| Budget Amount *help |
¥184,340,000 (Direct Cost: ¥141,800,000、Indirect Cost: ¥42,540,000)
Fiscal Year 2020: ¥30,680,000 (Direct Cost: ¥23,600,000、Indirect Cost: ¥7,080,000)
Fiscal Year 2019: ¥38,090,000 (Direct Cost: ¥29,300,000、Indirect Cost: ¥8,790,000)
Fiscal Year 2018: ¥33,020,000 (Direct Cost: ¥25,400,000、Indirect Cost: ¥7,620,000)
Fiscal Year 2017: ¥32,110,000 (Direct Cost: ¥24,700,000、Indirect Cost: ¥7,410,000)
Fiscal Year 2016: ¥50,440,000 (Direct Cost: ¥38,800,000、Indirect Cost: ¥11,640,000)
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| Outline of Final Research Achievements |
Multicellular organisms have stem cells, which self-proliferate and give rise to various types of differentiated cells. In plants, stem cells in meristems play crucial roles in growth and development. We have established a new vascular cell differentiation system, VISUAL, in which mesophyll cells differentiate into vascular cells via vascular stem cells. In this study, we studied regulation of stem cell fates in the vascular meristem mainly using VISUAL. As a result, we found some key transcription factors governing stem cell fates in stem cell-establishment stage, vascular cell differentiation-commitment stage and switching process between each vascular cell specification. In addition, we also discovered that GSK3 kinase activity plays a crucial role in switching in differentiation of phloem companion cells and sieve element cells. Based on these results, we proposed hypotheses about signaling pathways regulating vascular stem cell fates in review articles.
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