Budget Amount *help |
¥184,340,000 (Direct Cost: ¥141,800,000、Indirect Cost: ¥42,540,000)
Fiscal Year 2020: ¥24,960,000 (Direct Cost: ¥19,200,000、Indirect Cost: ¥5,760,000)
Fiscal Year 2019: ¥33,800,000 (Direct Cost: ¥26,000,000、Indirect Cost: ¥7,800,000)
Fiscal Year 2018: ¥33,800,000 (Direct Cost: ¥26,000,000、Indirect Cost: ¥7,800,000)
Fiscal Year 2017: ¥37,050,000 (Direct Cost: ¥28,500,000、Indirect Cost: ¥8,550,000)
Fiscal Year 2016: ¥54,730,000 (Direct Cost: ¥42,100,000、Indirect Cost: ¥12,630,000)
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Outline of Final Research Achievements |
The project on “Studies on Chemical Synthesis of Polyketide-Derived, Biologically Active Complex Natural Products” has been performed at the total synthesis of various complex natural products derived from type-II polyketide biosynthesis. Particular focus was laid on the natural process of evolving the structure diversity and complexity, trying to gain inspiration in developing new synthetic strategies and tactics in organic synthesis. More specifically, we focused three biosynthetic processes by which molecular complexity is enhanced, 1) oxidative structure modification, 2) oligomerization, and 3) hybridization, and aimed at the realization of these complexity/diversity-generating processes in chemical synthesis. Throughout the five-year research, we have succeeded in developing several synthetic routes to some useful/interesting classes of bioactive molecules.
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