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Integrated studies of regulation of neuronal fuction and development by kinesin superfamily motors, KIFs

Research Project

Project/Area Number 16H06372
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Neurophysiology / General neuroscience
Research InstitutionThe University of Tokyo

Principal Investigator

HIROKAWA Nobutaka  東京大学, 大学院医学系研究科(医学部), 特任教授 (20010085)

Research Collaborator TANAKA Yosuke  
HOMMA Noriko  
OGAWA Tadayuki  
Project Period (FY) 2016-05-31 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥185,770,000 (Direct Cost: ¥142,900,000、Indirect Cost: ¥42,870,000)
Fiscal Year 2018: ¥49,530,000 (Direct Cost: ¥38,100,000、Indirect Cost: ¥11,430,000)
Fiscal Year 2017: ¥52,130,000 (Direct Cost: ¥40,100,000、Indirect Cost: ¥12,030,000)
Fiscal Year 2016: ¥84,110,000 (Direct Cost: ¥64,700,000、Indirect Cost: ¥19,410,000)
Keywords分子モーター / 細胞内輸送 / 微小管 / 神経機能 / キネシン分子モーター群 / キネシンモーター分子群 / 発生制御 / 神経科学 / 脳神経機能 / 発生 / 記憶・学習 / 痛覚 / キネシン
Outline of Final Research Achievements

This project studied and elucidated following mechanisms, fundamental for the life. (1) KIFs’ function and regulation. ① regulation of motility and transportation of cargoes by phosphorylation. ② microtubule depolymerization and motility by KIF2A and KIF19A. (2) Regulation of synaptic plasticity and neuronal function. ① a) regulation of synaptic plasticity and fear conditioning by KIF21B. b) regulation of synaptic plasticity and defect of its loss by KIF3B. c) regulation of synaptic plasticity in visual system by KIFs. d) KIF17's function during memory retrieval process. ② a) KIF1A's function for pain sensation. b) KIF26A's function for regulation of pain response. (3) Regulation of development. ① regulation of brain wiring by KIF2A and its defect. ② KIF3B's new function for regulation of development.

Academic Significance and Societal Importance of the Research Achievements

KIFは、神経細胞を始め全ての細胞で細胞内輸送及び、細胞の形作りに基本的な役割を果たす。本研究は、KIFs の機能の特にリン酸化による制御、KIFによる脳の高次機能及び神経機能の制御と関連疾患、及びKIF による発生制御と関連疾患について大きな成果を上げその学術的及び社会的意義は非常に大きい。

Assessment Rating
Verification Result (Rating)

A+

Assessment Rating
Result (Rating)

A: Progress in the research is steadily towards the initial goal. Expected research results are expected.

Report

(9 results)
  • 2019 Research Progress Assessment (Verification Result) ( PDF )
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2016 Abstract ( PDF )   Comments on the Screening Results ( PDF )   Annual Research Report
  • Research Products

    (65 results)

All 2019 2018 2017 2016 Other

All Journal Article (10 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 10 results,  Open Access: 10 results,  Acknowledgement Compliant: 2 results) Presentation (46 results) (of which Int'l Joint Research: 14 results,  Invited: 13 results) Remarks (9 results)

  • [Journal Article] KIF2A regulates the development of dentate granule cells and postnatal hippocampal wiring2018

    • Author(s)
      Homma Noriko、Zhou Ruyun、Naseer Muhammad Imran、Chaudhary Adeel G、Al-Qahtani Mohammed H、Hirokawa Nobutaka
    • Journal Title

      eLife

      Volume: 7 Pages: 1-26

    • DOI

      10.7554/elife.30935

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Atypical Kinesin KIF26A Facilitates Termination of Nociceptive Responses by Sequestering Focal Adhesion Kinase2018

    • Author(s)
      Wang Li、Tanaka Yosuke、Wang Doudou、Morikawa Momo、Zhou Ruyun、Homma Noriko、Miyamoto Yuki、Hirokawa Nobutaka
    • Journal Title

      Cell Reports

      Volume: 24 Issue: 11 Pages: 2894-2907

    • DOI

      10.1016/j.celrep.2018.05.075

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Molecular Motor KIF21B Mediates Synaptic Plasticity and Fear Extinction by Terminating Rac1 Activation2018

    • Author(s)
      Morikawa Momo、Tanaka Yosuke、Cho Hyun-Soo、Yoshihara Masaharu、Hirokawa Nobutaka
    • Journal Title

      Cell Reports

      Volume: 23 Issue: 13 Pages: 3864-3877

    • DOI

      10.1016/j.celrep.2018.05.089

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] KIF1Bβ mutations detected in hereditary neuropathy impair IGF1R transport and axon growth2018

    • Author(s)
      Xu Fang、Takahashi Hironori、Tanaka Yosuke、Ichinose Sotaro、Niwa Shinsuke、Wicklund Matthew P.、Hirokawa Nobutaka
    • Journal Title

      The Journal of Cell Biology

      Volume: 217 Issue: 10 Pages: 3480-3496

    • DOI

      10.1083/jcb.201801085

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport2018

    • Author(s)
      Shima Tomohiro、Morikawa Manatsu、Kaneshiro Junichi、Kambara Taketoshi、Kamimura Shinji、Yagi Toshiki、Iwamoto Hiroyuki、Uemura Sotaro、Shigematsu Hideki、Shirouzu Mikako、Ichimura Taro、Watanabe Tomonobu M.、Nitta Ryo、Okada Yasushi、Hirokawa Nobutaka
    • Journal Title

      The Journal of Cell Biology

      Volume: 217 Issue: 12 Pages: 4164-4183

    • DOI

      10.1083/jcb.201711178

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multiple analyses of protein dynamics in solution2017

    • Author(s)
      Ogawa Tadayuki、Hirokawa Nobutaka
    • Journal Title

      Biophysical Reviews

      Volume: 10 Issue: 2 Pages: 299-306

    • DOI

      10.1007/s12551-017-0354-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mechanism of Catalytic Microtubule Depolymerization via KIF2-Tubulin Transitional Conformation2017

    • Author(s)
      Ogawa Tadayuki、Saijo Shinya、Shimizu Nobutaka、Jiang Xuguang、Hirokawa Nobutaka
    • Journal Title

      Cell Reports

      Volume: 20 Issue: 11 Pages: 2626-2638

    • DOI

      10.1016/j.celrep.2017.08.067

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Motility and microtubule depolymerization mechanisms of the Kinesin-8 motor, KIF19A.2016

    • Author(s)
      Wang D, Nitta R, Morikawa M, Yajima H, Inoue S, Shigematsu H, Kikkawa M, Hirokawa N.
    • Journal Title

      Elife

      Volume: 5 Pages: 2728-2728

    • DOI

      10.7554/elife.18101

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Autoinhibition of a neuronal kinesin UNC-104/KIF1A regulates the size and density of synapses.2016

    • Author(s)
      Niwa S., Lipton DM., Morikawa M., Zhao C., Hirokawa N., Lu H., and Shen K.
    • Journal Title

      Cell Reports

      Volume: 16 Issue: 8 Pages: 2129-2141

    • DOI

      10.1016/j.celrep.2016.07.043

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The molecular motor KIF1A transports the TrkA neurotrophin receptor and is essential for sensory neuron survival and function.2016

    • Author(s)
      Tanaka, Y., S. Niwa, M. Dong, A. Farkhondeh, L. Wang, R. Zhou, and N. Hirokawa.
    • Journal Title

      Neuron

      Volume: 90 Issue: 6 Pages: 1215-1229

    • DOI

      10.1016/j.neuron.2016.05.002

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] The atypical kinesin KIF26A facilitates termination of nociceptive responses by sequestering focal adhesion kinase2019

    • Author(s)
      王 力,田中 庸介,森川 桃 ,周 如贇, 王 斗斗,宮本 祐希, 廣川信隆
    • Organizer
      第124回日本解剖学会総会・全国学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] KIF1Bβ mutations detected in hereditary neuropathy impair IGF1R transport and axon growth2019

    • Author(s)
      徐方、高橋光規、田中 庸介、一ノ瀬聡太郎、丹羽伸介、Matthew P. Wicklund, 廣川信隆
    • Organizer
      第124回日本解剖学会総会・全国学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Cryo-EM structures reveal that kinesin-1 triggers conformational switching of microtubules as a base for polarized transport2019

    • Author(s)
      Manatsu Morikawa
    • Organizer
      第124回日本解剖学会総会・全国学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The molecular motor KIF21B mediates synaptic plasticity and fear extinction by terminating Rac1 activation2019

    • Author(s)
      Momo Morikawa
    • Organizer
      第124回日本解剖学会総会・全国学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Mechanism of Intracellular transport and molecular motors, KIFs2018

    • Author(s)
      Nobutaka Hirokawa
    • Organizer
      The Kingdon of Saudi Arabia’s First International R & D Collaboration Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanism of Cytoskeletal Protein Dynamics Revealed by the Combination of Multiple Protein Analyses2018

    • Author(s)
      Tadayuki Ogawa and Nobutaka Hirokawa
    • Organizer
      Mass Spectrometry and Proteomics 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Mechanism of Catalytic Microtubule Depolymerization via KIF2-tubulin Transitional Conformation2018

    • Author(s)
      Tadayuki Ogawa, Shinya Saijo, Nobutaka Shimizu, Xuguang Jiang and Nobutaka Hirokawa
    • Organizer
      Tokyo 2018 Cell and Developmental Biology Meeting
    • Related Report
      2018 Annual Research Report
  • [Presentation] 微小管脱重合反応を推進する遷移段階KIF2-チューブリン複合体の溶液解析2018

    • Author(s)
      小川覚之、西條慎也、清水伸隆、蒋緒光、廣川信隆
    • Organizer
      第18回東京大学生命科学ネットワークシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Mechanism of Protein Dynamics Revealed by the Combination of Multiple Protein Analyses in Solution2018

    • Author(s)
      Tadayuki Ogawa and Nobutaka Hirokawa
    • Organizer
      生物物理学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 微小管脱重合反応を推進する遷移段階KIF2-チューブリン複合体の溶液解析2018

    • Author(s)
      小川覚之、西條慎也、清水伸隆、蒋緒光、廣川信隆
    • Organizer
      分子生物学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The Smart Nano-Machine that demolishes the Microtubule Cytoskeleton in Cells2018

    • Author(s)
      Tadayuki Ogawa and Nobutaka Hirokawa
    • Organizer
      2nd International BMS Symposium 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞情報を運ぶキネシン分子モーター ~KIF12とβ細胞脂肪毒性~2018

    • Author(s)
      田中庸介、廣川信隆
    • Organizer
      Islet Biology 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] KIF26Aによる疼痛反応の短縮2018

    • Author(s)
      王 力,田中 庸介,森川 桃,本間 典子,周 如贇, 王 斗斗,宮本 祐希,廣川 信隆
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] KIF21Bによる恐怖記憶消去メカニズムの制御2018

    • Author(s)
      森川 桃、田中庸介、趙顯洙、吉原雅大、廣川信隆
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Cryo-EM structures reveal Kinesin-1 triggers conformational switching of microtubules as a base for polarized transport2018

    • Author(s)
      Manatsu Morikawa et al.
    • Organizer
      ASCB2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The molecular motor KIF21B mediates synaptic plasticity and fear extinction by terminating Rac1 activation2018

    • Author(s)
      Momo Morikawa
    • Organizer
      ASCB2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The molecular motor KIF21B mediates synaptic plasticity and fear extinction by terminating Rac1 activation2018

    • Author(s)
      Momo Morikawa et al.
    • Organizer
      第41回 日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The moleculer motors, KIFs and intracellular transport: Regulation of neuronal functions, development and disease.2018

    • Author(s)
      Nobutaka Hirokawa
    • Organizer
      International Congress of Cell Biology 2018
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 分子モーターと細胞内輸送:脳機能、発生の制御から代謝関連疾患まで2018

    • Author(s)
      廣川信隆
    • Organizer
      第32回日本糖尿病・肥満動物学会年次学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 微小管脱重合反応を推進する遷移段階KIF2-チューブリン複合体の溶液解析2018

    • Author(s)
      小川覚之
    • Organizer
      量子ビームサイエンスフェスタ
    • Related Report
      2017 Annual Research Report
  • [Presentation] 神経形成を支える分子機構 -微小管脱重合機構と神経突起伸長制御-2018

    • Author(s)
      小川覚之
    • Organizer
      第123回日本解剖学会全国学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] キネシン分子モーターKIF1AはNGFレセプターTrkAを輸送し一次侵害受容ニューロンの感受性と生存に必須である2017

    • Author(s)
      田中庸介、丹羽伸介、董銘、Atena Farkhondeh、王力、周如贇、廣川信隆
    • Organizer
      日本解剖学会第122回総会・全国学術集会
    • Place of Presentation
      長崎大学坂本キャンパス(長崎市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Motility and Microtubule Depolymerization Mechanisms of the Kinesin-8 motor, KIF19A.2017

    • Author(s)
      D. Wang, R. Nitta, M. Morikawa, H. Yajima, S. Inoue, H. Shigematsu, M. Kikkawa & N. Hirokawa
    • Organizer
      第122回日本解剖学会総会・全国学術集会
    • Place of Presentation
      長崎大学坂本キャンパス(長崎市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] 多階層イメージング研究について:分子モーターと脳神経機能;遺伝子・分子・動態・細胞・脳そして行動をつないで2017

    • Author(s)
      廣川信隆
    • Organizer
      日本学術会議2部基礎医学委員会
    • Place of Presentation
      日本学術会議講義堂(東京都港区)
    • Year and Date
      2017-01-22
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Molecular motors, KIFs: Regulation of activity dependent trafficking, neuronal function, and development.2017

    • Author(s)
      Nobutaka Hirokawa
    • Organizer
      37th Blankenese Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular motors, KIFs and Regulation of Neuronal Function, Morphogenesis, and Brain Wiring.2017

    • Author(s)
      Nobutaka Hirokawa
    • Organizer
      EMBO Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular motors, KIFs: Intracellular transport and regulation of neuronal functions.2017

    • Author(s)
      Nobutaka Hirokawa
    • Organizer
      3rd Symposium on Cell Biology, India
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular motors, KIFs: from intracellular transport to regulation of fundamental phenol in life and diseases2017

    • Author(s)
      Nobutaka Hirokawa
    • Organizer
      第69回日本細胞生物学会大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Motility and microtubule depolymerizeation mechanism of the Kinesin-8 motor, KIF19A.2017

    • Author(s)
      Wong Doudou
    • Organizer
      第69回日本細胞生物学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] KIF1A分子モーターはNGF受容体TrkAを輸送し感覚神経細胞の機能と生存に必須である2017

    • Author(s)
      田中庸介
    • Organizer
      第69回日本細胞生物学会大会(シンポジウム)
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] KIF1A分子モーターはNGF受容体TrkAを輸送し感覚神経細胞の機能と生存に必須である2017

    • Author(s)
      田中庸介
    • Organizer
      第40回日本神経科学大会(口演およびポスター発表)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Solution-based Analyses on Microtubule Depolymerization via Depolymerizing Machine2017

    • Author(s)
      小川覚之
    • Organizer
      生物物理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Mechanism of Catalytic Microtubule Depolymerization via KIF2-tubulin Transitional Conformation.2017

    • Author(s)
      Tadayuki Ogawa
    • Organizer
      ASCB/EMBO 2017 meeting
    • Related Report
      2017 Annual Research Report
  • [Presentation] Conformational switching of microtubule and cooperative binding of kinesin-1 as a base for polarized transport.2017

    • Author(s)
      Manatsu Morikawa
    • Organizer
      ASCB/EMBO 2017 meeting
    • Related Report
      2017 Annual Research Report
  • [Presentation] The Molecular Motor KIF1A Transports the TrkA Neurotrophin Receptor and Is Essential for Sensory Neuron Survival and Function.2016

    • Author(s)
      Y. Tanaka, S. Niwa, M. Dong, A. Farkhondeh, L. Wang, R. Zhou, N. Hirokawa.
    • Organizer
      American Society for Cell Biology Meeting 2016
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      2016-12-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Motility and Microtubule Depolymerization Mechanisms of the Kinesin-8 motor, KIF19A.2016

    • Author(s)
      D. Wang, R. Nitta, M. Morikawa, H. Yajima, S. Inoue, H. Shigematsu, M. Kikkawa & N. Hirokawa
    • Organizer
      American Society for Cell Biology Annual Meeting 2016
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      2016-12-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 微小管ダイナミクスを制御する異なる特異的リン酸化カスケード2016

    • Author(s)
      小川覚之、廣川信隆
    • Organizer
      第54回日本生物物理学会年会
    • Place of Presentation
      つくば国際会議場(つくば市)
    • Year and Date
      2016-11-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] Kinesin superfamily molecular motors, KIFs and Intracellular transport: regulation of neuronal function, development and diseases.2016

    • Author(s)
      Hirokawa N
    • Organizer
      30th Anniversary and Symposium of IMB, Institute of Molecular Biology
    • Place of Presentation
      Taipei (Taiwan)
    • Year and Date
      2016-11-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Kinesin superfamily motors, KIFs and intracellular transport: from regulation of brain function, development and related diseases. (Invited lecture)2016

    • Author(s)
      Hirokawa N.
    • Organizer
      Functional Organization of the Cell Nucleus Symposium
    • Place of Presentation
      Prague (Czech)
    • Year and Date
      2016-11-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 神経細胞における微小管脱重合の制御機構の解明:Phos-tagからリン酸化定量プロテオミクスまで2016

    • Author(s)
      小川覚之、廣川信隆
    • Organizer
      第67回日本電気泳動学会総会
    • Place of Presentation
      釧路市観光国際交流センター(北海道釧路市)
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 異なる特異的リン酸化カスケードによる微小管脱重合蛋白質の制御機構2016

    • Author(s)
      小川覚之、廣川信隆
    • Organizer
      日本プロテオーム学会2016年大会
    • Place of Presentation
      北里大学薬学部(東京都)
    • Year and Date
      2016-07-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] Mechanism of Activity-Dependent Cargo Loading via the Phosphorylation of KIF3A by PKA and CaMKIIa.2016

    • Author(s)
      S. Ichinose, T. Ogawa, and N. Hirokawa.
    • Organizer
      12th International Congress of Cell Biology
    • Place of Presentation
      Prague (Czech)
    • Year and Date
      2016-07-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Kinesin superfamily molecular motors, KIFs: from regulation of neuronal functions and development to diseases. (Special lecture)2016

    • Author(s)
      Hirokawa N.
    • Organizer
      12th International Congress of Cell Biology
    • Place of Presentation
      Prague (Czech)
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Microtubule Destabilizer KIF2A Undergoes Distinct Site-specific Phosphorylation Cascades that Differentially Affect Neuronal Morphogenesis.2016

    • Author(s)
      Tadayuki Ogawa and Nobutaka Hirokawa.
    • Organizer
      12th International Congress of Cell Biology
    • Place of Presentation
      Prague (Czech)
    • Year and Date
      2016-07-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 微小管脱重合蛋白質KIF2Aは異なる特異的リン酸化カスケードにより神経形態形成を制御する2016

    • Author(s)
      小川覚之、廣川信隆
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] 異なる特異的リン酸化カスケードによる微小管脱重合蛋白質KIF2Aの制御機構2016

    • Author(s)
      小川覚之、廣川信隆
    • Organizer
      第68回日本細胞生物学会
    • Place of Presentation
      京都テルサ(京都市)
    • Year and Date
      2016-06-15
    • Related Report
      2016 Annual Research Report
  • [Remarks] 痛みを運ぶ分子モーター: 細胞内の輸送が痛みニューロンの感受性を高める

    • URL

      https://www.u-tokyo.ac.jp/focus/ja/articles/a_00505.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 二刀流モーターの分子メカニズムの解明 :分子モータータンパク質KIF19Aの構造

    • URL

      https://www.u-tokyo.ac.jp/focus/ja/articles/a_00538.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 細胞内骨格の賢い解体屋: 微小管を脱重合する分子モーターが効率良く働く仕組みを解明

    • URL

      https://www.u-tokyo.ac.jp/focus/ja/articles/a_00611.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 東大リサーチ”細胞内骨格の賢い解体屋”

    • URL

      https://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/cellular-cytoskeleton-dismantled-by-smart-demolition-machine.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 二刀流モーターの分子メカニズムの解明 -分子モータータンパク質KIF19Aの構造-

    • URL

      http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/study-reveals-molecular-mechanism-of-dual-function-motor-protein.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] モータータンパク質KIF1AはNGFの受容体であるTrkAの軸索輸送により痛覚をささえる

    • URL

      http://first.lifesciencedb.jp/archives/12660

    • Related Report
      2016 Annual Research Report
  • [Remarks] 痛みを支える分子モーター

    • URL

      http://www.m.u-tokyo.ac.jp/news/admin/release_20160603.pdf

    • Related Report
      2016 Annual Research Report
  • [Remarks] 痛みを運ぶ分子モーター -細胞内の輸送が痛みニューロンの感受性を高める-

    • URL

      http://www.u-tokyo.ac.jp/ja/utokyo-research/research-news/molecular-motor-carries-sense-of-pain.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] Molecular motor carries sense of pain

    • URL

      http://www.technology.org/2016/07/12/molecular-motor-carries-sense-pain/

    • Related Report
      2016 Annual Research Report

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Published: 2016-06-01   Modified: 2023-10-16  

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