| Budget Amount *help |
¥180,830,000 (Direct Cost: ¥139,100,000、Indirect Cost: ¥41,730,000)
Fiscal Year 2020: ¥36,790,000 (Direct Cost: ¥28,300,000、Indirect Cost: ¥8,490,000)
Fiscal Year 2019: ¥40,040,000 (Direct Cost: ¥30,800,000、Indirect Cost: ¥9,240,000)
Fiscal Year 2018: ¥35,490,000 (Direct Cost: ¥27,300,000、Indirect Cost: ¥8,190,000)
Fiscal Year 2017: ¥33,670,000 (Direct Cost: ¥25,900,000、Indirect Cost: ¥7,770,000)
Fiscal Year 2016: ¥34,840,000 (Direct Cost: ¥26,800,000、Indirect Cost: ¥8,040,000)
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| Outline of Final Research Achievements |
We have identified the functional domains that have been acquired by viruses (natural DDS (drug delivery system) nanocarriers) during the evolutionary process, such as 1) strong stealth to escape elimination by the immune system,2) high active targeting to target organs/cells, 3) efficient entry into target cells, and 4) intracytoplasmic transfer of drugs to exert their medicinal effects. We have developed novel DDS nanocarrier with these capabilities for precise in vivo spatiotemporal control of drugs. In addition, we have developed related technologies, such as efficient selection method of targeted molecules and precise presentation methods on the carrier surface.
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