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Comprehensive research on statistical methodologies and their applications for development of personalized medicine

Research Project

Project/Area Number 16H06299
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Statistical science
Research InstitutionNagoya University

Principal Investigator

Matsui Shigeyuki  名古屋大学, 医学系研究科, 教授 (80305854)

Co-Investigator(Kenkyū-buntansha) 山田 誠  京都大学, 情報学研究科, 准教授 (00581323)
角田 達彦  東京大学, 大学院理学系研究科(理学部), 教授 (10273468)
山下 智志  統計数理研究所, データ科学研究系, 教授 (50244108)
服部 聡  大阪大学, 医学系研究科, 教授 (50425154)
Project Period (FY) 2016-05-31 – 2021-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥113,750,000 (Direct Cost: ¥87,500,000、Indirect Cost: ¥26,250,000)
Fiscal Year 2020: ¥24,960,000 (Direct Cost: ¥19,200,000、Indirect Cost: ¥5,760,000)
Fiscal Year 2019: ¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
Fiscal Year 2018: ¥23,010,000 (Direct Cost: ¥17,700,000、Indirect Cost: ¥5,310,000)
Fiscal Year 2017: ¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
Fiscal Year 2016: ¥21,190,000 (Direct Cost: ¥16,300,000、Indirect Cost: ¥4,890,000)
Keywords統計科学 / 生物統計学 / 機械学習 / 個別化医療 / 臨床研究 / 研究デザイン / データ解析 / 社会医学 / 薬剤反応性 / 臨床試験 / 統計解析 / 診断法開発 / 統計数学
Outline of Final Research Achievements

We have developed statistical and machine learning methods and tools for the clinical development of personalized medicine and conducted many case studies in a wide range of disease fields. By comprehensively covering the main phases for developing personalized medicine, including the development and evaluation of diagnostic markers, evaluation of the efficacy of treatments based on diagnostic markers, integration of evidence for personalized medicine based on diagnostic markers, and marker-based decision-making in selecting treatment in medical practice, we have developed statistical and machine learning methodologies that are truly useful for clinical development of personalized medicine.

Academic Significance and Societal Importance of the Research Achievements

個別化医療の臨床開発のための統計・機械学習の方法論の構築は、統計科学・情報学の発展につながり、健康医療領域での統計科学・情報学の応用研究の発展にもつながる。一方、個別化医療の開発に役立つ統計・機械学習の方法論を構築することで、限られた医療資源を用いた個別化医療開発の効率性、成功確率の向上につながり、個別化医療の推進に直接的に貢献する。

Assessment Rating
Verification Result (Rating)

A

Assessment Rating
Result (Rating)

A: Progress in the research is steadily towards the initial goal. Expected research results are expected.

Report

(11 results)
  • 2023 Research Progress Assessment (Verification Result) ( PDF )
  • 2022 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Abstract ( PDF )   Comments on the Screening Results ( PDF )   Annual Research Report
  • Research Products

    (189 results)

All 2021 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (9 results) Journal Article (82 results) (of which Int'l Joint Research: 40 results,  Peer Reviewed: 82 results,  Open Access: 37 results,  Acknowledgement Compliant: 4 results) Presentation (84 results) (of which Int'l Joint Research: 52 results,  Invited: 32 results) Book (8 results) Remarks (4 results) Funded Workshop (2 results)

  • [Int'l Joint Research] Cancer Research & Biostatistics(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Newcastle University/University of Cambridge(英国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Cancer Research And Biostatistics/Fred Hutchinson Cancer Research Center/Oregon Health & Science University(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Newcastle University(英国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Cancer Research And Biostatistics/Fred Hutchinson Cancer Research Center/Oregon Health & Science University(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Cancer Research and Biostatistics/University of Washington/National Cancer Institute(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] EORTC(ベルギー)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Gustave Roussy & INSERM CESP(フランス)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Cancer Research and Biostatistics/University of Washington/National Cancer Institute(米国)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Semi-parametric empirical Bayes factor for genome-wide association studies2021

    • Author(s)
      Morisawa Junji、Otani Takahiro、Nishino Jo、Emoto Ryo、Takahashi Kunihiko、Matsui Shigeyuki
    • Journal Title

      European Journal of Human Genetics

      Volume: 29 Issue: 5 Pages: 800-807

    • DOI

      10.1038/s41431-020-00800-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic value of desmoplastic reaction characterisation in stage II colon cancer: prospective validation in a Phase 3 study (SACURA Trial)2021

    • Author(s)
      Ueno Hideki、Ishiguro Megumi、Nakatani Eiji、Ishikawa Toshiaki、Uetake Hiroyuki、Murotani Kenta、Matsui Shigeyuki、Teramukai Satoshi、Sugai Tamotsu、Ajioka Yoichi、Maruo Hirotoshi、Kotaka Masahito、Tsujie Masaki、Munemoto Yoshinori、Yamaguchi Takashi、Kuroda Hisashi、Fukunaga Mutsumi、Tomita Naohiro、Sugihara Kenichi
    • Journal Title

      British Journal of Cancer

      Volume: 124 Issue: 6 Pages: 1088-1097

    • DOI

      10.1038/s41416-020-01222-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Statistical models in clinical studies2021

    • Author(s)
      Matsui S, Le-Rademacher J, Mandrekar SJ
    • Journal Title

      J Thorac Oncol

      Volume: 16 Issue: 5 Pages: 734-739

    • DOI

      10.1016/j.jtho.2021.02.021

    • NAID

      120007178398

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A large-scale multi-institutional study evaluating prognostic aspects of positive ascites cytology and effects of therapeutic interventions in epithelial ovarian cancer2021

    • Author(s)
      Yoshihara Masato、Emoto Ryo、Kitami Kazuhisa、Iyoshi Shohei、Uno Kaname、Mogi Kazumasa、Tano Sho、Yoshikawa Nobuhisa、Matsui Shigeyuki、Kajiyama Hiroaki
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 15154-15154

    • DOI

      10.1038/s41598-021-93718-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] DeepFeature: feature selection in nonimage data using convolutional neural network2021

    • Author(s)
      Sharma Alok、Lysenko Artem、Boroevich Keith A、Vans Edwin、Tsunoda Tatsuhiko
    • Journal Title

      Briefings in Bioinformatics

      Volume: 22 Issue: 6

    • DOI

      10.1093/bib/bbab297

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Blinded sample size re-estimation in comparative clinical trials with overdispersed count data: Incorporation of misspecification of the variance function2021

    • Author(s)
      Igeta M, Matsui S
    • Journal Title

      Stat Biopharm Res

      Volume: 13 Issue: 2 Pages: 170-180

    • DOI

      10.1080/19466315.2020.1835711

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outcome related to level of targeted temperature management in postcardiac arrest syndrome of low, moderate, and high severities: A nationwide multicenter prospective registry2021

    • Author(s)
      Nishikimi M, Ogura T, Nishida K, Hayashida K, Emoto R, Matsui S, Matsuda N, Iwami T
    • Journal Title

      Crit Care Med

      Volume: 49 Issue: 8 Pages: e741-e750

    • DOI

      10.1097/ccm.0000000000005025

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect-size estimation using semiparametric hierarchical mixture models in disease-association studies with neuroimaging data2020

    • Author(s)
      Emoto R, Kawaguchi A, Takahashi K, Matsui S.
    • Journal Title

      Computational and Mathematical Methods in Medicine

      Volume: - Pages: 7482403-7482403

    • DOI

      10.1155/2020/7482403

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optimal Criteria for G3 (Poorly Differentiated) Stage II Colon Cancer2020

    • Author(s)
      Ueno Hideki、Ishiguro Megumi、Nakatani Eiji、Ishikawa Toshiaki、Uetake Hiroyuki、Matsui Shigeyuki、Teramukai Satoshi、Murotani Kenta、Ajioka Yoichi、Shimazaki Hideyuki、Maeda Atsuyuki、Takuma Kunio、Yoshida Takefumi、Kambara Takeshi、Matsuda Keiji、Takagane Akinori、Tomita Naohiro、Sugihara Kenichi
    • Journal Title

      American Journal of Surgical Pathology

      Volume: 44 Issue: 12 Pages: 1685-1698

    • DOI

      10.1097/pas.0000000000001570

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies2020

    • Author(s)
      Kumagai S,Togashi Y,Kamada T,Sugiyama E,Nishinakamura H,Takeuchi Y,Vitaly K,Itahashi K,Maeda Y,Matsui S,Shibahara T,Yamashita Y,Irie T,Tsuge A,Fukuoka S,Kawazoe A,Udagawa H,Kirita K,Aokage K,Ishii G,Kuwata T,Nakama K,Kawazu M,Ueno T,Yamazaki N,Goto K,Tsuboi M,Mano H,Doi T,Shitara K,Nishikawa H
    • Journal Title

      Nature Immunology

      Volume: 21 Issue: 11 Pages: 1346-1358

    • DOI

      10.1038/s41590-020-0769-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of uterus‐preserving surgery on Stage I primary mucinous epithelial ovarian carcinoma: A multi‐institutional study with propensity score‐weighted analysis2020

    • Author(s)
      Yoshihara Masato、Kajiyama Hiroaki、Tamauchi Satoshi、Iyoshi Shohei、Yokoi Akira、Suzuki Shiro、Kawai Michiyasu、Nagasaka Tetsuro、Takahashi Kunihiko、Matsui Shigeyuki、Kikkawa Fumitaka
    • Journal Title

      International Journal of Gynecology & Obstetrics

      Volume: 150 Issue: 2 Pages: 177-183

    • DOI

      10.1002/ijgo.13244

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Doubly robust inference procedure for relative survival ratio in population‐based cancer registry data2020

    • Author(s)
      Komukai Sho、Hattori Satoshi
    • Journal Title

      Statistics in Medicine

      Volume: - Issue: 13 Pages: 1884-1900

    • DOI

      10.1002/sim.8521

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic impact of pelvic and para-aortic lymphadenectomy on clinically-apparent stage I primary mucinous epithelial ovarian carcinoma: a multi-institutional study with propensity score-weighted analysis2020

    • Author(s)
      Yoshihara Masato、Kajiyama Hiroaki、Tamauchi Satoshi、Iyoshi Shohei、Yokoi Akira、Suzuki Shiro、Kawai Michiyasu、Nagasaka Tetsuro、Takahashi Kunihiko、Matsui Shigeyuki、Kikkawa Fumitaka
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 50 Pages: 145-151

    • DOI

      10.1093/jjco/hyz163

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantification of multicellular colonization in tumor metastasis using exome‐sequencing data2020

    • Author(s)
      Nishino Jo、Watanabe Shuichi、Miya Fuyuki、Kamatani Takashi、Sugawara Toshitaka、Boroevich Keith A.、Tsunoda Tatsuhiko
    • Journal Title

      International Journal of Cancer

      Volume: 146 Issue: 9 Pages: 2488-2497

    • DOI

      10.1002/ijc.32910

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Statistical testing strategies for assessing treatment efficacy and marker accuracy in phase III trials2019

    • Author(s)
      Nonaka Takahiro、Igeta Masataka、Matsui Shigeyuki
    • Journal Title

      Pharmaceutical Statistics

      Volume: 18 Issue: 4 Pages: 459-475

    • DOI

      10.1002/pst.1937

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of novel diagnostic system for pancreatic cancer, including early stages, measuring mRNA of whole blood cells2019

    • Author(s)
      Sakai Yoshio、Honda Masao、Matsui Shigeyuki、Komori Osamu、Murayama Toshinori、Fujiwara Tadami、Mizuno Masaaki、Imai Yasuhito、Yoshimura Kenichi、Nasti Alessandro、Wada Takashi、Iida Noriho、Kitahara Masaaki、Horii Rika、Toshikatsu Tamai、Nishikawa Masashi、Okafuji Hirofumi、Mizukoshi Eishiro、et al
    • Journal Title

      Cancer Science

      Volume: 110 Issue: 4 Pages: 1364-1388

    • DOI

      10.1111/cas.13971

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Two‐stage analysis for selecting fixed numbers of features in omics association studies2019

    • Author(s)
      Kawabata Takanori、Emoto Ryo、Nishino Jo、Takahashi Kunihiko、Matsui Shigeyuki
    • Journal Title

      Statistics in Medicine

      Volume: 38 Issue: 16 Pages: 2956-2971

    • DOI

      10.1002/sim.8150

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical Frailty Scale Score Before ICU Admission Is Associated With Mobility Disability in Septic Patients Receiving Early Rehabilitation2019

    • Author(s)
      Nakajima Hiroki、Nishikimi Mitsuaki、Shimizu Miho、Hayashi Kazuhiro、Inoue Takayuki、Nishida Kazuki、Takahashi Kunihiko、Matsui Shigeyuki、Nishida Yoshihiro、Matsuda Naoyuki
    • Journal Title

      Critical Care Explorations

      Volume: 1 Issue: 12 Pages: e0066-e0066

    • DOI

      10.1097/cce.0000000000000066

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A randomised controlled trial of pectoral nerve‐2 (PECS2) block vs. serratus plane block for chronic pain after mastectomy2019

    • Author(s)
      Fujii Tasuku、Shibata Yasuyuki、Akane Akiko、Aoki Wakana、Sekiguchi Akiko、 Takahashi Kunihiko、Matsui Shigeyuki、Nishiwaki Kimitoshi
    • Journal Title

      Anaesthesia

      Volume: 74 Issue: 12 Pages: 1558-1562

    • DOI

      10.1111/anae.14856

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic factors and effects of fertility-sparing surgery in women of reproductive age with ovarian clear-cell carcinoma: a propensity score analysis2019

    • Author(s)
      Yoshihara Masato、Kajiyama Hiroaki、Tamauchi Satoshi、Suzuki Shiro、Takahashi Kunihiko、Matsui Shigeyuki、Kikkawa Fumitaka
    • Journal Title

      Journal of Gynecologic Oncology

      Volume: 30 Issue: 6

    • DOI

      10.3802/jgo.2019.30.e102

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Steeper Macular Curvature in Eyes With Non-Highly Myopic Retinitis Pigmentosa.2019

    • Author(s)
      Komori S, Ueno S, Ito Y, Sayo A, Meinert M, Kominami T, Inooka D, Kitagawa M, Nishida K, Takahashi K, Matsui S, Terasaki H.
    • Journal Title

      Investigative Ophthalmology & Visual Science

      Volume: 60 Issue: 8 Pages: 3135-3141

    • DOI

      10.1167/iovs.19-27334

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] External validation of a risk classification at the emergency department of post-cardiac arrest syndrome patients undergoing targeted temperature management2019

    • Author(s)
      Nishikimi Mitsuaki、Ogura Takayuki、Nishida Kazuki、Takahashi Kunihiko、Nakamura Mitsunobu、Matsui Shigeyuki、Matsuda Naoyuki、Iwami Taku
    • Journal Title

      Resuscitation

      Volume: 140 Pages: 135-141

    • DOI

      10.1016/j.resuscitation.2019.05.028

    • NAID

      120006645293

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prospective Multicenter Study on the Prognostic and Predictive Impact of Tumor Budding in Stage II Colon Cancer: Results From the SACURA Trial2019

    • Author(s)
      Ueno Hideki、Ishiguro Megumi、Nakatani Eiji、Ishikawa Toshiaki、Uetake Hiroyuki、Matsuda Chu、Nakamoto Yoshihiko、Kotake Masanori、Kurachi Kiyotaka、Egawa Tomohisa、Yasumasa Keigo、Murata Kohei、Ikawa Osamu、Shinji Seiichi、Murotani Kenta、Matsui Shigeyuki、Teramukai Satoshi、Tomita Naohiro、Sugihara Kenichi
    • Journal Title

      Journal of Clinical Oncology

      Volume: 37 Issue: 22 Pages: 1886-1894

    • DOI

      10.1200/jco.18.02059

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bigram-PGK: phosphoglycerylation prediction using the technique of bigram probabilities of position specific scoring matrix2019

    • Author(s)
      Chandra Abel、Sharma Alok、Dehzangi Abdollah、Shigemizu Daichi、Tsunoda Tatsuhiko
    • Journal Title

      BMC Molecular and Cell Biology

      Volume: 20 Issue: S2 Pages: 57-57

    • DOI

      10.1186/s12860-019-0240-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A comparison of machine learning classifiers for dementia with Lewy bodies using miRNA expression data2019

    • Author(s)
      Shigemizu Daichi、Akiyama Shintaro、Asanomi Yuya、Boroevich Keith A.、Sharma Alok、Tsunoda Tatsuhiko、Sakurai Takashi、Ozaki Kouichi、Ochiya Takahiro、Niida Shumpei
    • Journal Title

      BMC Medical Genomics

      Volume: 12 Issue: 1 Pages: 150-150

    • DOI

      10.1186/s12920-019-0607-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] DeepInsight: A methodology to transform a non-image data to an image for convolution neural network architecture2019

    • Author(s)
      Sharma Alok、Vans Edwin、Shigemizu Daichi、Boroevich Keith A.、Tsunoda Tatsuhiko
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 11399-11399

    • DOI

      10.1038/s41598-019-47765-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Brain wave classification using long short-term memory network based OPTICAL predictor2019

    • Author(s)
      Kumar Shiu、Sharma Alok、Tsunoda Tatsuhiko
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1

    • DOI

      10.1038/s41598-019-45605-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] HseSUMO: Sumoylation site prediction using half-sphere exposures of amino acids residues2019

    • Author(s)
      Sharma Alok、Lysenko Artem、L?pez Yosvany、Dehzangi Abdollah、Sharma Ronesh、Reddy Hamendra、Sattar Abdul、Tsunoda Tatsuhiko
    • Journal Title

      BMC Genomics

      Volume: 19 Issue: S9 Pages: 1-7

    • DOI

      10.1186/s12864-018-5206-8

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] EvolStruct-Phogly: incorporating structural properties and evolutionary information from profile bigrams for the phosphoglycerylation prediction2019

    • Author(s)
      Chandra Abel Avitesh、Sharma Alok、Dehzangi Abdollah、Tsunoda Tatushiko
    • Journal Title

      BMC Genomics

      Volume: 19 Issue: S9 Pages: 984-984

    • DOI

      10.1186/s12864-018-5383-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Risk prediction models for dementia constructed by supervised principal component analysis using miRNA expression data2019

    • Author(s)
      Shigemizu D, Akiyama S, Asanomi Y, Boroevich KA, Sharma A, Tsunoda T, Matsukuma K, Ichikawa M, Sudo H, Takizawa S, Sakurai T, Ozaki K, Ochiya T, Niida S.
    • Journal Title

      Communication Biology

      Volume: 2 Issue: 1 Pages: 77-77

    • DOI

      10.1038/s42003-019-0324-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Block HSIC Lasso: model-free biomarker detection for ultra-high dimensional data2019

    • Author(s)
      Climente-Gonzlez Hctor、Azencott Chlo-Agathe、Kaski Samuel、Yamada Makoto
    • Journal Title

      Bioinformatics

      Volume: 35 Issue: 14 Pages: i427-i435

    • DOI

      10.1093/bioinformatics/btz333

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] compound.Cox: univariate feature selection and compound covariate for predicting survival2019

    • Author(s)
      Emura T, Matsui S, Chen HY.
    • Journal Title

      Computer Methods and Programs in Biomedicine

      Volume: 168 Pages: 21-37

    • DOI

      10.1016/j.cmpb.2018.10.020

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Robust sample-specific stability selection with effective reror control2019

    • Author(s)
      Park H, Yamada M, Imoto S, Miyano S
    • Journal Title

      J Comput Biol

      Volume: 26(3) Issue: 3 Pages: 202-217

    • DOI

      10.1089/cmb.2018.0180

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Discovering MoRFs by trisecting intrinsically disordered protein sequence into terminals and middle regions2019

    • Author(s)
      Sharma Ronesh、Sharma Alok、Patil Ashwini、Tsunoda Tatsuhiko
    • Journal Title

      BMC Bioinformatics

      Volume: 19 Issue: S13

    • DOI

      10.1186/s12859-018-2396-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] GlyStruct: glycation prediction using structural properties of amino acid residues2019

    • Author(s)
      Reddy Hamendra Manhar、Sharma Alok、Dehzangi Abdollah、Shigemizu Daichi、Chandra Abel Avitesh、Tsunoda Tatushiko
    • Journal Title

      BMC Bioinformatics

      Volume: 19 Issue: S13

    • DOI

      10.1186/s12859-018-2547-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Navigating the disease landscape: knowledge representations for contextualizing molecular signatures.2018

    • Author(s)
      Mansoor Saqi, Artem Lysenko, Yi-Ke Guo, Tatsuhiko Tsunoda, Charles Auffray
    • Journal Title

      Briefings In Bioinformatics

      Volume: - Issue: 2 Pages: 609-623

    • DOI

      10.1093/bib/bby025

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Exploring predictive biomarkers from clinical genome-wide association studies via multidimensional hierarchical mixture models2018

    • Author(s)
      Otani Takahiro、Noma Hisashi、Sugasawa Shonosuke、Kuchiba Aya、Goto Atsushi、Yamaji Taiki、Kochi Yuta、Iwasaki Motoki、Matsui Shigeyuki、Tsunoda Tatsuhiko
    • Journal Title

      European Journal of Human Genetics

      Volume: 27 Issue: 1 Pages: 140

    • DOI

      10.1038/s41431-018-0251-y

    • NAID

      120006628002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Power and sample size calculation incorporating misspecifications of the variance function in comparative clinical trials with over-dispersed count data2018

    • Author(s)
      Igeta M, Takahashi K, Matsui S.
    • Journal Title

      Biometrics

      Volume: 印刷中 Issue: 4 Pages: 1459-1467

    • DOI

      10.1111/biom.12878

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Empirical Bayes estimation of semi-parametric hierarchical mixture models for unbiased characterization of polygenic disease architectures2018

    • Author(s)
      Nishino J, Kochi Y, Shigemizu D, Kato M, Ikari K, Ochi H, Noma H, Matsui K, Morizono T, Boroevich K, Tsunoda T, Matsui S.
    • Journal Title

      Frontiers in Genetics

      Volume: 9 Pages: 115-115

    • DOI

      10.3389/fgene.2018.00115

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sample Size for Successful Genome-Wide Association Study of Major Depressive Disorder2018

    • Author(s)
      Nishino Jo、Ochi Hidenori、Kochi Yuta、Tsunoda Tatsuhiko、Matsui Shigeyuki
    • Journal Title

      Frontiers in Genetics

      Volume: 9

    • DOI

      10.3389/fgene.2018.00227

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Re-assessment of multiple testing strategies for more efficient genome-wide association studies2018

    • Author(s)
      Otani, T., Noma, H., Nishino, J., Matsui, S.
    • Journal Title

      European Journal of Human Genetics

      Volume: 26 Issue: 7 Pages: 1038-1048

    • DOI

      10.1038/s41431-018-0125-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treatment of patients with sepsis in a closed intensive care unit is associated with improved survival: a nationwide observational study in Japan2018

    • Author(s)
      Ogura Takayuki、Nakamura Yoshihiko、Takahashi Kunihiko、Nishida Kazuki、Kobashi Daisuke、Matsui Shigeyuki
    • Journal Title

      Journal of Intensive Care

      Volume: 6 Issue: 1

    • DOI

      10.1186/s40560-018-0322-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multiple-cluster detection test for purely temporal disease clustering: Integration of scan statistics and generalized linear models2018

    • Author(s)
      Takahashi Kunihiko、Shimadzu Hideyasu
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 11 Pages: e0207821-e0207821

    • DOI

      10.1371/journal.pone.0207821

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An integrative machine learning approach for prediction of toxicity-related drug safety2018

    • Author(s)
      Lysenko Artem、Sharma Alok、Boroevich Keith A、Tsunoda Tatsuhiko
    • Journal Title

      Life Science Alliance

      Volume: 1 Issue: 6 Pages: 1-14

    • DOI

      10.26508/lsa.201800098

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] PhoglyStruct: Prediction of phosphoglycerylated lysine residues using structural properties of amino acids2018

    • Author(s)
      Chandra Abel、Sharma Alok、Dehzangi Abdollah、Ranganathan Shoba、Jokhan Anjeela、Chou Kuo-Chen、Tsunoda Tatsuhiko
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 17923-17923

    • DOI

      10.1038/s41598-018-36203-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IMSindel: An accurate intermediate-size indel detection tool incorporating de novo assembly and gapped global-local alignment with split read analysis2018

    • Author(s)
      Shigemizu Daichi、Miya Fuyuki、Akiyama Shintaro、Okuda Shujiro、Boroevich Keith A、Fujimoto Akihiro、Nakagawa Hidewaki、Ozaki Kouichi、Niida Shumpei、Kanemura Yonehiro、Okamoto Nobuhiko、Saitoh Shinji、Kato Mitsuhiro、Yamasaki Mami、Matsunaga Tatsuo、Mutai Hideki、Kosaki Kenjiro、Tsunoda Tatsuhiko
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 5608-5608

    • DOI

      10.1038/s41598-018-23978-z

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Improving succinylation prediction accuracy by incorporating the secondary structure via helix, strand and coil, and evolutionary information from profile bigrams2018

    • Author(s)
      Dehzangi Abdollah、Lopez Yosvany、Lal Sunil Pranit、Taherzadeh Ghazaleh、Sattar Abdul、Tsunoda Tatsuhiko、Sharma Alok
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 2 Pages: e0191900-e0191900

    • DOI

      10.1371/journal.pone.0191900

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Success: evolutionary and structural properties of amino acids prove effective for succinylation site prediction2018

    • Author(s)
      Lopez Yosvany、Sharma Alok、Dehzangi Abdollah、Lal Sunil Pranit、Taherzadeh Ghazaleh、Sattar Abdul、Tsunoda Tatsuhiko
    • Journal Title

      BMC Genomics

      Volume: 19(Suppl 1) Issue: S1 Pages: 923-923

    • DOI

      10.1186/s12864-017-4336-8

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] OPAL: prediction of MoRF regions in intrinsically disordered protein sequences2018

    • Author(s)
      Sharma Ronesh、Raicar Gaurav、Tsunoda Tatsuhiko、Patil Ashwini、Sharma Alok
    • Journal Title

      Bioinformatics

      Volume: 34 Issue: 11 Pages: 1850-1858

    • DOI

      10.1093/bioinformatics/bty032

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] SumSec: Accurate Prediction of Sumoylation Sites Using Predicted Secondary Structure2018

    • Author(s)
      Dehzangi Abdollah、Lopez Yosvany、Taherzadeh Ghazaleh、Sharma Alok、Tsunoda Tatsuhiko
    • Journal Title

      Molecules

      Volume: 23 Issue: 12 Pages: 3260-3260

    • DOI

      10.3390/molecules23123260

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] MoRFPred-plus: Computational Identification of MoRFs in Protein Sequences using Physicochemical Properties and HMM profiles2018

    • Author(s)
      Sharma Ronesh、Bayarjargal Maitsetseg、Tsunoda Tatsuhiko、Patil Ashwini、Sharma Alok
    • Journal Title

      Journal of Theoretical Biology

      Volume: 437 Pages: 9-16

    • DOI

      10.1016/j.jtbi.2017.10.015

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Estimation of the average causal effect vis multiple propensity score stratification2018

    • Author(s)
      Nomura T, Hattori S
    • Journal Title

      Communications in Statistics, Simulation and Computation

      Volume: 47 Issue: 1 Pages: 48-62

    • DOI

      10.1080/03610918.2016.1208230

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Goodness-of-fit test for the parametric proportional hazard regression model with interval-censored data2018

    • Author(s)
      Sakurai Rieko、Hattori Satoshi
    • Journal Title

      Biostatistics & Epidemiology

      Volume: 2 Issue: 1 Pages: 115-131

    • DOI

      10.1080/24709360.2018.1529347

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] B-スプライン及びAdaptive Group LASSOに基づく正則化非線形ロジットモデルによるデフォルト確率の推定2018

    • Author(s)
      高部勲, 山下智志
    • Journal Title

      統計数理

      Volume: 66 Pages: 295-317

    • NAID

      120006727398

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Empirical Bayes estimation of semi-parametric hierarchical mixture models for unbiased characterization of polygenic disease architectures2018

    • Author(s)
      Nishino J, Kochi Y, Shigemizu D, Kato M, Ikari K, Ochi H, Noma H, Matsui K, Morizono T, Boroevich K, Tsunoda T, Matsui S.
    • Journal Title

      Frontiers in Genetics

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] オミクス研究における検証的解析と探索的解析:多重検定とP値を中心に2018

    • Author(s)
      松井茂之
    • Journal Title

      計量生物学

      Volume: 38 Pages: 127-139

    • NAID

      130006742188

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of administration of ramelteon, a melatonin receptor agonist, on the duration of stay in the ICU: A single-center randomized placebo-controlled trial2018

    • Author(s)
      Nishikimi M, Numaguchi A, Takahashi K, Miyagawa Y, Matsui K, Higashi M, Makishi G, Matsui S, Matsuda N
    • Journal Title

      Critical Care Medicine

      Volume: 印刷中 Issue: 7 Pages: 1099-1105

    • DOI

      10.1097/ccm.0000000000003132

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two-stage approach based on zone and dose findings for two-agent combination phase I/II trials2018

    • Author(s)
      Shimamura F, Hamada C, Matsui S, Hirakawa A
    • Journal Title

      Journal of Biopharmaceutical Statistics

      Volume: 印刷中 Issue: 6 Pages: 999-999

    • DOI

      10.1080/10543406.2018.1434190

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A dose-response meta-analysis to coffee consumption and colorectal cancer risk in the Japanese population: Application of a cubic-spline model2018

    • Author(s)
      Horisaki K, Takahashi K, Ito H, Matsui S
    • Journal Title

      Journal of Epidemiology

      Volume: 印刷中

    • NAID

      130007534681

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biomarker-stratified phase III clinical trials: Enhancement with a subgroup-focused sequential design2018

    • Author(s)
      Matsui S, Crowley J
    • Journal Title

      Clin Cancer Res

      Volume: 24 Issue: 5 Pages: 994-1001

    • DOI

      10.1158/1078-0432.ccr-17-1552

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Multi-subgroup gene screening using semi-parametric hierarchical mixture models and the optimal discovery procedure: Application to a randomized clinical trial in multiple myeloma2018

    • Author(s)
      Matsui S, Noma H, Qu P, Sakai Y, Matsui K, Heuck C, Crowley J
    • Journal Title

      Biometrics

      Volume: 74 Issue: 1 Pages: 313-320

    • DOI

      10.1111/biom.12716

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Sensitivity analysis for publication bias of diagnostic studies for a continuous biomarker2018

    • Author(s)
      Hattori S, Zhou XH
    • Journal Title

      Statistics in Medicine

      Volume: 37 Issue: 3 Pages: 327-342

    • DOI

      10.1002/sim.7510

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Personalized dynamic prediction of death according to tumour progression2017

    • Author(s)
      Emura T, Nakatochi M, Matsui S, Michimae H, Rondeau V.
    • Journal Title

      Statistical Methods in Medical Research

      Volume: In press Issue: 9 Pages: 2842-2858

    • DOI

      10.1177/0962280216688032

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] An efficient and flexible test for rare variant effects2017

    • Author(s)
      Sugasawa, S., Noma, H., Otani, T., Nishino, J. and Matsui, S.
    • Journal Title

      European Journal of Human Genetics

      Volume: 印刷中 Issue: 6 Pages: 19-35

    • DOI

      10.1038/ejhg.2017.43

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correcting estimation bias in randomized clinical trials with a test of treatment-by-biomarker interaction2017

    • Author(s)
      Toyoizumi K, Matsui S
    • Journal Title

      Statistics in Biopharmaceutical Research

      Volume: 9 Issue: 2 Pages: 172-179

    • DOI

      10.1080/19466315.2016.1255252

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatial analysis for regional behavior of patients with mental disorders in Japan2017

    • Author(s)
      Takahashi K, Tachimori H, Kan C, Nishi D, Okumura Y, Kato N, Takeshima T
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 71 Issue: 4 Pages: 254-261

    • DOI

      10.1111/pcn.12488

    • NAID

      120006328987

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epidemiology of overdose episodes from the period prior to hospitalization for drug poisoning until discharge in Japan: An exploratory descriptive study using a nationwide claims database2017

    • Author(s)
      Okumura Y, Sakata N, Takahashi K, Nishi D, Tachimori H
    • Journal Title

      Journal of Epidemiology

      Volume: 27 Issue: 8 Pages: 373-380

    • DOI

      10.1016/j.je.2016.08.010

    • NAID

      130005906915

    • ISSN
      0917-5040, 1349-9092
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 2D-EM clustering approach for high-dimensional data through folding feature vectors2017

    • Author(s)
      Sharma A, Kamola PJ, Tsunoda T
    • Journal Title

      BMC Bioinformatics

      Volume: 18 Issue: S16 Pages: 547-547

    • DOI

      10.1186/s12859-017-1970-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Divisive hierarchical maximum likelihood clustering2017

    • Author(s)
      Sharma A, Lopez Y, Tsunoda T
    • Journal Title

      BMC Bioinformatics

      Volume: 18 Issue: S16 Pages: 546-546

    • DOI

      10.1186/s12859-017-1965-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Arete - candidate gene prioritization using biological network topology with additional evidence types2017

    • Author(s)
      Lysenko A, Boroevich KA, Tsunoda T
    • Journal Title

      BioData Mining

      Volume: 10 Issue: 1 Pages: 22-22

    • DOI

      10.1186/s13040-017-0141-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The prediction models for postoperative overall survival and disease-free survival in patients with breast cancer2017

    • Author(s)
      Shigemizu Daichi、Iwase Takuji、Yoshimoto Masataka、Suzuki Yasuyo、Miya Fuyuki、Boroevich Keith A、Katagiri Toyomasa、Zembutsu Hitoshi、Tsunoda Tatsuhiko
    • Journal Title

      Cancer Medicine

      Volume: 6 Issue: 7 Pages: 1627-1638

    • DOI

      10.1002/cam4.1092

    • NAID

      120006894608

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Meta-analysis of prognostic studies evaluating time-dependent diagnostic and predictive capacities of biomarkers2017

    • Author(s)
      Hattori S, Zhou XH
    • Journal Title

      Frontiers of Biostatistical Methods and Applications in Clinical Oncology (Matsui S. and Crowley J. J., editors), Springer Monograph

      Volume: - Pages: 257-276

    • DOI

      10.1007/978-981-10-0126-0_16

    • ISBN
      9789811001246, 9789811001260
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Phase III clinical trial designs incorporating predictive biomarkers: an overview2017

    • Author(s)
      Matsui S
    • Journal Title

      Frontiers of Biostatistical Methods and Applications in Clinical Oncology (Matsui S. and Crowley J. J., editors), Springer Monograph

      Volume: - Pages: 85-104

    • DOI

      10.1007/978-981-10-0126-0_7

    • ISBN
      9789811001246, 9789811001260
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Efficient study designs and semiparametric inference methods for developing genomic biomarkers in cancer clinical research2017

    • Author(s)
      Noma H
    • Journal Title

      Frontiers of Biostatistical Methods and Applications in Clinical Oncology (Matsui S. and Crowley J. J., editors), Springer Monograph

      Volume: - Pages: 381-400

    • DOI

      10.1007/978-981-10-0126-0_23

    • ISBN
      9789811001246, 9789811001260
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Hierarchical Maximum Likelihood Clustering Approach.2017

    • Author(s)
      Sharma A, Boroevich KA, Shigemizu D, Kamatani Y, Kubo M, Tsunoda T.
    • Journal Title

      IEEE Transactions on Biomedical Engineering

      Volume: 64 Issue: 1 Pages: 112-122

    • DOI

      10.1109/tbme.2016.2542212

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Doubly robust estimators for net survival rates in analyses of cancer registry data2017

    • Author(s)
      Komukai S, Hattori S
    • Journal Title

      Biometrics

      Volume: 73 Issue: 1 Pages: 124-133

    • DOI

      10.1111/biom.12568

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] CAST: a new score for early prediction of neurological outcomes after cardiac arrest before therapeutic hypothermia with high accuracy.2016

    • Author(s)
      Nishikimi M, Matsuda N, Matsui K, Takahashi K, Ejima T, Liu K, Ogura T,
    • Journal Title

      Intensive Care Med.

      Volume: 42 Issue: 12 Pages: 2106-2107

    • DOI

      10.1007/s00134-016-4492-3

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genome-wide DNA Copy-number Analysis in ACTS-CC Trial of Adjuvant Chemotherapy for Stage III Colonic Cancer.2016

    • Author(s)
      Ishikawa T, Uetake H, Murotani K, Kobunai T, Ishiguro M, Matsui S, Sugihara K.
    • Journal Title

      Anticancer Res.

      Volume: 36 Pages: 853-860

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stepwise iterative maximum likelihood clustering approach2016

    • Author(s)
      Alok Sharma, Daichi Shigemizu, Keith A. Boroevich, Yosvany Lopez, Yoichiro Kamatani, Michiaki Kubo, Tatsuhiko Tsunoda
    • Journal Title

      BMC Bioinformatics

      Volume: 17 Issue: 1 Pages: 319-319

    • DOI

      10.1186/s12859-016-1184-5

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Time-dependent summary receiver operating characteristics for meta-analyses of prognostic studies2016

    • Author(s)
      Hattori S and Zhou XH
    • Journal Title

      Statistics in Medicine

      Volume: 35 Issue: 26 Pages: 4746-4763

    • DOI

      10.1002/sim.7029

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Evaluation of predictive capacities of biomarkers based on research synthesis.2016

    • Author(s)
      Hattori S and Zhou XH
    • Journal Title

      Statistics in Medicine

      Volume: 35 Issue: 25 Pages: 4559-4572

    • DOI

      10.1002/sim.7018

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Meta-analysis of prognostic studies for a biomarker with a study-specific cutoff value2016

    • Author(s)
      Sadashima E, Hattori S, Takahashi K
    • Journal Title

      Research Synthesis Methods

      Volume: 00 Issue: 4 Pages: 00-00

    • DOI

      10.1002/jrsm.1201

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] AI医療技術の検証に向けて:現状と課題2021

    • Author(s)
      松井茂之
    • Organizer
      IBISML 電子情報通信学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 脳画像を用いた疾患関連解析における神経学的,機能的領域を考慮した多重検定2020

    • Author(s)
      江本 遼, 松井茂之
    • Organizer
      2020年度統計関連学会連合大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 重み付き尤度関数を用いた治療効果のバイアス補正2020

    • Author(s)
      豊泉樹一郎, 松井茂之
    • Organizer
      2020年度統計関連学会連合大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Incorporating follow-up lengths in sample size re-estimation to compare over-dispersed count data.2020

    • Author(s)
      Masataka Igeta, Shigeyuki Matsui
    • Organizer
      ISCB 2020 International Society of Clinical Biostatistics
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Topological Bayesian optimization with persistence diagrams2020

    • Author(s)
      Tatsuya Shiraishi, Tam Le, Hisashi Kashima, Makoto Yamada
    • Organizer
      ECAI 2020 24th European Conference on Artificial Intelligence
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] More powerful selective kernel tests for feature selection2020

    • Author(s)
      Jen Ning Lim, Makoto Yamada, Wittawat Jitkrittum, Yoshikazu Terada, Shigeyuki Matsui, Hidetoshi Shimodaira
    • Organizer
      AISTAT2020 International Conference on Artificial Intelligence and Statistics
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sparse Hilbert-Schmidt independence criterion regression2020

    • Author(s)
      Benjamin Poignard, Makoto Yamada
    • Organizer
      AISTAT2020 International Conference on Artificial Intelligence and Statistics
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Unsupervised nonlinear feature selection from high-dimensional signed networks2020

    • Author(s)
      Qiang Huang, Tingyu Xia, Huiyan Sun, Makoto Yamada, Y. Chang
    • Organizer
      34th AAAI Conference on Artificial Intelligence
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] New directions in statistical methodology for precision medicine clinical studies.2020

    • Author(s)
      Shigeyuki Matsui
    • Organizer
      Royal Statistical Society North Eastern Local Group Seminar
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Personalized Cancer Medicine with Heterogeneity and Immunological Analysis.2020

    • Author(s)
      Tatsuhiko Tsunoda
    • Organizer
      CREST International Symposium on Big Data Application
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Unsupervised Nonlinear Feature Selection from High-dimensional Signed Networks.2020

    • Author(s)
      Qiang Huang, Tingyu Xia, Huiyan Sun, Makoto Yamada, Y. Chang
    • Organizer
      34th AAAI Conference on Artificial Intelligence (AAAI)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A model-based framework for voxel and region level inferences in neuroimaging disease-association studies.2019

    • Author(s)
      Ryo Emoto, Atsushi Kawaguchi, Takahiro Otani, Shigeyuki Matsui
    • Organizer
      16th International Conference on Information Technology : New Generations (ITNG 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Application of the multi-dimensional hierarchical mixture model to cross-disorder genome-wide association studies.2019

    • Author(s)
      Takahiro Otani, Jo Nishino, Ryo Emoto, Shigeyuki Matsui
    • Organizer
      16th International Conference on Information Technology: New Generations (ITNG 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] オミクス関連解析における選択マーカー数を固定した二段階スクリーニング法.2019

    • Author(s)
      川端 孝典,江本 遼,西野 穣,高橋 邦彦,松井 茂之
    • Organizer
      日本計量生物学会2019年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ゲノムワイド関連研究におけるセミパラメトリックベイズ因子解析.2019

    • Author(s)
      森澤 淳司,大谷 隆浩,西野 穣,高橋 邦彦,松井 茂之
    • Organizer
      日本計量生物学会2019年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Blinded Sample Size Re-estimation with Over-Dispersed Count Data under Incorrect Specification of the Working Variance Function.2019

    • Author(s)
      Masataka Igeta, Shigeyuki Matsui
    • Organizer
      Annual Meeting, Western North American Region of The International Biometric Society
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Screening Fixed Numbers of Genomic Features for Validation Studies Incorporating Statistical and Biological Consideration.2019

    • Author(s)
      Takanori Kawabata, Ryo Emoto, Jo Nishino, Kunihiko Takahashi, Shigeyuki Matsui
    • Organizer
      Annual Meeting, Western North American Region of The International Biometric Society
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Bias-Correction in Estimating Treatment Effect in Fallback Analysis: An Approach Based on Randomized Test with Smooth Rejection Functions.2019

    • Author(s)
      Kiichiro Toyoizumi, Shigeyuki Matsui
    • Organizer
      Joint Statistical Meeting 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Data-driven Medical Sciences with Omic Analysis.2019

    • Author(s)
      Tatsuhiko Tsunoda
    • Organizer
      Moonshot International Symposium 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Kernel Stein Tests for Multiple Model Comparison.2019

    • Author(s)
      Jen Ning Lim, Makoto Yamada, Bernhard Schölkopf, Wittawat Jitkrittum
    • Organizer
      NeurIPS 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Approximation Ratios of Graph Neural Networks for Combinatorial Problems2019

    • Author(s)
      Ryoma Sato, Makoto Yamada, Hisashi Kashima
    • Organizer
      NeurIPS 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Learning to Sample Hard Instances for Graph Algorithms.2019

    • Author(s)
      Ryoma Sato, Makoto Yamada, Hisashi Kashima
    • Organizer
      ACML 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Post Selection Inference with Incomplete Maximum Mean Discrepancy Estimator.2019

    • Author(s)
      Makoto Yamada, Denny Wu, Yao-Hung Hubert Tsai, Hirofumi Ohta, Ruslan Salakhutdinov, Ichiro Takeuchi, Kenji Fukumizu
    • Organizer
      ICLR 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Factorization Machinesを用いたCoxハザードモデル.2019

    • Author(s)
      佐竹 哉太, 山田 誠, 松井 孝太, 松井 茂之, 鹿島 久嗣
    • Organizer
      2019年度人工知能学会全国大会(第33回).
    • Related Report
      2019 Annual Research Report
  • [Presentation] Bayesian sensitivity analysis for publication bias in meta-analysis of diagnostic studies.2019

    • Author(s)
      Satoshi Hattori
    • Organizer
      The 3rd International Conference on Econometrics and Statistics (EcoSta 2019).
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 要約concordance indexによる予後因子研究のメタアナリシス.2019

    • Author(s)
      服部聡
    • Organizer
      2019年統計関連学会連合大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 臨床試験登録システムを用いたCopas選択モデルの推測.2019

    • Author(s)
      黄傲、小向翔、服部聡
    • Organizer
      2019年統計関連学会連合大会.
    • Related Report
      2019 Annual Research Report
  • [Presentation] Multiple testing and estimation of disease associations based on semi-parametric hierarchical mixture models, possibly incorporating brain areas.2019

    • Author(s)
      Ryo Emoto, Takahiro Otani, Shigeyuki Matsui
    • Organizer
      Eastern North American Region International Biometric Society 2019 Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Blinded sample size re-estimation in comparative clinical trials with over-dispersed count data: Incorporation of misspecification of the variance function.2019

    • Author(s)
      Masataka Igeta, Shigeyuki Matsui
    • Organizer
      Eastern North American Region International Biometric Society 2019 Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Phase III Clinical trial design for targeted therapies with uncertain biomarker evidence: controversies and solutions2018

    • Author(s)
      Shigeyuki Matsui
    • Organizer
      OHSU Cancer Biostatistics Workshop
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生物・医学分野の新たな展開:データを中心とした拡がり/繋がり2018

    • Author(s)
      松井茂之
    • Organizer
      2018年度統計関連学会連合大会日本計量生物学会シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Trans-omic Analysis strategy for precision medicine.2018

    • Author(s)
      Tatsuhiko Tsunoda
    • Organizer
      The 2nd International Symposium for Trans-Omics
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Omic big data analysis drives precision medicine.2018

    • Author(s)
      Tatsuhiko Tsunoda
    • Organizer
      The 8th Annual Translational Bioinformatics Conference/2018 Annual Conference of Korean Society for Bioinformatics
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Public big data accelerate medical science research.2018

    • Author(s)
      Tatsuhiko Tsunoda
    • Organizer
      The 63rd Annual Meeting of the Japan Society of Human Genetics.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Sensitivity analysis for publication bias in meta-analysis of diagnostic studies for a continuous biomarker.2018

    • Author(s)
      Satoshi Hattori
    • Organizer
      The 2nd International Conference on Econometrics and Statistics (EcoSta2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] AIと機械学習の直感的理解と金融への応用.2018

    • Author(s)
      山下智志
    • Organizer
      日本銀行金融機構局金融高度化センターWS
    • Related Report
      2018 Annual Research Report
  • [Presentation] 信用リスクの基礎,応用,最近の話題.2018

    • Author(s)
      山下智志
    • Organizer
      国際協力銀行信用リスクセミナー
    • Related Report
      2018 Annual Research Report
  • [Presentation] Hierarchical mixture modeling for multiple testing and effect size estimation in voxel-level inference of neuroimaging data2018

    • Author(s)
      Ryo Emoto, Atsushi Kawaguchi, Hisako Yoshida, Shigeyuki Matsui
    • Organizer
      Joint Statistical Meeting 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Bias-corrected estimation of treatment effects in biomarker-based adaptive subgroup analysis: New approach based on randomized tests with smooth rejection function.2018

    • Author(s)
      Kiichiro Toyoizumi, Shigeyuki Matsui
    • Organizer
      Joint Statistical Meeting 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Two-stage analysis for selecting fixed numbers of features in omics association studies.2018

    • Author(s)
      Takanori Kawabata, Ryo Emoto, Jo Nishino J, Kunihiko Takahashi, Shigeyuki Matsui
    • Organizer
      XXIX International Biometric Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A transfer learning method for multi-center prognostic prediction analysis.2018

    • Author(s)
      Kota Matsui, Kenta Kanamori, Wataru Kumagai, Mitsuaki Nishikimi, Shigeyuki Matsui
    • Organizer
      3rd International Workshop on Biomedical Informatics with Optimization and Machine Learning in conjunction with 27th International Joint Conference on Artificial Intelligence (IJCAI 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Multiple Testing Based on Semi-Parametric Hierarchical Mixture Models under Dependency in Disease-Association Studies with Neuroimaging Data2018

    • Author(s)
      Ryo Emoto, Atsushi Kawaguchi, Hisako Yoshida, Shigeyuki Matsui
    • Organizer
      Eastern North American Region International Biometric Society 2018 Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluating Sample Sizes in Comparing Over-Dispersed Count Data Under Incorrect Variance Structure2018

    • Author(s)
      Masataka Igeta, Kunihiko Takahashi and Shigeyuki Matsui
    • Organizer
      Eastern North American Region International Biometric Society 2018 Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 治療効果予測マーカーを用いた第三相試験: マーカー層別デザインの改良2018

    • Author(s)
      松井茂之, John Crowley
    • Organizer
      2018年日本計量生物学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 日本人におけるコーヒー摂取量と大腸がん発生リスクの用量反応関係メタアナリシス2018

    • Author(s)
      堀崎健,高橋邦彦,伊藤秀美,松井茂之
    • Organizer
      第28回日本疫学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Prognostic impact of MSI in stage II colon cancers: An additional translational study of the SACURA trial2017

    • Author(s)
      Ishikawa T, Ishiguro M, Nakatani E, Uetake H, Ueno H, Murotani K, Matsui S, Tomita N, Shimada Y, Takahashi K, Kotake K, Watanabe M, Mochizuki H, Teramukai S, Sugihara K
    • Organizer
      American Society of Clinical Oncology (ASCO) 2017 Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Prognostic impact of tumor budding in Stage II colon cancer: A Prospective study (SACURA trial).2017

    • Author(s)
      Ueno H, Ishiguro M, Nakatani E, Ishikawa T, Uetake H, Murotani K, Matsui S, Tomita N, Shimada Y, Takahashi K, Kotake K, Watanabe M, Mochizuki H, Tramukai S, Sugihara K
    • Organizer
      American Society of Clinical Oncology (ASCO) 2017 Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Omics 研究における検証的解析と探索的解析2017

    • Author(s)
      松井茂之
    • Organizer
      2017年度統計関連学会連合大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Two-level simple recourse programming problems with discrete random variables2017

    • Author(s)
      Hitoshi Yano, Ichiro Nishizaki, Kota Matsui
    • Organizer
      Modeling Decisions for Artificial Intelligence (MDAI).
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Exploring etiologies, sub-classification, and risk prediction of diseases based on big-data analysis of clinical and whole omics data in medicine2017

    • Author(s)
      Tatsuhiko Tsunoda
    • Organizer
      CREST Big Data Fields Joint Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Trans-omic analysis drives precision medicine2017

    • Author(s)
      Tatsuhiko Tsunoda
    • Organizer
      The 1st International Symposium for Trans-Omics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Multi-omic analysis for precision cancer medicine2017

    • Author(s)
      Tatsuhiko Tsunoda
    • Organizer
      DNA sequencing technologies and their application in practice WS
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Omic analysis drives precision medicine2017

    • Author(s)
      Tatsuhiko Tsunoda
    • Organizer
      International Conference for Precision Cancer Medicine 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Multiomics and clinical analysis of cancer2017

    • Author(s)
      Tatsuhiko Tsunoda
    • Organizer
      CREST International Symposium on Big Data Application 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 医学・医療ビッグデータによるマルチオミックス解析2017

    • Author(s)
      角田達彦
    • Organizer
      東京医科歯科大学‐早稲田大学連携ワークショップ
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ゲノムビッグデータと人工知能による未来の医療2017

    • Author(s)
      角田達彦
    • Organizer
      市民公開講座 2017
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Issue of selection bias in statistical analysis of observational studies2017

    • Author(s)
      服部聡
    • Organizer
      日本循環器学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Doubly robust estimator for net survival rate in analyses of cancer registry data2017

    • Author(s)
      Satoshi Hattori
    • Organizer
      EcoSta2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 時間依存性要約ROC 解析によるバイオマーカーの評価2017

    • Author(s)
      服部聡
    • Organizer
      日本計算機統計学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Time-dependent summary ROC analysis for meta-analysis of prognostic studies2017

    • Author(s)
      Satoshi Hattori
    • Organizer
      CMstatistics2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 国際ミクロ統計データベースの整備と利用2017

    • Author(s)
      岡本基, 山下智志
    • Organizer
      統計関連学会連合大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 多項ロジットモデル及び主成分分析を用いた統計的マッチング手法の提案2017

    • Author(s)
      高部勲, 山下智志
    • Organizer
      統計関連学会連合大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A new statistical matching methodology using multinomial logistic regression and multivariate analysis2017

    • Author(s)
      Takabe I, Yamashita S
    • Organizer
      International Federation of Classification Societies
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] セミパラメトリック階層混合モデルによる複雑疾患GWASの解析 - 多遺伝因子構造の理解に向けて2017

    • Author(s)
      西野穣, 高地雄太, 重水大智, 加藤護, 猪狩勝則, 越智秀典, 野間久史, 松井孝太, 大谷隆浩, 森園隆, Keith A Boroevich, 角田達彦, 松井茂之
    • Organizer
      第27回日本疫学会学術総会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 個別化医療に向けて進化する臨床試験デザイン2017

    • Author(s)
      松井茂之
    • Organizer
      科研費シンポジウム「統計科学が切り拓く個別化医療:方法論・実践のフロンティア」
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ゲノムワイド関連解析における多重検定手法の効率性評価2017

    • Author(s)
      大谷隆浩,野間久史,西野穣,松井茂之
    • Organizer
      科研費シンポジウム「統計科学が切り拓く個別化医療:方法論・実践のフロンティア」
    • Related Report
      2016 Annual Research Report
  • [Presentation] オミックス解析によるゲノム医療の新たな展開2017

    • Author(s)
      角田達彦
    • Organizer
      科研費シンポジウム「統計科学が切り拓く個別化医療:方法論・実践のフロンティア」
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Cancer outlier analysis based on a nested two-way clustering.2016

    • Author(s)
      Oura T, Matsui K, Matsui S
    • Organizer
      XXVIIIth International Biometric Conference
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A comparison of multiple testing methods for effective strategies in genome-wide association studies2016

    • Author(s)
      Otani T, Noma H, Nishino J, Matsui K, Matsui S
    • Organizer
      XXVIIIth International Biometric Conference
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A multiple cluster detection test for disease clustering based on scan statistics2016

    • Author(s)
      Takahashi K, Shimadzu H
    • Organizer
      XXVIIIth International Biometric Conference
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Spatial epidemiology: risk assessment of spatio-temporal events2016

    • Author(s)
      Takahashi K
    • Organizer
      13th DIA JAPAN Anuual Meeting 2016
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Socioeconomic impacts of policy on Rx-to-OTC switch to prescription of wthcal drugs in Japan2016

    • Author(s)
      Shimazaki K, Takano Y, Mochizuki M, Takahashi K, Urushihara H
    • Organizer
      32rd International Conference on Pharmacoepidemiology and Therapeutic Risk Management
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 複雑疾患GWASデータのセミパラメトリック階層混合モデル解析2016

    • Author(s)
      西野穣, 高地雄太, 重水大智, 加藤護, 猪狩勝則, 越智秀典, 野間久史, 松井孝太, 森園隆, Keith A Boroevich, 角田達彦, 松井茂之
    • Organizer
      第22回国際個別化医療学会学術集会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Heterogeneous Transfer Learning Based on Sparse Coding2016

    • Author(s)
      松井孝太,熊谷亘,金森敬文
    • Organizer
      第19回情報論的学習理論ワークショップ (IBIS2016)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Exploring etiologies, sub-classification, and risk prediction of diseases based on big-data analysis of clinical and whole omics data in medicine2016

    • Author(s)
      T.Tsunoda
    • Organizer
      CREST Big Data Fields Joint Meeting 2016
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Strategies for discovering disease-associated modules in integrated biological networks2016

    • Author(s)
      A.Lysenko, P.J.Kamola, K.A.Boroevich, T.Tsunoda.
    • Organizer
      9th Annual RECOMB/ISCB Conference on Regulatory & Systems Genomics 2016
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Trans-omic analysis strategy for precision medicine2016

    • Author(s)
      T.Tsunoda
    • Organizer
      The 26th Hot Spring Harbor International Symposium - Trans-omics: New Approaches in Biology and Medicine 2016
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Exploring etiologies, sub-classification, and risk prediction of diseases based on big-data analysis of clinical and whole omics data in medicine2016

    • Author(s)
      T.Tsunoda
    • Organizer
      CREST Big Data Field Joint Symposium 2016
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 医学・医療ビッグデータ解析による個別化医療と先制医療2016

    • Author(s)
      角田達彦
    • Organizer
      日本遺伝子診療学会大会シンポジウム「遺伝統計学の基礎と臨床応用」
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] メタアナリシスに基づくバイオマーカーの予測値曲線の推定2016

    • Author(s)
      服部聡
    • Organizer
      統計関連学会連合大会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 公的統計ミクロデータ研究コンソーシアムによる高等教育研究支援2016

    • Author(s)
      山下智志, 岡本基
    • Organizer
      統計関連学会連合大会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 「国際ミクロ統計データベース」の利活用について2016

    • Author(s)
      岡本基, 山下智志
    • Organizer
      統計関連学会連合大会
    • Related Report
      2016 Annual Research Report
  • [Presentation] リスク科学と目的・データ・統計的方法論2016

    • Author(s)
      山下智志
    • Organizer
      統計関連学会連合大会
    • Related Report
      2016 Annual Research Report
  • [Presentation] A new approach of micro-data analysis through international cooperation.2016

    • Author(s)
      Satoshi Yamashita
    • Organizer
      The 8th International Workshop on Analysis of Micro Data of Official Statistics
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] Dose-Finding Designs for Early-Phase Cancer Clinical Trials: A Brief Guidebook to Theory and Practice2019

    • Author(s)
      Daimon T, Hirakawa A, Matsui S
    • Total Pages
      133
    • Publisher
      Springer
    • ISBN
      9784431555858
    • Related Report
      2019 Annual Research Report
  • [Book] Survival Analysis with Correlated Endpoints: Joint Frailty-Copula Models2019

    • Author(s)
      Emura T, Chen YH, Matsui S, Rondeau V
    • Total Pages
      118
    • Publisher
      Springer
    • ISBN
      9789811335150
    • Related Report
      2019 Annual Research Report
  • [Book] Biomarker-based phase II and III clinical trials in oncology. In Textbook of Clinical Trials in Oncology. (eds. S. Halabi and S. Michiels).2019

    • Author(s)
      Matsui S, Igeta M, Toyoizumi K
    • Total Pages
      24
    • Publisher
      CRC Press
    • ISBN
      9781315112084
    • Related Report
      2019 Annual Research Report
  • [Book] Genome-Wide Association Studies,2019

    • Author(s)
      Tsunoda T, Tanaka T, Nakamura Y
    • Total Pages
      209
    • Publisher
      Springer
    • ISBN
      9789811381775
    • Related Report
      2019 Annual Research Report
  • [Book] Subject-Specific-Frequency-Band for Motor Imagery EEG Signal Recognition Based on Common Spatial Spectral Pattern. In: Nayak A., Sharma A. (eds) PRICAI 2019: Trends in Artificial Intelligence. PRICAI 2019. Lecture Notes in Computer Science, vol 116712019

    • Author(s)
      Kumar S, Sharma A, Tsunoda T
    • Total Pages
      10
    • Publisher
      Springer
    • ISBN
      9783030299118
    • Related Report
      2019 Annual Research Report
  • [Book] Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combination and Molecularly Targeted Agents2018

    • Author(s)
      Hirakawa A, Sato H, Daimon T, Matsui S
    • Total Pages
      89
    • Publisher
      Springer
    • Related Report
      2018 Annual Research Report
  • [Book] Frontiers of Biostatistical Methods and Applications in Clinical Oncology2017

    • Author(s)
      Matsui S, Crowley J.
    • Total Pages
      438
    • Publisher
      Springer
    • ISBN
      9789811001246
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Book] Modern Dose-Finding Designs for Cancer Phase I Trials: Drug Combination and Molecularly Targeted Agents.2017

    • Author(s)
      Hirakawa A, Sato H, Daimon T, Matsui S.
    • Total Pages
      89
    • Publisher
      Springer
    • ISBN
      9784431555735
    • Related Report
      2017 Annual Research Report
  • [Remarks] 名古屋大学医学系研究科生物統計学分野

    • URL

      http://nagoya-biostat.jp/

    • Related Report
      2020 Annual Research Report
  • [Remarks] 個別化医療のための統計的方法論の構築と実践に関する総合的研究

    • URL

      http://nagoya-biostat.jp/kaken-s/

    • Related Report
      2019 Annual Research Report
  • [Remarks] 個別化医療のための統計的方法論の構築と実践に関する研究

    • URL

      http://nagoya-biostat.jp/kaken-s/

    • Related Report
      2018 Annual Research Report
  • [Remarks] 個別化医療の開発のための統計的方法論の構築とその実践に関する総合的研究

    • URL

      http://www.nagoya-biostat.jp/kaken-s/index.html

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Funded Workshop] 3rd Pacific Rim Cancer Biostatistics Workshop2019

    • Related Report
      2019 Annual Research Report
  • [Funded Workshop] Second Pacific Rim Cancer Biostatistics Workshop2017

    • Related Report
      2017 Annual Research Report

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Published: 2016-06-01   Modified: 2024-03-28  

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