岡本浩嗣, 藤澤信義, 崎村建司, 南部篤
  • Organizer: 科学研究費補助金「新学術領域研究(研究領域提案型)」非線形発振現象を基盤としたヒューマンネイチャーの理解 略称名 : 「オシロロジー」 2017 年度第2回領域会議
• [Presentation] qAIM-MRIによるD1ドーパミン受容体コンディショナルノックダウンマウスの全脳活動解析 (2017)
  • Author(s): 小山内実、菊田里美、谷平大樹、本間経康、中尾聡宏、小田佳奈子、笹岡俊邦、南部篤
  • Organizer: 第32回 日本大脳基底核研究会
• [Presentation] Forroptosis : A Critical Review, Session V1 : Ferroptosis and cancer. Role of iron in carcinogenesis and tumor biology. (2017)
  • Author(s): Toyokuni S.
  • Organizer: Cold Spring Harbor Laboratory Symposium
  • Int'l Joint Research / Invited
• [Presentation] ワークショップ : 本気でがんを予防する : 鉄と酸素からがん予防を考える (2017)
  • Author(s): 豊國伸哉
  • Organizer: 生命科学系学会合同年次大会 ConBio2017
  • Invited
• [Presentation] 組織の固定について～モデル動物の最適な固定法を用いて～ (2017)
  • Author(s): 宮崎龍彦
  • Organizer: 第42回組織細胞化学講習会
  • Invited
• [Presentation] Lower brain ph as a shared endophenotype of psychiatric disorders (2017)
  • Author(s): Hidco Hagihara, Vibeke Catts, Yuta Katayama, Tsuyoshi Takagi, Freesia L Huang, Kuo-Ping Huang, Shunsuke Ishii, Isabella A Graef, Gerald R Crabtree, Keiichi I Nakayama, Cynthia Shannon Weickert, Tsuyoshi Miyakawa
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology(AsCNP).
  • Int'l Joint Research
• [Presentation] Endophenotype in the brain : A key concept for understanding the relationships between genes and behavior (2017)
  • Author(s): Tsuyoshi Miyakawa
  • Organizer: IBNS (International Behavioral Neuroscienco Society) 26th Annual Meeting
  • Int'l Joint Research
• [Presentation] Lower brain pH as a shared endophenotype of psychotic disorders (2017)
  • Author(s): Hideo Hagihara, Vibeke Catts, Yuta Katayama, Tsuyoshi Takagi, Freesia L Huang, Kuo-Ping Huang, Shunsuke Ishii, Isabella A Graef, Gerald R Crabtree, Keiichi I Nakayama, Cynthia Shannon Weickert, Tsuyoshi Miyakawa
  • Organizer: 第40回日本神経科学大会
• [Presentation] Lower brain pH as a shared endophenotype of psychotic disorders (2017)
  • Author(s): Tsuyoshi Miyakawa
  • Organizer: Association for the Study of Neurons and Diseases (ASND) Pain and Cortex Summer Meeting
  • Int'l Joint Research
• [Presentation] Maturational plasticity and its molecular basis. (2017)
  • Author(s): Tsuyoshi Miyakawa
  • Organizer: Association for the Stury of Neurons and Diseases (AND) The 12th International Conference of Neurons and Brain Diseases
  • Int'l Joint Research
• [Presentation] Endophenotype in the brain : A key concopt for understanding the relationships between genes and behavior (2017)
  • Author(s): Tsuyoshi Miyakawa
  • Organizer: CFC Symposium
  • Int'l Joint Research / Invited
• [Presentation] Endophenotype in the brain : A key concept for understanding the relationships between genes and behavior (2017)
  • Author(s): Tsuyoshi Miyakawa
  • Organizer: Socicty for Neuroscience (SFN) 47th Annual Meeting 2017
  • Int'l Joint Research
• [Presentation] Lower brain pH as a shared endophenotype of psychiatric disorders (2017)
  • Author(s): Hideo Hagihara, Vibeke S Catts, Yuta Katayama, Tsuyoshi Takagi, Freesia L Huang, Kuo-Ping Huang, Shunsuke Ishii, Isabella A Graef, Gerald R Crabtree, Keiichi I Nakayama, Cynthia Shannon Weicker, Tsuyoshi Miyakawa
  • Organizer: Society for Neuroscience (SFN) 47th Annual Meeting 2017
  • Int'l Joint Research
• [Presentation] Mouse Behavioral Phenotype Database (2017)
  • Author(s): Satoko Hattori, Hirotaka Shoji, Keizo Takao, Tsuyoshi Miyakawa
  • Organizer: 5th INCF Japan Node International Workshop -Advances in Neuroinformatics
  • Int'l Joint Research
• [Presentation] 脳内のエンドフェノタイプ : 遺伝子と行動の関係性を理解するためのキーコンセプト (2017)
  • Author(s): 荻原英雄、宮川剛
  • Organizer: ConBio2017(2017年度 生命科学系学会合同年次大会)日本分子生物学会、日本生化学会
  • Invited
• [Presentation] 脳内中間表現型 : 遺伝子と行動をつなぐためのキーコンセプト (2017)
  • Author(s): 宮川 剛
  • Organizer: Advans研究会2017
  • Invited
• [Presentation] マウスの大規模網羅的行動解析データの二次利用によるメタ解析 (2017)
  • Author(s): 服部聡子、昌子浩孝、高雄啓三、宮川剛
  • Organizer: 次世代脳 2017年度冬のシンポジウム
• [Presentation] 次世代型薬物依存研究 : 神経ペプチド神経系の理解 (2017)
  • Author(s): 池田和隆
  • Organizer: 第52回日本アルコール・アディクション医学会学術総会
  • Invited
• [Presentation] Transeriptomo profiling of dopaminc-deficient mouse brain. (2017)
  • Author(s): Kasai S, Hagino Y, Fujita M, Kobayashi K, Ikeda K
  • Organizer: 第60回日本神経化学会大会
  • Invited
• [Presentation] 鎮痛薬適量予測式の構築と臨床応用技術の開発 (2017)
  • Author(s): 池田和隆
  • Organizer: 第4回包括的緩和医療科学学術研究会/第5回Tokyo疼痛緩和次世代研究会 合同研究会
  • Invited
• [Presentation] 疼痛緩和における“テーラーメイド治療”の実現に向けて。 (2017)
  • Author(s): 井手聡一郎, 髙橋香央里, 西澤大輔, 福田謙一, 池田和隆
  • Organizer: 第11回日本緩和医療薬学会年会
  • Invited
• [Presentation] Molecular mechanisms underlying individual differences in pain and analgesic sensitivity. (2017)
  • Author(s): Kasai S, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology(AsCNP 2017)
  • Int'l Joint Research / Invited
• [Presentation] The involvemont of acetylcholine system in hyperactivity in dopamine-doficient (DD) mice. (2017)
  • Author(s): Ikeda K, Fujita M, Hagino Y, Kobayashi K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology(AsCNP 2017)
  • Int'l Joint Research / Invited
• [Presentation] NMDA recoptor channol subunit GluN2D : A dark horse molecule in Neuropsychopharmacology. (2017)
  • Author(s): Ikeda K, Hagino Y, Ide S
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology(AsCNP 2017)
  • Int'l Joint Research / Invited
• [Presentation] 薬理学的解析支援 (2017)
  • Author(s): 森屋由紀, 西澤大輔, 井手聡一郎, 池田和隆
  • Organizer: 平成29年度新学術領域研究 学術研究支援基盤形成【先端モデル動物支援プラットフォーム】成果発表会
• [Presentation] ゲノムワイド関連解析(GWAS)による腹腔鏡補助下大腸切除術中レミフェンタニル投与速度に寄与する遺伝子多型の同定 (2017)
  • Author(s): 西澤大輔, 三枝勉, 辻田美紀, 中川秀之, 山口茂樹, 笠井慎也, 長谷川準子, 福田謙一, 北村晶, 林田眞和, 池田和隆
  • Organizer: 平成29年度新学術領域研究 学術研究支援基盤形成【先端モデル動物支援プラットフォーム】成果発表会
• [Presentation] mTOR阻害剤投与による胎生期バルプロ酸曝露マウスの自閉症様行動への影響 (2017)
  • Author(s): 村上浩子, 小林敏之, 柏井洋文, 佐藤敦志, 萩野洋子, 田中美歩, 西藤泰昌, 高松幸雄, 内野茂夫, 池田和隆
  • Organizer: 2017年度生命科学系学会合同年次大会
• [Presentation] Circadian rhythm is maintained in dopamine-deficient mice. (2017)
  • Author(s): Fujita M, Hagino Y, Takeda TC, Kasai S, Tanaka M, Takamatsu Y, Kobayashi K, Ikeda K
  • Organizer: The 56th Annual Meeting of the American College of Neuropsychopharmacology(ACNP 56th Annual Meeting)
  • Int'l Joint Research
• [Presentation] 依存症に対する薬物治療 (2017)
  • Author(s): 池田和隆
  • Organizer: 平成29年度AMED脳と心の研究課 研究交流会
• [Presentation] 依存症患者における薬物療法の効果検討とfMRIを基点としたバイオマーカーの開発 (2017)
  • Author(s): 池田和隆
  • Organizer: 平成29年度AMED脳と心の研究課 研究交流会
• [Presentation] ゲノムワイド関連解析(GWAS)による慢性疼痛感受性遺伝子多型の同定 (2017)
  • Author(s): 西澤大輔, 有田英子, 花岡一雄, 矢島直, 井関雅子, 加藤実, 小川節郎, 森山彩子, 笠井慎也, 長谷川準子, 林田眞和, 池田和隆
  • Organizer: 日本人類遺伝学会 第62回大会
• [Presentation] Sex differences in drinking behavior following stress in mu-opioid receptor knockout mice. (2017)
  • Author(s): Moriya Y, Kasahara Y, Hall FS, Hagino Y, Uhl GR, Ikeda K, Sora I
  • Organizer: Society for Neuroscience 2017
  • Int'l Joint Research
• [Presentation] TANDに対するmTOR阻害剤の自覚的改善効果 (2017)
  • Author(s): 佐藤敦志, 池田和隆, 水口雅
  • Organizer: 第5回日本結節性硬化症学会学術総会
• [Presentation] Genomc-wide association study identifies candidatc loci associated with intraoperative remifentanil requirements during laparoscopic-assisted celectomy. (2017)
  • Author(s): Nishizawa D, Micda T, Tsujita M, Nakagawa H, Yamaguchi S, Kasai S, Hasegawa J, Fukuda K, Kitamura A, Hayashida M, Ikcda K
  • Organizer: ASHG2017 第67回米国人類遺伝学会
  • Int'l Joint Research
• [Presentation] 結節性硬化症モデルマウスにおける幼若期NMDA投与による点頭様発作の解析 (2017)
  • Author(s): 柏井洋文, 笠井慎也, 萩野洋子, 佐藤敦志, 古田島浩子, 田中美歩, 小林敏之, 樋野興夫, 岡明, 水口雅, 池田和隆
  • Organizer: 第51回日本てんかん学会年次学術集会
• [Presentation] インターロイキン-17Aの一塩基多型と痛み関連表現型との関連解析 (2017)
  • Author(s): 大岡静衣, 西澤大輔, 長谷川準子, 高橋香央里, 中山京子, 江畑裕子, 福田謙一, 池田和隆
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] ケタミンの抗うつ作用と認知機能障害におけるNMDA受容体GluN2Dサブユニットの役割 (2017)
  • Author(s): 井手聡一郎, 池窪結子, 橋本謙二, 三品昌美, 池田和隆
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] muオビオイド受容体欠損マウスにおけるストレスとアルコール嗜好性に対する雌雄差の解析 (2017)
  • Author(s): 森屋由紀, 笠原好之, 萩野洋子, 池田和隆, 曽良一郎
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] 日本人におけるN-methyl-D-aspartate receptor 2B subunit 遺伝子多型とアルコール依存症との関連研究 (2017)
  • Author(s): 成田心, 吉原英児, 西澤大輔, 川合厚子, 池田和隆, 岩橋和彦
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] ゲノムワイド関連解析(GWAS)による腹腔鏡補助下大腸切除術中レミフェンタニル投与速度に影響する遺伝子多型の同定 (2017)
  • Author(s): 西澤大輔, 三枝勉, 辻田美紀, 山口茂樹, 笠井慎也, 長谷川準子, 福田謙一, 北村晶, 林田眞和, 池田和隆
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] 胎生期バルプロ酸曝露マウスの社会性行動障害のラパマイシン投与による改善 (2017)
  • Author(s): 古田島(村上)浩子, 小林敏之, 柏井洋文, 佐藤敦志, 萩野洋子, 田中美歩, 西藤泰昌, 高松幸雄, 内野茂夫, 池田和隆
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] Weaver変異型マウスにおけるmethamphetamineの報酬効果消失 (2017)
  • Author(s): 池窪結子, 井手聡一郎, 高松幸雄, 池田和隆
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] Tsc2ヘテロ欠損マウスの自閉症様行動に対するrapamycinの継続投与の効果とその副作用の検討 (2017)
  • Author(s): 柏井洋文, 笠井慎也, 萩野洋子, 佐藤敦志, 古田島浩子, 田中美歩, 小林敏之, 樋野興夫, 水口雅, 池田和隆
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] セロトニントランスポーターノックアウトおよびヘテロ欠損マウスにおける自閉症様行動とトリプトファン欠乏食による改善効果 (2017)
  • Author(s): 田中美歩, 佐藤敦志, 笠井慎也, 萩野洋子, 古田島浩子, 柏井洋文, 西藤泰昌, 稲垣真澄, 曽良一郎, 池田和隆
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] 各種自発行動におけるドーパミン依存性の解析 (2017)
  • Author(s): 藤田雅代, 萩野洋子, Takoda T, 笠井慎也, 高松幸雄, 池田和隆
  • Organizer: 第52回日本アルコール・アディクション医学会学術総会
• [Presentation] 外側視床下部脳内自己刺激におけるオピオイド神経とドパミン神経系の役割 (2017)
  • Author(s): 井手聡一郎, 高橋雄大, 高松幸雄, Uh1 GR, 曽良一郎, 池田和隆
  • Organizer: 第37回鎮痛薬・オピオイドベブチドシンポジウム
• [Presentation] Association study of a candidate genetic variant with the development of taxane-induced peripheral neuropathy. (2017)
  • Author(s): Tanabe Y, Nishizawa D, Hasegawa J, Ikeda K, Shimomura A, Takano T, Shimizu C
  • Organizer: 第15回日本臨床腫瘍学会学術集会
• [Presentation] The effects of chronic stress on alcohol consumption in mu-opioid receptor knockout mice. (2017)
  • Author(s): Moriya Y, Kasahara Y, Hall FS, Uhl GR, Ikeda K, Sora I
  • Organizer: International Narcotics Research Conference 2017(INRC2017)
  • Int'l Joint Research
• [Presentation] Stress-induccd alcohol drinking in mice lacking mu-opioid rcceptors. (2017)
  • Author(s): Moriya Y, Kasahara Y, Hall FS, Uhl GR, Ikeda K, Sora I
  • Organizer: 26th Annual Mceting of the International Behavioral Neuroscience Society(IBNS2017)
  • Int'l Joint Research
• [Presentation] 遺伝子多型と疼痛感受性・オピオイド感受性 (2017)
  • Author(s): 林田眞和, 福田謙一, 西澤大輔, 池田和隆
  • Organizer: 日本麻酔科学会第64回学術集会
• [Presentation] Inhibition of mTOR imprves autism-like behaviors in mice in utero exposed to valproic acid. (2017)
  • Author(s): Kotajima-Murakami H, Kobayashi T, Kashii H, Sato A, Hagino Y, Nishito Y, Takamatsu Y, Uchino S, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology(AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Rapamycin treatment of impaired social behavior in adolescent Tsc2+/-mice. (2017)
  • Author(s): Kashii H, Hagino Y, Kasai S, Kotajima H, Sato A, Kobayashi T, Hino O, Mizuguchi M, Ikeda K
  • Organizer: 5th Congress of Asian Collcge of Neuropsychopharmacology(AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Association between genetic polymorphisms in Cav2, 3 (R-type) Ca2+ channels and fentanyl sensitivity in patients undergoing painful cosmetic surgery. (2017)
  • Author(s): Ide S, Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Hayashida M, Ikeda K
  • Organizer: 5th Congress of Asian College of Ncuropsychopharmacology(AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Associations between polymorphisms close to the cAMP responsive element binding protein 1 (CREB1) gene and the activating transcription factor 2 (ATF2) gene and fentany1 sensitivity. (2017)
  • Author(s): Aoki Y, Nishizawa D, Yoshida K, Hasegawa J, Kasai S, Takahashi K, Koukita Y, Ichinohe T, Hayashida M, Fukuda K, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology(AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Single nucleotide polymorphisms in the 5' flanking region of interleukin-17A gene significantly associate with pain sensitivity. (2017)
  • Author(s): Ohka S, Nishizawa D, Hasegawa J, Takahashi K, Nakayama K, Ebata Y, Fukuda K, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology(AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Genetic polymorphisms in the orexin system (focusing on a polymorphlsm associated with nicotine dependence) (2017)
  • Author(s): Nishizawa D, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology(AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Association of proopioimeranocortin gene polymorphism with vulnerability to alcohol dependence in Japanese. (2017)
  • Author(s): Kasai S, Nishizawa D, Higuchi S, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology(AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Genome-wide association study identifies candidate loci associated with intraoperative remifentanil infusion rate in patients undergoing laparoscopic-assisted colectomy. (2017)
  • Author(s): Nishizawa D, Mieda T, Tsujita M, Yamaguchi S, Kasai S, Hasegawa J, Fukuda K, Kitamura A, Hayashida M, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology(AsCNP 2017)
  • Int'l Joint Research
• [Presentation] The relationship between stress and alcohol consumption in female mice. (2017)
  • Author(s): Moriya Y, Kasahara Y, Hall FS, Uhl GR, Ikeda K, Sora I
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology(AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Multiplex imaging of neural activity and signaling dynamics. (2017)
  • Author(s): Bito H.
  • Organizer: 16th Annual Meeting of the Molecular & Cellular Cognition Society-ASIA.
  • Int'l Joint Research / Invited
• [Presentation] Multiplex imaging of neural activity and signaling dynamics. (2017)
  • Author(s): Bito H.
  • Organizer: 40th Annual Meeting of the Japan Neuroscience Society.
  • Int'l Joint Research / Invited
• [Presentation] 学習行動研究を志向したマウス用バーチャルリアリティ行動実験系の開発 (2017)
  • Author(s): 町田祉永, 片山統裕, 中澤邑支朗, 和田みなみ, 中尾光之
  • Organizer: 電子情報通信学会MEとバイオサイバネティクス研究会
• [Presentation] In vivo Integrative Optical lmaging 法によるマウス大脳皮質の細胞外拡散特性解析 (2017)
  • Author(s): 廣谷唯, 田中健也, 吉田侑冬, 辛島彰洋, 中尾光之, 片山統裕
  • Organizer: 電子情報通信学会MEとバイオサイバネティクス研究会
• [Presentation] バーチャル直線通路におけるストロボ効果の数理モデル化と解析 (2017)
  • Author(s): 片山統裕, 中澤邑支朗, 町田祉永, 中尾光之
  • Organizer: 第22回日本バーチャルリアリティ学会大会
• [Presentation] 視覚再建技術評価のための脳イメージングに基づくマウス視覚能力定量化法の開発 (2017)
  • Author(s): 奥畑大悟, 片山統裕, 吉田侑冬, 中尾光之
  • Organizer: 計測自動制御学会ライフエンジニアリング部門シンポジウム
• [Presentation] Comparison between functional networks estimated by marginal and parital correlation analysis of the optical intrinsic signals of the mouse neocortex (2017)
  • Author(s): Yuto Yoshida, Mitsuyuki Nakao, Norihiro Katayama
  • Organizer: The 40th Annual Meeting of the Japan Neuroscience Society
• [Presentation] Sleep-wake state-dependent synaptic plasticity in the hippocampus (2017)
  • Author(s): Akihiro Karashima, Yukiteru Masuda, Norihiro Katayama, Hiroshi Tsubokawa, Mitsuyuki Nakao
  • Organizer: The 40th Annual Mccting of the Japan Neuroscience Society
• [Presentation] Correlation and temporal relationship between the mouse hippocampal theta activity and its locomotion speed (2017)
  • Author(s): Norihiro Katayama, Yushiro Nakazawa, Yoshihisa Machida, Mitsuyuki Nakao, Hajime Mushiake
  • Organizer: The 40th Annual Meeting of the Japan Neuroscience Society
• [Presentation] 短期間で学習可能なマウス用オペラント学習装置の開発とその評価 (2017)
  • Author(s): 外川龍之介, 高橋優斗, 奥畑大悟, 虫明元, 中尾光之, 片山統裕
  • Organizer: 文部科学省新学術領域研究 学術研究支援基盤形成 先端モデル動物支援プラットフォーム若手支援技術講習会
• [Presentation] 経頭蓋内因性光信号イメージングによるマウス大脳皮質自発性活動の解析 (2017)
  • Author(s): 片山統裕
  • Organizer: 電子情報通信学会医用画像研究会
  • Invited
• [Presentation] マウス大脳皮質における緑色自家蛍光の時空間ダイナミクス血液量動態の偏相関解析に基づいた機能的ネットワークの睡眠・覚醒状態依存性解析 (2017)
  • Author(s): 吉田侑冬, 中尾光之, 片山統裕
  • Organizer: 日本睡眠学会第42回定期学術集会
• [Presentation] 睡眠-覚醒状態に依存した海馬神経回路におけるシナプスホメオスタシス (2017)
  • Author(s): 辛島彰洋, 益田幸輝, 片山統裕, 坪川宏, 中尾光之
  • Organizer: 日本睡眠学会第42回定期学術集会
• [Presentation] Integrative Optical Imaging法を用いたマウス大脳皮質拡散特性の計測と解析 (2017)
  • Author(s): 廣谷唯, 中尾光之, 片山統裕
  • Organizer: 日本睡眠学会第42回定期学術集会
• [Presentation] Integrative Optical Imaging法を用いたマウス大脳皮質拡散特性の計測と解析 (2017)
  • Author(s): 片山統裕, 佐藤杏莉, 田中健也, 中尾光之
  • Organizer: 日本睡眠学会第42回定期学術集会
• [Presentation] Dovelopmcnt of Si opto ncural probe with embcddcd optical fibcr cnabling laycr-by-layer optical stimulation in the brain (2017)
  • Author(s): Takumi Morikawa, Takuya Harashima, Hisashi Kino, Takafumi Fukushima, Norihiro Katayama, Hajime Mushiake, Tetsu Tanaka
  • Organizer: 第56回日本生体医工学会大会
• [Presentation] Development of vertically-stackcd multi-shank si neural probe array with sharpened tip for 3-dimensional neural recording (2017)
  • Author(s): Takuya Harashima, Takumi Morikawa, Hisashi Kino, Takafumi Fukushima, Norihiro Katayama, Hajime Mushiake, Tctsu Tanaka
  • Organizer: 第56回日本生体医工学会大会
• [Presentation] Development of an auditory stimulator synchronized with cortical EEG slow oscillation (2017)
  • Author(s): Kenya Tanaka, Anri Sato, Yuto Yoshida, Mitsuyuki Nakao, Norihiro Katayama
  • Organizer: 第56回日本生体医工学会大会
• [Presentation] Correlation betwen locomotion speed and hippocampal theta activity of mice in a virtual corridor (2017)
  • Author(s): Norihiro Katayama, Yushiro Nakazawa, Yoshihisa Machida, Mitsuyuki Nakao, Hajime Mushiake
  • Organizer: 第56回日本生体医工学会大会
• [Presentation] 皮質層別刺激可能なシリコンオプト神経プローブの開発 (2017)
  • Author(s): 森川 拓実, 原島 卓也, 張 博文、土居 史弥, 木野 久志, 福島 誉史, 田中 徹
  • Organizer: 第78回応用物理学会秋季学術講演会
• [Presentation] 三次元神経活動記録のための積層シリコン神経プローブアレイの開発 (2017)
  • Author(s): 原島 卓也, 森川 拓実, 張 博文, 土居 史弥, 木野 久志, 福島 誉史, 田中 徹
  • Organizer: 第78回応用物理学会秋季学術講演会
• [Presentation] Developmcnt of vertically-stacked multi-shank si neural probe array with sharpened tip for cubic spacial recording (2017)
  • Author(s): Takuya Harashima, Takumi Morikawa, Hisashi Kino, Takafumi Fukushima, Norihiro Katayama, Tetsu Tanaka
  • Organizer: 2017 International Conference on Solid State Devices and Materials
  • Int'l Joint Research
• [Presentation] 3D-IC technology and its application to fully implantable retinal prosthesis (2017)
  • Author(s): Tetsu Tanaka, Takafumi Fukushima, Hisashi Kino
  • Organizer: 14th International Conference on Flow Dynamics
  • Int'l Joint Research / Invited
• [Presentation] 3D-IC tcchnology : rcliability challenges and biomedical application (2017)
  • Author(s): Tetsu Tanaka
  • Organizer: 2017 IEEE Electrical Design of Advanced Packaging and Systems Symposium
  • Int'l Joint Research / Invited
• [Presentation] Ultra-thin fluorescence endoscope imaging system for functional brain imaging (2017)
  • Author(s): Osanai M, Ohkawa N, Sakamoto K, Miwa H, Kikuta S, Tamura A, Sato M, Ohkura M, Kojima T, Kohmura Y, Nakai J, Hayashi Y, Yanagawa Y, Inokuchi K, Homma N, Mushiake H
  • Organizer: 第40回日本神経科学大会
• [Presentation] Unraveling the dynamism of engram cells during contextual memory processing (2017)
  • Author(s): Ghandour K, Ohkawa N, Fung C, Saitoh Y, Takekawa T, Asai H, Okubo-Suzuki R, Nomoto M Soya S, Tsujimura S, Nishizono H, Matsuo M, Sato M, Ohkura M, Nakai J, Hayashi Y, Sakurai T, Osanai M, Fukai T, Inokuchi K
  • Organizer: NEUROSCIENCE 2017(STN)
  • Int'l Joint Research
• [Presentation] Ultra-thin fluorescence endoscope imaging system for functional biological imaging. (2017)
  • Author(s): Osanai M, Ohkawa N, Kamiya A, Inami C, Sato M, Ohkura M, Kojima T, Kohmura Y, Hayashi Y, Yanagawa Y, Ohsawa M, Nakai J, Inokuchi K, Homma N, Mushiake H
  • Organizer: SICE SSI 2017
• [Presentation] 極微細蛍光内視鏡による脳深部機能イメージング (2017)
  • Author(s): 小山内 実
  • Organizer: 次世代脳プロジェクト冬のシンポジウム
• [Presentation] 前頭葉内側領域によるパフォーマンスモニタリングと行動調節 (2017)
  • Author(s): 虫明 元, 松坂 義哉
  • Organizer: 第40回日本神経科学大会 幕張メッセ
  • Int'l Joint Research
• [Presentation] マウス用ヴァーチャル・リアリティ装置を用いた齧歯類の高次脳機能解明システムの開発 (2017)
  • Author(s): 洞口学志, Janos Nogyesi, 片山統裕, 虫明元, 坂本一寛
  • Organizer: 第49回東北生理談話会
• [Presentation] 遺伝子改変マウスの行動解析を起点とした精神疾患研究 (2017)
  • Author(s): 高雄 啓三
  • Organizer: 2017年度 生命科学系学会合同年次大会 ConBio2017
• [Presentation] ノンコードゲノム領域の機能理解へのGenome Architectureの試み (2017)
  • Author(s): 北野翔平, 金子真也, 高雄啓三, 相澤康則
  • Organizer: 2017年度生命科学系学会合同年次大会 ConBio2017
• [Presentation] マウス大脳皮質におけるパルブアルブミンニューロンと神経細胞周囲網の年齢に関連した変化 (2017)
  • Author(s): 上野浩司, 高雄啓三, 末光俊介, 岡本 基, 石原武士
  • Organizer: 2017年度生命科学系学会合同年次大会 ConBio2017
• [Presentation] Bidirectional role of postsynaptic cAMP and cGMP in synaptic plasticity and memory (2017)
  • Author(s): Borovac J, Luyben T, Takao K, Okamoto K
  • Organizer: 47th Annual meeting of Socicty for Neurosciencc
  • Int'l Joint Research
• [Presentation] CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus, and regulatos seizure susceptibility, as well as emotional behaviors and memory (2017)
  • Author(s): Tanaka T, Okuda K, Kobayashi S, Fukaya M, Takao K, Watanabe A, Murakami T, Hagiwara M, Komano- Inoue S, Manabe H, Yamaguchi M, Sakagami H, Miyakawa T, Mizuguchi M, Manabe T
  • Organizer: 47th Annual mceting of Society for Nouroscience
  • Int'l Joint Research
• [Presentation] 「こころ」の物質的基盤を探る行動生理学的アプローチ (2017)
  • Author(s): 高雄啓三
  • Organizer: 第9回 光操作研究会
• [Presentation] シプナスオーガナイザ一遺伝子点変異導入マウスを用いた神経発達障害発症機構の解明 (2017)
  • Author(s): 吉田知之、山形敦史、田端彩子、和泉宏謙、城島知子、金 主賢、深田優子、深田正紀、高雄啓三、森 寿、深井周也
  • Organizer: 第39回日本生物学的精神医学会, 第47回日本神経精神薬理学会
• [Presentation] 恒常性維持機構の破綻としての精神疾患 (2017)
  • Author(s): 高雄啓三
  • Organizer: 第7回オルソオルガノジェネシス検討会
• [Presentation] 空間弁別に必要なセプチン依存的シナプス制御 (2017)
  • Author(s): 上田(石原)奈津実, 深澤有吾, 鈴木悠大, 増田啓吾, 高雄啓三, 宮川 剛, 尾藤晴彦, 木下 専
  • Organizer: 第40回日本神経科学大会
• [Presentation] West症候群・Rett症候群の原因遺伝子CDKL5の相互作用蛋白探索とloss-of -function解析による統合的機能解明 (2017)
  • Author(s): 田中輝幸, 奥田耕助, 小林静香, 村上拓冬, 深谷昌弘, 高雄啓三, 渡邊 紀, 萩原 舞, 阪上洋行, 水口 雅, 宮川 剛, 真鍋俊也
  • Organizer: 第40回日本神経科学大会
• [Presentation] 転写因子ATF5の欠損は行動異常を引き起こす (2017)
  • Author(s): 梅村真理子, 小倉多恵, 金子泰之, 中野春男, 高橋 滋, 高雄啓三, 宮川 剛, 高橋勇二
  • Organizer: 第40回日本神経科学大会
• [Presentation] 統合失調症モデル Schnurri-2 ノックアウトマウスの歯状回顆粒細胞における三次元電子顕微鏡解析 (2017)
  • Author(s): 中尾章人, 高雄啓三, 大平耕司, 宮崎直幸, 村田和義, 宮川 剛
  • Organizer: 第40回日本神経科学大会
• [Presentation] オーファン代謝型受容体 Prrt 3の大脳特異的ノックアウトマウスの行動解析、およびそのリガンド同定に向けた小分子ライブラリーのスクリーニング (2017)
  • Author(s): 陳 以珊, 山本友美, 周 麗, 夏目里恵, 今野幸太郎, 上杉志成, 渡辺雅彦, 高雄啓三, 宮川 剛, 崎村健司, 久保義弘
  • Organizer: 第40回日本神経科学大会
• [Presentation] ミクログリアに発現する電位依存性プロトンチャネルの脳内における発現差異とその機能 (2017)
  • Author(s): 河合喬文, 高雄啓三, 崎村健司, 宮川 剛, 岡村康司
  • Organizer: 第40回日本神経科学大会
• [Presentation] ノンコードゲノム領域の機能理解へのCenome Architectureの試み (2017)
  • Author(s): 北野翔平, 金子真也, 高雄啓三, 相澤康則
  • Organizer: 2017年度生命科学系学会合同年次大会 ConBio2017
• [Presentation] Mouse behavioral phenotype database. Advances in Neuroinformatics (2017)
  • Author(s): S. Hattori, H. Shoji, K. Takao, T. Miyakawa
  • Organizer: Advances in Neuroinformatics
• [Presentation] Bidircctional role of postsynaptic cAMP and cGMP in synaptic plasticity and memory (2017)
  • Author(s): J. Borovac, T. Luyben, K, Takao, K. Okamoto
  • Organizer: 47th Annual meeting of, Society for Neuroscience
  • Int'l Joint Research
• [Presentation] CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus, and regulates seizure susceptibility, as well as emotional behaviors and memory (2017)
  • Author(s): T. Tanaka, K. Okuda, S. Kobayashi, M. Fukaya, K. Takao, A. Watanabe, T. Murakami, M, Hagiwra, S. Komano-Inoue, H. Manabe, M. Yamaguchi, H. Sakagami, T. MiyakawaI, M. Mizuguchi, T. Manabe
  • Organizer: 47th Annual meeting of Society for Neuroscience
  • Int'l Joint Research
• [Presentation] 空間弁別に必要なセプチン依存的シナブス制御 (2017)
  • Author(s): 上田(石原)奈津実, 深澤有吾, 鈴木悠大, 増田啓吾, 高雄啓三, 宮川 剛, 尾藤晴彦, 木下 専
  • Organizer: 第40回日本神経科学大会
• [Presentation] West症候群・Rett症候群の原因遺伝子CDKL5の相互作用蛋白探索とloss-of -function 解析による統合的機能解明 (2017)
  • Author(s): 田中輝幸, 奥田耕助, 小林静香, 村上拓冬, 深谷昌弘, 高雄啓三, 渡邊 紀, 萩原 舞, 阪上洋行, 水口 雅, 宮川 剛, 真鍋俊也
  • Organizer: 第40回日本神経科学大会
• [Presentation] 鶴尾隆賞受賞講演 : テロメアを起点としたがんの本態解明と分子標的治療薬の開発 (2017)
  • Author(s): 清宮啓之
  • Organizer: 第21回日本がん分子標的治療学会学術集会
  • Invited
• [Presentation] G-quadruplex in cancer biology and drug dcvelopment (2017)
  • Author(s): 清宮啓之
  • Organizer: Tokyo Modical University, Instituto of Medical Science, Ist International Symposium "Role of Aging and Cancer"
  • Int'l Joint Research / Invited
• [Presentation] 分子プロファイリング支援活動のご紹介 (2017)
  • Author(s): 清宮啓之
  • Organizer: 先端モデル動物支援プラットフォーム平成29年度若手支援技術講習会
  • Invited
• [Presentation] 大腸がん幹細胞を標的とする化合物の探索と細胞傷害性抗がん剤との併用効果 (2017)
  • Author(s): 張明奎、馬島哲夫、清宮啓之
  • Organizer: 先端モデル動物支援プラットフォーム平成29年度若手支援技術講習会
• [Presentation] テロメラーゼ阻害剤MST-312の即時的制がん効果を規定する因子 (2017)
  • Author(s): 藤原千明、村松由起子、水谷アンナ、矢守隆夫、杉本芳一、清宮啓之
  • Organizer: 先端モデル動物支援プラットフォーム平成29年度若手支援技術講習会
• [Presentation] 細胞形態・表現型解析による分子プロファイリング (2017)
  • Author(s): 井本正哉
  • Organizer: 先端モデル動物支援プラットフォーム平成29年度若手支援技術講習会
  • Invited
• [Presentation] シスプラチン持続暴露によるEMT誘導機構の解析 (2017)
  • Author(s): 田代悦、井本正哉
  • Organizer: 第21回日本がん分子標的治療学会学術集会
• [Presentation] 謎解きと宝探しの天然物ケミカルバイオロジー (2017)
  • Author(s): 井本正哉
  • Organizer: 第52回天然物化学談話会
  • Invited
• [Presentation] Synthetic lethal killing of b-catenin mutant cancer cells by small molecules (2017)
  • Author(s): 井本正哉
  • Organizer: 3rd KRIBB-RIKEN Chemical Biology Joint Symposium
  • Int'l Joint Research / Invited
• [Presentation] Screening of the compounds that modulate cellular bilirubin level in hopatocellular carcinoma HepG2 cells (2017)
  • Author(s): 片浦哲志、井本正哉
  • Organizer: AACR-NCI-EORTC International Conference
  • Int'l Joint Research
• [Presentation] Extracellular RNA is promising biomarker for eary detection of cane (2017)
  • Author(s): 田原 栄俊
  • Organizer: ISEV2017
  • Int'l Joint Research
• [Presentation] マイクロRNA・エクソソームの臨床応用 (2017)
  • Author(s): 田原 栄俊
  • Organizer: 第17階日本抗加齢医学学会総会
  • Invited
• [Presentation] MicroRNA and exosome in aging (2017)
  • Author(s): 田原 栄俊
  • Organizer: 日本基礎老化学会
  • Invited
• [Presentation] 動脈硬化におけるバイオマーカー (2017)
  • Author(s): 田原 栄俊
  • Organizer: 第49回日本動脈硬化学会総会・学術集会
  • Invited
• [Presentation] マイクロRNAを用いた革新的抗癌剤の開発 (2017)
  • Author(s): 田原 栄俊
  • Organizer: Oncology Seminar
  • Invited
• [Presentation] DNA解析装置とがん早期発見システム (2017)
  • Author(s): 田原 栄俊
  • Organizer: 第25回日本がん検診・診断学会総会
  • Invited
• [Presentation] miRNA in aging and cancer (2017)
  • Author(s): 田原 栄俊
  • Organizer: Tokyo Medical University, Institute of Medical Science, lst International Symposium "Role of Aging and Cancer"
  • Int'l Joint Research / Invited
• [Presentation] Senescence-associated microRNAs act as tumor suppressor hor both cancer stem cells and anti-cancer drug cancer cells (2017)
  • Author(s): 田原 栄俊
  • Organizer: 2nd Global Insight Conference on Breast Cancer
  • Int'l Joint Research
• [Presentation] MicroRNA and exosomo in aging (2017)
  • Author(s): 田原 栄俊
  • Organizer: MIRAIセミナー
  • Int'l Joint Research / Invited
• [Presentation] Validation of circulating microRNA using NGS (2017)
  • Author(s): 田原 栄俊
  • Organizer: 第5回JMACシンポジウム
  • Invited
• [Presentation] 頭頸部がんに領域における核酸医薬治療の可能性 (2017)
  • Author(s): 田原 栄俊
  • Organizer: 第395回東北医学会例会シンポジウム
  • Invited
• [Presentation] 細胞外小胞・エクソソームとマイクロRNAの臨床応用の可能性 (2017)
  • Author(s): 田原 栄俊
  • Organizer: 日本唾液腺学会
  • Invited
• [Presentation] Screening of the compounds that modulate cellular bilirubin level in hepatocellular carcinoma HepG2 cells (2017)
  • Author(s): 片浦哲志、井本正哉
  • Organizer: The AACR-NCI-EORTC International Conference on "Molecular Targets and Cancer Therapeutics : Discovery, Biology, and Clinical Applications 2017"
  • Int'l Joint Research
• [Presentation] 細胞内ビリルビン量を指標とするパーキンソン病治療薬の探索 (2017)
  • Author(s): 片浦哲志、斉木臣二、井本正哉
  • Organizer: 先端モデル動物支援プラットフォーム若手支援技術講習会
• [Presentation] Distinct roles of opioid and dopamine systems in lateral hypothalamic intracranial self-stimulation. (2016)
  • Author(s): Ikeda K, Ide S, Takahashi T, Takamatsu Y, Uhl GR, Niki H, Sora I
  • Organizer: The 55th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 55th Annual Meeting)
  • Place of Presentation: Hollywood, Florida, USA
  • Year and Date: 2016-12-05
  • Int'l Joint Research
• [Presentation] Identification and Selective Stabilization of G-quadruplexes by Small Molecules (2016)
  • Author(s): 長澤和夫
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: バシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2016-11-30
  • Invited
• [Presentation] Quantitative analysis of T cell repertoire and homeostasis (2016)
  • Author(s): Taishin Akiyama and Tetsuya J. Kobayashi
  • Organizer: 第54回生物物理学会
  • Place of Presentation: つくば国際会議場(茨城県つくば市)
  • Year and Date: 2016-11-26
  • Invited
• [Presentation] Three dimensional analysis of walking legs and their controlling muscles in the centipede Scolopendra subspinipes mutilans using micro-CT technique (2016)
  • Author(s): H. Aonuma, S. Kuroda, K. Yasui, T. Kano and A. Ishiguro
  • Organizer: 22nd International congree of Zoology and 87th meeting of Zoological Society of Japan
  • Place of Presentation: OIST, 沖縄コンベンションセンター, 沖縄県, 恩納村宜野湾市
  • Year and Date: 2016-11-14
  • Int'l Joint Research
• [Presentation] Role of R-type calcium channel (Cav2.3) in medial habenula to interpeduncular nucleus pathway (2016)
  • Author(s): Bhandari P, Parajuli LK, Takao K, Miyakawa T, Kobayashi Y, Tanaka KF, Shigemoto R.
  • Organizer: 46th Annual meeting of Society for Neuroscience
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2016-11-13
• [Presentation] Tutorial contents on neuroinfomrmatics platforms. (2016)
  • Author(s): Yamaguchi Y, Hattori S, Takao K, Okumura Y, Suenaga S, Ishii I, Honda A, Ogawa M, Usui S, Miyakawa T
  • Organizer: 46th Annual meeting of Socisty for Neuroscience
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2016-11-12
• [Presentation] Functional analysis of the RNA-binding protein PTBP1 and its paralogue PTBP2 in development (2016)
  • Author(s): 吉田進昭
  • Organizer: Mechanisms of Molecular and Cellular Immunity 1964-2016
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2016-11-04
  • Invited
• [Presentation] Partial correlation-based functional connectivity analysis of the optical intrinsic signals of the mouse neocortex during resting state (2016)
  • Author(s): Yuto Yoshida, Mitsuyuki Nakao, Norihiro Katayama
  • Organizer: 8th Internat Workshop Biosignal Interpret (BSI2016)
  • Place of Presentation: 大阪国際交流センター(大阪府大阪市)
  • Year and Date: 2016-11-01
  • Int'l Joint Research
• [Presentation] Role of iron in carcinogenesis. (2016)
  • Author(s): Toyokuni S.
  • Organizer: International Symposium on Redox Biology and Mitochondrial Medicine & 2016 Cross-Strait Free Radical Symposium
  • Place of Presentation: New Taipei City, Taiwan
  • Year and Date: 2016-10-21
  • Int'l Joint Research / Invited
• [Presentation] Analysis of Asxl1-MT conditional knock-in mice (2016)
  • Author(s): 永瀬玲奈
  • Organizer: 第78会日本血液学会学術総会
  • Place of Presentation: バシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2016-10-13
• [Presentation] CRISPR/Cas9 mediated genome editing in mice (2016)
  • Author(s): 伊川 正人
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: バシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2016-10-06
  • Invited
• [Presentation] Targeting distant metastasis of colorectal cancer with a combination of anti-claudin-4 antibody (2016)
  • Author(s): Fujiwara R, Luo Y, Sasaki T, Nishiguchi Y, Ohmori H, Hashimoto Y, Kondo M, Kuniayasu H
  • Organizer: 76th Annual Meeting of Japanese Association for Cancer
  • Place of Presentation: バシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2016-10-06
• [Presentation] Genetic mechanisms underlying individual differences in sensitivity to pain and opioids. (2016)
  • Author(s): Ikeda K, Nishizawa D, Hayashida M, Fukuda K
  • Organizer: 16th World Congress on Pain
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2016-09-27
  • Int'l Joint Research / Invited
• [Presentation] Genome-wide association study identifies candidate loci associated with intraoperative remifentanil infusion rate in patients undergoing laparoscopic-assisted colectomy. (2016)
  • Author(s): Nishizawa D, Mieda T, Tsujita M, Yamaguchi S, Kasai S, Hasegawa J, Fukuda K, Kitamura A, Hayashida M, Ikeda K
  • Organizer: 16th World Congress on Pain
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2016-09-27
  • Int'l Joint Research
• [Presentation] Insertion Characteristics Evaluation of Si Opto-Neural Probe with Embedded Optical fiber (2016)
  • Author(s): Takumi Morikawa, Takuya Harashima, Takafumi Fukushima, Hisashi Kino, and Tetsu Tanaka
  • Organizer: 2016 International Conference on Solid State Devices and Materials
  • Place of Presentation: つくば国際会議場(茨城県つくば市)
  • Year and Date: 2016-09-26
  • Int'l Joint Research
• [Presentation] Development of Si Neural Probe with Piezoresistive Force Sensor for Insertion Force Monitoring (2016)
  • Author(s): Takuya Harashima, Takumi Morikawa, Hisashi Kino, Takafumi Fukushima, Tetsu Tanaka
  • Organizer: 2016 International Conference on Solid State Devices and Materials
  • Place of Presentation: つくば国際会議場(茨城県つくば市)
  • Year and Date: 2016-09-26
  • Int'l Joint Research
• [Presentation] ES細胞を用いたゲノム編集とキメラ解析 (2016)
  • Author(s): 伊川 正人
  • Organizer: 第89回日本生化学会大会
  • Place of Presentation: 仙台国際センター(宮城県仙台市)
  • Year and Date: 2016-09-25
  • Invited
• [Presentation] Plenary lecture 1 : Insights into chemical reaction mechanism in plasma medicine from the viewpoint of oxidative stress. (2016)
  • Author(s): Toyokuni S.
  • Organizer: th International Conference on Plasma Medicine.
  • Place of Presentation: Bratislava, Slovakia
  • Year and Date: 2016-09-04
  • Int'l Joint Research / Invited
• [Presentation] Analysis of MDS mice model induced by ASXL1 and RUNX1 mutants (2016)
  • Author(s): Nagase R, Inoue D, Saika M, Hou HA, Chou WC, Kawabata KC, Harada H, Kanai A, Goyama S, Honda H, Tien HF, Kitamura T
  • Organizer: 45th Annual Scientific Meeting of ISEH
  • Place of Presentation: San Diego, California, USA
  • Year and Date: 2016-08-25
• [Presentation] Prediction formulas for individual opioid analgesic requirements based on genetic polymorphism analyses. (2016)
  • Author(s): Nishizawa D, Yoshida K, Ichinomiya T, Ichinohe T, Hayashida M, Fukuda K, Ikeda K
  • Organizer: The International Narcotics Research Conference 2016
  • Place of Presentation: Bath, UK
  • Year and Date: 2016-07-14
  • Int'l Joint Research
• [Presentation] Increased number of glial and neuronal cells in the periaqueductal gray matter (PAG) of mu-opioid receptor knockout mice. (2016)
  • Author(s): Sasaki K, Sora I, Kasahara Y, Ikeda K, Hall FS, Uhl GR, Kawashima R
  • Organizer: The International Narcotics Research Conference 2016
  • Place of Presentation: Bath, UK
  • Year and Date: 2016-07-11
  • Int'l Joint Research
• [Presentation] Sex differences in voluntary drinking by mu-opioid receptor knockout mice following early stress. (2016)
  • Author(s): Moriya Y, Kasahara Y, Hall FS, Uhl GR, Ikeda K, Sora I
  • Organizer: The International Narcotics Research Conference 2016
  • Place of Presentation: Bath, UK
  • Year and Date: 2016-07-11
  • Int'l Joint Research
• [Presentation] The abolished rewarding effect of methylphenidate in dopamine transporter knockout mice, a model for attention deficit/hyperactivity disorder. (2016)
  • Author(s): Ide S, Takamatsu Y, Ikekubo Y, Takeda TC, Nagasawa S, Hua J, Ikeda K
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] Transcriptome analysis in Tsc2 heterozygous knockout mice. (2016)
  • Author(s): Kasai S, Sato A, Kashii H, Kobayashi T, Hino O, Mizuguchi M, Ikeda K
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] Genome-wide association study identifies candidate loci associated with postoperative fentanyl requirements after laparoscopic-assisted colectomy. (2016)
  • Author(s): Nishizawa D, Mieda T, Nakagawa H, Tsujita M, Imanishi H, Terao K, Yoshikawa H, Itoh K, Amano K, Tashiro J, Ishii T, Ariyama J, Yamaguchi S, Kasai S, Hasegawa J, Ikeda K, Kitamura A, Hayashida M
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul, Kores
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] Opposite associations between the rs3845446 single-nucleotide polymorphism of the CACNA1E gene and postoperative pain-related phenotypes in gastrointestinal surgery versus previously reported orthognathic surgery. (2016)
  • Author(s): Amano K, Nishizawa D, Mieda T, Tsujita M, Kitamura A, Hasegawa J, Inada E, Hayashida M, Ikeda K
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] Association between the rs7583431single-nucleotide polymorphism close to the activating transcription factor 2(ATF2) gene and the analgesic effect of fentanyl in the preoperative cold pressor-induced pain test. (2016)
  • Author(s): Aoki Y, Nishizawa D, Yoshida K, Hasegawa J, Kasai S, Takahashi K, Koukita Y, Ichinohe T, Hayashida M, Fukuda K, Ikeda K
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] Therapsutic effects of cholinergic drug on mechanical allodynia in the mouse partial sciatic nerve ligation model. (2016)
  • Author(s): Yamanishi Y, Takamatsu Y, Ikeda K
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] Effects of chronic tryptophan depletion on autism spectrum disorder like behaviors in serotonin transporter knockout and heterozygous mice. (2016)
  • Author(s): Tanaka M, Sato A, Hagino Y, Sora I, Murphy D, Ikeda K
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-04
  • Int'l Joint Research
• [Presentation] Novel embryonic precursor cells of medullary thymic epithelial cells expressing Aire (2016)
  • Author(s): Nobuko Akiyama, Riko Yoshinaga, Jun-ichiro Inoue, and Taishin Akiyama
  • Organizer: ThymUS International Confernce
  • Place of Presentation: Maui, Hawaii, USA
  • Year and Date: 2016-06-06
  • Int'l Joint Research
• [Presentation] Mouse Behavioral Phenotype Database. (2016)
  • Author(s): Hattori S, Shoji H, Takao K, Miyakawa T
  • Organizer: INCF Japan International Workshop : Advances in Neuroinformatics
  • Place of Presentation: 理化学研究所(埼玉県和光市)
  • Year and Date: 2016-05-28
• [Presentation] CRISPR/Cas9 mediated genome editing and its application for the study of reproduction (2016)
  • Author(s): 伊川 正人
  • Organizer: 2016 AMMRA meeting
  • Place of Presentation: ホテルおかだ(神奈川県足柄下郡箱根町)
  • Year and Date: 2016-05-20
  • Int'l Joint Research / Invited
• [Presentation] Cancer as a ferrotoxic disease : what we have learned from animal studies toward its prevention. (2016)
  • Author(s): Toyokuni S.
  • Organizer: The 9th International Conference on the Biology, Chemistry, and the Therapeutic Applications of Nitric Oxide.
  • Place of Presentation: 仙台国際センター(宮城県仙台市)
  • Year and Date: 2016-05-20
  • Int'l Joint Research / Invited
• [Presentation] Iron overload and genome alteration. (2016)
  • Author(s): Toyokuni S.
  • Organizer: Oxygen Club of California 2016 : Oxidants and antioxidants in biology ; Redox medicine and nutrition.
  • Place of Presentation: University of California Davis, Davis, CA, USA
  • Year and Date: 2016-05-04
  • Int'l Joint Research / Invited
• [Book] 脳卒中病態学のススメ 第3部 各論 「動物実験の基本と倫理」 (2018)
  • Author(s): 笹岡俊邦, 藤澤信義
  • Pages: 167-176
  • Total Pages: 354
  • Publisher: 南山堂
• [Book] 喫煙科学研究の歩み-2006年から2015年- (2017)
  • Author(s): 池田和隆
  • Pages: 21-24
  • Total Pages: 356
  • Publisher: 公益財団法人 喫煙科学研究財団
• [Book] Japanese Scientists in Science 2015 (2016)
  • Author(s): 宮田 治彦、伊川 正人
  • Pages: 64-64
  • Total Pages: 80
  • Publisher: American Association for the Advancement of Science (AAAS)
• [Book] HORMONE FRONTIER IN GYNECOLOGY Vol.23 No.2 (2016)
  • Author(s): 伊川 正人
  • Pages: 13-20
  • Total Pages: 84
  • Publisher: メディカルレビュー社
• [Book] 実験医学別冊 マウス表現型解析スタンダード (2016)
  • Author(s): 美野輪 治、八尾 良司
  • Pages: 46-55
  • Total Pages: 347
  • Publisher: 羊土社
• [Book] 実験医学別冊 マウス表現型解析スタンダード (2016)
  • Author(s): 野田 大地、大字 亜沙美、伊川 正人
  • Pages: 74-82
  • Total Pages: 351
  • Publisher: 羊土社
• [Book] Addiction Medicine (Second Edition) (2016)
  • Author(s): Nishizawa D, Ikeda K
  • Pages: 52-53
  • Total Pages: 672
  • Publisher: OXFORD UNIVERSITY PRESS
  • Description: 分担執筆
• [Book] The Neuropathology of Drug Addictions and Substance Misuse. (2016)
  • Author(s): Nishizawa D, Ikeda K
  • Pages: 909-919
  • Total Pages: 1132
  • Publisher: Academic Press
• [Book] The Neuropathology of Drug Addictions and Substance Misuse. (2016)
  • Author(s): Yamamoto H, Sawada W, Kamegaya E, Hagino Y, Ikeda K, Sora I, Mishina M, Yamamoto T
  • Pages: 604-612
  • Total Pages: 1182
  • Publisher: Academic Press
• [Book] Current Research in Cancer 10-Role of CD10 in the metastasis of colorectal cancer to the liver. (2016)
  • Author(s): Kuniyasu H, Fujii K, Ohmori H, Fujiwara-Tani R, Luo Y, Sasaki T
  • Pages: 31-40
  • Total Pages: 188
  • Publisher: Research Media, Karela, India
• [Book] Current Research in Cancer 10-Significance of anti-CLDN4 extracellular domain antibody in cancer treatment. (2016)
  • Author(s): Fujiwara-Tani R, Ohmori H, Fujii K, Sasaki T, Luo Y, Kuniyasu H
  • Pages: 41-51
  • Total Pages: 188
  • Publisher: Research Media, Karela, India
• [Remarks] 先端モデル動物支援プラットフォームホームページ
  • URL: http://modcl.umin.jp/
• [Remarks] 学術研究基盤支援室
  • URL: http://www.acadcmicsupport.jp/
• [Remarks] 新潟大学脳研究所動物資源開発研究分野ホームページ
  • URL: http://www.bri.nilgata-u.ac.jp/field/lab_animal/indcx.html
• [Remarks] 新潟大学脳研究所脳研コラムホームページ
  • URL: http://www.bri.niigata-u.ac.jp/rcsult/lab_animal/000126.html
• [Remarks] 新潟大学脳研究所研究成果・実績ホームページ
  • URL: http://www.bri.niigata-u.ac.jp/result/lab_animal/000833.html
• [Remarks] 伊川研究室ホームページ(支援ページリンク掲載)
  • URL: http://www.cgr.bikcn.osaka-u.ac.jp/information/indcx.html
• [Remarks] 筑波大学生命科学動物資源センターホームページ
  • URL: http://www.md.tsukuba.ac.jp/LabAnimalRcsCNT/
• [Remarks] 筑波大学医学医療系解剖学・発生学研究室ホームベージ
  • URL: http://www.md.tsukuba.ac.jp/basic-mcd/analomy/cmbryology/indcx.html
• [Remarks] システム医科学研究部門(宮川研究室)ホームページ
  • URL: http://www.fujita-hu.ac.jp/smodsei/indcx.html
• [Remarks] 公益財団法人東京都医学総合研究所ホームページ
  • URL: http://www.igakuken.or.jp/
• [Remarks] 依存性薬物プロジェクトホームページ
  • URL: http://www.igakuken.or.jp/abuse/
• [Remarks] 先端モデル動物生理機能支援ホームページ
  • URL: http://www.biomdl.ccci.tohoku.ac.jp/physio-shicn/