| Budget Amount *help |
¥183,170,000 (Direct Cost: ¥140,900,000、Indirect Cost: ¥42,270,000)
Fiscal Year 2020: ¥35,100,000 (Direct Cost: ¥27,000,000、Indirect Cost: ¥8,100,000)
Fiscal Year 2019: ¥38,090,000 (Direct Cost: ¥29,300,000、Indirect Cost: ¥8,790,000)
Fiscal Year 2018: ¥33,020,000 (Direct Cost: ¥25,400,000、Indirect Cost: ¥7,620,000)
Fiscal Year 2017: ¥32,110,000 (Direct Cost: ¥24,700,000、Indirect Cost: ¥7,410,000)
Fiscal Year 2016: ¥44,850,000 (Direct Cost: ¥34,500,000、Indirect Cost: ¥10,350,000)
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| Outline of Final Research Achievements |
Same-sex sexual behavior is prevalent among Drosophila males that are mutant for the fruitless (fru) locus, which, in wild type, encodes a set of transcription factors functioning as the master regulator for the formation of a neural circuit underlying male mating behavior. Recent studies unraveled that this same-sex sexual behavior in fru mutant males is inhibited by deprivation of social interactions among males after emergence, providing an opportunity to explore the gene-environment interplay in shaping complex behaviors. To seek for the possible molecular and cellular underpinnings of this gene-environment interplay, we focused on the mating decision-making neurons P1 neurons in the brain, the artificial activation of which effectively elicits male courtship even in the absence of a courtship target. In vivo whole-cell patch clamp recordings from P1 neurons revealed that K+ outward currents are markedly affected by social interactions.
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