Co-Investigator(Kenkyū-buntansha) |
大庭 伸介 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (20466733)
酒井 崇匡 東京大学, 大学院工学系研究科(工学部), 教授 (70456151)
北條 宏徳 東京大学, 大学院医学系研究科(医学部), 准教授 (80788422)
位高 啓史 東京大学, 大学院医学系研究科(医学部), 特任准教授 (60292926)
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Budget Amount *help |
¥164,580,000 (Direct Cost: ¥126,600,000、Indirect Cost: ¥37,980,000)
Fiscal Year 2020: ¥33,540,000 (Direct Cost: ¥25,800,000、Indirect Cost: ¥7,740,000)
Fiscal Year 2019: ¥34,840,000 (Direct Cost: ¥26,800,000、Indirect Cost: ¥8,040,000)
Fiscal Year 2018: ¥34,060,000 (Direct Cost: ¥26,200,000、Indirect Cost: ¥7,860,000)
Fiscal Year 2017: ¥26,780,000 (Direct Cost: ¥20,600,000、Indirect Cost: ¥6,180,000)
Fiscal Year 2016: ¥35,360,000 (Direct Cost: ¥27,200,000、Indirect Cost: ¥8,160,000)
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Outline of Final Research Achievements |
In this study, we aimed at development of high-performance biomaterials that enable to control signaling molecules in a spatial-temporal manner for skeletal regeneration. We identified signaling molecules for bone and cartilage regeneration, optimized a method for constructing three-dimensional artificial bones, and developed “Tetra-PEG sponge”, a novel biomaterial that functions to integrate the signaling molecules and artificial bones. The Tetra-PEG sponge has μm-scale pore structures and drug-carrier properties, which may allow the spatial regulation of drug release and cell invasion into the materials. This study provides a potential to develop a regenerative strategy by integrating the novel interface material.
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