コホート・生体試料支援プラットフォーム

• Project/Area Number: 16H06277
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas ― Platforms for Advanced Technologies and Research Resources
• Allocation Type: Single-year Grants
• Research Institution: The University of Tokyo
• Principal Investigator: 村上 善則 (2019) 東京大学, 医科学研究所, 教授
• Principal Investigator(Support): 今井 浩三 (2016-2018) 東京大学, 医科学研究所, 客員教授 (60117603)
• Co-Investigator(Kenkyū-buntansha)(Support): 若井 建志 名古屋大学, 大学院医学系研究科, 教授 (50270989) ; 村上 善則 東京大学, 医科学研究所, 教授 (30182108) ; 松尾 恵太郎 愛知県がんセンター(研究所), がん予防研究分野, 分野長 (80393122) ; 三上 春夫 千葉県がんセンター(研究所), がん予防センター, 部長 (10332355) ; 鈴木 貞夫 名古屋市立大学, 大学院医学研究科, 教授 (20226509) ; 喜多 義邦 敦賀市立看護大学, 看護学部, 准教授 (30147524) ; 渡辺 能行 (渡邊 能行) 京都府立医科大学, 大学院医学研究科, 教授 (00191809) ; 田中 恵太郎 佐賀大学, 医学部, 教授 (50217022) ; 嶽崎 俊郎 鹿児島大学, 医歯学域医学系, 教授 (50227013) ; 栗木 清典 静岡県立大学, 食品栄養科学部, 教授 (20543705) ; 古庄 憲浩 九州大学, 大学院医学研究院, 准教授 (10346786) ; 有澤 孝吉 徳島大学, 大学院医歯薬学研究部, 教授 (30203384) ; 玉腰 暁子 北海道大学, 大学院医学研究院, 教授 (90236737) ; 今田 恒夫 山形大学, 大学院医学系研究科, 教授 (60333952) ; 武林 亨 慶應義塾大学, 医学部, 教授 (30265780) ; 三浦 克之 滋賀医科大学, 医学部, 教授 (90257452) ; 成松 宏人 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所・がん予防・情報学部, 部長 (50524419) ; 鈴木 康司 藤田保健衛生大学, 保健学研究科, 教授 (60288470) ; 村山 繁雄 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (50183653) ; 高尾 昌樹 (高雄 昌樹) 公益財団法人脳血管研究所, 美原記念病院, 研究員 (50245487) ; 赤津 裕康 医療法人さわらび会福祉村病院長寿医学研究所, 長寿医学研究所, 研究員 (00399734) ; 齊藤 祐子 国立研究開発法人国立精神・神経医療研究センター, 病院臨床検査科, 医長 (60344066) ; 矢部 博興 福島県立医科大学, 医学部, 教授 (60210316) ; 中杤 昌弘 名古屋大学, 医学部附属病院, 病院講師 (10559983) ; 清水 厚志 岩手医科大学, いわて東北メディカル・メガバンク機構, 特命教授 (30327655) ; 醍醐 弥太郎 東京大学, 医科学研究所, 特任教授 (30345029) ; 高橋 隆 名古屋大学, 大学院医学系研究科, 教授 (50231395) ; 宮城 洋平 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所・がん分子病態学部, 総括部長 (00254194) ; 渡邉 俊樹 東京大学, 名誉教授 (30182934) ; 安井 寛 東京大学, 医科学研究所, 特任准教授 (40448593) ; 田中 英夫 愛知県がんセンター研究所, 疫学・予防部, 部長 (60470168) ; 内藤 真理子 名古屋大学, 大学院医学系研究科, 准教授 (10378010) ; 大中 佳三 九州大学, 医学研究院, 講師 (30325518) ; 森 満 札幌医科大学, 医学部, 教授 (50175634) ; 川崎 良 山形大学, 大学院医学系研究科, 准教授 (70301067)
• Project Period (FY): 2016 – 2021
• Project Status: Granted (Fiscal Year 2019)
• Budget Amount: ¥2,276,040,000 (Direct Cost: ¥1,750,800,000、Indirect Cost: ¥525,240,000); Fiscal Year 2018: ¥379,340,000 (Direct Cost: ¥291,800,000、Indirect Cost: ¥87,540,000); Fiscal Year 2017: ¥379,340,000 (Direct Cost: ¥291,800,000、Indirect Cost: ¥87,540,000); Fiscal Year 2016: ¥379,340,000 (Direct Cost: ¥291,800,000、Indirect Cost: ¥87,540,000)
• Keywords: 生体試料支援 / コホート / 臨床検体 / 一般健常人 / 大規模ゲノム解析 / 大規模ゲノム解析・オミックス解析 / オミックス解析

Outline of Annual Research Achievements

①総括支援活動 : 従来のシンポジウムに代え、「若手支援研究成果発表会」を豊橋市にて1泊2日で開催し、支援受給若手研究者など32名が参加して成果を発表し、活発な情報交換を行った。東北メディカル・メガバンクと、本プラットフォーム(PF)の基盤の1つである日本多施設共同コーホート(J-MICC)研究の間で、共同研究契約を締結し、両者の連携による研究支援の道を開いた。また、日本生化学会、日本癌学会、日本人類遺伝学会、日本分子生物学会、日本疫学会の学術総会に各々出展し、本支援プラットフォームの研究支援内容を紹介した。
②コホートによるバイオリソース支援活動 : コホート研究のデータ・生体試料の提供、大規模バイオデータの解析などにより、222件の研究支援を実施した。またJ-MICC研究の初回調査データ(SNPタイピング情報含む)を用いた研究の解析テーマ募集を開始した。支援基盤の整備では、主要な基盤であるJ-MICC研究において、参加者の2回目の調査を終了するとともに、死亡追跡データを整備した。
③ブレインリソースの整備と活用支援 : 死後脳リソース蒐集を促進するため、ブレインバンク生前ドナー登録推進を沖縄、四国、中国、近畿に拡大した。高齢者ブレインバンクプロトコールに基づく神経病理診断と、RIN、apoE genotypingにより、NIH基準を満たすリソースを提供可能とした。また大阪大学、広島大学に加え、香川大学に拠点を構築した。
④生体試料による支援活動 : 247課題に生体機能分子の高感度解析・技術支援と連携構築支援を実施した。また、155課題にがん試料・情報(組織、血液)の提供支援を実施し、6,088試料を新規に収集した。最新の研究動向と支援ニーズに応じた解析支援・連携支援・試料支援体制、健常者血液試料収集体制、研究デザイン・倫理支援活動を強化した。さらに、教育・普及・啓発講演を実施した。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

①総括支援活動 : 「若手支援研究成果発表会」では、被支援者同士、並びに支援者と被支援者間の議論、情報共有が行われ、支援による研究の活性化が強く期待された。また長年、必要性が指摘されながら実現が困難であったゲノムコホート研究問の連携が、一部進捗した。さらにこれまで広報活動が十分でなかった社会医学系学会を含む5学会に関して、学術総会への出展、学会メーリングリストでの研究支援活動の広報を実施し、本PF支援活動の内容を周知することができた。
②コホートによるバイオリソース支援活動 : 200件以上の研究支援を実施するとともに、被支援研究の成果が、一流国際雑誌掲載論文も含め多数の論文として公表された。またコホート研究のベースライン調査データによる、研究支援メニューの充実を図ることができた。がん、虚血性心疾患、脳卒中の罹患データの整備が今後の課題である。
③ブレインリソースの整備と活用支援 : 生前献脳同意に基づく死後脳リソース構築が順調に進展した。また、ブレインリソースの国際基準に基づく高品質化、並びに大阪、広島、香川3大学における新規拠点形成が達成できた。また被支援研究の成果の、Nature姉妹誌4論文を含む国際雑誌への発表に貢献できた。ただ、新型コロナウイルス感染症(COVID-19)により剖検が3月期より激減しており、次年度への影響が懸念される。
④生体試料による支援活動 : 最新のニーズと研究動向を踏まえて、高精度分子解析技術による解析支援体制の充実、生体試料バンクのタイムスタンプ記録や手順書整備による国際標準化体制の整備、組織・血液形態学的支援の強化と支援内容・成果の広報・啓発を進めることができた。支援課題数は、生体機能分子解析・技術・連携支援および生体試料収集・提供支援ともに、平成30年度の研究支援実施計画を上回り、国際的にインパクトのある学術発表にも貢献した。

Strategy for Future Research Activity

①総括支援活動 : 令和2年度も「若手支援研究成果発表会」を実施し、本PFの支援による研究、特に共同研究の活性化を目指す。東北メディカル・メガバンクとの連携を具体化するとともに、国内の他の生体試料バンクやゲノムコホート研究とも連携を図る。また社会医学系研究者への広報では、日本疫学会に加え日本公衆衛生学会も対象として、学術総会への出展、ホームページやメーリングリストなどで研究支援活動を紹介する。
②コホートによるバイオリソース支援活動 : 支援件数の増加を図るため、関係学会のホームページ、メーリングリスト、学会展示などで支援活動の広報を行う。支援の主な基盤であるJ-MICC研究(参加者数10.2万人)について、第二次調査データ、および、がん・虚血性心疾患・脳卒中罹患データを、研究支援に活用できるよう整備する。また、がん早期診断マーカー検証支援を、大腸がんを対象として実施する。
③ブレインリソースの整備と活用支援 : 大阪大学の班長機能を整備し、COVID-19に対する剖検の安全性に配慮しつつ、自閉症、自殺関連気分障害研究リソースの構築、発達障害・精神・神経疾患ブレインバンクの創設を目指す。死後鼻腔スメアによる新型コロナウイルス検査の陰性結果や、院内感染がないことなどの条件に加え、陽性症例についても分担施設ごとの基準に従って、死後脳リソース構築を推進する。
④生体試料による支援活動 : 多様化する生命科学領域における支援ニーズと技術革新に対応して、支援成果を研究者に還元するため、先進的な分子解析支援技術の導入・強化と人材育成を進め、より多彩で国際水準を確保した試料収集と迅速な提供体制の整備を進める。支援班と先進的研究拠点等との連携、情報共有を維持・強化し、学際的共同研究の構築支援を行う。また、学会や教育の場で若手を含む研究者向け啓発活動を展開し、斬新な研究アイデアの創出を支援する。

Research Products

• [Int'l Joint Research] George Mason University/University of Texas, MD Anderson Cancer Center/National Institute on Aging(アメリカ)
• [Int'l Joint Research] McGill University(カナダ)
• [Int'l Joint Research] リエージュ大学(ベルギー)
• [Int'l Joint Research] デューク大学/ユタ大学/南カリフォルニア大学（アメリカ合衆国）
• [Int'l Joint Research] ケンブリッジ大学/エジンバラ大学（イギリス）
• [Int'l Joint Research] クイーンズランド大学（オーストラリア）
• [Int'l Joint Research] 国立がんセンター（韓国）
• [Int'l Joint Research] センメルヴェイス大学（ハンガリー）
• [Int'l Joint Research] ハーバード大学 ダナファーバーがん研究所/シカゴ大学/NIH(アメリカ合衆国)
• [Int'l Joint Research] University of Chicago/NCI/Vanderbilt University(米国)
• [Int'l Joint Research] University of Hong Kong/Shandong Academy of Medical Sciences/Tianjin Medical University Cancer Institute and Hospital(中国)
• [Int'l Joint Research] NHRI, Taiwan/Academia Sinica/National Yang-Ming University(台湾)
• [Int'l Joint Research] Chonnam National University, Korea/Seoul National University College of Medicine/Korea University Anam Hospital(韓国)
• [Int'l Joint Research] Institute of Predictive and Personalized Medicine of Cancer(スペイン)
• [Int'l Joint Research] National University of Singapore/Genome Institute of Singapore(シンガボール)
• [Journal Article] Differential effect of polymorphisms on body mass index across the life course of Japanese : the Japan Multi-Institutional Collaborative Cohort Study (2021)
  • Author(s): Iwase M, Matsuo K, Nakatochi M, Oze I, Ito H, Koyanagi Y, Ugai T, Kasugai Y, Kuriki K, wakai K, et al.
  • Journal Title: Journal of Epidemiology Volume: - Issue: 3 Pages: 0-0
  • DOI: 10.2188/jea.je20190296 10.2188/jea.JE20190296
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2021-03-05
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Alcohol consumption and risk of gastric cancer : The Japan Collaborative Cohort study. (2021)
  • Author(s): Li Y, Eshak ES, Kokoro S, Liu K, Jy D, Iso H, Tamakoshi A
  • Journal Title: Journal of Epidemiology Volume: - Issue: 1 Pages: 30-36
  • DOI: 10.2188/jea.je20190304 10.2188/jea.JE20190304
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2021-01-05
  • Description: in press
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Relationships between reproductive history and mortality from cardiovascular diseases among Japanese women : the Japan Collaborative Cohort (JACC) Study (2020)
  • Author(s): Tanigawa K, Ikehara S, Kimura T, Imano H, Muraki I, Shirai K, Tamakoshi A, Iso H.
  • Journal Title: Journal of Epidemiology Volume: - Issue: 11 Pages: 509-515
  • DOI: 10.2188/jea.je20190020 10.2188/jea.JE20190020
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2020-11-05
  • Description: in press
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Diabetes and mortality from respiratory diseases : the Japan Collaborative Cohort Study. (2020)
  • Author(s): Wang M, Muraki I, Liu K, Shirai K, Tamakoshi A, Hu Y, Iso H.
  • Journal Title: Journal of Epidemiology Volume: - Issue: 10 Pages: 457-463
  • DOI: 10.2188/jea.je20190091 10.2188/jea.JE20190091
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2020-10-05
  • Description: in press
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Associations of circulating microRNAs (miR-17, miR-21, and miR-150) and chronic kidney di-sease in a Japanese population (2020)
  • Author(s): Fujii R, Yamada H, Munetsuna E, Yamazaki M, Ohashi K, Ishikawa H, Keisuke Maeda K, Hagiwara C, Ando Y, Hashimoto S, Hamajima N, Suzuki K.
  • Journal Title: Journal of Epidemiology Volume: 30 Issue: 4 Pages: 177-182
  • DOI: 10.2188/jea.je20180233 10.2188/jea.JE20180233
  • NAID: 130007620477
  • ISSN: 0917-5040, 1349-9092
  • Year and Date: 2020-04-05
  • Peer Reviewed
• [Journal Article] A case of high-grade mucinous tubular and spindle cell carcinoma. (2020)
  • Author(s): Miura K, Adachi Y, Shirahase T, Nagashima Y, Suemune K, Sakaida N, Nakano Y, Sakai Y, Shimizu S, Ikehara S.
  • Journal Title: J Surg Case Rep Volume: 2020 Issue: 2
  • DOI: 10.1093/jscr/rjaa014
  • Peer Reviewed / Open Access
• [Journal Article] A novel diagnostic system to evaluate the impact of epidermal growth factor receptor as a prognostic and therapeutic indicator for lung adenocarcinoma (2020)
  • Author(s): Kazuya Takakuwa, Kaoru Mogushi, Min Han, Tomoaki Fujii, Masaki Hosoya, Arina Yamanami, Tomomi Akita, Chicamasa Yamashita, Shunsuke Kato, and Shigeo Yamaguchi
  • Journal Title: Scientific Reports Volume: 10 Pages: 6214-6214
  • DOI: 10.1038/s41598-020-63200-7
  • Peer Reviewed / Open Access
• [Journal Article] A retrospective study for investigating the relationship between old and new staging systems with prognosis in ovarian cancer using gynecologic cancer registry of Japan Society of Obstetrics and Gynecology (JSOG) : disparity between serous carcinoma and clear cell carcinoma. (2020)
  • Author(s): Yamagami W, Nagase S, Takahashi F, Ino K, Hachisuga T, Mikami M, Enomoto T, Katabuchi H, Aoki D.
  • Journal Title: J Gynecol Oncol Volume: 31(3)
  • DOI: 10.3802/jgo.2020.31.e45
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Across-site differences in the mechanism of alcohol-induced digestive tract carcinogenesis : an evaluation by mediation analysis (2020)
  • Author(s): Koyanagi YN, Suzuki E, Imoto I, Kasugai Y, Oze I, Ugai T, Iwase M, Usui Y, Kawakatsu Y, Sawabe M, Tanaka T, Abe T, Ito S, Tajika M, Ito H, Matsuo K
  • Journal Title: Cancer Research Volume: 80 Issue: 7 Pages: 1601-1610
  • DOI: 10.1158/0008-5472.can-19-2685
  • Peer Reviewed / Open Access
• [Journal Article] Activation of PERK-ATF4-CHOP pathway as a novel therapeutic approach for efficient elimination of HTLV-1-infected cells (2020)
  • Author(s): Ikebe E, Matsuoka S, Tezuka K, Kuramitsu M, Okuma K, Nakashima M, Sciichiro Kobayashi S, Makiyama J, Yamagishi M, Oyadomari S, Uchimaru K, Hamaguchi I
  • Journal Title: Blood adv Volume: 4 Issue: 9 Pages: 1845-1858
  • DOI: 10.1182/bloodadvances.2019001139
  • Peer Reviewed
• [Journal Article] Adverse respiratory outcomes among head and neck cancer survivors in the Utah Cancer Survivors Study. (2020)
  • Author(s): Kawakita D, Abdelaziz S, Chen Y, Rowe K, Snyder J, Fraser A, Smith K, Herget K, Deshmukh V, Newman M, Monroe M, Hashibe M.
  • Journal Title: Cancer Volume: 126 Issue: 4 Pages: 879-885
  • DOI: 10.1002/cncr.32617
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] ALDH4A1 expression levels are elevated in postmortem brains of patients with schizophrenia and are associated with genetic variants in enzymes related to proline metabolism (2020)
  • Author(s): Nagaoka A, Kunii Y, Hino M, Izumi R, Nagashima C, Takeshima A, Sainouchi M, Nawa H, Kakita A, Yabe H.
  • Journal Title: J Psychiatr Res Volume: 123 Pages: 119-127
  • DOI: 10.1016/j.jpsychires.2020.02.001
  • Peer Reviewed / Open Access
• [Journal Article] Association between dietary inflammatory index and serum C-reactive protein concentrations in the Japan Collaborative Cohort Study. (2020)
  • Author(s): Suzuki K, ShivappaN, Kawado M, Yamada H, Hashimoto S, Wakai K, Iso H, Okada E, Fujii R, Hebert JR, Tamakoshi A.
  • Journal Title: Nagoya J Med Sci Volume: 82
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Birt-Hogg-Dube syndrome-associated renal cell carcinoma : Histopathological features and diagnostic conundrum. (2020)
  • Author(s): Furuya M, Hasumi H, Yao M, Nagashima Y.
  • Journal Title: Cancer Sci Volume: 111 Pages: 15-22
  • DOI: 10.1111/cas.14255
  • Peer Reviewed / Open Access
• [Journal Article] Blood Metabolite Signature of Metabolic Syndrome Implicates Alterations in Amino Acid Metabolism : Findings from the Baltimore Longitudinal Study of Aging (BLSA) and the Tsuruoka Metabolomics Cohort Study (TMCS). (2020)
  • Author(s): Roberts JA, Varma VR, Huang CW, An Y, Oommen A, Tanaka T, Ferrucci L, Elango P, Takebayashi T, Harada S, Iida M, Thambisetty M.
  • Journal Title: International journal of molecular sciences Volume: 21
  • DOI: 10.3390/ijms21041249
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Circulating Antibodies against Epstein-Barr Virus (EBV) and p53 in EBV-Positive and -Negative Gastric Cancer (2020)
  • Author(s): Camargo MC, Kim KM, Matsuo K, Torres J, Liao LM, Morgan D, Michel A, Waterboer T, Song M, Gulley ML. Pawlita M, Rabkin CS.
  • Journal Title: Cancer Epidemiol Biomarkers Prev Volume: 29 Pages: 414-419
  • DOI: 10.1158/1055-9965.epi-19-0790
  • Peer Reviewed / Int'l Joint Research
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  • Journal Title: Psychiatry Clin Neurosci Volume: 73 Issue: 9 Pages: 566-573
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• [Journal Article] Altered immunoreactivity of ErbB4, a causative gene product for ALS19, in the spinal cord of patients with sporadic ALS (2019)
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• [Journal Article] Assessment of soluble immune mediators as potential biomarkers during immune checkpoint inhibitor therapy. (2019)
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• [Journal Article] Association of genetic risk score and chronic kidney disease in a Japanese population (2019)
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  • Journal Title: Nephrology (Carlton) Volume: 24 Issue: 6 Pages: 670-673
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• [Journal Article] Association of Radical Hysterectomy Surgical Volume and Survival for Early-Stage Cervical Cancer. (2019)
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  • Journal Title: Obstet Gynecol Volume: 133 Issue: 6 Pages: 1086-1098
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• [Journal Article] Associations of Daily Walking Time With Pneumonia Mortality Among Elderly Individuals With or Without a Medical History of Myocardial Infarction or Stroke : Findings From the Japan Collaborative Cohort Study. (2019)
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• [Journal Article] Associations of Nutrient Patterns with the Prevalence of Metabolic Syndrome : Results from the Baseline Data of the Japan Multi-Institutional Collaborative Cohort Study (2019)
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• [Journal Article] Blood pressure levels and risk of cardiovascular disease mortality among Japanese men and women : The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study) (2019)
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• [Journal Article] Clinical significance of PD-L1-positive cancer-associated fibroblasts in pNOMO non-small cell lung cancer (2019)
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• [Journal Article] Comparing different definitions of prediabetes with subsequent risk of diabetes : an individual participant data meta-analysis involving 76 513 individuals and 8208 cases of incident diabetes. (2019)
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  • Journal Title: Microbiology and Immunology Volume: 63(11) Issue: 11 Pages: 458-464
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• [Journal Article] Differential protein expression of DARPP-32 versus Calcineurin in the prefrontal cortex and nucleus accumbens in schizophrenia and bipolar disorder (2019)
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• [Journal Article] Helicobacter pylori (HP) infection alone, but not HP-induced atrophic gastritis, increases the risk of gastric lymphoma : a case-control study in Japan (2019)
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• [Journal Article] Identification of Novel HLA Class II-Restricted Neoantigens Derived from Driver Mutations (2019)
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• [Journal Article] Selective loss of cortical endothelial tight junction proteins during Alzheimer's disease progression. (2019)
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• [Journal Article] The basis of clinicopathological heterogeneity in TDP-43 proteinopathy. (2019)
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  • Journal Title: American Journal of Epidemiology Volume: 188 Pages: 991-1012
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• [Journal Article] Trends and characteristics of epithelial ovarian cancer in Japan between 2002 and 2015 : A JSGO-JSOG joint study. (2019)
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• [Journal Article] 一般住民における降圧薬治療の有無別に見た血圧と循環器疾患死亡との関連 (2019)
  • Author(s): 山岸良匡, 磯博康
  • Journal Title: 血圧 Volume: 26 Pages: 726-727
• [Journal Article] 沖縄型神経原性筋萎縮症の自然史-2019年における臨床研究の現状 (2019)
  • Author(s): 諏訪園秀吾
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• [Journal Article] 魚摂取と大動脈疾患死亡リスク (2019)
  • Author(s): 山岸良匡
  • Journal Title: 医学のあゆみ Volume: 270 Pages: 1214-1215
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  • Journal Title: Prev Med Volume: 118 Pages: 220-225
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• [Journal Article] No substantial effect of polymorphisms in CPT1B and CPT2 on plasma carnitine levels in Japanese. (CPT遺伝子多型と血漿カルニチン濃度に関する研究) (2019)
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  • Journal Title: Nagoya J Med Sci
  • Description: in press
  • Peer Reviewed / Open Access
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  • Journal Title: Clin Nucl Med Volume: 44 Issue: 6 Pages: 507-509
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• [Journal Article] Intensity-specific and modified effects of physical activity on serum adiponectin in a middle-aged population (2019)
  • Author(s): Yuichiro Nishida, Yasuki Higaki, Naoto Taguchi, Megumi Hara, Kazuyo Nakamura, Hinako Nanri, Takeshi Imaizumi, Tatsuhiko Sakamoto, Chisato Shimanoe, Mikako Horita, Koichi Shinchi, Keitaro Tanaka
  • Journal Title: Journal of the Endocrine Society Volume: 3 Issue: 1 Pages: 13-26
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• [Journal Article] Identification of 28 novel susceptibility loci for type 2 diabetes in the Japanese population (2019)
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• [Journal Article] Fat-soluble vitamins from diet in relation to risk of type 2 diabetes mellitus in Japanese population. (2019)
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  • Journal Title: 自律神経
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• [Journal Article] Transferrin isoforms in cerebrospinal fluid and their relation to neurological diseases. (2019)
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  • Journal Title: Proceedings of the Japan Academy, Series B
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  • Author(s): Yamagishi K, Iso H, Shimazu T, Tamakoshi A, Sawada N, Matsuo K, Ito H, Wakai K, Nakayama T, Kitamura Y, Sado J, Tsuji I, Sugawara Y, Mizoue T, Inoue M, Nagata C, Sadakane A, Tanaka K, Tsugane S, Sasazuki S
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  • Journal Title: Clinical and Experimental Nephrology Volume: 23 Pages: 380-386
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• [Journal Article] Serum nardilysin, a surrogate marker for epithelial-mesenchymal transition, predicts prognosis of intrahepatic cholangiocarcinoma after surgical resection (2019)
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  • Journal Title: Diabetes Volume: 68 Issue: 3 Pages: 617-630
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• [Journal Article] Handling has an anxiolytic effect that is not affected by the inhibition of the protein kinase C pathway in adult prenatal undernourished male rat offspring. (2019)
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  • NAID: 210000155421
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• [Journal Article] Ethanol Preference and Drinking Behavior Are Controlled by RNA Editing in the Nucleus Accumbens (2019)
  • Author(s): Takahira Shirahase, Yoshihisa Watanabe, Atsushi Tsujimura, Shin Kwak, Toshiro Yamamoto, Narisato Kanamura and Masaki Tanaka
  • Journal Title: Front. Behav. Neurosci Volume: 12 Pages: 1-12
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• [Journal Article] Direct targeting of MYCN gene amplification by site-specific DNA alkylation in neuroblastoma (2019)
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  • Journal Title: Cancer Research Volume: 79 Issue: 4 Pages: 830-840
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• [Journal Article] Correlation of two distinct metastasis-associated proteins, MTA1 and S100A4, in angiogenesis for promoting tumor growth. (2019)
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• [Journal Article] Cell death cascade and molecular therapy in ADAR2-deficient motor neurons of ALS. (2019)
  • Author(s): Yamashita T, Kwak S
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  • Peer Reviewed
• [Journal Article] Associations of serum microRNA-20a, -27a, and -103a with cognitive function in a Japanese population : the Yakumo Study (2019)
  • Author(s): Kondo M, Yamada H, Munetsuna E, Yamazaki M, Hatta T, Iwahara A, Ohashi K, Ishikawa H, Tsuboi Y, Inoue T, Fujii R, Suzuki K
  • Journal Title: Archives of Gerontology and Geriatrics Volume: 82 Pages: 155-160
  • DOI: 10.1016/j.archger.2019.01.007
  • Peer Reviewed / Open Access
• [Journal Article] Association between soluble immune mediators and tumor responses in patients with nonsmall cell lung cancer treated with anti-PD-1 inhibitor. (2019)
  • Author(s): Matsuo N, Azuma K, Hattori S, Ohtake J, Kawahara A, Ishii H, Tokito T, Yamada K, Shibata Y, Shimokawaji T, Kondo T, Kato T, Saito H, Yamada K, Sasada T, Hoshino T.
  • Journal Title: Int J Cancer. Volume: 144 Issue: 5 Pages: 1170-1179
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  • Peer Reviewed / Open Access
• [Journal Article] APOE4-mediated amyloid-βpathology depends on its neuronal receptor LRP1 (2019)
  • Author(s): Tachibana M, Holm ML, Liu CC, Shinohara M, Aikawa T, Oue H, Yamazaki Y, Martens YA, Murray ME, Sullivan PM, Weyer K, Glerup S, Dickson DW, Bu G, Kanekiyo T.
  • Journal Title: J Clin Invest Volume: 129 Issue: 3 Pages: 1272-1277
  • DOI: 10.1172/jci124853
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• [Journal Article] Adult T-Cell Leukemia/Lymphoma-Related Ocular Manifestations : Analysis of the First Large-Scale Nationwide Survey. (2019)
  • Author(s): Kamoi K, Okayama A, Izumo S, Hamaguchi I, Uchimaru K, Tojo A, Ohno-Matsui K.
  • Journal Title: Frontiers in Microbiology Volume: 9 Pages: 3240-3240
  • DOI: 10.3389/fmicb.2018.03240
  • Peer Reviewed / Open Access
• [Journal Article] ADAR2-dependent A-to-I RNA editing in the extracellular linear and circular RNAs (2019)
  • Author(s): Hosaka T, Yamashita T, Teramoto S, Hirose N, Tamaoka A, Kwak S
  • Journal Title: Neurosci Res Volume: 印刷中
  • DOI: 10.1016/j.neures.2018.11.005
  • Peer Reviewed
• [Journal Article] 5-HT3 Antagonist Ondansetron Increases ApoE Secretion by Modulating the LXR-ABCA1 Pathway (2019)
  • Author(s): Shinohara M, Shinohara M, Zhao J, Fu Y, Liu C C, Kanekiyo T, Bu G.
  • Journal Title: Int. J. Mol. Sci Volume: 20 Issue: 6 Pages: 1488-1488
  • DOI: 10.3390/ijms20061488
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Heterogeneous impact of smoking on major salivary gland cancer according to histopathological subtype : A case-control study. (2018)
  • Author(s): Sawabe M, Ito H, Takahara T, Oze I, Kawakita D, Yatabe Y, Hasegawa Y, Murakami S, Matsuo K.
  • Journal Title: Cancer Volume: 124 Issue: 1 Pages: 118-124
  • DOI: 10.1002/cncr.30957
  • Peer Reviewed / Open Access
• [Journal Article] Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation. (2018)
  • Author(s): Ghoussaini M, Edwards SL, Matsuo K, Dunning AM, et al.
  • Journal Title: Nat Commun Volume: 9 Pages: 16193-16193
  • DOI: 10.1038/ncomms16193
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility. (2018)
  • Author(s): Earp M, Tyrer JP, Matsuo K, Goode EL, Phelan CM, et al.
  • Journal Title: PLoS ONE Volume: 13 Issue: 7
  • DOI: 10.1371/journal.pone.0197561
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between ALDH2 and ADH1B polymorphisms, alcohol drinking and gastric cancer : a replication and mediation analysis. (2018)
  • Author(s): Ishioka K, Masaoka H, Ito H, Oze I, Ito S, Tajika M, Shimizu Y, Niwa Y, Nakamura S, Matsuo K.
  • Journal Title: Gastric Cancer Volume: 印刷中 Issue: 6 Pages: 936-945
  • DOI: 10.1007/s10120-018-0823-0
  • NAID: 40021694566
  • Peer Reviewed / Open Access
• [Journal Article] Value assignment of the reference material for human T-cell leukemia virus type l quantitative PCR in Japan (2018)
  • Author(s): Madoka Kuramitsu, Kaoru Uchimaru, Yasuko Sagara, Toshiki Watanabe, Isao Hamaguchi, et al.
  • Journal Title: Microbiol Immunol Volume: 62 Issue: 10 Pages: 673-676
  • DOI: 10.1111/1348-0421.12644
  • NAID: 40021702629
  • Peer Reviewed / Open Access
• [Journal Article] The association between self-rated health and high-sensitivity C-reactive protein level : a cross-sectional and 5-year longitudinal study. (2018)
  • Author(s): Tamura T, Naito M, Maruyama K, Tsukamoto M, Sasakabe T, Okada R, Kawai S, Hishida A, Wakai K.
  • Journal Title: BMC Public Health Volume: 18 Issue: 1 Pages: 1380-1380
  • DOI: 10.1186/s12889-018-6251-6
  • Peer Reviewed / Open Access
• [Journal Article] TDP-43 and DISC1 Co-Aggregation Disrupts Dendritic Local Translation and Mental Function in FTLD. (2018)
  • Author(s): Endo, R., Takashima, N., Nekooki-Machida, Y., Komi, Y., Hui, K. K., Takao, M., Akatsu, H., Murayama, S., Sawa, A., and Tanaka, M.
  • Journal Title: Biol. Psychiatry Volume: 84(7) Pages: 509-521
  • DOI: 10.1016/j.biopsych.2018.03.008
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Potential anti-lymphoma effect of M-CSFR inhibitor in adult T-cell leukemia/lymphoma (2018)
  • Author(s): Yoshihiro Komohara, Osamu Noyori, Yoichi Saito, Hiroto Takeya, Muhammad Baghdadi, Fumihito Kitagawa, Naoki Hama, Kozo Ishikawa, Yutaka Okuno, Kisato Nosaka, Ken-ichiro Seino, Masao Matsuoka, Shinya Suzu
  • Journal Title: J Clin Exp Hematopathol Volume: Vol. 58 No.4 Issue: 4 Pages: 152-160
  • DOI: 10.3960/jslrt.18034
  • NAID: 130007529824
  • ISSN: 1346-4280, 1880-9952
  • Peer Reviewed / Open Access
• [Journal Article] Methylation changes and aberrant expression of FGFR3 in Lewy body disease neurons (2018)
  • Author(s): Takeyuki Tsuchida, Tatsuo Mano, Kagari-Koshi-Mano, Taro Bannai, Satoshi Yamashita, Toshikazu Ushijima, Kenichi Nagata, Shigeo Murayama, Tatsushi Toda, Shoji Tsuji, Atsushi Iwata
  • Journal Title: Brain Research Volume: 1697 Pages: 59-66
  • DOI: 10.1016/j.brainres.2018.06.017
  • Peer Reviewed
• [Journal Article] Inverse association between soy food consumption, especially fermented soy products intake and soy isoflavone, and arterial stiffness in Japanese men (2018)
  • Author(s): Hirokazu Uemura, Sakurako Katsuura-Kamano, Mariko Nakamoto, Miwa Yamaguchi, Miho Fujioka, Yuki Iwasaki, Kokichi Arisawa
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 9667-9667
  • DOI: 10.1038/s41598-018-28038-0
  • NAID: 120006535059
  • Peer Reviewed / Open Access
• [Journal Article] Interleukin-34, a comprehensive review (2018)
  • Author(s): Muhammad Baghdadi, Yui Umeyama, Naoki Bama, Takuto Kobayashi, Nanumi Han, Haruka Wada, Ken-ichiro Seino
  • Journal Title: Journal of leukocyte biology Volume: 104 Issue: 5 Pages: 931-951
  • DOI: 10.1002/jlb.mr1117-457r
  • Peer Reviewed / Open Access
• [Journal Article] High co-expression of IL-34 and M-CSF correlates with tumor progression and poor survival in lung cancers (2018)
  • Author(s): Baghdadi M, Endo H, Takano A, Ishikawa K, Kameda Y, Wada H, Miyagi Y, Yokose T, Ito H, Nakayama H, Daigo Y, Suzuki N, Seino K
  • Journal Title: Sci Rep. Volume: 11;8(1) Issue: 1 Pages: 418-418
  • DOI: 10.1038/s41598-017-18796-8
  • NAID: 120006414003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genome-Wide Association Study to Identify a New Susceptibility Locus for Central Serous Chorioretinopathy in the Japanese Population. (2018)
  • Author(s): MikiA, SakuradaY, TanakaK, SembaK, MitamuraY, YuzawaM, TajimaA, NakatochiM, YamamotoK, MatsuoK, ImotoI, HondaS.
  • Journal Title: Invest Ophtalmol Vis Sci Volume: 59(13) Issue: 13 Pages: 5542-5542
  • DOI: 10.1167/iovs.18-25497
  • NAID: 120006550257
  • Peer Reviewed / Open Access
• [Journal Article] Genome-Wide Association Study of Renal Function Traits : Results from the Japan Multi-Institutional Collaborative Cohort Study. (2018)
  • Author(s): Hishida A, Nakatochi M, Akiyama M, Kamatani Y, Nishiyama T, Ito H, Oze I, Nishida Y, Hara M, Takashima N, Turin TC, Watanabe M, Suzuki S, Ibusuki R, Shimoshikiryo I, Nakamura Y, Mikami H, Ikezaki H, Furusyo N, Kuriki K, Endoh K, Koyama T, Matsui D, Uemura
  • Journal Title: American Journal of Nephrol Volume: 47 Issue: 5 Pages: 304-316
  • DOI: 10.1159/000488946
  • NAID: 120006504382
  • Peer Reviewed
• [Journal Article] Genomewide Association Study of Leisure-Time Exercise Behavior in Japanese Adults. (2018)
  • Author(s): Hara M, Hachiya T, Sutoh Y, Matsuo K, Nishida Y, Shimanoe C, Tanaka K, Shimizu A, Ohnaka K, Kawaguchi T, Oze I, Matsuda F, Ito H, Kawai S, Hishida A, Okada R, Sasakabe T, Hirata A, Ibusuki R, Nindita Y, Furusyo N, Ikezaki H, Kuriyama N, Ozaki E, Mikami H.
  • Journal Title: Med Sci Sports Exerc Volume: 50 Issue: 12 Pages: 2433-2441
  • DOI: 10.1249/mss.0000000000001712
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide association study for pollinosis identified two novel loci in interleukin (IL)-IB in a Japanese population. (2018)
  • Author(s): Fujii R, Hishida A, Wu MC. Kondo T, Hattori Y, Naito M, Endoh K, Nakatochi M, Hamajima N, Kubo M, Kuriki K, Wakai K.
  • Journal Title: Nagoya Journal of Medical Science Volume: 80 Issue: 1 Pages: 109-120
  • DOI: 10.18999/nagjms.80.1.109
  • NAID: 120006410517
  • ISSN: 0027-7622
  • URL: http://hdl.handle.net/2237/00027495
  • Peer Reviewed / Open Access
• [Journal Article] Enhanced IL-34 expression in Nivolumab-resistant metastatic melanoma (2018)
  • Author(s): Nanumi Han, Muhammad Baghdadi, Kozo Ishikawa, Hiraku Endo, Takuto Kobayashi, Haruka Wada, Keisuke Imafuku, Hiroo Hata, Ken-ichiro Seino
  • Journal Title: Inflammation and Regeneration Volume: 5 Pages: 3-3
  • DOI: 10.1186/s41232-018-0060-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Enhanced expression of IL-34 in an inflammatory cyst of the submandibular gland : a case report (2018)
  • Author(s): Muhammad Baghdadi, Kozo Ishikawa, Hiraku Endo, Yui Umeyama, Tsukasa Ataka, Haruka Wada, Yumiko Oyamada, Naoki Hyakushima, Ken-ichiro Seino
  • Journal Title: Inflammation and Regeneration Volume: 38 Issue: 12
  • DOI: 10.1186/s41232-018-0069-6
  • Peer Reviewed / Open Access
• [Journal Article] Effects of the -141C insertion/deletion polymorphism in the dopamine D2 receptor gene on the dopamine system in the striatum in patients with schizophrenia (2018)
  • Author(s): Matsumoto J, Nagaoka A, Kunii Y, Miura I, Hino M, Niwa SI, Nawa H, Takahashi H, Kakita A, Yabe H
  • Journal Title: Psychiatry Res Volume: 264 Pages: 116-118
  • DOI: 10.1016/j.psychres.2018.03.029
  • Peer Reviewed
• [Journal Article] Dietary Antioxidant Micronutrients and All-Cause Mortality : The Japan Collaborative Cohort Study for Evaluation of Cancer Risk. (2018)
  • Author(s): Ma E, Iso H, Yamagishi K, Ando M, Wakai K, Tamakoshi A.
  • Journal Title: Journal of Epidemiology Volume: 28 Issue: 9 Pages: 388-396
  • DOI: 10.2188/jea.je20170023 10.2188/jea.JE20170023
  • NAID: 130006745191
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed / Open Access
• [Journal Article] Common variant of BCAS3 is associated with gout risk in Japanese population : the first replication study after gout GWAS in Han Chinese. (2018)
  • Author(s): Sakiyama M, Matsuo H, Nakaoka H, Kawamura Y, Kawaguchi M, Higashino T, Nakayama A, Akashi A, Ueyama J, Kondo T, Wakai K, Sakurai Y, Yamamoto K, Ooyama H, Shinomiya N.
  • Journal Title: BMC Med Genet Volume: 19 Issue: 1 Pages: 96-96
  • DOI: 10.1186/s12881-018-0583-z
  • Peer Reviewed / Open Access
• [Journal Article] Cardiovascular disease mortality in relation to physical activity during adolescence and adulthood in Japan : Does school-based sport club participation matter? (2018)
  • Author(s): Gero K, Iso H, Kitamura A, Yamagishi K, Yatsuya H, Tamakoshi A.
  • Journal Title: Prev Med Volume: 113 Pages: 102-108
  • DOI: 10.1016/j.ypmed.2018.05.012
  • NAID: 120006492211
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association of exposure level to passive smoking with hypertension among lifetime nonsmokers in Japan : a cross-sectional study. (2018)
  • Author(s): Tamura T, Kadomatsu Y, Tsukamoto M, Okada R, Sasakabe T, Kawai S, Hishida A, Hara M, Tanaka K, Shimoshikiryo I, Takezaki T, Watanabe I, Matsui D, Nishiyama T, Suzuki S, Endoh K, Kuriki K, Kita Y, Katsuura-Kamano S, Arisawa K, Ikezaki H, Furusyo N, Koyanag
  • Journal Title: Medicine (Baltimore) Volume: 97 Issue: 48
  • DOI: 10.1097/md.0000000000013241
  • Peer Reviewed / Open Access
• [Journal Article] A genome-wide association study in the Japanese population identifies the 12q24 locus for habitual coffee consumption : The J-MICC Study (2018)
  • Author(s): Nakagawa-Senda H, Hachiya T, Shimizu A, Hosono S, Oze I, Watanabe M, Matsuo K, Ito H, Hara M, Nishida Y, Endoh K, Kuriki K, Katsuura-Kamano S, Arisawa K, Nindita Y, Ibusuki R, Suzuki S, Hosono A, Mikami H, Nakamura Y, Takashima N, Nakamura Y, Kuriyama N.
  • Journal Title: Sci Rep Volume: 8 Issue: 1 Pages: 1493-1493
  • DOI: 10.1038/s41598-018-19914-w
  • NAID: 120006535054
  • Peer Reviewed / Open Access
• [Journal Article] Water intake from foods and beverages and risk of mortality from CVD : the Japan Collaborative Cohort (JACC) Study. (2018)
  • Author(s): Cui R, Iso H, Eshak ES, Maruyama K, Tamakoshi A
  • Journal Title: Public Health Nutr Volume: 21 Issue: 16 Pages: 3011-3017
  • DOI: 10.1017/s1368980018001386
  • Peer Reviewed / Open Access
• [Journal Article] Multiancestry genome-wide association study of 520.000 subjects identifies 32 loci associated with stroke and stroke subtypes. (2018)
  • Author(s): Malik R, Chauhan G, Wakai K, Weir D, Williams SR, Wolfe CDA, Wong Q, Xu H, Yamaji T, Sanghera DK, Melander O, Jern C, Strbian D, Fernandez-Cadenas I, Longstreth WT Jr, Rolfs A, Hata J, Woo D, Rosand J, Pare G, Hopewell JC, Saleheen D, Stefansson K, Worral
  • Journal Title: Nature Genetics Volume: 50 Issue: 4 Pages: 524-537
  • DOI: 10.1038/s41588-018-0058-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ikigai, Subjective Wellbeing, as a Modifier of the Parity-Cardiovascular Mortality Association- The Japan Collaborative Cohort Study. (2018)
  • Author(s): Yasukawa S, Eguchi E, Ogino K, Tamakoshi A, Iso H.
  • Journal Title: Circ J Volume: 82 Issue: 5 Pages: 1302-1308
  • DOI: 10.1253/circj.cj-17-1201 10.1253/circj.CJ-17-1201
  • NAID: 130006725979
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Genome-wide association study identifies gastric cancer susceptibility loci at 12q24. 11-12 and 20q11. 21 (2018)
  • Author(s): Tanikawa C, Kamatani Y, Toyoshima O, Sakamoto H, Ito H, Takahashi A, Momozawa Y, Hirata M, Fuse N, Takai-Igarashi T, Shimizu A, Sasaki M, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Naito M, Hishida A, Wakai K, Furusyo N, Murakami Y, Nakamura Y, Imoto I, In
  • Journal Title: Cancer Science Volume: 109 Issue: 12 Pages: 4015-4024
  • DOI: 10.1111/cas.13815
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide association study (GWAS) of ovarian cancer in Japanese predicted regulatory variants in 22q13. 1. (2018)
  • Author(s): Yodsurang V, Tang Y, Takahashi Y, Tanikawa C, Kamatani Y, Takahashi A, Momozawa Y, Fuse N, Sugawara J, Shimizu A, Fukushima A, Hishida A, Furusyo N, Naito M, Wakai K, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Hirata M, Murakami Y, Kubo M, Matsuda K.
  • Journal Title: PLOS ONE Volume: 13 Issue: 12
  • DOI: 10.1371/journal.pone.0209096
  • Peer Reviewed / Open Access
• [Journal Article] Fish Intake and Death From Pulmonary Embolisms Among Japanese Men and Women- The Japan Collaborative Cohort (JACC) Study. (2018)
  • Author(s): Ohira T, Iso H, Yamagishi K, Tamakoshi A
  • Journal Title: Circ J Volume: 82 Issue: 8 Pages: 2063-2070
  • DOI: 10.1253/circj.cj-18-0040 10.1253/circj.CJ-18-0040
  • NAID: 130007419808
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] 脳脊髄液減少症(特発性低髄液圧症候群)と脳型トランスフェリン (2018)
  • Author(s): 村上友太、高橋浩一、星 京香、伊藤浩美、齋藤 清、宮嶋雅一、新井 一、美馬達夫、橋本康弘
  • Journal Title: 日本頭痛学会誌 Volume: 45 Issue: 1 Pages: 25-33
  • Peer Reviewed
• [Journal Article] Novel Common Genetic Susceptibility Loci for Colorectal Cancer. (2018)
  • Author(s): Schmit SL, Edlund CK, Matsuo K, Conti DV, Gruber SB, et al.
  • Journal Title: J Natl Cancer Inst Volume: 111 Issue: 2 Pages: 146-157
  • DOI: 10.1093/jnci/djy099
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Spontaneous intracranial hypotension is diagnosed by a combination of lipocalin-type prostaglandin D synthase and brain-type transferrin in cerebrospinal fluid (2018)
  • Author(s): Yuta Murakami, Koichi Takahashi, Kyoka Hoshi, Hiromi Ito, Mayumi Kanno, Kiyoshi Saito, Kenneth Nollet, Yoshiki Yamaguchi, Masakazu Miyajima, Hajime Arai, Yasuhiro Hashimoto, Tatsuo Mima
  • Journal Title: Biochimica et Biophysica Acta (BBA) - General Subjects Volume: 1862 Pages: 1835-1842
  • DOI: 10.1016/j.bbagen.2018.03.027
  • Peer Reviewed
• [Journal Article] Rapid increase of "brain-type" transferrin in cerebrospinal fluid after shunt surgery for idiopathic normal pressure hydrocephalus : a prognosis marker for cognitive recovery (2018)
  • Author(s): Yuta Murakami, Yuka Matsumoto, Kyoka Hoshi, Hiromi Ito, Takashi J, Fuwa, Yoshiki Yamaguchi, Madoka Nakajima, Masakazu Miyajima, Hajime Arai, Kenneth Nollet, Naho Kato, Rie Nishikata, Naohito Kuroda, Takashi Honda, Jun Sakuma, Kiyoshi Saito, Yasuhiro Hashi
  • Journal Title: The Journal of Biochemistry Volume: 164 Issue: 3 Pages: 205-213
  • DOI: 10.1093/jb/mvy043
  • NAID: 40021678439
  • Peer Reviewed / Open Access
• [Journal Article] Quantitative Analysis of Surface Electromyography for Pediatric Neuromuscular Disorders (2018)
  • Author(s): Higashihara M, Somoo M, Ishiyama A, Nagashima Y, Matsumoto K, Uesugi H, et al.
  • Journal Title: Muscle Nerve Volume: 58 Issue: 6 Pages: 824-827
  • DOI: 10.1002/mus.26299
  • Peer Reviewed
• [Journal Article] Prediction model for pancreatic cancer risk in the general Japanese population. (2018)
  • Author(s): Nakatochi M, Lin Y, Ito H, Hara K, Kinoshita F, Kobayashi Y, Ishii H, Ozaka M, Sasaki T, Sasahira N, Morimoto M, Kobayashi S, Ueno M, Ohkawa S, Egawa N, Kuruma S, Mori M, Nakao H, Wang C, Nishiyama T, Kawaguchi T, Takahashi M, Matsuda F, Kikuchi S, Matsuo
  • Journal Title: PloS ONE Volume: 13(9)
  • DOI: 10.1371/journal.pone.0203386
  • Peer Reviewed / Open Access
• [Journal Article] Pathological alterations of chondroitin sulfate moiety in postmortem hippocampus of patients with schizophrenia (2018)
  • Author(s): Yukawa t, Iwakura Y, Takei N, Saito M, Watanabe Y, Toyooka K, Igarashi, M, Niizato K, Oshima K, Kunii Y, Yabe H, Matsumoto J, Wada A, Hino M, Iritani S, Niwa S, Takeuchi R. Takahashi H, Kakita A, Someya T, *Nawa H
  • Journal Title: Psychiatry Res Volume: 270 Pages: 940-946
  • DOI: 10.1016/j.psychres.2018.10.062
  • Peer Reviewed / Open Access
• [Journal Article] p53-inducible DPYSL4 associates with mitochondrial supercomplexes and regulates energy metabolism in adpocytes and cancer cells. (2018)
  • Author(s): Nagano H, Hashimoto N, Nakayama A, Suzuki S, Miyabayashi Y, Yamato A, Higuchi S, Fujimoto M, Sakuma I, Beppu M, Yokoyama M, Suzuki Y, Sugano S, Ikeda K, Tatsuno I, Manabe I, Yokote K, Inoue S, Tanaka T.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 115 Issue: 33 Pages: 8370-8375
  • DOI: 10.1073/pnas.1804243115
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mutational intratumor heterogeneity is a complex and early event in the development of adult T-cell leukemia/lymphoma. (2018)
  • Author(s): Farmanbar A, Firouzi S, Nakalowski W, Kneller R, Iwanaga M, Utsunomiya A, Nakai K, Watanabe T.
  • Journal Title: Neoplasia Volume: 9 Issue: 9 Pages: 883-893
  • DOI: 10.1016/j.neo.2018.07.001
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lectin-based assay for glycoform-specific detection of ・2, 6sialylated transferrin and carcinoembryonic antigen in tissue and body fluid (2018)
  • Author(s): Hiromi Ito, Kyoka Hoshi, Takashi Honda, Yasuhiro Hashimoto
  • Journal Title: Molecule Volume: 23 Pages: 1314-1314
  • DOI: 10.3390/molecules23061314
  • Peer Reviewed
• [Journal Article] Interethnic analyses of blood pressure loci in populations of East Asian and European descent. (2018)
  • Author(s): Takeuchi F, Akiyama M, Matoba N, Katsuya T, Nakatochi M, Tabara Y, Narita A, Saw WY, et al.
  • Journal Title: Nature Communications Volume: 9 Pages: 5052-5052
  • DOI: 10.1038/s41467-018-07345-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identification of somatic mutations in postmortem human brains by whole genome sequencing and their implications for psychiatric disorders. (2018)
  • Author(s): Nishioka M, Bundo M, Ueda J, Katsuoka F, Sato Y, Kuroki Y, Ishii T, Ukai W, Murayama S, Hashimoto E, Nagasaki M, Yasuda J, Kasai K, Kato T, Iwamoto K.
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 72 Issue: 4 Pages: 280-294
  • DOI: 10.1111/pcn.12632
  • Peer Reviewed / Open Access
• [Journal Article] HTLV-1-Mediated Epigenetic Pathway to Adult T-Cell Leukemia-Lymphoma. (2018)
  • Author(s): Yamagishi M, Fujikawa D, Watanabe T, Uchimaru K.
  • Journal Title: Front Microbiol Volume: 9 Pages: 1686-1686
  • DOI: 10.3389/fmicb.2018.01686
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide analysis of polymorphism?×?sodium interaction effect on blood pressure identifies a novel 3′-BCL11B gene desert locus (2018)
  • Author(s): Hachiya T, Narita A, Ohmomo H, Sutoh Y, Komaki S, Tanno K, Satoh M, Sakata K, et al.
  • Journal Title: Scientific Reports Volume: 8 Pages: 14162-14162
  • DOI: 10.1038/s41598-018-32074-1
  • Peer Reviewed / Open Access
• [Journal Article] Genetic determinants and an epistasis of LILRA3 and HLA-B*52 in Takayasu arteritis. (2018)
  • Author(s): Terao C, Yoshifuji H, Matsumura T, Naruse TK, Ishii T, Nakaoka Y, Kirino Y, Matsuo K, Origuchi T, Shimizu M, Maejima Y, Amiya E, Tamura N, Kawaguchi T, Takahashi M, Setoh K, Ohmura K, Watanabe R, Horita T, Atsumi T, Matsukura M, Miyata T, Kochi Y, Suda T,
  • Journal Title: Proc Natl Acad Sci U S A Volume: 115 Pages: 13045-13050
  • DOI: 10.1073/pnas.1808850115
  • Peer Reviewed / Open Access
• [Journal Article] Cigarette smoking and cervical cancer risk : an evaluation based on a systematic review and meta-analysis among Japanese women (2018)
  • Author(s): Sugawara Y, Tsuji I, Mizoue T, Inoue M, Sawada N, Matsuo K, Ito H, Naito M, Nagata C, Kitamura Y, Sadakane A, Tanaka K, Tamakoshi A, Tsugane S, Shimazu T ; Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan.
  • Journal Title: Jpn J Clin Oncol
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• [Journal Article] CD30 Characterizes Polylobated Lymphocytes and Disease Progression in HTLV-1-Infected Individuals. (2018)
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  • Journal Title: Clin Cancer Res. Volume: 24 Issue: 21 Pages: 5445-5457
  • DOI: 10.1158/1078-0432.ccr-18-0268
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• [Journal Article] Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production. (2018)
  • Author(s): Ito Y, Nakamura S, Sugimoto N, Shigemori T, Kato Y, Ohno M, Sakuma S, Ito K, Kumon H, Hirose H, Okamoto H, Nogawa M, Iwasaki M, Kihara S, Fujio K, Matsumoto T, Higashi N, Hashimoto K, Sawaguchi A, Harimoto KI, Nakagawa M, Yamamoto T, Handa M, Watanabe N.
  • Journal Title: Cell Volume: 174(3) Issue: 3 Pages: 636-648
  • DOI: 10.1016/j.cell.2018.06.011
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• [Journal Article] Trogocytosis of ligand-receptor complex and its intracellular transport in CD30 signalling. (2018)
  • Author(s): Nakashima M, Watanabe M, Uchimaru K, Horie R.
  • Journal Title: Biol Cell Volume: 110 Issue: 5 Pages: 109-124
  • DOI: 10.1111/boc.201800002
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• [Journal Article] Targeting miR-223 in neutrophils enhances the clearance of Staphylococcus aureus in infected wounds. (2018)
  • Author(s): de Kerckhove M, Tanaka K, Umehara T, Okamoto M, Kanematsu S, Hayashi H, Yano H, Nishiura S, Tooyama S, Matsubayashi Y, Komatsu To. Park S, Okada Y, Takahashi R, Kawano Y, Hanawa T, Iwasaki K, Nozaki T, Torigoe H, Ikematsu K, Suzuki Y, Tanaka K, Martin P, Shimokawa I, Mori R
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• [Journal Article] Study on the tumor-induced angiogenesis using mathematical models. (2018)
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  • Journal Title: Cancer Sci Volume: 109 Pages: 15-23
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• [Journal Article] Relationship between Long Interspersed Nuclear Element-1 DNA Methylation in Leukocytes and Dyslipidemia in the Japanese General Population. (2018)
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  • Journal Title: J Atheroscler Thromb Volume: 25 Issue: 12 Pages: 1231-1239
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  • NAID: 130006655021
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• [Journal Article] Relationship Between Dietary Vitamin D and Deaths From Stroke and Coronary Heart Disease : The Japan Collaborative Cohort Study. (2018)
  • Author(s): Sheerah HA, Eshak ES, Cui R, Imano H, Iso H, Tamakoshi A
  • Journal Title: Stroke Volume: 49 Issue: 2 Pages: 454-457
  • DOI: 10.1161/strokeaha.117.019417
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• [Journal Article] Reduced gray matter volume is correlated with frontal cognitive and behavioral impairments in Parkinson's disease (2018)
  • Author(s): Terada T, Miyata J, Obi T, Kubota M, Yoshizumi M, Murai T.
  • Journal Title: J Neurol Sci Volume: 390 Pages: 231-238
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• [Journal Article] Prednisolone-responsive Postpartum IgG4-related Hypophysitis. (2018)
  • Author(s): Koide H, Shiga A, Komai E, Yamato A, Fujimoto M, Tamura A, Kono T, Nakayama A, Takiguchi T, Higuchi S, Sakuma I, Nagano H, Hashimoto N, Suzuki S, Takeda Y, Shibuya M, Nishioka H, Yamada S, Inoshita N, Ishiwatari N, Horiguchi K, Yokote K, Tanaka T.
  • Journal Title: Intern Med Volume: 57 Issue: 3 Pages: 367-375
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• [Journal Article] Phosphatidylinositol 3-kinase-δ (PI3K-δ) is a potential therapeutic target in adult T-cell leukemia-lymphoma (2018)
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  • Journal Title: Biomark Res Volume: 6 Pages: 24-24
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• [Journal Article] Neuroimaging-pathological correlations of [18F]THK5351 PET in progressive supranuclear palsy. (2018)
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  • Journal Title: Acta Neuropathol Commun. Volume: 6 Pages: 53-53
  • DOI: 10.1186/s40478-018-0556-7
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• [Journal Article] Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation. (2018)
  • Author(s): Kanda K, Sakamoto J, Matsumoto Y, Ikuta K, Goto N, Morita Y, Ohno M, Nishi K, Eto K, Kimura Y, Nakanishi Y, Ikegami K, Yoshikawa T, Fukuda A, Kawada K, Sakai Y, Ito A, Yoshida M, Kimura T, Chiba T, Nishi E, Seno H.
  • Journal Title: JCI insight Volume: 3 Issue: 8 Pages: 1-15
  • DOI: 10.1172/jci.insight.91316
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• [Journal Article] Maternal undernutrition during early pregnancy inhibits postnatal growth of the tibia in the female offspring of rats by alteration of chondrogenesis. (2018)
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  • Journal Title: Gen Comp Endocrinol. Volume: 260 Issue: 1 Pages: 58-60
  • DOI: 10.1016/j.ygcen.2017.12.008
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• [Journal Article] Identification of proteolytic cleavage sites of EphA2 by membrane type-1 matrix metalloproteinase on the surface of cancer cells (2018)
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  • Journal Title: Methods in Molecular Biology Volume: 1731 Pages: 29-37
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• [Journal Article] Identification of a novel HLA-A24-restricted cytotoxic T lymphocyte epitope peptide derived from mesothelin in pancreatic cancer. (2018)
  • Author(s): Tsukagoshi M, Wada S, Hirono S, Yoshida S, Yada E, Sasada T, Shirabe K, Kuwano H, Yamaue H.
  • Journal Title: Oncotarget Volume: 9 Issue: 59 Pages: 31448-31458
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• [Journal Article] Identification and functional analysis of inflammation-related miRNAs in skin wound repair. (2018)
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  • Journal Title: Dev Growth Differ Volume: 60 Issue: 6 Pages: 306-315
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• [Journal Article] HIV LTR-driven antisense RNA by itself has regulatory function and may curtail virus reactivation from latency. (2018)
  • Author(s): Kobayashi-Ishihara M, Terahara K, Martinez JP, Yamagishi M, Iwabuchi R, Brander C, Ato M, Watanabe T, Meyerhans A, Tsunetsugu-Yokota Y
  • Journal Title: Front. Microbiol. Volume: 9 Pages: 1066-1066
  • DOI: 10.3389/fmicb.2018.01066
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• [Journal Article] Glucagonoma With Necrolytic Migratory Erythema : Metabolic Profile and Detection of Biallelic Inactivation of DAXX Gene. (2018)
  • Author(s): Tamura A, Ogasawara T, Fujii Y, Kaneko H, Nakayama A, Higuchi S, Hashimoto N, Niyabayashi Y, Fujimoto M, Komai E, Kono T, Sakuma I, Nagano H, Suzuki S, Koide H, Yokote K, Iseki K, Oguma R, Matsue H, Nojima H, Sugiura K, Yoshitomi H, Ohtsuka M, Rahmutulla B, Kaneda A, Inoshita N, Ogawa S, Tanaka T.
  • Journal Title: J Clin Endocrinol Metab Volume: 23 Issue: 7 Pages: 2417-2423
  • DOI: 10.1210/jc.2017-02646
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• [Journal Article] Fracture risk assessment tool (FRAX) and for the diagnosis of osteoporosis in Japanese middle-aged and elderly women : Chiba bone survey. (2018)
  • Author(s): Oka R, Ohira M, Suzuki S, Yoshida T, Koide H, Tanaka T, Tatsuno I.
  • Journal Title: Endocr J Volume: 65 Issue: 2 Pages: 193-202
  • DOI: 10.1507/endocrj.ej17-0331 10.1507/endocrj.EJ17-0331
  • NAID: 130006402991
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• [Journal Article] Epigenetic changes around the pX region and spontaneous HTLV-1 transcription are CTCF-independent. (2018)
  • Author(s): Miura M, Miyazato P, Satou Y, Tanaka Y, Bangham CRM.
  • Journal Title: Wellcome Open Res. Volume: 3
  • DOI: 10.12688/wellcomeopenres
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• [Journal Article] Enhanced expression of PD-L1 in non-muscle-invasive bladder cancer after treatment with Bacillus Calmette-Guerin. (2018)
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  • Journal Title: Oncotarget. Volume: 9 Issue: 75 Pages: 34066-34078
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• [Journal Article] Dietary intakes of fat soluble vitamins as predictors of mortality from heart failure in a large prospective cohort study. (2018)
  • Author(s): Eshak ES, Iso H, Yamagishi K, Cui R, Tamakoshi A.
  • Journal Title: Nutrition Volume: 47 Pages: 50-55
  • DOI: 10.1016/j.nut.2017.09.009
  • NAID: 120006559006
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• [Journal Article] Chronic inflammatory demyelinating polyneuropathy in adult T-cell leukemia-lymphoma patients following allogeneic stem cell transplantation. (2018)
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  • Journal Title: Bone Marrow Transplant Volume: 53 Issue: 11 Pages: 1470-1473
  • DOI: 10.1038/s41409-018-0202-9
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• [Journal Article] Associations between dietary intakes of iron, copper and zinc with risk of type 2 diabetes mellitus : A large population-based prospective cohort study. (2018)
  • Author(s): Eshak ES, Iso H, Maruyama K, Muraki I, Tamakoshi A.
  • Journal Title: Clin Nutr Volume: 印刷中 Issue: 2 Pages: 667-674
  • DOI: 10.1016/j.clnu.2017.02.010
  • NAID: 120006600946
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• [Journal Article] Associations between copper and zinc intakes from diet and mortality from cardiovascular disease in a large population-based prospective cohort study. (2018)
  • Author(s): Eshak ES, Iso H, Yamagishi K, Maruyama K, Umesawa M, Tamakoshi A.
  • Journal Title: J Nutr Biochem Volume: 56 Pages: 126-132
  • DOI: 10.1016/j.jnutbio.2018.02.008
  • Peer Reviewed / Open Access
• [Journal Article] Association of subcutaneous and visceral fat with circulating microRNAs in a middle-aged Japanese population. (2018)
  • Author(s): Munetsuna E, Yamada H, Ando Y, Yamazaki M, Tsuboi Y, Kondo M, Mizuno G, Ishikawa H, Sugimoto K, Osakabe K, Ichino N, Ohashi K, Hamajima N, Suzuki K.
  • Journal Title: Annals of Clinical Biochemistry Volume: 55 Issue: 4 Pages: 437-445
  • DOI: 10.1177/0004563217735124
  • Peer Reviewed / Open Access
• [Journal Article] Association of Decreased Handgrip Strength with Reduced Cortical Thickness in Japanese Female Patients with Type 2 Diabetes Mellitus. (2018)
  • Author(s): Nakamura M, Inaba M, Yamada S, Ozaki E, Maruo S, Okuno S, Imanishi Y, Kuriyama N, Watanabe Y, Emoto M, Motoyama K.
  • Journal Title: Sci Rep. Volume: 17 Pages: 10767-10767
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• [Journal Article] Activated EphA2 processing by MT1-MMP is involved in malignant transformation of ovarian tumours in vivo (2018)
  • Author(s): Takahashi Y, Hamasaki M, Aoki M, Koga K, Koshikawa N, Miyamoto S, Nabeshima K.
  • Journal Title: Anticancer Res. Volume: 38 Pages: 4257-4266
  • DOI: 10.21873/anticanres.12722
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• [Journal Article] A Potential New Risk Factor for Stroke : Streptococcus Mutans With Collagen-Binding Protein. (2018)
  • Author(s): Inenaga C, Hokamura K, Nakano K, Nomura R, Naka S, Ohashi T, Ooshima T, Kuriyama N, Hamasaki T, Wada K, Umemura K, Tanaka T.
  • Journal Title: World Neurosurg Volume: 113 Pages: 77-81
  • DOI: 10.1016/j.wneu.2018.01.158
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• [Journal Article] Complete Sequences of the HTLV-1 Proviral Genomes from Newly Established ATL cell-lines in Oita Prefecture, Japan (2018)
  • Author(s): Takuro Fukumoto, Emi Ikebe, Masao Ogata, Kazuhiro Kohno, Madoka Kuramitsu, Yusuke Sato, Nichole Fife, Takashi Matsumoto, Takaaki Yahiro, Masanori Ikeda, Shuichi Kusano, Akihiko Okayama, Mitsuo Hori, Naoki Hijiya, Yoshiyuki Tsukamoto, Yuka Hirashita, Masatsugu Moriyama, Kamruddin Ahmed, Hiroo Hasegawa, Akira Nishizono, Masumichi Saito*, and Hidekatsu Iha*
  • Journal Title: Genome Announcements Volume: 6 Issue: 25
  • DOI: 10.1128/genomea.00090-18
  • Peer Reviewed / Open Access
• [Journal Article] 成人T細胞白血病・リンパ腫のエピゲノム異常と新規EZH1/2阻害剤の開発 (2018)
  • Author(s): 山岸誠
  • Journal Title: 臨床血液 Volume: 59 Pages: 432-438
• [Journal Article] HTLV-1感染細胞におけるゲノム・エピゲノム異常 (2018)
  • Author(s): 山岸誠
  • Journal Title: 医学の歩み Volume: 267 Pages: 771-775
• [Journal Article] 悪性リンパ腫におけるEZH1/EZH2依存性エピゲノム異常と創薬 (2018)
  • Author(s): 山岸誠
  • Journal Title: 血液内科 Volume: 78 Pages: 87-92
• [Journal Article] Modification of the associations of alcohol intake with serum low-density lipoprotein cholesterol and triglycerides by ALDH2 and ADHIB polymorphisms in Japanese men (2018)
  • Author(s): Sasakabe T, Wakai K, Kawai S, Hishida A, Naito M, Suzuki S, Nindita Y, Arisawa K, Kita Y, Hara M, Kuriyama N, Hirata A, Mikami H, Oze I, Kubo M, Tanaka H, Hamajima N.
  • Journal Title: Journal of Epidemiology Volume: 28 Issue: 4 Pages: 185-193
  • DOI: 10.2188/jea.je20160189 10.2188/jea.JE20160189
  • NAID: 130006638863
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  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Association of genetic polymorphisms with erythrocyte traits : Verification of SNPs reported in a previous GWAS in a Japanese population (2018)
  • Author(s): Seiki T, Naito M, Hishida A, Takagi S, Matsunaga T, Sasakabe T, Hattori Y, Kawai S, Okada R, Yin G, Hamajima N, Wakai K.
  • Journal Title: Gene Volume: 642 Pages: 172-177
  • DOI: 10.1016/j.gene.2017.11.031
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• [Journal Article] Genome-wide association study identifies seven novel susceptibility loei for primary open-angle glaucoma (2018)
  • Author(s): Shiga Y, Akiyama M, Nishiguchi K M, Sato K, Shimozawa N, Takahashi A, Momozawa Y, Hirata M, Matsuda K, Yamaji T, Iwasaki M, Tsugane S, Oze I, Mikami H, Naito M, Wakai K, Yoshikawa M, Miyake M, Yanaka T, et al.
  • Journal Title: Human Molecular Genetics Volume: 27 Issue: 8 Pages: 1486-1496
  • DOI: 10.1093/hmg/ddy053
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12. (2018)
  • Author(s): Tanikawa C, Kamatani Y, Takahashi A, Nagayama S, Mimori K, Mori M, Yasuda J, Tsuboi A, Shimizu A, Sasaki M, Yamaji T, Tsugane S, Naito M, Wakai K, Koyama T, Takezaki T, Yuji K, Murakami Y, Nakamura Y, Matsuda K, et al.
  • Journal Title: Carcinogenesis Volume: Epub Pages: 652-660
  • DOI: 10.1093/carcin/bgy026
  • Peer Reviewed / Open Access
• [Journal Article] Correlation between thyroid stimulating hormone and the renal function of cuthyroid residents of Japan : Results from the Kyushu and Okinawa Population Study(KOPS) (2018)
  • Author(s): Tanaka Y, Furusyo N, Kato Y, Ueyama T, Yamasaki S, Murata M, Hayashi J.
  • Journal Title: J Atheroscler Thromb Volume: 25 Issue: 4 Pages: 335-343
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• [Journal Article] A Common variant of MAF/c-MAF, transcriptional factor genc in the kidney, is associated with gout susceptjbility. (2018)
  • Author(s): Toshihide Higashino, Hirotaka Matsuo, Yukinori Okada, Hiroshi Nakashima, Seiko Shimizu, Masayuki Sakiyama, Shin Tadokoro, Akiyoshi Nakayama, Makoto Kawaguchi, Mako Komatsu, Asahi Hishida, Masahiro Nakatochi, Hiroshi Ooyama, Junko Imaki, Nariyoshi Shinomiy
  • Journal Title: Hum Cell. Volume: 31 Pages: 10-13
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• [Journal Article] Relationship Between Dietary Vitamin D and Deaths From Stroke and Coronary Hcart Disease : The Japan Collaborative Cohort Study (2018)
  • Author(s): Sheerah HA, Eshak ES, Cui R, Imano H, Iso H, Tamakoshi A.
  • Journal Title: Stroke Volume: 49 Issue: 2 Pages: 454-457
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• [Journal Article] The prospective association between plasma concentrations of cellular growth factors and risk of heart failure mortality in Japanese population. (2018)
  • Author(s): Ehab S Eshak, Koutatsu Maruyama, Hiroyasu Iso, Akiko Tamakoshi.
  • Journal Title: J of Epidemiology
  • NAID: 130007607770
  • Description: in press
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• [Journal Article] Physical activity earlier in life is inversely associated with insulin resistance among adults in Japan (2018)
  • Author(s): Fujita H. Hosono A. Shibata K. Tsujimura S. Oka K. Okamoto N. Kamiya M. Kondo F. Wakabayashi R. Ichikawa M. Yamada T. Suzuki S.
  • Journal Title: Journal of Epidemiology
  • NAID: 130007488353
  • Description: in press
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• [Journal Article] 地域住民の身体活動量と運動に対する自己評価 (2018)
  • Author(s): 藤田ひとみ、鈴木貞夫
  • Journal Title: 日本福祉大学健康科学論集 Volume: 21 Pages: 37-43
  • NAID: 120006456092
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• [Journal Article] Association of birth weight with diabetes and insulin resistance among community residents (2018)
  • Author(s): Kamiya M. Hosono A. Tamai Y. Watanabe M. Shibata K. Tsujimura S. Oka K. Fujita H. Okamoto X. Kondo F. Wakabayashi R, Yamada T. Suzuki S.
  • Journal Title: Nagoya Medical Journal
  • Description: in press
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• [Journal Article] Does waist circumference give us any significant information rcgarding obcsity? (2018)
  • Author(s): Tsujimura S. Tamai Y. Hosono A. Shibata K. Oka K, Fujita H. Okamoto N. Kamiya M. Kondo F. Wakabayashi R. Ichikawa M. Yamada T. Suzuki S.
  • Journal Title: Nagoya Medical Journal
  • Description: in press
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• [Journal Article] Unusual tau pathology of the cerebellum in patients with amyotrophic latoral sclerosis/parkinsonism-dementia complex from the kii peninsula, Japan. (2018)
  • Author(s): Morimoto S, Hatsuta H, Kokubo Y, Nakano Y, Hasegawa M, Yoneda M, Hirokawa Y, Kuzuhara S, Shiraishi T, Murayama S.
  • Journal Title: Brain Pathol Volume: - Issue: 2 Pages: 287-291
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• [Journal Article] Prion-Like seeding of misfolded alpha-synuclein in the brains of dementia with lewy body patients in RT-QUIC. (2018)
  • Author(s): Sano K, Atarashi R, Satoh K, Ishibashi D, Nakagaki T, Iwasaki Y, Yoshida M, Murayama S, Mishima K, Nishida N.
  • Journal Title: Mol Neurobiol Volume: - Issue: 5 Pages: 3916-3930
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• [Journal Article] Clinicopathological characteristics of distant metastases of adenocarcinoma, squamous cell carcinoma and urothelial carcinoma : An autopsy study of older Japanese patients. (2018)
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  • Journal Title: Geriatrics & Gerontology International Volume: 18 Issue: 2 Pages: 211-215
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• [Journal Article] Pathological and immunoblot analysis of phosphorylated TDP-43 in sporadic amyotrophic lateral sclerosis with pallido-nigro-luysian degeneration. (2018)
  • Author(s): Uchino A, Ogino M, Takahashi-Fujigasaki J, Oonuma S, Kanazawa N, Kajita S. Ichinoo M, Hasegawa M, Nishiyama K, Murayama S.
  • Journal Title: Neuropathology Volume: 38 Issue: 2 Pages: 171-178
  • DOI: 10.1111/neup.12430
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• [Journal Article] Optineurin pathology in the spinal cord of amyotrophic latoral sclerosis/parkinsonism-dementia complex patients in kii peninsula, Japan. (2018)
  • Author(s): Morimoto S, Hatsuta H, Motoyama R, Kokubo Y, Ishiura H, Tsuji S, Kuzubara S, Murayama S.
  • Journal Title: Brain Pathol. Volume: 28 Pages: 422-426
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• [Journal Article] Intractable epilepsy due to a rosette-forming glioneuronal tumor with a dysembryoplastic neuroepithelial background. (2018)
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  • Journal Title: Neuropathology Volume: 12 Pages: 300-304
  • DOI: 10.1111/neup.12450
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Marked accumulation of oligodendroglia-like cells in temporal lobe epilcpsy with amygdala enlargement and hippocampal sclerosis. (2018)
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  • Journal Title: Neuropathology Volume: 38 Issue: 2 Pages: 154-158
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• [Journal Article] Complement activation in capillary cerebral amyloid angiopathy. (2018)
  • Author(s): Matsuo K, Shindo A, Niwa A, Tabei KI, Akatsu H, Hashizume Y, Akiyama H, Ayaki T, Maki T, Sawamoto N, Takahashi R, Oikawa S, Tomimoto H.
  • Journal Title: Dement Geriatr Cogn Disord. Volume: 44 Pages: 343-343
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• [Journal Article] Targeting tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology. (2018)
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  • Journal Title: Nat Commun. Volume: 9 Issue: 1 Pages: 433-433
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• [Journal Article] Characterization of KIF11 as a novel prognostic biomarker and therapeutic target for oral cancer (2018)
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  • Journal Title: Int J Oncol Volume: 52(1) Pages: 155-165
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• [Journal Article] Helicobacter pylori infection is associated with favorable outcome in advanced gastric cancer patients treated with S-1 adjuvant chemotherapy. (2018)
  • Author(s): Nishizuka SS, Tamura G, Nakatochi M, Fukushima N, Ohmori Y, Sumida C, Iwaya T, Takahashi T, Koeda K ; Northern Japan Gastric Cancer Study Consortium
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  • Journal Title: Cancer Res Volume: 78 Issue: 7 Pages: 1766-1778
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• [Journal Article] Different clonal dynamics of chronic myeloid leukaemia betwecn bone marrow and the central nervous system (2018)
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  • Journal Title: Br J Haematol Volume: - Pages: 842-845
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  • DOI: 10.1080/10428194.2018.1443335
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• [Journal Article] The effect of forced expression of mutated K-RAS gene on gastrointestinal cancer cell lines and the IGF-1R targeting therapy. (2017)
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• [Journal Article] Cancer Transitional Care for Terminally Ill Cancer Patients Can Reduce the Number of Emergency Admissions and Emergency Department Visits. (2017)
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  • Journal Title: American Journal of Hospiec & Palliative Mcdicine Volume: 34 Issue: 9 Pages: 831-837
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• [Journal Article] Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer. (2017)
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  • Journal Title: Oncotarget Volume: 8 Issue: 29 Pages: 46856-46874
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• [Journal Article] HEG1 is a novel mucin-like membrane protein that serves as a diagnostic and therapeutic target for malignant mesothelioma. (2017)
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  • Journal Title: Sci Rep Volume: 7 Pages: 45768-45768
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  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Inhibition of PRDM14 expression in pancrcatic cancer suppresses cancer stem-like properties and liver mctastasis in mice. (2017)
  • Author(s): Moriya C, Taniguchi H, Imai K.
  • Journal Title: Carcinogenesis Volume: 38 Issue: 6 Pages: 638-648
  • DOI: 10.1093/carcin/bgx040
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• [Journal Article] Establishment of a refined culture mothod for rat colon organoids. (2017)
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  • Journal Title: Biochemical and Biophysical Research Communications Volume: 489 Issue: 3 Pages: 305-311
  • DOI: 10.1016/j.bbrc.2017.05.142
  • Peer Reviewed / Open Access
• [Journal Article] 日本の疾患コホートとしてのバイオバンクジャパンの取組 (2017)
  • Author(s): 村上善則
  • Journal Title: 実験医学 Volume: 35 Issue: 17 Pages: 2861-2866
• [Journal Article] Macronutrient intakes and serum oestrogen, and interaction with polymorphisms in CYP19A1 and HSD17B1 genes : a cross-sectional study in postmenopausal Japanese women (2017)
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  • Journal Title: British Journal of Nutrition Volume: 118 Issue: 6 Pages: 463-472
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• [Journal Article] Identification of six new genetic loci associated with atrial fibrillation in the Japancse population (2017)
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  • Journal Title: Nature Genetics Volume: - Issue: 6 Pages: 953-958
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• [Journal Article] Genetic variants of RAMP2 and CLR are associated with stroke (2017)
  • Author(s): Koyama T, Kuriyama N, Ozaki E, Matsui D, Watanabe I, Takeshita W, Iwai K, Watanabe Y, Xakatochi M, Tanaka K, Ito H, Uemura H, Katsuura-Kamano S, Kadota A, Kawai S, Sasakabe T, Okada R, Hishida A, Naito M, Kuriki K, et al.
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• [Journal Article] Actual daily intakes of tea catechins and their estimation according to four season 3 day weighed dietary records and a short food frequency questionnaire among Japanese men and women. (2017)
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  • Journal Title: Asian Pac J Cancer Prev Volume: 18 Issue: 10 Pages: 2875-2881
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• [Journal Article] Interactions between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases among the Japanese population. (2017)
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  • Journal Title: Journal of Epidemiology Volume: 27 Issue: 9 Pages: 420-427
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  • NAID: 130006067768
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• [Journal Article] Identification of novel mutations in Japanese ovarian clear cell carcinoma patients using optimized targeted NGS for clinical diagnosis. (2017)
  • Author(s): Maru Y, Tanaka N, Ohira M, Itami M, Hippo Y and Nagase H.
  • Journal Title: Gynecologic Oncology Volume: - Issue: 2 Pages: 377-383
  • DOI: 10.1016/j.ygyno.2016.11.045
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association analysis identifies 65 new breast cancer risk loci (2017)
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• [Journal Article] Decrease in PSCA expression caused by helicobacter pylori infection may promote progression to severe gastritis (2017)
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  • Journal Title: Oncotarget Volume: 9 Issue: 3 Pages: 3936-3945
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• [Journal Article] Cardiovascular disease prevalence and insulin resistance in the Kyushu-Okinawa population study and the framingham offspring study. (2017)
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• [Journal Article] The relation between serum endostatin level and carotid atherosclerosis in hoalthy residents of Japan : Results from the Kyushu and Okinawa Population Study(KOPS). (2017)
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  • Peer Reviewed
• [Journal Article] Higher dietary cholesterol and omega-3 fatty acid intakes aro assoejatod with a lower succossful rate of Helicobacter pylori oradication therapy in Japan. (2017)
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  • Journal Title: American Journal of Clinical Nutrition Volume: 106 Issue: 2 Pages: 581-588
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• [Journal Article] Recurrent pregnancy loss and cardiovascular disease mortality in Japanese Women : A population-based, prospective cohort study. (2017)
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  • Peer Reviewed
• [Journal Article] Accuracy of self-reported height, weight and waist circumference in a Japanese sample (2017)
  • Author(s): Okamoto, N. Hosono, A. Shibata, K. Tsujimura, S. Oka, K. Fujita, H. Kamiya, M. Kondo, F. Wakabayashi, R. Yamada, T. Suzuki, S.
  • Journal Title: Obesity science & practice. Volume: 3 Issue: 4 Pages: 417-24
  • DOI: 10.1002/osp4.122
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• [Journal Article] Excess APP O-glycosylation by GalNAc-T6 decreases Aβ production. (2017)
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  • Journal Title: J Biochem. Volume: 161 Issue: 1 Pages: 99-111
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  • NAID: 40021091544
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• [Journal Article] LRRK2 Levels and phosphorylation in Parkinson's disease brain and cases with restricted Lewy bodies. (2017)
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  • Journal Title: Mov Disord. Volume: 32 Issue: 3 Pages: 423-432
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serum microRNA miR-501-3p as a potential biomarker related to the progression of Alzheimer's diseasc. (2017)
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  • Peer Reviewed / Open Access
• [Journal Article] Simultaneous skin, nerve and muscle biopsy of neuronal intranuclear inclusion body disease. (2017)
  • Author(s): Morimoto S, Takao M, Murayama S
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  • Peer Reviewed / Open Access
• [Journal Article] Homovanillic acid and 5-hydroxyindole acetic acid as biomarkers for demcntia with Lowy bodies and coincident Alzheimer's disease : An autopsy-confirmed study. (2017)
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  • Journal Title: PLoS One Volume: 12 Issue: 2
  • DOI: 10.1371/journal.pone.0171524
  • Peer Reviewed / Open Access
• [Journal Article] Beta-N-methylamino-l-alanine analysis in the brains of patients with Kii ALS/PDC. (2017)
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  • Journal Title: Neurology Volume: 89 Issue: 10 Pages: 1091-1092
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Histopathology and florbetaben PET in patients incorrectly diagnosed with Alzheimer's disease. (2017)
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• [Journal Article] Beyond the midbrain atrophy : wide spectrum of structural MRI finding in cases of pathologically proven progressive supranuclear palsy. (2017)
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  • Journal Title: Neuroradiology. Volume: 印刷中 Issue: 5 Pages: 431-433
  • DOI: 10.1007/s00234-017-1812-4
  • Peer Reviewed
• [Journal Article] Expression of secreted phosphoprotein 1 (osteopontin) in human sensorimotor cortex and spinal cord : Changes in patients with amyotrophic lateral sclerosis. (2017)
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  • Journal Title: Brain Res Volume: 1655 Pages: 168-175
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  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Technical feasibility of visualizing myenteric plexus using confocal lasor endomicroscopy. (2017)
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  • Journal Title: J Gastroenterol Hepatol Volume: Epub ahead of print Issue: 9 Pages: 1604-10
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  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] PML nuclear bodies are altered in adult-onset neuronal intranuclear hyaline inclusion disease. (2017)
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  • Journal Title: J Neuropathol Exp Neurol. Volume: 76 Issue: 7 Pages: 585-594
  • DOI: 10.1093/jnen/nlx039
  • Peer Reviewed
• [Journal Article] Carbohydrate Antigen 19-9-Positive Gastric Adenocarcinoma: Autopsy Findings and Review of the Literature (2017)
  • Author(s): Wang T, Matsuda Y, Seki A, Nonaka K, Kakizaki M, Kaneda D, Takahashi-Fujigasaki J, Murayama S, Arai T.
  • Journal Title: Case Reports in Gastroenterology Volume: 11 Pages: 545-553
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• [Journal Article] Pathologic study of intracranial large artery atherosclerosis in 7260 autopsy cases. (2017)
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  • Journal Title: J Stroke Cerebrovasc Dis. Volume: 26 Issue: 12 Pages: 2821-2827
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• [Journal Article] Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease. (2017)
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Distinct deposition of amyloid-β species in brains with Alzheimer's disease pathology visualized with MALDI imaging mass spectrometry. (2017)
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  • Journal Title: Acta Neuropathol Commun Volume: 5 Issue: 1 Pages: 73-73
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  • Peer Reviewed / Open Access
• [Journal Article] Reduccd LRRK2 in association with retromer dysfunction in postmortem brain tissue from LRRK2 mutation carriers. (2017)
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  • Journal Title: Brain Volume: 141 Issue: 2 Pages: 486-495
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 成人型エオジン好性核内封人体病の診断電子顕微鏡所見の有用性. (2017)
  • Author(s): 長谷川文雄, 村山繁雄
  • Journal Title: 検査と技術 Volume: 45 Issue: 11 Pages: 1286-1290
• [Journal Article] Ⅳ. 神経系 1. 末梢神経. 2017 (2017)
  • Author(s): 村山繁雄, 齊藤祐子
  • Journal Title: 病理と臨床 Volume: 35 Pages: 61-70
• [Journal Article] Autopsy case of C12orf65 mutation in a patient with signs of mitochondrial dysfunction. (2017)
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  • Journal Title: Neurology Genetics Volume: 3
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• [Journal Article] 脳病理からみた超高齢者 (2017)
  • Author(s): 高尾 昌樹, 美原 盤, 新井 康通, 広瀬 信義, 三村 將
  • Journal Title: 認知神経科学 Volume: 19 Pages: 158-63
  • NAID: 130007588598
• [Journal Article] 神経核内封入体病(NIID)の頭部MRI経時的変化 (2017)
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  • Journal Title: 臨床神経学 Volume: 57 Pages: 791-791
• [Journal Article] 大脳皮質基底核変性症の1剖検例 (2017)
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• [Journal Article] Transgenic monkey model of the polyglutamine diseases recapitulating progressive nourological symptoms. (2017)
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• [Journal Article] Estrogen-Related Factors in the frontal lobe of Alzheimer's disease patients and importance of body mass index. (2017)
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• [Journal Article] Re-evaluation of soluble APP-α and APP-β in cerebrospinal fluid as potential biomarkers for early diagnosis of dementia disorders (2017)
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• [Journal Article] MR imaging features of the cerebellum in adult-onset neuronal intranuclear inclusion disease : 8 cases. (2017)
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• [Journal Article] 臨床医のための神経病理 再入門 アストログリアの病理 (2017)
  • Author(s): 齊藤祐子, 村山繁雄
  • Journal Title: Clinical Neuroscience Volume: 35 Issue: 10 Pages: 1152-1153
• [Journal Article] 嗜銀顆粒性認知症 (2017)
  • Author(s): 齊藤祐子
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• [Journal Article] Comparative analysis of cortical microinfarcts and microbleeds using 3.0-tesla postmortem magnetic resonance images and histopathology. (2017)
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• [Journal Article] Factors associated with pneumonia-caused death in older adults with autopsy-confirmed dementia. (2017)
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• [Journal Article] Lysophosphatidylcholine export by human ABCA7. (2017)
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  • Journal Title: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Volume: 印刷中 Issue: 7 Pages: 658-665
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  • Author(s): 高山卓大、水野初、豊岡利正、井之上浩一、赤津裕康、轟木堅一郎
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  • Journal Title: Oncogene Volume: 524 Issue: 26 Pages: 3740-3748
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• [Journal Article] Thyroid transcription factor-1-regulated miR-532-5p targets KRAS and MKL2 oncogenes and induces apoptosis in lung adenocarcinoma cells (2017)
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• [Journal Article] Clonality of HTLV-1-infected T cells as a risk indicator for development and progression of adult T-cell leukemia (2017)
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• [Journal Article] Evaluation of Sensitivity and Specificity Performance of Elecsys HTLV-I/II Assay in a Multicenter Study in Europe and Japan (2017)
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• [Journal Article] Cancor progression by reprogrammed BCAA metabolism in myeloid leukemia (2017)
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  • Journal Title: Gastric Cancer Volume: ahead of print Pages: 246-253
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• [Journal Article] Comparison of weighed food record procedures for the reference methods in two validation studies of food frequency questionnaires. (2017)
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  • Peer Reviewed / Open Access
• [Journal Article] Systemic inflammation and family history in relation to the prevalence of type 2 diabetes based on an alternating decision tree (2017)
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• [Journal Article] Interactions between Inflammatory Gene Polymorphisms and HTLV-I Infection for Total Death, Incidence of Cancer, and Atherosclerosis-Related Diseases among the Japanese Population. (2017)
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• [Journal Article] No modifying effect of education level on the association between lifestyle behaviors and cardiovascular mortality : the Japan Collaborative Cohort Study (2017)
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• [Journal Article] Recurrent MYB rearrangement in blastic plasmacytoid dendritic cell neoplasm (2017)
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• [Journal Article] Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations. (2017)
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• [Journal Article] The influence of personality and perceived stress on the development of breast cancer : 20-year follow-up of 29,098 Japanese women (2016)
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  • Journal Title: Scientific Reports Volume: － Pages: 23281-23281
  • DOI: 10.1038/srep23281
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Estradiol facilitates functional integration of induced pluripotent stem cell-derived dopaminergic neurons into striatal neuronal circuits via activation of integrin α5β1 (2016)
  • Author(s): Nishimura K, Doi D, Samata B, Murayama S, Tahara T, Onoe H, Takahashi J.
  • Journal Title: Stem Cell Reports. Volume: 6 Pages: 511-524
  • DOI: 10.1016/j.stemcr.2016.02.008
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Significant association of cadaveric dura mater grafting with subpial Abeta deposition and meningeal amyloid angiopathy. (2016)
  • Author(s): Hamaguchi T, Taniguchi Y, Sakai K, Kitamoto T, Takao M, Murayama S, Iwasaki Y, Yoshida M, Shimizu H, Kakita A, Takahashi H, Suzuki H, Naiki H, Sanjo N, Mizusawa H, Yamada M
  • Journal Title: Acta Neuropathol Volume: 132(2) Pages: 313-315
  • DOI: 10.1007/s00401-016-1588-3
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Histopathologic analysis of cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) : a report of a new genetically confirmed case and comparison to 2 previous cases. (2016)
  • Author(s): Ito S, Takao M, Fukutake T, Hatsuta H, Funabe S, Ito N, Shimoe Y, Niki T, Nakano I, Fukayama M, Murayama S
  • Journal Title: J Neuropath Exp Neurol Volume: 75 Issue: 11 Pages: 1020-1030
  • DOI: 10.1093/jnen/nlw078
  • Peer Reviewed
• [Journal Article] Extranodal NK/T-cell lymphoma, nasal type, manifesting as rapidly progressive dementia without any mass or enhancing brain lesion. (2016)
  • Author(s): Shimatani Y, Nakano Y, Tsuyama N, Murayama S, Oki R, Miyamoto R, Murakami N, Fujita K, Watanabe S, Uehara H, Abe T, Nodera H, Kawarai T, Izumi Y, Kaji R
  • Journal Title: Neuropathology Volume: 36 Pages: 456-463
  • DOI: 10.1111/neup.12285
  • Peer Reviewed / Open Access
• [Journal Article] Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma. (2016)
  • Author(s): Shiraishi K, Takahashi A, Takano A, Watanabe Y, Hishida T, Tsuchihara K, Miyagi Y, Tanaka K, Imai K, Minamiya Y, Sakamoto H, Inazawa J, Nakamura Y, Yoshida T, Yokota J, Matsuda F, Matsuo K, Daigo Y, Kubo M, Kohno T, et. al.
  • Journal Title: Nature Communications Volume: 7 Pages: 12451-12451
  • DOI: 10.1038/ncomms12451
  • NAID: 120005829411
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Chemotherapy-Induced IL34 Enhances Immunosuppression by Tumor-Associated Macrophages and Mediates Survival of Chemoresistant Lung Cancer Cells. (2016)
  • Author(s): Baghdadi M, Wada H, Nakanishi S, Abe H, Han N, Putra WE, Endo D, Watari H, Sakuragi N, Hida Y, Kaga K, Miyagi Y, Yokose T, Takano A, Daigo Y, Seino KI
  • Journal Title: Cancer Res Volume: 76 Pages: 6030-6042
  • DOI: 10.1158/0008-5472.can-16-1170
  • NAID: 120006347198
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women. (2016)
  • Author(s): Wang Z, Kohno T, Yokota J, Kunitoh H, Daigo Y, Mitsudomi T, Yatabe Y, Hida T, Iwasaki M, Shimazu T, Tsugane S, Li YJ, Yang TY, Lin CC, Yu J, Shen H, Kubo M, Chanock SJ, Rothman N, Lan Q, et. al.
  • Journal Title: Hum Mol Genet Volume: 25 Pages: 620-629
  • DOI: 10.1093/hmg/ddv494
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dysregulation of c-Myb Pathway by Aberrant Expression of Proto-oncogene MYB Provides the Basis for Malignancy in Adult T-cell Leukemia/lymphoma Cells (2016)
  • Author(s): Nakano K, Uchimaru K, Utsunomiya A, Yamaguchi K, Watanabe T.
  • Journal Title: Clin Cancer Res. Volume: 22 Pages: 5915-5928
  • DOI: 10.1158/1078-0432.ccr-15-1739
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Incidence of human T-lymphotropic virus 1 infection in adolescent and adult blood donors in Japan : a nationwide retrospective cohort analysis (2016)
  • Author(s): Satake M, Iwanaga M, Sagara Y, Watanabe T, Okuma K, Hamaguchi I
  • Journal Title: Lancet Infect Dis. Volume: 16 Pages: 1246-1254
  • DOI: 10.1016/s1473-3099(16)30252-3
  • Peer Reviewed
• [Journal Article] Polycomb-dependent epigenetic landscape in adult T-cell leukemia (2016)
  • Author(s): Fujikawa D, Nakagawa S, Hori M, Kurokawa N, Soejima A, Nakano K, Yamochi T, Nakashima M, Kobayashi S, Tanaka Y, Iwanaga M, Utsunomiya A, Uchimaru K, Yamagishi M, Watanabe T
  • Journal Title: Blood Volume: 127 Pages: 1790-1802
  • DOI: 10.1182/blood-2015-08-662593
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 20歳からの体重増加に対する家庭環境要因と食品・栄養素摂取の関連 : J-MICC Study静岡・桜ヶ丘地区 (2020)
  • Author(s): 鈴木和香子, 鳥仁, 栗木清典
  • Organizer: 第30回日本疫学会学術総会
• [Presentation] Implications from Alzheimer's disease risk factors (2020)
  • Author(s): Mitsuru Shinohara
  • Organizer: The 5th NCGG-ICAH Symposium
  • Int'l Joint Research / Invited
• [Presentation] In vivo association of mitochondrial dysfunction with tau pathology in early Alzheimer's disease (2020)
  • Author(s): Tatsuhiro Terada, Joseph Therriault, Min Su Peter Kang, Melissa Savard, Yasuomi Ouchi, Pedro Rosa-Neto
  • Organizer: Human Amyloid Imaging Conference 2020
  • Int'l Joint Research
• [Presentation] Influence of age on the relation between green tea consumption and prevalent risk of obesity among Japanese men and women : Japan Multi- Institutional Collaborative Cohort Study (2020)
  • Author(s): Kawata K, Nakano K, Kuriki K, Wakai K.
  • Organizer: 令和元年度 若手支援研究成果発表会(コホート・生体試料支援プラットフォーム)
• [Presentation] Mid-regional pro- adrenomedullin as a novel biomarker for vascular failure and its risk factors. (2020)
  • Author(s): 小山晃英, 栗山長門, 上原里程
  • Organizer: CVMW2019 心血管代謝週間
• [Presentation] mTORにより抑制されるtrefoil factor-1の発現、転写機序と肺癌における意義 (2020)
  • Author(s): 土橋 洋、中村 律子、椙村 春彦、山田 茂樹、大井 章史
  • Organizer: 第109回日本病理学会総会