コホート・生体試料支援プラットフォーム

• Project/Area Number: 16H06277
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas ― Platforms for Advanced Technologies and Research Resources
• Allocation Type: Single-year Grants
• Research Institution: The University of Tokyo
• Principal Investigator(Support): 今井 浩三 東京大学, 医科学研究所, 客員教授 (60117603)
• Co-Investigator(Kenkyū-buntansha)(Support): 若井 建志 名古屋大学, 大学院医学系研究科, 教授 (50270989) ; 村上 善則 東京大学, 医科学研究所, 教授 (30182108) ; 松尾 恵太郎 愛知県がんセンター(研究所), がん予防研究分野, 分野長 (80393122) ; 三上 春夫 千葉県がんセンター(研究所), がん予防センター, 部長 (10332355) ; 鈴木 貞夫 名古屋市立大学, 大学院医学研究科, 教授 (20226509) ; 喜多 義邦 敦賀市立看護大学, 看護学部, 准教授 (30147524) ; 渡辺 能行 (渡邊 能行) 京都府立医科大学, 大学院医学研究科, 教授 (00191809) ; 田中 恵太郎 佐賀大学, 医学部, 教授 (50217022) ; 嶽崎 俊郎 鹿児島大学, 医歯学域医学系, 教授 (50227013) ; 栗木 清典 静岡県立大学, 食品栄養科学部, 教授 (20543705) ; 古庄 憲浩 九州大学, 大学院医学研究院, 准教授 (10346786) ; 有澤 孝吉 徳島大学, 大学院医歯薬学研究部, 教授 (30203384) ; 玉腰 暁子 北海道大学, 大学院医学研究院, 教授 (90236737) ; 今田 恒夫 山形大学, 大学院医学系研究科, 教授 (60333952) ; 武林 亨 慶應義塾大学, 医学部, 教授 (30265780) ; 三浦 克之 滋賀医科大学, 医学部, 教授 (90257452) ; 成松 宏人 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所・がん予防・情報学部, 部長 (50524419) ; 鈴木 康司 藤田保健衛生大学, 保健学研究科, 教授 (60288470) ; 村山 繁雄 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (50183653) ; 高尾 昌樹 (高雄 昌樹) 公益財団法人脳血管研究所, 美原記念病院, 研究員 (50245487) ; 赤津 裕康 医療法人さわらび会福祉村病院長寿医学研究所, 長寿医学研究所, 研究員 (00399734) ; 齊藤 祐子 国立研究開発法人国立精神・神経医療研究センター, 病院臨床検査科, 医長 (60344066) ; 矢部 博興 福島県立医科大学, 医学部, 教授 (60210316) ; 中杤 昌弘 名古屋大学, 医学部附属病院, 病院講師 (10559983) ; 清水 厚志 岩手医科大学, いわて東北メディカル・メガバンク機構, 特命教授 (30327655) ; 醍醐 弥太郎 東京大学, 医科学研究所, 特任教授 (30345029) ; 高橋 隆 名古屋大学, 大学院医学系研究科, 教授 (50231395) ; 宮城 洋平 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), 臨床研究所・がん分子病態学部, 総括部長 (00254194) ; 渡邉 俊樹 東京大学, 名誉教授 (30182934) ; 安井 寛 東京大学, 医科学研究所, 特任准教授 (40448593) ; 田中 英夫 愛知県がんセンター研究所, 疫学・予防部, 部長 (60470168) ; 内藤 真理子 名古屋大学, 大学院医学系研究科, 准教授 (10378010) ; 大中 佳三 九州大学, 医学研究院, 講師 (30325518) ; 森 満 札幌医科大学, 医学部, 教授 (50175634) ; 川崎 良 山形大学, 大学院医学系研究科, 准教授 (70301067)
• Project Period (FY): 2016 – 2021
• Project Status: Granted (Fiscal Year 2018)
• Budget Amount: ¥2,276,040,000 (Direct Cost: ¥1,750,800,000、Indirect Cost: ¥525,240,000); Fiscal Year 2018: ¥379,340,000 (Direct Cost: ¥291,800,000、Indirect Cost: ¥87,540,000); Fiscal Year 2017: ¥379,340,000 (Direct Cost: ¥291,800,000、Indirect Cost: ¥87,540,000); Fiscal Year 2016: ¥379,340,000 (Direct Cost: ¥291,800,000、Indirect Cost: ¥87,540,000)
• Keywords: 生体試料支援 / コホート / 臨床検体 / 一般健常人 / 大規模ゲノム解析・オミックス解析 / 大規模ゲノム解析 / オミックス解析

Outline of Annual Research Achievements

①総括支援活動 : 10.1万名の健常人コホートにより、経時的生活情報とともに血清、DNA等のバイオリソースを、また、がん、脳疾患、高齢者等から、倫理面に十分配慮された、1万件に達する生体試料を、それぞれ収集してきたが、これらの研究基盤リソースを提供するとともに、これをさらに全国規模で発展継続させ、生命科学研究者の独創的な基盤的研究に貢献しようとする、この分野における我が国最大規棋の支援である。当プラットフォームの支援活動自体が国民一人ひとりとの関わりが強い活動であることから、総括支援活動においては、その支援内容や知見について広く市民の理解を得られるよう、青少年を含む一般市民に向けた公開講座を、シンポジウム等とならんで首都圏以外の各地でも積極的に開催してきた。
②一般健常人コホートを利用したバイオリソースの整備と活用支援、大規模バイオデータ解析支援、ならびに、発症情報を活用した支援として、肺腺癌の早期診断マーカー検証支援を公募・採択した。また生活習慣・健診データ(提供可能分は9.2万名)の整備、ゲノムワイド関連解析用タイピングデータとの結合を行い、提供準備を終えた。
③ブレインリソースの整備と活用支援 : 剖検で得られた死後脳をオープンリソースとした、精神・神経疾患の解明を目指した研究支援のための、日本ブレインバンクネットワークの構築と、実質的な運用の促進を行った。生前同意登録範囲を沖縄まで拡大した。さらに、国際ブレインネットワークとの連携を試みた。
④生体試料による支援活動 : 181課題に生体機能分子の高感度解析・技術支援と連携構築支援を実施。150課題にがん試料(組織、血液)を提供、8568試料を収集。論文23編に貢献。解析支援・試料支援体制を強化。普及・啓発講演を実施した。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

①総括支援活動 : これまで扱ってこなかった関東、東北、北海道などのコホートも加え、名実ともに我が国を代表するバイオリソースに育ちつつある。また、一般市民に対する公開講座等を首都圏以外の各地で積極的に開催して、国民の理解を得て進めようとしている。
②一般健常人コホートを利用したバイオリソースの整備と活用支援、大規模バイオデータ解析支援 : 本プラットフォームおよび関連学会のホームページを通じた情報発信を実施した。また増加した発症アウトカム情報を活用し、肺腺癌の早期診断マーカー検証支援を公募、審査を経て2件を採択した。さらに「がん支援活動」以来継続している10.1万名のコホートについても、第二次調査、疾病罹患・死亡調査を継続し、研究支援として生体試料、データを提供できる体制を発展させた。とくに生活習慣・健診データの整備を行い、提供の準備を終えた。
③ブレインリソースの整備と活用支援 : ブレインバンク拠点構築事業が大きく進展した。大阪大学ブレインバンクが、同大神経内科教授等の努力により構築され、生前同意登録制度、リソース保管施設の構築、主任研究者(特任教授)による神経病理診断援助などが整備されて、スタートした(既に4例の登録有り)。徳島大学神経内科では、高齢者ブレインバンクが凍結半脳の保管と固定半脳の診断援助を行なうことで、神経難病の凍結死後脳リソース構築(12例)を行った。
④生体試料による支援活動 : 支援依頼者のニーズの検討、新規の高感度分子解析技術を導入した解析支援体制の整備、生体試料バンクの国際標準化を視野に入れた収集体制の整備、ヴァーチャルスライドによる組織形態学的支援体制の強化と支援内容・成果の広報・啓発を進めつつ、支援課題数は生体機能分子解析・技術・連携支援および生体試料収集・提供支援ともに平成29年度の研究支援実施計画を上回り、国際的にインパクトのある論文・学会発表に貢献した。

Strategy for Future Research Activity

①総括支援活動 : 我が国にこれまで存在する他のコホート研究と連携して、統一された日本のコホート研究となるよう推進する。
②一般健常人コホートを利用したバイオリソースの整備と活用支援、大規模バイオデータ解析支援 : 支援件数の増加を図るため、引き続き本プラットフォームのホームページ(HP)上で、提供可能な生体試料・データ、大規模バイオデータ解析支援の情報を発信する。また関係学会に、学会HPからの上記HPへのリンクによる情報提供を依頼する。さらに、がん早期診断マーカー検証支援の継続、GWAS用タイピングデータの提供、9.2万名分の生活習慣・健診データの提供など、支援メニューの充実を図る。
③ブレインリソースの整備と活用支援 : 班長が日本神経病理学会、神経学会の要職に選任されたため、学会支援を元に、公約であるオールジャパンブレインバンクネットワーク構築と神経難病リソース構築を推進する。阪大型施設内ブレインバンク拠点、徳島大型委託保管ブレインバンク拠点を範例にして、拠点構築を拡充する。リソース利用の啓発活動を推進する。提供に関しては迅速化を図る一方、オプトアウト、リソースロケーション管理など、改訂ヒト対象医学研究倫理指針を遵守する
④生体試料による支援活動 : 多様な支援依頼者のニーズに迅速に対応してオンデマンド型の支援成果を研究者に還元するため、国際的にも先進的な分子解析支援技術のさらなる向上や新規技術の導入・強化を図り、その試料の質を国際水準以上に高めるために保存方法等を吟味し、併せて支援班内の連携、情報共有を強化し学際的共同研究の構築支援を行う。また、研究者コミュニティーや大学院教育の場でトップレベル研究者や若手向けの普及・啓発活動を積極的に展開し、支援の裾野を広げる。

Research Products

• [Int'l Joint Research] ハーバード大学 ダナファーバーがん研究所/シカゴ大学/NIH(アメリカ合衆国)
  • Country Name: アメリカ合衆国
  • Counterpart Institution: ハーバード大学 ダナファーバーがん研究所/シカゴ大学/NIH
• [Int'l Joint Research] University of Chicago/NCI/Vanderbilt University(米国)
  • Country Name: 米国
  • Counterpart Institution: University of Chicago/NCI/Vanderbilt University
  • # of Other Institutions: 5
• [Int'l Joint Research] University of Hong Kong/Shandong Academy of Medical Sciences/Tianjin Medical University Cancer Institute and Hospital(中国)
  • Country Name: 中国
  • Counterpart Institution: University of Hong Kong/Shandong Academy of Medical Sciences/Tianjin Medical University Cancer Institute and Hospital
  • # of Other Institutions: 16
• [Int'l Joint Research] NHRI, Taiwan/Academia Sinica/National Yang-Ming University(台湾)
  • Country Name: 台湾
  • Counterpart Institution: NHRI, Taiwan/Academia Sinica/National Yang-Ming University
  • # of Other Institutions: 10
• [Int'l Joint Research] Chonnam National University, Korea/Seoul National University College of Medicine/Korea University Anam Hospital(韓国)
  • Country Name: 韓国
  • Counterpart Institution: Chonnam National University, Korea/Seoul National University College of Medicine/Korea University Anam Hospital
  • # of Other Institutions: 6
• [Int'l Joint Research] Institute of Predictive and Personalized Medicine of Cancer(スペイン)
  • Country Name: スペイン
  • Counterpart Institution: Institute of Predictive and Personalized Medicine of Cancer
• [Int'l Joint Research] National University of Singapore/Genome Institute of Singapore(シンガボール)
  • Country Name: シンガボール
  • Counterpart Institution: National University of Singapore/Genome Institute of Singapore
• [Journal Article] Modification of the associations of alcohol intake with serum low-density lipoprotein cholesterol and triglycerides by ALDH2 and ADHIB polymorphisms in Japanese men (2018)
  • Author(s): Sasakabe T, Wakai K, Kawai S, Hishida A, Naito M, Suzuki S, Nindita Y, Arisawa K, Kita Y, Hara M, Kuriyama N, Hirata A, Mikami H, Oze I, Kubo M, Tanaka H, Hamajima N.
  • Journal Title: Journal of Epidemiology Volume: 28 Issue: 4
  • DOI: 10.2188/jea.JE20160189
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] A genome-wide association study in the Japanese population identifies the 12q24 locus for habftual coffee consumption : The J-MICC Study (2018)
  • Author(s): Nakagawa-Senda H, Hachiya T, Shimizu A, Hosono S, Watanabe M, Ito H, Hara M, Nishida Y, Kuriki K, Katsuura-Kamano S, Arisawa K, Nindita Y, Suzuki S, Hosono A, Mikami H, Nakamura Y, Takashima N, Nakamura Y, Kuriyama N, Wakai K, et al.
  • Journal Title: Sci Rep Volume: 8 Issue: 1 Pages: 1493
  • DOI: 10.1038/s41598-018-19914-w
  • Peer Reviewed / Open Access
• [Journal Article] Association of genetic polymorphisms with erythrocyte traits : Verification of SNPs reported in a previous GWAS in a Japanese population (2018)
  • Author(s): Seiki T, Naito M, Hishida A, Takagi S, Matsunaga T, Sasakabe T, Hattori Y, Kawai S, Okada R, Yin G, Hamajima N, Wakai K.
  • Journal Title: Gene Volume: 642 Pages: 172-177
  • DOI: 10.1016/j.gene.2017.11.031
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide association study identifies seven novel susceptibility loei for primary open-angle glaucoma (2018)
  • Author(s): Shiga Y, Akiyama M, Nishiguchi K M, Sato K, Shimozawa N, Takahashi A, Momozawa Y, Hirata M, Matsuda K, Yamaji T, Iwasaki M, Tsugane S, Oze I, Mikami H, Naito M, Wakai K, Yoshikawa M, Miyake M, Yanaka T, et al.
  • Journal Title: Human Molecular Genetics Volume: 27 Issue: 8 Pages: 1486-1496
  • DOI: 10.1093/hmg/ddy053
  • Peer Reviewed / Open Access
• [Journal Article] GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12. (2018)
  • Author(s): Tanikawa C, Kamatani Y, Takahashi A, Nagayama S, Mimori K, Mori M, Yasuda J, Tsuboi A, Shimizu A, Sasaki M, Yamaji T, Tsugane S, Naito M, Wakai K, Koyama T, Takezaki T, Yuji K, Murakami Y, Nakamura Y, Matsuda K, et al.
  • Journal Title: Carcinogenesis
  • DOI: 10.1093/carcin/bgy026
  • Peer Reviewed / Open Access
• [Journal Article] A genome-wide association study of coping behaviors suggests FBX045 is associated with emotional expression (2018)
  • Author(s): Shimanoe C, Hachiya T, Tanaka K, Sutoh Y, Shimizu A, Hishida A, Tamura T, Matsuo K, Ito H, Matsui D, Suzuki S, Watanabe M, Kuriki K, Mikami H, Nakamura Y, Momozawa Y, Kubo M, Nakatochi M, Naito M, Wakai K, et al.
  • Journal Title: Genes, Brain and Behavior
  • DOI: 10.1111/gbb.12481
  • Peer Reviewed
• [Journal Article] Genome-wide association study for pollinosis identified two novel loci in interleukin (IL)-1B in a Japanese population (2018)
  • Author(s): Fujii R, Hishida A, Wu M. C, Kondo T, Hattori Y, Naito M, Endoh K, Nakatochi M, Hamajima N, Kubo M, Kuriki K, Wakai K.
  • Journal Title: Nagoya Journal of Medical Science Volume: 80 Pages: 109-120
  • DOI: 10.18999/nagjms.80.1.109
  • Peer Reviewed / Open Access
• [Journal Article] A Common variant of MAF/c-MAF, transcriptional factor genc in the kidney, is associated with gout susceptjbility. (2018)
  • Author(s): Toshihide Higashino, Hirotaka Matsuo, Yukinori Okada, Hiroshi Nakashima, Seiko Shimizu, Masayuki Sakiyama, Shin Tadokoro, Akiyoshi Nakayama, Makoto Kawaguchi, Mako Komatsu, Asahi Hishida, Masahiro Nakatochi, Hiroshi Ooyama, Junko Imaki, Nariyoshi Shinomiy
  • Journal Title: Human Cell Volume: 31 Pages: 10-13
  • DOI: 10.1007/s13577-017-0186-6
  • Peer Reviewed / Open Access
• [Journal Article] Associations between dietary intakes of iron, copper and zinc with risk of type 2 diabetes mellitus : A large population-based prospective cohort study. (2018)
  • Author(s): Eshak ES, Iso H, Maruyama K, Muraki I, Tamakoshi A.
  • Journal Title: Clin Nutr. Volume: 37 Issue: 2 Pages: 667-674
  • DOI: 10.1016/j.clnu.2017.02.010
  • Peer Reviewed / Open Access
• [Journal Article] Relationship Between Dietary Vitamin D and Deaths From Stroke and Coronary Hcart Disease : The Japan Collaborative Cohort Study (2018)
  • Author(s): Sheerah HA, Eshak ES, Cui R, Imano H, Iso H, Tamakoshi A.
  • Journal Title: Stroke Volume: 49 Issue: 2 Pages: 454-457
  • DOI: 10.1161/STROKEAHA.117.0194178
  • Peer Reviewed / Open Access
• [Journal Article] The prospective association between plasma concentrations of cellular growth factors and risk of heart failure mortality in Japanese population. (2018)
  • Author(s): Ehab S Eshak, Koutatsu Maruyama, Hiroyasu Iso, Akiko Tamakoshi.
  • Journal Title: J of Epidemiology
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Physical activity earlier in life is inversely associated with insulin resistance among adults in Japan (2018)
  • Author(s): Fujita H. Hosono A. Shibata K. Tsujimura S. Oka K. Okamoto N. Kamiya M. Kondo F. Wakabayashi R. Ichikawa M. Yamada T. Suzuki S.
  • Journal Title: Journal of Epidemiology
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] 地域住民の身体活動量と運動に対する自己評価 (2018)
  • Author(s): 藤田ひとみ、鈴木貞夫
  • Journal Title: 日本福祉大学健康科学論集 Volume: 21 Pages: 37-43
  • Peer Reviewed / Open Access
• [Journal Article] Association of birth weight with diabetes and insulin resistance among community residents (2018)
  • Author(s): Kamiya M. Hosono A. Tamai Y. Watanabe M. Shibata K. Tsujimura S. Oka K. Fujita H. Okamoto X. Kondo F. Wakabayashi R, Yamada T. Suzuki S.
  • Journal Title: Nagoya Medical Journal
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Does waist circumference give us any significant information rcgarding obcsity? (2018)
  • Author(s): Tsujimura S. Tamai Y. Hosono A. Shibata K. Oka K, Fujita H. Okamoto N. Kamiya M. Kondo F. Wakabayashi R. Ichikawa M. Yamada T. Suzuki S.
  • Journal Title: Nagoya Medical Journal
  • Description: in press
  • Peer Reviewed / Open Access
• [Journal Article] Unusual tau pathology of the cerebellum in patients with amyotrophic latoral sclerosis/parkinsonism-dementia complex from the kii peninsula, Japan. (2018)
  • Author(s): Morimoto S, Hatsuta H, Kokubo Y, Nakano Y, Hasegawa M, Yoneda M, Hirokawa Y, Kuzuhara S, Shiraishi T, Murayama S.
  • Journal Title: Brain Pathol Volume: 28 Issue: 2 Pages: 287-291
  • DOI: 10.1111/bpa.12500
  • Peer Reviewed / Open Access
• [Journal Article] Prion-Like seeding of misfolded alpha-synuclein in the brains of dementia with lewy body patients in RT-QUIC. (2018)
  • Author(s): Sano K, Atarashi R, Satoh K, Ishibashi D, Nakagaki T, Iwasaki Y, Yoshida M, Murayama S, Mishima K, Nishida N.
  • Journal Title: Mol Neurobiol Volume: 55 Issue: 5 Pages: 3916-3930
  • DOI: 10.1007/s12035-017-0624-1
  • Peer Reviewed / Open Access
• [Journal Article] Clinicopathological characteristics of distant metastases of adenocarcinoma, squamous cell carcinoma and urothelial carcinoma : An autopsy study of older Japanese patients. (2018)
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• [Journal Article] Identification of somatic mutations in postmortem human brains by whole gonome scquencing and their implications for psychiatric disorders. (2018)
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  • Journal Title: Neuropathology
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• [Journal Article] Mogamulizumab (Anti-CCR4) in HTLV-1-Associated myelopathy (2018)
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• [Journal Article] The effect of forcod expression of mutated K-RAS gene on gastrointestinal cancer cell lines and the IGF-IR targeting therapy. (2017)
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  • Journal Title: Oncotarget Volume: 8 Issue: 29 Pages: 46856-46874
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• [Journal Article] HEGI is a novel mucin-like membrane protein that serves as a diagnostic and therapeutic target for malignant mesothelioma. (2017)
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• [Journal Article] Inhibition of PRDM14 expression in pancreatic cancer suppresses cancer stem-like properties and liver metastasis in mice. (2017)
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  • Journal Title: Carcinogenesis Volume: 38 Issue: 6 Pages: 638-648
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• [Journal Article] 日本の疾患コホートとしてのバイオバンクジャパンの取組 (2017)
  • Author(s): 村上善則
  • Journal Title: 実験医学 Volume: 35 Issue: 17 Pages: 2861-2866
• [Journal Article] Macronutrient intakes and serum oestrogen, and interaction with polymorphisms in CYP19A1 and HSD17B1 genes : a cross-sectional study in postmenopausal Japanese women (2017)
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• [Journal Article] Interactions between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases among the Japanese population. (2017)
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• [Journal Article] Cardiovascular disease prevalence and insulin resistance in the Kyushu-Okinawa population study and the framingham offspring study. (2017)
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• [Journal Article] The relation between serum endostatin level and carotid atherosclerosis in hoalthy residents of Japan : Results from the Kyushu and Okinawa Population Study(KOPS). (2017)
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• [Journal Article] Higher dietary cholesterol and omega-3 fatty acid intakes aro assoejatod with a lower succossful rate of Helicobacter pylori oradication therapy in Japan. (2017)
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• [Journal Article] Correlation between thyroid stimulating hormone and the renal function of cuthyroid residents of Japan : Results from the Kyushu and Okinawa Population Study(KOPS) (2017)
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• [Journal Article] Recurrent pregnancy loss and cardiovascular disease mortality in Japanese Women : A population-based, prospective cohort study. (2017)
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• [Journal Article] Accuracy of self-reported height, weight and waist circumference in a Japanese sample (2017)
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  • Journal Title: Obesity science & practice. Volume: 3 Issue: 4 Pages: 417-24
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• [Journal Article] Excess APP O-glycosylation by GalNAc-T6 decreases Aβ production. (2017)
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• [Journal Article] LRRK2 Levels and phosphorylation in Parkinson's disease brain and cases with restricted Lewy bodies. (2017)
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  • Peer Reviewed / Open Access / Int'l Joint Research
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• [Journal Article] Simultaneous skin-nerve-muscle biopsy and abnormal mitochondrial inclusions in intranuclear hyaline inclusion body disease. (2017)
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• [Journal Article] Homovanillic acid and 5-hydroxyindole acetic acid as biomarkers for demcntia with Lowy bodies and coincident Alzheimer's disease : An autopsy-confirmed study. (2017)
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• [Journal Article] Beta-N-methylamino-l-alanine analysis in the brains of patients with Kii ALS/PDC. (2017)
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• [Journal Article] Expression of secreted phosphoprotein 1 (osteopontin) in human sensorimotor cortex and spinal cord : Changes in patients with amyotrophic lateral sclerosis. (2017)
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• [Journal Article] Technical feasibility of visualizing myenteric plexus using confocal lasor endomicroscopy. (2017)
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• [Journal Article] PML nuclear bodies are altered in adult-onset neuronal intranuclear hyaline inclusion disease. (2017)
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• [Journal Article] Pathologic study of intracranial large artery atherosclerosis in 7260 autopsy cases. (2017)
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• [Journal Article] Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease. (2017)
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• [Journal Article] Distinct deposition of amyloid-β species in brains with Alzheimer's disease pathology visualized with MALDI imaging mass spectrometry (2017)
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• [Journal Article] Reduccd LRRK2 in association with retromer dysfunction in postmortem brain tissue from LRRK2 mutation carriers. (2017)
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  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 成人型エオジン好性核内封人体病の診断電子顕微鏡所見の有用性. (2017)
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• [Journal Article] Autopsy case of C12orf65 mutation in a patient with signs of mitochondrial dysfunction. (2017)
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• [Journal Article] 脳病理からみた超高齢者 (2017)
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  • Journal Title: 認知神経科学 Volume: 19 Pages: 158-63
• [Journal Article] 神経核内封入体病(NIID)の頭部MRI経時的変化 (2017)
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• [Journal Article] 大脳皮質基底核変性症の1剖検例 (2017)
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  • Author(s): Watanabe I, Kuriyama N, Miyatani F, Nomura R, Naka S, Nakano K, Ihara M, Iwai K, Matsui D, Ozaki E, Koyama T, Nishigaki M, Yamamoto T, Tamura A, Mizuno T, Akazawa K, Takada A, Takeda K, Yamada K, Nakagawa M, Tanaka T, Kanamura N, Friedland RP, Watanabe Y.
  • Journal Title: Sci Rep Volume: 6 Pages: 38561
  • DOI: 10.1038/srep38561.
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ethnic Differences in Glucose Homeostasis Markers between the Kyushu-Okinawa Population Study and the Framingham Offspring Study. (2016)
  • Author(s): Ikezaki H, Ai M, Schaefer EJ, Otokozawa S, Asztalos BF, Nakajima K, Zhou Y, Liu CT, Jacques PF, L. Cupples LA, Furusyo N.
  • Journal Title: Scientific Reports Volume: 6 Pages: 36725
  • DOI: 10.1038/srep36725
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Bowel Movement Frequency, Laxative Use, and Mortality From Coronary Heart Disease and Stroke Among Japanese Men and Women : The Japan Collaborative Cohort (JACC) Study (2016)
  • Author(s): Kubota Y, Iso H, Tamakoshi A
  • Journal Title: J Epidemiol Volume: 26 Pages: 242-248
  • DOI: 10.2188/jea.JE20150123
  • Peer Reviewed
• [Journal Article] The influence of personality and perceived stress on the development of breast cancer : 20-year follow-up of 29,098 Japanese women (2016)
  • Author(s): Sawada T, Nishiyama T, Kikuchi N, Wang C, Lin Y, Mori M, et al
  • Journal Title: Sci Rep Volume: 6 Pages: 32559
  • DOI: 10.1038/srep32559
  • Peer Reviewed
• [Journal Article] Watching Television and Risk of Mortality From Pulmonary Embolism Among Japanese Men and Women : The JACC Study (Japan Collaborative Cohort) (2016)
  • Author(s): Shirakawa T, Iso H, Yamagishi K, Yatsuya H, Tanabe N, Ikehara S, et al
  • Journal Title: Circulation Volume: 134 Pages: 355-357
  • DOI: 10.1161/CIRCULATIONAHA.116.023671
  • Peer Reviewed
• [Journal Article] Selective Expression of Osteopontin in ALS-resistant Motor Neurons is a Critical Determinant of Late Phase Neurodegeneration Mediated by Matrix Metalloproteinase-9. (2016)
  • Author(s): Morisaki Y, Niikura M, Watanabe M, Onishi K, Tanabe S, Moriwaki Y, Okuda T, Ohara S, Murayama S, Takao M, Uchida S, Yamanaka K, Misawa H.
  • Journal Title: Sci Rep Volume: 6 Pages: 27354
  • DOI: 10.1038/srep27354
  • Peer Reviewed / Open Access
• [Journal Article] Immunolocalization of Toml in relation to protein degradation systems in Alzheimer's disease. (2016)
  • Author(s): Makioka K, Yamazaki T, Takatama M, Ikeda M, Murayama S, Okamoto K, Ikeda Y.
  • Journal Title: J Neurol Sci. Volume: 365 Pages: 101-107
  • DOI: 10.1016/j.jns.2016.03.035.
  • Peer Reviewed
• [Journal Article] Impact of Training Method on the Robustness of the Visual Assessment of 18F-Florbetaben PET Scans : Results from a Phase-3 Study. (2016)
  • Author(s): Seibyl J, Ishii K, Rowe CC, Leverenz JB, Ghetti B, Ironside JW, Takao M, Akatsu H, Murayama S, Bullich S, Mueller A, Koglin N, Schulz-Schaeffer WJ, Hoffmann A, Sabbagh MN, et. al
  • Journal Title: J Nucl Med Volume: 57 Pages: 900-906
  • DOI: 10.2967/jnumed.115.161927
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistanttau. (2016)
  • Author(s): Taniguchi-Watanabe S, Arai T, Kametani F, Nonaka T, Masuda-Suzukake M, Tarutani A, Murayama S, Saito Y, Arima K, Yoshida M, Akiyama H, Robinson A, Mann DM, Iwatsubo T, Hasegawa M.
  • Journal Title: Acta Neuropathol. Volume: 131 Pages: 267-280
  • DOI: 10.1007/s00401-015-1503-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serine 403-phosphorylated p62/SQSTM1 immunoreactivity in inclusions of neurodegenerative diseases. (2016)
  • Author(s): Kurosawa M, Matsumoto G, Sumikura H, Hatsuta H, Murayama S, Sakurai T, Shimogori T, Hattori N, Nukina N
  • Journal Title: Neurosci Res Volume: 103 Pages: 64-70
  • DOI: 10.1016/j.neures.2015.08.002
  • Peer Reviewed
• [Journal Article] The Abundance of Nonphosphorylated Tau in Mouse and Human Tauopathy Brains Revealed by the Use of Phos-Tag Method. (2016)
  • Author(s): Kimura T, Hatsuta H, Masuda-Suzukake M, Hosokawa M, Ishiguro K, Akiyama H, Murayama S, Hasegawa M, Hisanaga S.
  • Journal Title: Am J Pathol. Volume: 186 Pages: 398-409
  • DOI: 10.1016/j.ajpath.2015.10.009.
  • Peer Reviewed / Open Access
• [Journal Article] Mass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains. (2016)
  • Author(s): Kametani F, Obi T, Shishido T, Akatsu H, Murayama S, Saito Y, Yoshida M, Hasegawa M
  • Journal Title: Scientific Reports Volume: 6 Pages: 23281
  • DOI: 10.1038/srep23281
  • Peer Reviewed / Open Access
• [Journal Article] Estradiol Facilitates Functional Integration of iPSC-Derived Dopaminergic Neurons into Striatal Neuronal Circuits via Activation of Integrin α561. (2016)
  • Author(s): Nishimura K, Doi D, Samata B, Murayama S, Tahara T, Onoe H, Takahashi J.
  • Journal Title: Stem Cell Reports. Volume: 6 Pages: 511-524
  • DOI: 10.1016/j.stemcr.2016.02.008.
  • Peer Reviewed / Open Access
• [Journal Article] Significant association of cadaveric dura mater grafting with subpial Abeta deposition and meningeal amyloid angiopathy. (2016)
  • Author(s): Hamaguchi T, Taniguchi Y, Sakai K, Kitamoto T, Takao M, Murayama S, Iwasaki Y, Yoshida M, Shimizu H, Kakita A, Takahashi H, Suzuki H, Naiki H, Sanjo N, Mizusawa H, Yamada M
  • Journal Title: Acta Neuropathol Volume: 132 Pages: 313-5
  • DOI: 10.1007/s00401-016-1588-3
  • Peer Reviewed
• [Journal Article] Histopathologic analysis of cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) : a report of a new genetically confirmed case and comparison to 2 previous cases. (2016)
  • Author(s): Ito S, Takao M, Fukutake T, Hatsuta H, Funabe S, Ito N, Shimoe Y, Niki T, Nakano I, Fukayama M, Murayama S
  • Journal Title: J Neuropath Exp Neurol Volume: 75 Issue: 11 Pages: 1020-1030
  • DOI: 10.1093/jnen/nlw078
  • Peer Reviewed
• [Journal Article] Extranodal NK/T-cell lymphoma, nasal type, manifesting as rapidly progressive dementia without any mass or enhancing brain lesion. (2016)
  • Author(s): Shimatani Y, Nakano Y, Tsuyama N, Murayama S, Oki R, Miyamoto R, Murakami N, Fujita K, Watanabe S, Uehara H, Abe T, Nodera H, Kawarai T, Izumi Y, Kaji R
  • Journal Title: Neuropathology Volume: 36 Pages: 456-463
  • DOI: 10.1111/neup.12285
  • Peer Reviewed / Open Access
• [Journal Article] Association of variations in HLA class Ⅱ and other loci with susceptibility to EGFR-mutated lung adenocarcinoma. (2016)
  • Author(s): Shiraishi K, Takahashi A, Takano A, Watanabe Y, Hishida T, Tsuchihara K, Miyagi Y, Tanaka K, Imai K, Minamiya Y, Sakamoto H, Inazawa J, Nakamura Y, Yoshida T, Yokota J, Matsuda F, Matsuo K, Daigo Y, Kubo M, Kohno T, et. al.
  • Journal Title: Nature Communications Volume: 7 Pages: 12451
  • DOI: 10.1038/ncomms12451
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Chemotherapy-Induced IL34 Enhances Immunosuppression by Tumor-Associated Macrophages and Mediates Survival of Chemoresistant Lung Cancer Cells. (2016)
  • Author(s): Baghdadi M, Wada H, Nakanishi S, Abe H, Han N, Putra WE, Endo D, Watari H, Sakuragi N, Hida Y, Kaga K, Miyagi Y, Yokose T, Takano A, Daigo Y, Seino KI
  • Journal Title: Cancer Res Volume: 76 Pages: 6030-6042
  • DOI: 10.1158/0008-5472.CAN-16-1170
  • Peer Reviewed / Open Access
• [Journal Article] Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women. (2016)
  • Author(s): Wang Z, Kohno T, Yokota J, Kunitoh H, Daigo Y, Mitsudomi T, Yatabe Y, Hida T, Iwasaki M, Shimazu T, Tsugane S, Li YJ, Yang TY, Lin CC, Yu J, Shen H, Kubo M, Chanock SJ, Rothman N, Lan Q, et. al.
  • Journal Title: Hum Mol Genet Volume: 25 Pages: 620-629
  • DOI: 10.1093/hmg/ddv494
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dysregulation of c-Myb Pathway by Aberrant Expression of Proto-oncogene MYB Provides the Basis for Malignancy in Adult T-cell Leukemia/lymphoma Cells (2016)
  • Author(s): Nakano K, Uchimaru K, Utsunomiya A, Yamaguchi K, Watanabe T.
  • Journal Title: Clin Cancer Res. Volume: 22 Pages: 5915-5928
  • DOI: 10.1158/1078-0432.CCR-15-1739
  • Peer Reviewed
• [Journal Article] Incidence of human T-lymphotropic virus 1 infection in adolescent and adult blood donors in Japan : a nationwide retrospective cohort analysis (2016)
  • Author(s): Satake M, Iwanaga M, Sagara Y, Watanabe T, Okuma K, Hamaguchi I
  • Journal Title: Lancet Infect Dis. Volume: 16 Pages: 1246-1254
  • DOI: 10.1016/S1473-3099(16)30252-3
  • Peer Reviewed
• [Journal Article] Polycomb-dependent epigenetic landscape in adult T-cell leukemia (2016)
  • Author(s): Fujikawa D, Nakagawa S, Hori M, Kurokawa N, Soejima A, Nakano K, Yamochi T, Nakashima M, Kobayashi S, Tanaka Y, Iwanaga M, Utsunomiya A, Uchimaru K, Yamagishi M, Watanabe T
  • Journal Title: Blood Volume: 127 Pages: 1790-1802
  • DOI: 10.1182/blood-2015-08-662593
  • Peer Reviewed
• [Journal Article] Carbohydrate antigen 19-9- positive gastric adenocarcinoma : autopsy findings and review of the literature. Case Rep Gastroenterol. 11 3 545-553 2017
  • Author(s): Wang T, Matsuda Y, Seki A, Nonaka K, Kakizaki M, Kaneda D, Takahashi-Fujigasaki J, Murayama S, Arai T.
  • DOI: 10.1159/000479223
  • Peer Reviewed / Open Access
• [Presentation] HEGI is a novel mucin-like membrane protein that is useful for the diagnosis of malignant mesothelioma. (2018)
  • Author(s): Hiroshima K, Miyagi Y, Tsuji S, Imai K.
  • Organizer: USCAP 2018 Annual Meeting
  • Int'l Joint Research
• [Presentation] 個別化医療とゲノム診療 (2018)
  • Author(s): 村上善則
  • Organizer: 新潟大学医歯薬学総合病院生命科学センター遺伝子医療セミナー
  • Invited
• [Presentation] ゲノム医療基礎研究成果によるオーダーメイド医療の実現へ向けた取り組み (2018)
  • Author(s): 村上善則
  • Organizer: ゲノム医療基礎研究成果によるオーダーメイド医療の実現へ向けた取り組み
  • Invited
• [Presentation] 住民健診受診者における新規高血圧発症のリスク : J-MICC Study静岡・大幸地区 (2018)
  • Author(s): 門松由佳, 内藤真理子, 丸山健太, 塚本峰子, 篠壁多恵, 川合紗世, 岡田理恵子, 田村高志, 菱田朝陽, 若井建志
  • Organizer: 第28回日本疫学会学術総会
• [Presentation] 手指の長さの比(第2指 : 第4指)と閉経の関連 (2018)
  • Author(s): 川合紗世, 内藤真理子, 丸山健太, 門松由佳, 塚本峰子, 篠壁多恵, 田村高志, 岡田理恵子, 菱田朝陽, 若井建志
  • Organizer: 第28回日本疫学会学術総会
• [Presentation] 日本人集団における全がん罹患とGGTI遺伝子多型(rs4820599)および血中γ-GTP濃度との関連 (2018)
  • Author(s): 丸山健太, 川合紗世, 内藤真理子, 門松由佳, 塚本峰子, 篠壁多恵, 田村高志, 菱田朝陽, 若井建志
  • Organizer: 第28回日本疫学会学術総会
• [Presentation] 脂質異常症と脂肪酸・炭水化物摂取の関連のKCNJ11遺伝子多型による修飾 : 縦断研究による検討 (2018)
  • Author(s): 篠壁多恵, 内藤真理子, 丸山健太, 門松由佳, 塚本峰子, 田村高志, 岡田理恵子, 川合紗世, 菱田朝陽, 若井建志
  • Organizer: 第28回日本疫学会学術総会
• [Presentation] 内臓脂肪面積とBMIに対する緑茶フラボノイド摂取量の関連における季節変動 : J-MICC Sakura Diet Study (2018)
  • Author(s): 栗木清典、遠藤香、後藤千穂
  • Organizer: 第28回日本疫学会学術総会
• [Presentation] 日常身体活動とPYCARD遺伝子メチル化の縦断的関連 (2018)
  • Author(s): 西田裕一郎、原めぐみ、桧垣靖樹、田口尚人、島ノ江千里、南里妃名子、中村和代、今泉猛、坂本龍彦、安方惇、三好伸幸、山田陽介、堀田美加子、東元健、副島英伸、新地浩一、田中恵太郎
  • Organizer: 第28回日本疫学会学術総会
• [Presentation] 就業状況と仕事ストレスの生活習慣への交互作用 : J-MICC Study 静岡・桜ヶ丘地区 (2018)
  • Author(s): 遠藤 香, 栗木清典 for Shizuoka-SakuragaokaJ-MICC Study group.
  • Organizer: 第28回日本疫学会学術総会
• [Presentation] 「エビゲノムを基盤とした新規治療戦略」PIポリアミド化合物によるエビゲノム治療薬開発への挑戦 (2018)
  • Author(s): 永瀬浩喜
  • Organizer: 第13回 日本癌分子標的治療学会トランスレーショナルリサーチ(TR)ワークショップ
• [Presentation] 化学の目でがんを考える (2018)
  • Author(s): 永瀬浩喜
  • Organizer: お茶ノ水がん学アカデミア集会
  • Invited
• [Presentation] 『これからの治療薬』ボリアミド化合物の開発 (2018)
  • Author(s): 永瀬浩喜
  • Organizer: 第3回 ミトコンドリア病研究・患者公開フォーラム
• [Presentation] 血清中の元素含有量を用いた新たながんスクリーニング法開発に関する研究～メタロバランス～ (2018)
  • Author(s): 三上 春夫
  • Organizer: 第18回千葉県立病院 学術集会
• [Presentation] 地域住民における出生体重の糖尿病関連因子への影響 (2018)
  • Author(s): 神谷真有美
  • Organizer: 第28回日本疫学会学術総会
• [Presentation] Hclicobacter pylori感染者における萎縮性胃炎と生活習慣、DHEA-Sとの関連～J-MICC岡崎study～ (2018)
  • Author(s): 渡邉美貴
  • Organizer: 第28回日本疫学会学術総会
• [Presentation] 日本人男性における大豆食品摂取と動脈スティフネスとの関連 (2018)
  • Author(s): 上村浩一、釜野桜子、Bahari Tirani、藤岡美穂、岩崎夕貴、有澤孝吉
  • Organizer: 第28回日本疫学会総会
• [Presentation] 5年間の精神ストレスとCRPの関連は、対処行動や社会的支援の変化により異なる (2018)
  • Author(s): 島ノ江 千里、原 めぐみ、西田 裕一郎、南里 妃名子、安方 惇、三好信行、山田陽介、桧垣靖樹、田中 恵太郎
  • Organizer: 第88回日本衛生会学術総会
• [Presentation] QTL GWAS of serum anti-helicobacter pylori IgG in Japanese-data from the J-MICC Study (2018)
  • Author(s): Asahi Hishida, Masahiro Nakatochi, Sayo Kawai, Rieko Okada, Daisuke Matsui, Teruhide Koyama, Isao Watanabe, Etsuko Ozaki, Nagato Kuriyama, Yoshiyuki Watanabe, Akihiro Hosono, Miki Watanabe, Sadao Suzuki, Isao Oze, Hidemi Ito, Keitaro Matsuo, Yukihide Momo
  • Organizer: 第28回日本疫学会学術集会
• [Presentation] Interaction between genetic and environmental factors of smoking and drinking habits for HDL-C levels from GWAS. (2018)
  • Author(s): Yora Nindita, Masahiro Nakatochi, Rie Ibusuki, Ippei Shimoshikiryo, Toshiro Takezaki, J-MICC Study Group.
  • Organizer: 第28回日本疫学会学術集会
• [Presentation] GWASメタアナリシスおよびメンデルランダム化による睡眠時間の因果パスウェイの解明 (2018)
  • Author(s): 西山毅, 中杤昌弘, 久保充明, J-MICC Study Group, JPHC Study Group, TMM Project Group
  • Organizer: 第28回日本疫学会学術集会
• [Presentation] Risk prediction model for chronic kidney disease using regularized regression methods : J-MICC Study (2018)
  • Author(s): Ryosuke Fujii, Asabi Hishida, Masahiro Nakatochi, Takaaki Kondo, Mariko Naito, Yukihide Momozawa, Michiaki Kubo, Kenji Wakai, Study Group J-MICC
  • Organizer: 第28回日本疫学会学術集会
• [Presentation] Dietary intakes of fat soluble vitamins and risk of type 2 diabetes mellitus. (2018)
  • Author(s): Ehab S. Eshak, Hiroyasu Iso, Akiko Tamakoshi
  • Organizer: American Society For Nutrition
  • Int'l Joint Research
• [Presentation] 海藻の摂取頻度と循環器疾患死亡リスクとの関連 : The JACC study (2018)
  • Author(s): 臼杵里恵, 村木功, 山岸良匡, 玉腰暁子, 磯博康
  • Organizer: 第54回日本循環器病予防学会学術集会
• [Presentation] 統合失調症脳における慢性炎症関連分子のジェネティックニューロパソロジー (2018)
  • Author(s): 和田明、國井泰人、日野瑞城、松本純弥、長岡敦子、丹羽真一、竹島明、高橋均、那波宏之、柿田明美、笠井清登、矢部博興
  • Organizer: 第13回日本統合失調症学会
• [Presentation] 精神疾患死後脳研究の最前線 (2018)
  • Author(s): 國井泰人、日野瑞城、松本純弥、長岡敦子、丹羽真一、矢部博興
  • Organizer: 第13回日本統合失調症学会
  • Invited
• [Presentation] がんの分子病態に基づいたトランスレーショナルリサーチと創薬開発 (2018)
  • Author(s): 醍醐弥太郎
  • Organizer: 第32回札幌冬季がんセミナー
  • Invited
• [Presentation] 腫瘍遺伝学の基礎 (2018)
  • Author(s): 醍醐弥太郎
  • Organizer: 第9回日本人類遺伝学会・遺伝医学セミナー入門編
  • Invited
• [Presentation] HTLV-I関連疾患撲減をめざすHTLV-I感染者コホート共同研究班(JSPFAD)の紹介 (2018)
  • Author(s): 岩永正子
  • Organizer: コホート・生体試料支援プラットフォーム市民公開講座
  • Invited
• [Presentation] Development and molecular analysis of synthetic lethality by targeting EZHI and EZH2 in T cell lymphomas (2018)
  • Author(s): Yamagishi M, Hori M, Fujikawa D, Honma D, Adachi N, Ohsugi T, Nakano K, Nakashima M, Kobayashi S, Iwanaga M, Utsunomiya A, Okada S, Tsukasaki K, Tobinai K, Araki K, Watanabe T, Uchimaru K
  • Organizer: 10th Annual T-Celll Lymphoma Forum
  • Int'l Joint Research
• [Presentation] EZH1/2, SWI/SNF, and MLL2 dependent heterochromatin formation and abnormal transcriptome in hematological malignancies (2018)
  • Author(s): Yamagishi Makoto, Fujikawa Dai, Hori Makoto, Honma Daisuke, Adachi Nobuaki, Kobayashi Seiichiro, Iwanaga Masako, Utsunomiya Atae, Okada Seiji, Tsukasaki Kunihiro, Tobinai Kensei, Araki Kazushi, Watanabe Toshiki, Uchimaru Kaoru
  • Organizer: 59th ASH Annual Meeting & Exposition
  • Int'l Joint Research
• [Presentation] 成人T細胞白血病・リンパ腫(ATL)の発症機構理解の進歩と発症予防・治療法開発の現状 (2018)
  • Author(s): 渡邉俊樹
  • Organizer: 平成29年度難病治療研究センター年次報告会
  • Invited
• [Presentation] 国際的視点から見たHTLV-1および関連疾患研究の現状と課題 (2018)
  • Author(s): 渡邉俊樹
  • Organizer: 平成29年度第1回長崎大学大学院セミナー
  • Invited
• [Presentation] ゲノム医療実現に向けたオーダーメイド医療の実現化プログラムの取り組みと病理組織バンキングの構築 (2017)
  • Author(s): 村上善則、湯地晃一郎、松田浩一
  • Organizer: 第11回ゲノム病理標準化センター講習会
  • Invited
• [Presentation] ゲノム医科学研究を支える基盤としてのバイオバンクジャパン (2017)
  • Author(s): 村上善則、平田真、湯地晃一郎、松田浩一
  • Organizer: 第62回日本人類遺伝学会シンポジウム「我が国のバイオバンクジャパンやコホートの現状とその将来」
  • Invited
• [Presentation] ゲノム解析に基づくがん研究と臨床応用 (2017)
  • Author(s): 村上善則
  • Organizer: ゲノム解析に基づくがん研究と臨床応用
  • Invited
• [Presentation] 若年者の睡眠特性-中高年の大規模一般集団の睡眠疫学調査との比較より (2017)
  • Author(s): 森田えみ, 内藤真理子, 若井建志, 角谷寛, 山田尚登
  • Organizer: 日本睡眠学会第42回定期学術集会
• [Presentation] 加齢による朝型化とセロトニントランスポーター遺伝子多型との関連 (2017)
  • Author(s): 森田えみ, 山田尚登, 角谷寛, 内藤真理子, 篠壁多恵, 岡田理恵子, 川合紗世, 菱田朝陽, 浜島信之, 若井建志
  • Organizer: 日本睡眠学会第42回定期学術集会
• [Presentation] Interaction between job status and psychological stress to life-style factors : the Shizuoka-Sakuragaoka J-MICC Study (2017)
  • Author(s): Endoh K, Kuriki K, J-MICC Study Gruop for Shizuoka-Sakuragaoka.
  • Organizer: The 21st International Epidemiological Association (IEA) World Congress of Epidemiology (WCE 2017)
  • Int'l Joint Research
• [Presentation] Risk of non-alcoholic fatty liver disease and lifestyle factors : the Shizuoka-Sakuragaoka J-MICC Study (2017)
  • Author(s): Kuriki K, Endoh K, Shizuoka-Sakuragaoka J-MICC Study Group.
  • Organizer: The 21st International Epidemiological Association (IEA) World Congress of Epidemiology (WCE 2017)
  • Int'l Joint Research
• [Presentation] Associations between body weight gain from 20 years old and family factors : the Shizuoka-Sakuragaoka J-MICC Study. (2017)
  • Author(s): Suzuki W, Wu Ren, Endoh K, Kuriki K, Shizuoka-Sakuragaoka J-MICC Study Group.
  • Organizer: The 21st International Epidemiological Association (IEA) World Congress of Epidemiology (WCE 2017)
  • Int'l Joint Research
• [Presentation] LDL-C concentration is estimated by dietary factors with considering the genetic variation among Japanese : the J-MICC Sakura Diet Study. (2017)
  • Author(s): Akimoto S, Endoh K, Wu. Re, Suzuki W, Goto C, Kuriki K.
  • Organizer: The 21st International Epidemiological Association (IEA) World Congress of Epidemiology (WCE 2017)
  • Int'l Joint Research
• [Presentation] Effccts of eating rate for each risk of metabolic syndrome and potential metabolic syndrome patients and the confounding factors : the Shizuoka-Sakuragaoka J-MICC Study. (2017)
  • Author(s): Wu Ren, Suzuki W, Endoh K, Kuriki K, Shizuoka-Sakuragaoka J-MICC Study Group.
  • Organizer: The 21st International Epidemiological Association (IEA) World Congress of Epidemiology (WCE 2017)
  • Int'l Joint Research
• [Presentation] Association between four season's average of urinary sodium execration in 24-hours and salty foods in a food frequency questionnaire : the J-MICC Sakura Diet Study. (2017)
  • Author(s): Goto C, Endoh K, Kuriki K.
  • Organizer: The 21st International Epidemiological Association (IEA) World Congress of Epidemiology (WCE 2017)
  • Int'l Joint Research
• [Presentation] 農業従事者と非従事者における高LDL-血症と野菜・果物摂取の関連 : the J-MICC Study 静岡・桜ヶ丘地区 (2017)
  • Author(s): 栗木清典、遠藤香、the J-MICC Study静岡・桜ヶ丘地区 Research Group
  • Organizer: 第64回 日本栄養改善学会学術総会
• [Presentation] Association between objectively measured physical activity and methylation of PYCARD gene in the Japanese general population (2017)
  • Author(s): Yuichiro Nishida, Yasuki Higaki, Naoto Taguchi, Megumi Hara, Kazuyo Nakamura, Hinako Nanri, Takeshi Imaizumi, Tatsuhiko Sakamoto Mikako Horita, Koichi Shinchi, Chisato Shimanoe, Ken Higashimoto, Hidenobu Soejima, and Keitaro Tanaka
  • Organizer: The 21st International Epidemiological Association (IEA) World Congress of Epidemiology
  • Int'l Joint Research
• [Presentation] CAVI値の経年変化に影響を与える要因に関する研究 (2017)
  • Author(s): 下敷領一平、指宿りえ、Yora Nindita、嶋谷圭一、桑原和代、中畑典子、新村英士、前之原茂穂、嶽崎俊郎
  • Organizer: 第28回日本疫学会学術総会
• [Presentation] 肥満及び糖代謝異常に対する間食習慣と宿主要因の相互作用に関する研究 (2017)
  • Author(s): 指宿りえ、Yora Nindita、下敷領一平、嶋谷圭一、桑原和代、中畑典子、前之原茂穂
  • Organizer: 第28回日本疫学会学術総会
• [Presentation] 栄養素摂取量と遺伝要因による血清LDL-C濃度の推定式の確立 : J-MICC Sakura Diet Studyの横断的検討 (2017)
  • Author(s): 秋元柊、遠藤香、後藤千穂、栗木清典、J-MICC Sakura Diet Study Group
  • Organizer: 第64回 日本栄養改善学会学術総会
• [Presentation] Development and validation of estimation model on LDL-C concentration according to dietary and genetic factors : the J-MICC Sakura Diet Study. (2017)
  • Author(s): Akimoto S, Endoh K, Wu. Re, Suzuki W, Goto C, Kuriki K.
  • Organizer: The 22nd Shizuoka Forum on Health and Longevity
• [Presentation] 睡眠障害と口腔内環境の関連 (2017)
  • Author(s): 岩井浩明、渡邉功、山本俊郎、栗山長門、尾崎悦子、小山晃英、松井大輔、武下和久子、金村成智、渡邊能行
  • Organizer: 第76回日本公衆衛生学会総会
• [Presentation] ヘリコバクター・ビロリ感染者における慢性萎縮性胃炎の進展に及ぼす因子-摂取栄養素分析による検討- (2017)
  • Author(s): 瀬古 千佳子
  • Organizer: 第56回日本消化器がん検診学会総会
• [Presentation] 抗がん剤の進歩・最新の話題 (2017)
  • Author(s): 永瀬浩喜
  • Organizer: 第15回 県民公開セミナー
• [Presentation] がんゲノムを標的にしたピロールイミダゾールポリアミド化合物薬物複合体 (2017)
  • Author(s): 永瀬浩喜、越川信子
  • Organizer: 第21回 日本がん分子標的治療学会学術集会
• [Presentation] ピロール・イミダゾール・ポリアミドによる標的ゲノム領域におけるエピジェネティクスへの容喙 (2017)
  • Author(s): 永瀬浩喜、高取敦志、越川信子、渡部隆義、井上貴博、クリシュナムーティ サクティシリ、Jason Lin、篠﨑喜脩
  • Organizer: 第30回モロシヌス研究会
• [Presentation] 千葉県がんセンター・バイオバンクの取り組みについて (2017)
  • Author(s): 巽康年、筆宝義隆、横井左奈、下里修、清宮淳、滝口伸浩、伊丹真紀子、山口武人、永瀬浩喜
  • Organizer: 第3回 クリニカルバイオバンク研究会シンポジウム
• [Presentation] 「がん」そして「癌」 : 克服と共存に向けて (2017)
  • Author(s): 永瀬浩喜
  • Organizer: 大人が楽しむ科学教室 DNA科学シリーズ
  • Invited
• [Presentation] 肺癌・大腸癌における病因性mtDNA ND 遺伝子変異と転移との関連の再評価 (2017)
  • Author(s): 越川信子、秋元美穂、永瀬浩喜、竹永啓三
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 国民病であるがんの克服 (2017)
  • Author(s): 永瀬浩喜
  • Organizer: かずさDNA研究所 開所記念講演会
  • Invited
• [Presentation] Design of a next-generation affinity-enrichment Chem-seq sequencing procedure to assess the biochemistry of minor-groove-binding pyrrole-imidazole polyamides. (2017)
  • Author(s): J. Lin、高取敦志、平岡桐子、養田 裕行1、S. Krishnamurthy、井上貴博、渡部隆義、T. Kuo、篠崎喜脩、越川信子、P. Horton、永瀬浩喜
  • Organizer: 2017年度生命科学系学会合同年次大会 ConBio2017
• [Presentation] がんのアキレス腱を標的にKRAS変異標的配列特異的アルキル化 (2017)
  • Author(s): 永瀬浩喜
  • Organizer: 第22回 がん研究会 国際がん化学療法シンポジウム
• [Presentation] 血清中の微量元素含有量を用いた新たながんスクリーニング法の開発に関する研究 (2017)
  • Author(s): 三上 春夫、宮城 洋平、中村 洋子、永瀬 浩喜
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 前向きコホート研究による胃がん高リスク群でのアミノ酸変化を伴う多型の解析 (2017)
  • Author(s): 中村洋子、滝口伸浩、三上春夫、永瀬浩喜
  • Organizer: 第26回癌病態治療研究会
• [Presentation] 千葉利根川水系におけるがんの高罹患率の原因究明 (2017)
  • Author(s): 中村 洋子、高山 喜美子、三上 春夫、永瀬 浩喜
  • Organizer: 日本がん登録協議会 第26回学術集会
• [Presentation] 地域コーホート研究と千葉県のがんの地理的特性 (2017)
  • Author(s): 三上 春夫
  • Organizer: 第4回千葉県遺伝医療研究会
• [Presentation] 壮年期における地域組織への社会参加と高血圧の関連についてJ-MICC岡崎研究 (2017)
  • Author(s): 野口泰司
  • Organizer: 第76回日本公衆衛生学会総会
• [Presentation] 腹囲はBMIと比べてHbAlcの上昇を予見するか (2017)
  • Author(s): 細野晃弘
  • Organizer: 第76回日本公衆衛生学会総会
• [Presentation] ビロリ菌感染者における除菌治療の体重変化に与える影響 (2017)
  • Author(s): 玉井裕也
  • Organizer: 第76回日本公衆衛生学会総会
• [Presentation] 主観的な食意識が身体に及ぼす影響について-食塩に着目した検討- (2017)
  • Author(s): 上島寛之
  • Organizer: 第76回日本公衆衛生学会総会
• [Presentation] 出生年別Helicobacter pylori(ピロリ菌)感染率の特微～J-MICC岡崎study (2017)
  • Author(s): 渡邉美貴
  • Organizer: 第76回日本公衆衛生学会総会
• [Presentation] ピロリ菌感染、慢性胃炎とBMI, 腹囲との関連について (2017)
  • Author(s): 鈴木貞夫
  • Organizer: 第76回日本公衆衛生学会総会
• [Presentation] 血圧脈波検査のための非肥満者腹部脂肪面積の測定意義 (2017)
  • Author(s): 原口 夏歩、小山 晃英、栗山 長門、尾﨑 悦子、松井 大輔、渡邉 功、田中 里佳、武下 和久子、渡邊 能行
  • Organizer: 第17回臨床血圧脈波研究会
• [Presentation] 一般住民女性のサプリメント・健康食品の利用有無における実態の検討 (2017)
  • Author(s): 尾崎悦子、武下和久子
  • Organizer: 第64回日本栄養改善学会学術総会
• [Presentation] Amino acid replacement (K14Q) of mitochondria-derived MOTS-c affects typc 2 diabetes in men with lower physical activity (2017)
  • Author(s): Zempo H, Fuku N, Kumagai H, Nishida Y, Higaki Y, Naito H, Hara M, Tanaka K
  • Organizer: The 3rd Congress, International Academy of Sportology
  • Int'l Joint Research
• [Presentation] ミトコンドリアDNA由来ペブチドMOTS-cのアミノ酸置換(K14Q)は身体活動量の低い男性における2型糖尿病に関連する (2017)
  • Author(s): 膳法浩史、福典之、熊谷仁、西田裕一郎、桧垣靖樹、内藤久士、原めぐみ、田中恵太郎
  • Organizer: 第72回日本体力医学会大会
• [Presentation] A genome-wide association study in the Japanese population identifies 12q24. 12-13 locus for habitual coffee consumption (2017)
  • Author(s): Hiroko Nakagawa, Hidemi Ito, Isao Oze, Keitaro Matsuo, Study Group J-MICC
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] Rccurrent myb rearrangement in blastic plasmacytoid dendritic cell neoplasm (2017)
  • Author(s): Kyogo Suzuki, Yusuke Okuno, Yuka Suzuki, Asahito Hama, Hideki Muramatsu, Masahiro Nakatochi, Masaharu Gunji, Daisuke Ichikawa, Motoharu Hamada, Rieko Taniguchi, Shinsuke Kataoka, Norihiro Murakami, Daiei Kojima, Yuko Sekiya, Eri Nishikawa, Nozomu Kawashim
  • Organizer: The 22nd Congress of the European Hematology Association
  • Int'l Joint Research
• [Presentation] Genome wide association study on pollinosis in a Japancse population : The J-MICC Study. (2017)
  • Author(s): Ryosuke FUJII, Asahi HISHIDA, Wu MC, Takaaki KONDO, Mariko NAITO, Yuta HATTORI, Masahiro NAKATOCHI, Kaori ENDOH, Kiyonori KURIKI, Nobuyuki HAMAJIMA, Kenji WAKAI
  • Organizer: The 21st International Epidemiological Association (IEA) World Congress of Epidemiology (WCE2017)
  • Int'l Joint Research
• [Presentation] ジャポニカアレイを活用した痛風のゲノムワイド関連解析 (2017)
  • Author(s): 中杤昌弘, 松尾洋孝
  • Organizer: 第2回ジャポニカアレイ研究会
  • Invited
• [Presentation] The association between the TLR2 gene and risk of H. pylorirelated gastric atrophy detected by SKAT. (2017)
  • Author(s): Hishida Asahi, Fujii Ryosuke, Nakatochi Masahiro, Kawai Sayo, Oze Isao, Matsuo Keitaro, Tamai Yuya, Suzuki Sadao, Kuriyama Nagato, Watanabe Yoshiyuki, Naito Mariko, Wakai Kenji
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] Genome-wide association meta-analysis of usual sleep duration in 31,703 Japanese population (2017)
  • Author(s): T. Nishiyama, C. Wang, M. Nakatochi, A. Hishida, M. Naito, K. Wakai, M. Kubo, A. Goto, M. Iwasaki, A. Hozawa, M. Yamamoto, T. Hachiya, A. Shimizu, K. Tanno, M. Sasaki, S. Suzuki.
  • Organizer: ASHG2017
  • Int'l Joint Research
• [Presentation] Relationship of genetic and clinical factors and prevalence of CKD in a Japanese population : J-MICC Study (2017)
  • Author(s): R. Fujii, A. Hishida, M. Nakatochi, N. Furusho, H. Ikezaki, K. Tanaka, C. Shimanoe, S. Suzuki, T. Koyama, N. Kuriyama, R. Ibusuk I. Shimoshikiryo, N. Takashima, TC. Turin, K. Kuriki, K. Endoh, H. Mikami, H. Nagase, I. Oze, H. Ito, et al.
  • Organizer: ASHG2017
  • Int'l Joint Research
• [Presentation] Possible confounding of genetic associations by alcohol consumption in GWAS meta-analysis of usual sleep duration. (2017)
  • Author(s): Takeshi Nishiyama, Chaochen Wang, Masahiro Nakatochi, Mariko Naito, Kenji Wakai, Michiaki Kubo, Atsushi Goto, Motoki Iwasaki, Atsushi Hozawa, Masayuki Yamamoto, Atsushi Shimizu, Tsuyoshi Hachiya, Kozo Tanno, Makoto Sasaki, Sadao Suzuki
  • Organizer: 日本人類遺伝学会 第62回大会
• [Presentation] 家庭での受動喫煙とその後のCOPDによる死亡との関連 : JACC Study (2017)
  • Author(s): 鵜川重和, 玉腰暁子, 八谷寛, 山岸良匡, 安藤昌彦, 磯博康
  • Organizer: 第69回北海道公衆衛生学会
• [Presentation] Intake of potato and mortality from cardiovascular disease in community-based population (2017)
  • Author(s): Kimura H, Yamagishi K, Muraki I, Iso H, Tamakoshi A ; for the JACC Group
  • Organizer: Tsukuba Global Science Week 2017
  • Int'l Joint Research
• [Presentation] 喫煙および禁煙年数と肺炎の死亡リスクとの関連 : The JACC study (2017)
  • Author(s): 木原朋未, 山岸良匡, 磯博康, 玉腰暁子
  • Organizer: 第52回日本アルコール・アディクション医学会学術集会
• [Presentation] Epidemiology and prevention of cardiovascular disease : Experiences from CIRCS, JPHC and JACC studies (2017)
  • Author(s): Yamagishi K
  • Organizer: The 21st International Epidemiological Assocjation (IEA) World Congress of Epidemiolgy (WCE2017)
  • Int'l Joint Research / Invited
• [Presentation] Boiled bean intake and colorectal cancer incidence among Japanese : The JACC Study (2017)
  • Author(s): Itagaki T, Yamagishi K, Umesawa M, Wakai K, Watanabe Y, Iso H, Tamakoshi A
  • Organizer: The 21st International Epidemiological Association (IEA) World Congress of Epidemiology (WCE2017)
  • Int'l Joint Research
• [Presentation] 女性の生殖歴と循環器疾患死亡との関連 : The JACC study (2017)
  • Author(s): 谷川果菜美, 磯博康, 木村尚史, 池原賢代, 玉腰暁子
  • Organizer: 第76回日本公衆衛生学会総会
• [Presentation] Television viewing time'and mortality from chronic kidney disease among Japanese men and women : the JACC Study (2017)
  • Author(s): Ikchara S, Iso H, Shirakawa T, Ukawa S, Tamakoshi A
  • Organizer: The 21st International Epidemiological Association (IEA) World Congress of Epidemiology (WCE2017)
  • Int'l Joint Research
• [Presentation] Annual report of bibank of aging research, a joint project of Tokyo metropolitan geriatric hospital and institute of gerontolog (TMGHIG) and national center of gerontology and geriatrics (NCGG). (2017)
  • Author(s): Murayama S, Sengoku R, Shibukawa M, Kanemaru K, Sato N, Yanagisawa K
  • Organizer: Alzheimer' s Association International Conference (AAIC 2017).
  • Int'l Joint Research
• [Presentation] Identification of serum microRNA as a potential biomarker related to the prigression of Alzheimer's disease. (2017)
  • Author(s): Kuwano R, Hara N, Kikuchi M, Miyashita A, Hatsuta H, SaitoY, Kasuga K, Murayama S, Ikeuchi T :
  • Organizer: Alzheimer's Association International Conference (AAIC 2017)
  • Int'l Joint Research
• [Presentation] Possible Human-to-Human transmission of cerebral β-Amyloidosis via cadaveric dura matter grafting. (2017)
  • Author(s): Yamada M, Hamaguchi T, Taniguchi Y, Sakai K, Kitamoto T, Takao M, Murayama S, Iwasaki Y, Yoshida M, Shimizu H, Naiki H, Sanjo M, Mizusawa H
  • Organizer: Alzheimer's Association International Conference (AAIC 2017).
  • Int'l Joint Research
• [Presentation] Where are the main lesions that cause orthostatic hypotension in parkinson's disease? (2017)
  • Author(s): Sengoku R, Shibukawa M, Yamazaki M, Eguchi K, Higashihara M, Kaneda D, Nishina Y, Kanemaru K, Murayama S
  • Organizer: 21st International Congress of Parkinson's Disease and Movement Disorders. Vancouver Convention Centre
  • Int'l Joint Research
• [Presentation] Cathecholamine levels and cardiac MIBG scintigraphy in patients with parkinson disease without and with orthostatic hypotension. (2017)
  • Author(s): Shibukawa M, Songoku R, Yamazaki M, Nishina Y, Kanemaru K, Murayama S
  • Organizer: International Society for Autonomic Neuroscience 2017
  • Int'l Joint Research
• [Presentation] The brain bank for aging research project, Tokyo, Japan. (2017)
  • Author(s): Murayama S, Sengoku R., Takada T, Matsubara T, Yamazaki M, Kobayashi M, Sakashita Y, Shibukara M, Morimoto S, Motoyama R, Hiroyoshi Y, Higashihara M, Nishina Y, Kanemaru K, Yanagisawa K, Saito Y
  • Organizer: 23th World Congress of Neurology
  • Int'l Joint Research
• [Presentation] The color of the iris in patients with neuronal intranuclear hyaline inclusion disease will change. (2017)
  • Author(s): Sengoku R, Shibukawa M, Morimoto S, Motoyama R, Sunakawa M, Kaneda D, Nishina Y, Kanemaru K, Murayama S :
  • Organizer: 23th World Congress of Neurology.
  • Int'l Joint Research
• [Presentation] A neuropathological report of familial Amyotrophic lateral sclerosis with an R521S FUS/TLS mutation. (2017)
  • Author(s): Takata T, Haraguchi T, Yokota O, Chiba Y, Kamada M, Deguchi K, Ueno M, Masaki T, Murayama S
  • Organizer: 23th World Congress of Neurology.
  • Int'l Joint Research
• [Presentation] N autopsied case with novel mutated hereditary diffuse leukoencephalopathy with spheroid (HDLS). (2017)
  • Author(s): Izumi Y, Takata T, Miyamoto R, Kawarai T, Saito Y, Murayama S, Kaji R
  • Organizer: 23th World Congress of Neurology.
  • Int'l Joint Research
• [Presentation] Transthoracic echocardiography is useful to detect right-to-left shunt in the olderly. (2017)
  • Author(s): Motoyama R, Morimoto S, Tanaka J, Murayama S
  • Organizer: 23th World Congress of Neurology.
  • Int'l Joint Research
• [Presentation] Validation of the simple smell identification test for evaluation of olfactory dysfunction in patients with Parkinson's diseasc. (2017)
  • Author(s): Yamazaki M, Sengoku R, Kanemaru K, Murayama S
  • Organizer: 23th World Congress of Neurology.
  • Int'l Joint Research
• [Presentation] Enteric nervous system visualization of Hirschsprung's disease using confocal laser endomicroscopy : ex vivo human trial. (2017)
  • Author(s): Kobayashi M, Shimojima N, Kamba S, Takahashi-Fujigasaki J, Sumiyama K
  • Organizer: DDW 2017
  • Int'l Joint Research
• [Presentation] The Japancse brain bank network and α-synucleinopathy ; The spread of Lewy body pathology in the peripheral autonomic nervous system. (2017)
  • Author(s): Murayama S
  • Organizer: Scoul National University Hospital Brain Bank Symposim. Seoul, Korea, 2017.12.1
  • Int'l Joint Research / Invited
• [Presentation] Lewy body pathology includes olfactory cells in Parkinson's and related diseases. (2017)
  • Author(s): Murayama S
  • Organizer: National University Hospital Brain Bank Symposim, Seoul, Korea, 2017. 12. 1
  • Int'l Joint Research / Invited
• [Presentation] Atheromatious Embolizationの源流を探る～大動脈血管内視鏡の挑戦～Session I 「Atheromatous Embolizationの概念は大動脈内視鏡でどう変わるか」I-I大動脈内視鏡で同定される大動脈プラークの臨床的意義 (2017)
  • Author(s): 村山繁雄
  • Organizer: THE 11th TRANS CATHETER IMAGING FORUM
• [Presentation] アルツハイマー病の神経病理診断基準 (2017)
  • Author(s): 村山繁雄
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] 家族性脊髓小脳変性症の家系に発生した、経過2年の進行性筋力低下を示した43歳男性剖検例 (2017)
  • Author(s): 小林万希子, 平田秀爾, 能重 歩, 村山繁雄
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] 誤嚥性肺炎で入院し、急速な意識障害を呈し死亡したパーキンソン病の90歳女性剖検例 (2017)
  • Author(s): 白石朋敬, 仙石錬平, 土田真吏奈, 高田忠幸, 德丸阿耶, 金丸和富, 村山繁雄
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] RT-QuIC法陽性で孤発性クロイツフェルト・ヤコブ病(sCJDMV2K)が疑われた前頭側頭型変性症(FTLD-TDP)の一剖検例 (2017)
  • Author(s): 本山りえ, 中野雄太, 藤ヶ﨑純子, 仙石錬平, 石井賢二, 佐藤克也, 村山繁雄
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] RT-QuIC法陽性で孤発性クロイツフェルト・ヤコブ病(sCJDMV2K)が疑われた前頭側頭型変性症(FTLD-TDP)の一剖検例 (2017)
  • Author(s): 藤ヶ﨑純子, Nascimento C, Leite Renata EP, Pasqualucci Carlos A, Grinberg Lea T, Jacob-Filho W, Nagahashi M, Suely K, 和泉唯信, 山繁雄
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] 特発性正常圧水頭症神経病理検索システムの構築 (2017)
  • Author(s): 渋川茉莉, 仙石錬平, 高梨成彦, 金田大太, 藤ヶ﨑純子, 德丸阿耶, 金丸和富
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] 進行性核上性麻痺の臨床画像病理関連 (2017)
  • Author(s): 金田大太, 高田忠幸, 中野雄太, 石井賢二, 德丸阿耶, 金丸和富, 仙石錬平, 島田 斉, 佐原成彦, 須原哲也, 藤ヶ﨑純子, 村山繁雄
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] 歩行障害で発症し、進行性核上性麻痺の臨床像を呈した淡蒼球黒質ルイ体萎縮症(PNLA)の一剖検例 (2017)
  • Author(s): 竹内亮子, 荒木邦彦, 片多史明, 佐藤 進, 柴山秀博, 村山繁雄, 福武敏夫
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] 徐々に拡大する広範脳梗塞を呈した真性多血症86歳男性剖検例 (2017)
  • Author(s): 中野雄太, 渋川茉莉, 小林万希子, 高田忠幸, 仙石錬平, 藤ヶ﨑純子, 金丸和富, 村山繁雄
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] EGFRチロシンキナーゼ阻害薬中止後、急速な経過で進行する粟粒性脳転移を認めた1剖検例 (2017)
  • Author(s): 栗原正典, 森 正也, 櫻井靖久, 佐野輝典, 齊藤祐子, 村山繁雄
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] 歩行障害と認知症を呈し、病理学的に嗜銀顆粒性変化と進行性核上性麻痺様変化(PSP-like change)を認めた86歳男性解剖例 (2017)
  • Author(s): 金田大太, 高田忠幸, 中野雄太, 石井賢二, 德丸阿耶, 金丸和富, 仙石錬平, 藤ヶ﨑純子, 村山繁雄
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] 福祉村Brain Bank 2016年次報告 (2017)
  • Author(s): 兼坂岳志, 小川倫弘, 赤津裕康, 谷口知恵, 山本左近, 山本孝之, 高尾昌樹, 村山繁雄, 橋詰良夫
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] 美原記念病院ブレインバンクからの年次報告(2016年度) (2017)
  • Author(s): 田野光敏, 田村未来, 佐藤愛海, 青柳真一, 飯島仁美, 谷津隆之, 諏訪部 桂, 木村浩晃, 高橋陽子, 相澤勝健, 赤津裕康, 村山繁雄, 高尾樹, 美原 盤, 美原恵里, 美原 樹
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] 高齢者ブレインバンク年次報告 (2017)
  • Author(s): 村山繁雄, 仙石錬平, 小幡真希, 森島真帆, 高田忠幸, 中野雄太, 藤ヶ﨑純子, 齊藤祐子
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] 経過11年の時間的分散や軸索再生像を伴ったアミロイドニューロパチーの76歳男性剖検例 (2017)
  • Author(s): 北村明日香, 平賢一郎, 新井冨生, 池村雅子, 中村文彦, 岩田 淳, 清水 潤, 村山繁雄, 辻 省次
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] FUS/TLS遺伝子変異(R521S)を認めた筋萎縮性側索硬化症の親子剖検例の病理学的評価 (2017)
  • Author(s): 高田忠幸, 原口 俊, 横田 修, 鎌田正紀, 出口一志, 村山繁雄
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] MJD家系のALS剖検例 (2017)
  • Author(s): 平田秀爾, 能重 歩, 小林万希子, 村山繁雄
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] CSFIR新規変異を認めたhereditary diffuse leukoencephalopathy with spheoroid (HDLS)の1例 (2017)
  • Author(s): 和泉唯信, 高田忠幸, 宮本亮介, 瓦井俊孝, 齊藤祐子, 村山繁雄, 梶 龍兒
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] 大脳皮質基底核症候群を呈し、剖検でアルツハイマー病と診断された1例 (2017)
  • Author(s): 山﨑幹大, 仙石錬平, 中野雄太, 德丸阿耶, 金丸和富, 村山繁雄
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] 教育講演)剖検における神経・筋病理の検索法、高齢者ブレインバンクの経験より (2017)
  • Author(s): 村山繁雄
  • Organizer: 第91回Neuromuscular Conference (NMC)
• [Presentation] Pathogenic mechanism on propagation of alpha-synuclein, a pathological point of view. (2017)
  • Author(s): Murayama S, Saito Y
  • Organizer: 第60回日本神経化学会大会
• [Presentation] 2016 annual report of Japanese brain bank for neuroscience research. (2017)
  • Author(s): Obata M, Murayama S, Takao M, Akatsu Y, Saito Y
  • Organizer: The 40th Annual Meeting of the Japan Neuroscience Society
• [Presentation] (教育講演)ブリオン病の神経病理Update (2017)
  • Author(s): 村山繁雄
  • Organizer: 第35回日本神経治療学会総会
• [Presentation] 「Alzheimer's disease : phenotypic variability and its molecular backgrounds」 Neuropathological variations in Alzheimer' s disease. (2017)
  • Author(s): 村山繁雄
  • Organizer: 第36回日本認知症学会NINPRO-JSDR2017 Joint International Symposium
• [Presentation] 認知症を呈する白質脳症 : 画像の観点から (2017)
  • Author(s): 徳丸阿耶, 櫻井圭太, 下地啓五, 亀山征史, 村山繁雄, 齊藤祐子
  • Organizer: 第36回日本認知症学会
• [Presentation] 「ブレインバンク」ドナー登録者の意識-高齢遺族のグリーフケアにかかる予備的研究- (2017)
  • Author(s): 小幡真希, 畠山幸子, 松原知康, 坂下泰浩, 小林万希子, 高田忠幸, 東原真奈, 仙石錬平, 仁科裕史, 広吉祐子, 森島真帆, 金丸和富, 古田光, 新井冨生, 村山繁雄
  • Organizer: 第36回日本認知症学会
• [Presentation] レビー小体病における認知機能低下とCSFバイオマーカーとの関連 (2017)
  • Author(s): 金丸和富, 金丸晶子, 仁科裕史, 仙石錬平, 村山繁雄
  • Organizer: 第36回日本認知症学会
• [Presentation] 神経細胞特異的DNAメチローム解析によるレビー小体病の新規病態の探索 (2017)
  • Author(s): 土田剛行, 坂内太郎, 野間達雄, 永田健一, 山下 聡, 藤ヶ﨑純子, 村山繁雄, 西道隆臣, 牛島俊和, 辻 省次, 岩田 淳
  • Organizer: 第36回日本認知症学会
• [Presentation] Creutzfeldt-Jakob disease associated with PRNP V180I-129M mutation as a cause of dementia in elderly individuals. (2017)
  • Author(s): Takao M, Kimura H, Mihara B, Kanda T, Yoshizawa K, Koide M, Arai K, Arai Y, Hirose N, Mimura M, Kitamoto T.
  • Organizer: The 93rd Annual Meeting, American Association of Neuropathologists, Inc.,
  • Int'l Joint Research
• [Presentation] Neuropathological study of two cases with false positive real time quakeinduced conversion result of cerebrospinal fluid for prion protein. (2017)
  • Author(s): Murayama S, Motoyama R, Shimizu S, Nakano Y, Fujigasaki J, Sengoku R, Sato K, Takao M.
  • Organizer: The 93rd Annual Meeting, American Association of Neuropathologists, Inc.,
  • Int'l Joint Research
• [Presentation] Investigation of cerebral microbleeds in cases of ischemic stroke/hemorrhagic stroke using only 3.0T MRI data. (2017)
  • Author(s): Abe T, Maruyama H, Deguchi I, Mihara B, Tanahashi N, Takao M.
  • Organizer: The XXIII World Congress of Neurology
  • Int'l Joint Research
• [Presentation] 美原記念病院ブレインバンクからの年次報告 (2017)
  • Author(s): 田野光俊, 田村未来, 佐藤愛美, 青柳真一, 飯島仁美, 谷津隆之, 諏訪部桂, 木村浩晃, 高橋陽子, 相澤勝健, 赤津祐康, 村山繁雄, 高尾昌樹, 美原盤, 美原恵理, 美原樹
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] C9orf72遺伝子にリピート伸長変異を認めたFTLD-ALSの死亡時67歳男性例 (2017)
  • Author(s): 佐藤亮太, 尾本雅俊, 清水文崇, 吉野浩代, 高尾昌樹, 伊藤浩史, 神田隆
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] 遺伝子改変技術を用いた精神・神経疾患モデル霊長類の作出と評価(S-1-3) (2017)
  • Author(s): 関和彦, 富岡郁夫, 永井義隆, 齊藤祐子, 石橋英俊, 花川隆, 尾張健介, 野上尚武, 小泉昌司, 皆川栄子, 中谷輝実, 川野邊哲代
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] パーキンソン病(S-2-2) (2017)
  • Author(s): 齊藤祐子
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] 過去2年のpure skinesia with gait freezingの1剖検例(0-1-AOI) (2017)
  • Author(s): 関大成, 佐野輝典, 勝又淳子, 前川理沙, 日出山拓人, 岸田由紀子, 田村浩一, 齊藤祐子, 椎尾康
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] 精神症状と顕著な姿勢反射障害を呈した、過去5年の進行性核上性麻痺の一解剖例(P-1-D09) (2017)
  • Author(s): 佐野輝典, 川添僚也, 塚本忠, 杉山淳比古, 佐藤典子, 高橋祐二, 村田美穂, 齊藤祐子
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] 腫瘍様の大脳白質病変を呈し、脳生検にて皮質基底核変性症と診断した1例(P-1-D13) (2017)
  • Author(s): 荒川晶, 齊藤祐子, 関大成, 光武明彦, 佐藤達哉, 勝又淳子, 前川理沙, 日出山拓人, 長谷川成人, 椎尾康
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] 盗汗で発症し、治療後再発に至った中枢神経浸潤を伴うBurkitt Lymphomaの78歳男性の1解剖例(P-1-H04) (2017)
  • Author(s): 永迫友規, 藤野悟央, 内尾直裕, 平賢一郎, 那須涼, 寺尾安生, 清水潤, 辻省次, 國松聡, 高橋美和子, 百瀬敏光, 池村雅子, 村山繁雄, 齊藤祐子
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] 意識障害が亜急性に進行し、頭部MRI上白質脳症を呈した癌性髄膜症の72歳男性例(P-1-H10) (2017)
  • Author(s): 塩谷彩子, 辻浩史, 高屋敷典生, 梶有貴, 児玉泰介, 玉岡晃, 齊藤祐子
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] 国立精神・神経医療研究センターブレインバンク 年次報告(P-2-C10) (2017)
  • Author(s): 齊藤祐子, 村山繁雄, 柿田明美, 吉田眞理, 入谷修司, 横田修, 寺田修司, 大島健一, 矢部博興, 國井泰人, 井上悠輔, 田中紀子, 村田美穂, 水澤英洋
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] サルコイド慢性ミオパチーでの筋周鞘のアルカリフォスファターゼ(ALP)陽性所見(P-2-E04) (2017)
  • Author(s): 大矢寧, 若杉憲孝, 濱由香, 森まどか, 齊藤祐子, 西野一三
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] 難治性てんかんの1歳11か月女児例(SS-3) (2017)
  • Author(s): 平澤絢香, 本橋裕子, 須貝研司, 佐々木征行, 岩崎真樹, 中嶋英子, 福山哲広, 佐野輝典, 齊藤祐子
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] 改良ガリアスーブラーク簡易法のキット化の検討(TF-2-B01) (2017)
  • Author(s): 國仲伸男, 佐藤裕子, 梅戸克之, 村山繁雄, 齊藤祐子
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] ボディアン染色に適したプロテイン銀の開発と有用性(TF-2-H04) (2017)
  • Author(s): 國仲伸男, 佐藤裕子, 梅戸克之, 村山繁雄, 齊藤祐子
  • Organizer: 第58回日本神経病理学会総会学術研究会
• [Presentation] 皮質基底核変性症候群の経過中に暖徐に拡大する大脳白質のT2延長域を認め、生検にて皮質基底核変性症と診断した66歳女性例 (2017)
  • Author(s): 荒川晶, 関大成, 光部明彦, 佐藤達哉, 勝又淳子, 前川理沙, 日出山拓人, 齊藤祐子, 長谷川成人, 椎尾康 :
  • Organizer: 第221回日本神経学会関東・甲信越地方会
• [Presentation] 日本ブレインネットの構築 (2017)
  • Author(s): 齊藤祐子
  • Organizer: 第40回日本神経科学大会
• [Presentation] Transgenic monkey model of the polyglutamine disease recapitulating progressive neurological symptoms and polyglutamine protein inclusions (2017)
  • Author(s): Nagai Y, Tomioka H, Ishibashi H, Minakawa E N, Motohasi H H, Takayama O, Saito Y, Popiel H A, Puentes S, Owari K, Nakatani T, Nogami N, Yamamoto K, Noguchi S, Nagano S, Nishino I, Ichinohe N, Wada K, Kohsaka S, Seki k
  • Organizer: XXIII World Congress of Nourology
  • Int'l Joint Research
• [Presentation] Histological findings of cerebral infarction treated with recombinant tissue plasminogen activator (RT-PA) : Two autopsy cases died of non-neurologic complications within a manth after RT-AP treatment (2017)
  • Author(s): Kodama S, Imafuku I, Kakuta Y, Shimizu J, Tsuji S, Murayama S, Saito Y
  • Organizer: XXIII World Congress of Neurology
  • Int'l Joint Research
• [Presentation] Establishment of Japan brain bank net (2017)
  • Author(s): Saito Y, Kakita A, Yoshida M, Murayama S, Iritani S, Yokota O, Terada S, Ohshima K, Yasuta K, Yabe H, Inoue Y, Tanaka N, Motoyoshi Y, Murata M, Mizusawa, H
  • Organizer: XXIII World Congress of Neurology
  • Int'l Joint Research
• [Presentation] Two autopsy cases of parkinson's disease with impulsive-compulsive disorders (2017)
  • Author(s): Sano T, Shioya A, Furusawa Y, Kimura Y, Sato N, Takahashi Y, Murata M, Saito Y
  • Organizer: XXIII World Congress of Neurology
  • Int'l Joint Research
• [Presentation] Neuropathological background of autonomic dysfunction in dementia (2017)
  • Author(s): Murayama S, Saito Y
  • Organizer: The internasional society for autonomic neuroscience 2017
  • Int'l Joint Research
• [Presentation] 83 歳頃発症の認知症で、画像上、著明な脳萎縮と高度の微小出血を示した 99歳・女性 (2017)
  • Author(s): 橋詰良夫
  • Organizer: 第54回名古屋臨床神経病理アカデミー
• [Presentation] 球麻痺で発症し、全経過1年7か月の経過で死亡した71歳・女性 (2017)
  • Author(s): 橋詰良夫、横井風兒
  • Organizer: 第9回日本神経病理学会東海・北睦地方会
• [Presentation] 成人型neuronal ceroid lipofuscinosisの剖検例 (2017)
  • Author(s): 橋詰良夫、兼坂岳志、小川倫弘、谷口知恵、園田尚子、赤津裕康、吉田眞理
  • Organizer: 第45回臨床神経懇話会
• [Presentation] MCIとアルツハイマー病の血液バイオ マーカーとしての補体タンパク質プロファイル (2017)
  • Author(s): 劉珊、鈴木秀昭、目野浩二、赤津裕康、松川則之
  • Organizer: 第36回日本認知症学会学術集会
• [Presentation] Fmoc誘導体化LC-MS/MSを用いたヒト脳脊髄液中のアミノ酸骨格代謝系の網羅的定量分析 (2017)
  • Author(s): 六車宜央、筒井陽仁、赤津裕康
  • Organizer: 第30回バイオメディカル分析科学シンポジウム
• [Presentation] 安定同位体誘導体化を基盤とする高精度キラルメタボロミクスの開発とアルツハイマー病患者CSF解析 (2017)
  • Author(s): 高山卓大、水野初、豊岡利正、井之上浩一、赤津裕康、轟木堅一郎
  • Organizer: 第30回バイオメディカル分析科学シンポジウム
• [Presentation] LC-MS/MSを用いたヒト脳脊髄液中における アルツハイマー病の新規バイオマーカー探索 (2017)
  • Author(s): 野田 巧、六車宜央、筒井陽仁、赤津裕康、井之上浩一
  • Organizer: 第42回日本医用マススペクトル学会年会
• [Presentation] LC-HR/MSによるアルツハイマー病患者脳脊髄液のキラルメタボロミクス (2017)
  • Author(s): 高山卓大、水野 初、井之上浩一、赤津裕康、豊岡利正、轟木堅一郎
  • Organizer: 第42回日本医用マススペクトル学会年会
• [Presentation] 認知症内患者の肺炎による死亡の検討 : システマティックレビュー&メタアナリシス (2017)
  • Author(s): 間辺利江、水上勝義、赤津裕康、工藤宏一郎
  • Organizer: 第59回日本老年医学会学術集会
• [Presentation] アルツハイマー病ヒト脳とアルツハイマー病 モデルマウス脳に置けるα1-chimaerinの発現と局在について (2017)
  • Author(s): 加藤智子、小西吉裕、椎野顕彦、下濱 俊、Beach Thomas G、赤津裕康、遠山育夫
  • Organizer: 第58回日本神経病理学会学術研究会
• [Presentation] 美原記念病院ブレインバンクからの年次報告(2016年) (2017)
  • Author(s): 田野光敏、田村未来、佐藤愛海、青柳真一、飯島仁美、谷津隆之、諏訪部 桂、木村浩晃、高橋陽子、相沢勝健、赤津裕康、村山繁雄、高尾昌樹、美原 盤、美原恵里、美原 樹
  • Organizer: 第58回日本神経病理学会学術研究会
• [Presentation] 死後脳内において高頻度にコピー数多型(CNV)が観察された統合失調症3症例の臨床的特徴について (2017)
  • Author(s): 長岡敦子、國井泰人、松本純弥、和田明、日野瑞城、丹羽真一、那波宏之、高橋 均、柿田明美、赤津裕康、橋詰良夫、山本左近、尾関祐二、矢部博興
  • Organizer: 第12回日本統合失調症学会
• [Presentation] 死後脳内において高頻度にコピー数多型(CNV)が観察された統合失調症3症例の臨床的特徴について (2017)
  • Author(s): 長岡敦子, 國井泰人, 松本純弥, 和田明, 日野瑞城, 丹羽真一, 那波宏之, 高橋均, 柿田明美, 赤津裕康, 橋詰良夫, 山本左近, 尾関祐二, 矢部博興
  • Organizer: 第12回日本統合失調症学会
• [Presentation] 生前登録制度に基づく精神疾患プレインバンクの実践～当事者と研究者が協働する研究体制とは～ (2017)
  • Author(s): 國井泰人、松本純弥、長岡敦子、日野瑞城、丹羽真一、矢部博興
  • Organizer: 第113回日本精神神経学会総会学術総会
• [Presentation] 精神疾患死後脳研究 : ジェネティックニューロパソロジー及びリソース利用の有用性 (2017)
  • Author(s): 國井泰人
  • Organizer: 第39回 日本生物学的精神医学会
• [Presentation] がんの免疫チェックポイント制御 (2017)
  • Author(s): 醍醐弥太郎
  • Organizer: 第14回日本癌治療学会アップデート教育コース
  • Invited
• [Presentation] 肺がん薬物療法のトピックスと展望 (2017)
  • Author(s): 醍醐弥太郎
  • Organizer: 第34回滋賀医学会総会
  • Invited
• [Presentation] 腫瘍免疫学と臨床試験 (2017)
  • Author(s): 醍醐弥太郎
  • Organizer: 帝京大学大学院講義・腫瘍内科学特論
  • Invited
• [Presentation] ヒト生体試料リソースによる研究支援 (2017)
  • Author(s): 醍醐弥太郎
  • Organizer: コホート・生体試料支援プラットフォーム・シンボジウム
• [Presentation] がんの悪性化・難治化に関与する新規因子IL-34に関する研究 (2017)
  • Author(s): 清野研一郎
  • Organizer: コホート・生体試料支援プラットフォーム・シンポジウム
  • Invited
• [Presentation] Dentification of candidate lung cancer neoantignes by systematic screening with next gencration sequencing (2017)
  • Author(s): Sumimoto H, Takano A, Teramoto K, Daigo Y
  • Organizer: 第76回日本癌学会学術集会
• [Presentation] Characterization of URSTI as a biomarker and therapeutic target for respiratory tract cancers (2017)
  • Author(s): Takano A, Yoshitake Y, Shinohara M, Miyagi Y, Daigo Y
  • Organizer: 第76回日本癌学会学術集会
• [Presentation] Improvement of anti-tumor responses by targeting hypoxia-mediated immunosuppression (2017)
  • Author(s): Teramoto K, Kataoka Y, Igarashi T, Sumimoto H, Daigo Y
  • Organizer: 第76回日本癌学会学術集会
• [Presentation] Monitoring of soluble PD-L1 levels in sera in non-small-cell lung cancer. (2017)
  • Author(s): Igarashi T, Hanaka J, Teramoto K, Daigo Y
  • Organizer: 第76回日本癌学会学術集会
• [Presentation] Identification of URSTI as a novel prognostic biomarker and therapeutic target for breast cancer (2017)
  • Author(s): Nakamura M, Takano A, Thang PM, Miyagi Y, Daigo Y
  • Organizer: 第76回日本癌学会学術集会
• [Presentation] Analysis of UROC4 as a new prognostic biomarker and therapeutic target for oral cancer (2017)
  • Author(s): Daigo K, Takano A, Yoshitake Y, Shinohara M, Daigo Y, Tohnai I, Murakami Y, Maegawa J
  • Organizer: 第76回日本癌学会学術集会
• [Presentation] Characterization of LASK2 as a therapeutic target for lung cancer (2017)
  • Author(s): Takahashi K, Takano A, Nakamura Y, Daigo Y
  • Organizer: 第76回日本癌学会学術集会
• [Presentation] Association of variations in HLA-class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma (2017)
  • Author(s): Shiraishi K, Daigo Y, Kubo M, Kohno T, et al.
  • Organizer: 第76回日本癌学会学術集会
• [Presentation] Immunological activities of adoptively transferred tumor antigen-specific CTLs costimulated with OX40 signaling in vitro (2017)
  • Author(s): Pham NM, Murata S, Daigo Y, Tani M, et al.
  • Organizer: 第76回日本癌学会学術集会
• [Presentation] Knockdown of TTK in ovarian cancer cells caused dysfunction of cell division, multinuclear cell formation and cell death (2017)
  • Author(s): Deng B, Park JH, Daigo Y, Nakamura Y
  • Organizer: 第76回日本癌学会学術集会
• [Presentation] RORI : An Achilles Heel of Lung Cancer (2017)
  • Author(s): Takahashi T
  • Organizer: 24th Asia Pacific Cancer Conference
  • Int'l Joint Research / Invited
• [Presentation] 受容体型チロシンキナーゼRORIによる生存シグナル維持の分子基盤 (2017)
  • Author(s): 高橋隆
  • Organizer: 第21回日本がん分子標的治療学会学術集会
  • Invited
• [Presentation] 作製条件によるセルブロックのゲノム診断試料としての品質評価 (2017)
  • Author(s): 宮城洋平
  • Organizer: 第36回神奈川県臨床細胞学会学術集会・教育セミナー
  • Invited
• [Presentation] 生命科学研究を支援する医療機関パイオバンク (2017)
  • Author(s): 宮城洋平
  • Organizer: 横浜市立大学先端医科学研究センターセミナー
  • Invited
• [Presentation] 電気泳動法を基盤とする多発性骨髓腫の臨床と研究の進歩～はじめに～ (2017)
  • Author(s): 安井 寛
  • Organizer: 第68回日本電気泳動学会総会
  • Invited
• [Presentation] 臨床薬理学集中講座修了後の研究活動 ～橋渡し研究と医師主導治験を中心に～ (2017)
  • Author(s): 安井 寛
  • Organizer: 第38回日本臨床薬理学会学術総会
  • Invited
• [Presentation] Toll様受容体CD180を介した多発性骨髄腫の進展機序 (2017)
  • Author(s): 菊池次郎、黒田芳明、小山大輔、長田直希、和泉透、安井寛、川瀬孝和、一戸辰夫、古川雄祐
  • Organizer: 第42回日本骨髄腫学会学術集会
• [Presentation] 成人T細胞白血病リンパ腫に合併した急性骨髄性白血病治療中のウィルス感染症の発症 (2017)
  • Author(s): 神保光児、今井陽一、小川弥穂、平野光人、越智清純、川俣豊隆、横山和明、安井寛、大野伸広、内丸薫、東條有伸
  • Organizer: 第79回日本血液学会学術集会
• [Presentation] Toll様受容体CD180を介した多発性骨髄腫の進展機序 (2017)
  • Author(s): 菊地次郎、黒田芳明、小山大輔、長田直希、和泉透、安井 寛、川瀬孝和、一戸辰夫, 古川雄祐
  • Organizer: 第79回日本血液学会学術集会
• [Presentation] A response to HTLV-1 in Japan”, HTLV-1 ; Re-awaking to HTLV-1 in indigenous communities (2017)
  • Author(s): Watanabe Toshiki
  • Organizer: The 9th International Global Virus Network Meeting
  • Int'l Joint Research / Invited
• [Presentation] Phase 1/2 study of mogamulizumab, an anti-CCR4 Monoclonal antibody, in Patients with HTLV-1-associated myelopathy(HAM/TSP) (2017)
  • Author(s): Yamano Y, Sato T, A. Coler-Reilly, Yanagisawa N, Araya N, Inoue E, Furuta R, Watanabe T, Uchimaru K, Matsuoka M, Matsumoto N, Hasegawa Y
  • Organizer: XXIII World Congress of Neurology
  • Int'l Joint Research
• [Presentation] ATL研究の現状-発症予防と個別化治療へ向けた展開- (2017)
  • Author(s): 渡邉俊樹
  • Organizer: 第79回日本血液学会学術集会
  • Invited
• [Presentation] 成人T細胞白血病・リンパ腫(急性型・リンパ腫型)に対する治療と予後の実際に関する検討 (2017)
  • Author(s): 今泉芳孝、岩永正子、野坂生郷、伊藤薫樹、石塚賢治、宇都宮與、戸倉新樹、仲地佐和子、下田和哉、飛内賢正、渡邉俊樹、内丸薫、塚崎邦弘
  • Organizer: 第79回日本血液学会学術集会
• [Presentation] EZH1/2阻害による悪性リンパ腫のエピゲノム制御 (2017)
  • Author(s): 山岸誠、堀真琴、藤川大、本間大輔、安達宣明、大杉剛生、中野和民、中島誠、小林誠一郎、岩永正子、宇都宮與、岡田誠治、塚崎邦弘、飛内賢正、荒木一司、渡邉俊樹
  • Organizer: 第79回日本血液学会学術集会
• [Presentation] ATL細胞の組織特異的遊走メカニズムの探索 (2017)
  • Author(s): 中野和民、野田奈津美、渡邉俊樹、内丸薫
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] Molecular basis for clonal and malignant growth of HTLV-1-infected T-cells (2017)
  • Author(s): Toshiki Watanabe
  • Organizer: Seminar, NIH, Washington
  • Invited
• [Presentation] Current status of HTLV-1 infection in Japan and molecular basis for ATL development (2017)
  • Author(s): Toshiki Watanabe
  • Organizer: Seminar, Institut IMAGINE
  • Invited
• [Presentation] Current status of HTLV-1 infection in Japan and molecular basis for ATL development (2017)
  • Author(s): Toshiki Watanabe
  • Organizer: Seminar, The University of Liege
  • Invited
• [Presentation] Current status of HTLV-1 infection in Japan and molecular basis for ATL development (2017)
  • Author(s): Toshiki Watanabe
  • Organizer: Seminar, ENS de Lyon
  • Invited
• [Presentation] ATL研究の現状-発症予防と個別化治療へ向けた展開- (2017)
  • Author(s): 渡邉俊樹
  • Organizer: Kushiro Homatology Forum
  • Invited
• [Presentation] 細胞起源と遺伝子変異に基づいたEZH1/2標的個別化医療の開発 (2017)
  • Author(s): 山岸誠、藤川大、堀真琴、本間大輔、安達宣明、岩永正子、宇都宮與、岡田誠治、塚崎邦弘、飛内賢正、荒木一司、渡邉俊樹、内丸薫
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 慢性型およびくすぶり型ATL の予後の検討 : 第11次全国実態調査の解析結果 (2017)
  • Author(s): 今泉芳孝、岩永正子、野坂生郷、伊藤薫樹、石塚賢治、宇都宮與、戸倉新樹、仲地佐和子、森内幸美、林正樹、下田和哉、飛内賢正、渡邉俊樹、内丸薫、塚崎邦弘
  • Organizer: 第4回日本HTLV-1学会学術集会
• [Presentation] FoxM1 : ATL細胞の新たな治療標的因子としての可能性 (2017)
  • Author(s): 山本菜央佳、中野和民、宇都宮與、渡邉俊樹、内丸薫
  • Organizer: 第4回日本HTLV-1学会学術集会
• [Presentation] 新規治療薬開発とATL発症予防介入へ向けた展開 (2017)
  • Author(s): 渡邉俊樹、山岸誠、中野和民、本間大輔、荒木一司、内丸薫
  • Organizer: 第4回日本HTLV-1学会学術集会
• [Presentation] HTLV-1感染細胞におけるJAK/STAT経路の標的遺伝子の同定と機能的意義の検討 (2017)
  • Author(s): 石崎伊純、山岸誠、志賀遥菜、宇都宮與、田中勇悦、渡邉俊樹、内丸薫
  • Organizer: 第4回日本HTLV-1学会学術集会
• [Presentation] ATLの分子病態に基づく発症予防と個別化治療へ向けた展開 (2017)
  • Author(s): 渡邉俊樹
  • Organizer: 第57回日本リンバ網内系学会総会
  • Invited
• [Presentation] Keynote Presentation : “Recent advances in HTLV-1 and ATL research” (2017)
  • Author(s): Watanabe T
  • Organizer: 18th International Conference on Human Retrovirology, HTLV and Related Viruses.
  • Place of Presentation: ホテルグランドアーク半蔵門(東京都港区)
  • Year and Date: 2017-03-07 – 2017-03-10
  • Int'l Joint Research / Invited
• [Presentation] TTF-1/NKX2-1 : An Enigmatic Double-Edged Sword in Lung Adenocarcinoma (2017)
  • Author(s): Takahashi T
  • Organizer: The 2017 Japan-NIH joint Symposium on Advances in Biomedical Research and Disease
  • Place of Presentation: 東北大学星陵キャンパス(宮城県仙台市)
  • Year and Date: 2017-02-17
  • Invited
• [Presentation] 遺伝性腫瘍症 (2016)
  • Author(s): 醍醐弥太郎
  • Organizer: 第27回日本人類遺伝学会・遺伝医学セミナー
  • Invited
• [Presentation] Physical activity reduces the risk of type 2 diabetes associated with m. 1382A>c polymorphism encoding 12S rRNA and mitochondria derived MOTS-c (2016)
  • Author(s): Fuku N, Zempo H, Nishida Y, Higaki Y, Naito H, Hara M, Tanaka K
  • Organizer: APS Intersociety Meeting : The Integrative Biology of Exercise Ⅶ
  • Place of Presentation: Phoenix, Arizona, USA
  • Year and Date: 2016-11-02 – 2016-11-04
  • Int'l Joint Research
• [Presentation] The Japan Multi-Institutional Collaborative Cohort Study. Genome-wide association study of sleep duration in the 14,000 Japanese general population (2016)
  • Author(s): Nishiyama T, Nakatochi M, Hosono A, Tamai Y, Suzuki S, Hishida A, Wakai K, Tanaka H, Matsuo K
  • Organizer: ASHG2016
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2016-10-18 – 2016-10-22
  • Int'l Joint Research
• [Presentation] Analysis of non-synonymous genetic variations associated with cancer risk by a prospective cohort study (2016)
  • Author(s): Yohko Nakamura, Yoshiaki Maru, Yasutoshi Tatsumi, Kazuhiro Okumura, Sana Yokoi, Miki Ohira, Yoshihiro Nabeya, Satoshi Fukasawa, Jin Katayama Hiroki Nagase, Haruo Mikami
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2016-10-06 – 2016-10-08
• [Presentation] Monitoring of circulating PD-1+ cells and PD-1+ tumor-infiltrating lymphocytes in non-small-cell lung cancer (2016)
  • Author(s): Igarashi T, Kataoka Y, Hanaka J, Teramoto K, Daigo Y
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2016-10-06 – 2016-10-08
• [Presentation] Characterization of UROC3 protein as a novel biomarker and a therapeutic target for oral cancer (2016)
  • Author(s): Thang PM, Takano A, Yoshitake Y, Shinohara M, Murakami Y, Daigo Y
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2016-10-06 – 2016-10-08
• [Presentation] Non-coding RNA-mediated regulation of genes that are crucially involved in the molecular pathogenesis of lung cancer (2016)
  • Author(s): Takahashi T
  • Organizer: 第75回日本癌学会総会(シンボジウム)
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2016-10-06
  • Invited
• [Presentation] Serum uric acid in associated with within-visit blood pressure variability among women : the results of a five year survey from the J-MICC Daiko Study (2016)
  • Author(s): Okada R, Naito M, Morita E, Takagi S, Matsunaga T, Seiki T, Sasakabe T, Hattori Y, Kawai S, Hishida A, Hamajima N, Wakai K
  • Organizer: Hypertension Seoul 2016 (The 26th Scientific Meeting of the International Society of Hypertension)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-09-24 – 2016-09-29
  • Int'l Joint Research
• [Presentation] 液性検体の質とTime Stampシンボジウム1・臨床検査と液性試料(検体) : 質の観点から (2016)
  • Author(s): 宮城洋平
  • Organizer: 第63回日本臨床検査医学会学術集会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
  • Year and Date: 2016-09-06 – 2016-09-07
  • Invited
• [Presentation] Eating rate as obese risk and seasonal variation of abdominal fat. (2016)
  • Author(s): Kuriki K.
  • Organizer: The 2016 International Congress on Obesity and Metabolic Syndrome in conjunction with the 45th Annual Scientific Meeting of the Korean Society for the Study of Obesity (ICOMES)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-09-01 – 2016-09-03
  • Int'l Joint Research / Invited
• [Presentation] 多発性骨髄腫における先端医療開発の今後 (2016)
  • Author(s): 安井 寛
  • Organizer: 第67回日本電気泳動学会
  • Place of Presentation: 釧路市観光国際交流センター(北海道釧路市)
  • Year and Date: 2016-08-25 – 2016-08-26
  • Invited
• [Presentation] Polycomb-dependent epigenetic landscape in ATL : proof of concept for targeting EZH1/2 (2016)
  • Author(s): Watanabe T
  • Organizer: Malignant Lymphoma Academy 2016
  • Place of Presentation: シェラトン都ホテル東京(東京都港区)
  • Year and Date: 2016-08-06 – 2016-08-17
  • Invited
• [Presentation] Association Between Remnal Functions and SCFBiomarkers in Alzheimer's Disease. (2016)
  • Author(s): Kanemaru K, Kanemaru A, Murayama S.
  • Organizer: Alzheimer's Association International Conference (AAIC2016)
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2016-07-23 – 2016-07-28
  • Int'l Joint Research
• [Presentation] Epigenetic Regulation of BRCA1 in Alzheimer's Disease. Evaluation of Post-Mortem Brain-and Model Mice Reveals Importance of Aggregated Tau (2016)
  • Author(s): Mano T, Ohtomo R, Nagata K, Murayama S, Saido T. C, Yamashita S, Ushijima T, Hashimoto T, Tamaoka A, Iwatsubo T, Tsuji S, Iwata A
  • Organizer: Alzheimer's Association International Conference (AAIC2016)
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2016-07-23 – 2016-07-28
  • Int'l Joint Research
• [Presentation] Enhanced Pla2g3 Expression By Oxidative Stress Decreases the Ide and Exacerbates AD (2016)
  • Author(s): Nishida Y, Yui D, Nishina T, Mogushi K, Ishibashi S, Ajioka I, Ishikawa K, Mizusawa H, Murayama S, Yokota T
  • Organizer: Alzheimer's Association International Conference (AAIC2016)
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2016-07-23 – 2016-07-28
  • Int'l Joint Research
• [Presentation] Relationship between the cholesterol and triglyceride content of lipoprotein subclasses and carotid intima media thickness : Results from the Kyushu and Okinawa Population Study (2016)
  • Author(s): Furusyo N, Shimizu M, Kato Y, Tanaka Y, Hayashi J.
  • Organizer: The 84th European Atherosclerosis Society (EAS) Congress
  • Place of Presentation: Innsbruck, Austria
  • Year and Date: 2016-05-29 – 2016-06-01
  • Int'l Joint Research
• [Presentation] エオジン好性核内封入体病における機能画像・髄液バイオマーカーの検討 (2016)
  • Author(s): 仙石錬平, 渋川菜莉, 本山りえ, 森本 悟, 砂川昌子, 金田大太, 仁科裕史, 豊原 潤, 藤ヶ﨑純子, 石井賢二, 金丸和富, 村山繁雄
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸コンベンションセンター(兵庫県神戸市)
  • Year and Date: 2016-05-18 – 2016-05-21
• [Presentation] Neuropathological examination of familial Parkinson's disease with LRRK2I2020T mutation. (2016)
  • Author(s): Uchino A, Fujigasaki J, Hasegawa K, Yagishita S, Oonuma S, Ogino M, Ogino Y, Nakano Y, Murayama S, Nishiyama K
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸コンペンションセンター(兵庫県神戸市)
  • Year and Date: 2016-05-18 – 2016-05-21
• [Book] Newton : 「死」と「生」の境界線 死とは何か? 寿命をのばすことは可能なのか? (2017)
  • Author(s): 岩瀬博太郎, 岡田隆夫, 川上嘉明, 小林武彦, 村山繁雄
  • Pages: (13) 114-121
  • Total Pages: 37
  • Publisher: ニュートンプレス
• [Book] A Literature Review of the Associations between Sedentary Behavior and Health-Related Outcomes in Japan. Leon V. Berhardt, eds. (2017)
  • Author(s): Ukawa S, Shirakawa T, Kikuchi H, Ikehara S, Inoue S, Iso H, Tamakoshi A.
  • Pages: 93-107
  • Total Pages: 239
  • Publisher: NOVA science publishers. New York
• [Book] 神経内科 第84巻第6号 (2016)
  • Author(s): 小山晃英、渡邊能行、栗山長門
  • Pages: 527-612(550-556)
  • Publisher: 科学評論社
• [Remarks] コホート・生体試料支援プラットフォームホームページ
  • URL: http://cohort.umin.jp/
• [Remarks] 東京大学医科学研究所 学術研究基盤支援室ホームページ
  • URL: http://academicsupport.jp/index.html
• [Remarks] J-MICC STUDYホームページ
  • URL: http://www.jmicc.com
• [Remarks] ICOMES : 2016 International Congress on Obesity and Metabolic Syndrome "Understanding, Manageing & Preventing Obesity and Meatabolic Syndrome" Symmposium 10 Looking for Successful Nutritional Approaches to Obesity & Metabolic Syndrome
  • URL: http://www.icomes.or.kr/register/2016_icomos/program/sub02_03.html
• [Remarks] 千葉県がんセンター研究所ホームページ
  • URL: http://www.pref.chiba.lg.jp/gan/kenkyujo/
• [Remarks] 千葉県がんセンター研究所フェイスブック
  • URL: https://m.faccbook.com/CCCRI.chiba.gan.kenkyu.jo
• [Remarks] 京都府立医科大学地域保健医療疫学教室ホームページ
  • URL: http://www.f.kpu-m.ac.jp/k/cpid/index.html
• [Remarks] 九州大学医学研究院 感染制御医学分野ホームページ
  • URL: http://www.soshin.med.kyushu-u.ac.jp/
• [Remarks] 精神疾患プレインバンク・DNAバンクホームページ
  • URL: http://www.fmu-bb.jp/
• [Remarks] 2017年10月29日(日)毎日新聞記事掲載
  • URL: https://mainichi.jp/articles/20171029/ddm/016/040/048000c
• [Remarks] J-MICC Study
  • URL: http://www.jmicc.com
• [Remarks] 千葉県がんセンター研究所 予防疫学研究部
  • URL: https://www.pref.chiba.lg.jp/gan/kenkyujo/soshiki/yoboekigaku/index.html
• [Remarks] ICOMES : 2016 International Congress on Obesity and Metabolic Syndrome "Understanding, Manageing & Preventing Obesity and Meatabolic Syndrome" Symposium 10 Looking for Successful Nutritional Approaches to Obesity & Metabolic Syndrome
  • URL: http://www.icomes.or.kr/register/2016_icomes/program/sub02_03.html
• [Remarks] J-MICC Study(ジェイミック・スタディ)佐賀フィールドとは
  • URL: http://www.prevent.med.saga-u.ac.jp/jmiccsaga.html
• [Remarks] 九州大学病院 総合診療科(感染環境医学分野)
  • URL: http://www.soshin.med.kyushu-u.ac.jp/
• [Remarks] JACC Study
  • URL: http://publichealth.med.hokudai.ac.jp/jacc/
• [Remarks] コホート・生体試料支援プラットフォーム「生体試料による支援活動」
  • URL: http://cohort.umin.jp/about/bio-specimen.html
• [Remarks] プラットフォームHPのURL
  • URL: http://cohort.umin.jp/index.html
• [Patent(Industrial Property Rights)] AD診断技術 (2017)
  • Inventor(s): 吉宗一晃、赤津裕康、神野英毅
  • Industrial Property Rights Holder: 吉宗一晃、赤津裕康、神野英毅
  • Industrial Property Rights Type: 特許権, 特願
  • Industrial Property Number: 特願2017-45244
  • Application Year: 2017