• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of lifestyle-related diseases development due to environmental factors and epigenetic memory

Research Project

Project/Area Number 16H06390
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Metabolomics
Research InstitutionTohoku University (2017-2021)
The University of Tokyo (2016)

Principal Investigator

SAKAI Juro  東北大学, 医学系研究科, 教授 (80323020)

Co-Investigator(Kenkyū-buntansha) 松村 欣宏  東京大学, 先端科学技術研究センター, 准教授 (20375257)
川村 猛  東京大学, アイソトープ総合センター, 准教授 (70306835)
Project Period (FY) 2016-05-31 – 2021-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥182,910,000 (Direct Cost: ¥140,700,000、Indirect Cost: ¥42,210,000)
Fiscal Year 2020: ¥34,970,000 (Direct Cost: ¥26,900,000、Indirect Cost: ¥8,070,000)
Fiscal Year 2019: ¥38,090,000 (Direct Cost: ¥29,300,000、Indirect Cost: ¥8,790,000)
Fiscal Year 2018: ¥32,890,000 (Direct Cost: ¥25,300,000、Indirect Cost: ¥7,590,000)
Fiscal Year 2017: ¥32,110,000 (Direct Cost: ¥24,700,000、Indirect Cost: ¥7,410,000)
Fiscal Year 2016: ¥44,850,000 (Direct Cost: ¥34,500,000、Indirect Cost: ¥10,350,000)
Keywords肥満 / 生活習慣病 / 脂肪細胞 / エピゲノム / 翻訳後修飾 / 適応熱産生 / メタボリックシンドローム / エビゲノム
Outline of Final Research Achievements

Adipose tissue plays an important role in the development of obesity and lifestyle-related diseases. Adipose tissue plays a major role in the adaptation of individuals to their living environment: white adipocytes store fat and become hypertrophied under nutritional surpluses, while they turn browning and develop heat-producing capacity in cold environments. Failure of this adaptation can lead to lifestyle-related diseases.
Epigenomics is a mechanism to control gene expression by chemical modification of histones and DNA. We have elucidated a stepwise mechanism by which epigenomic modification enzymes undergo post-translational modification in response to environmental stimuli to form specific protein complexes (1st step) and continuously induce heat-producing gene expression via histone demethylation (2nd step) to adapt to cold environment. We also demonstrated the possibility of targeting this mechanism for the treatment of lifestyle-related diseases.

Academic Significance and Societal Importance of the Research Achievements

2型糖尿病を始め、肥満に起因した生活習慣病の発症進展に脂肪組織は重要な役割を持つ。脂肪組織は個体がおかれた環境に応じて動的に量と質を変化させる。余剰な栄養環境下では白色脂肪細胞は脂肪として蓄え肥大化する一方、寒冷刺激下で脂肪を燃焼する熱を産生する脂肪細胞が脂肪組織に集簇してくるなど、個体の生活環境の適応に大きく関与する。この適応がうまくなされないと生活習慣病の原因となる。本研究では脂肪細胞の質を制御する環境を感知するエピゲノム酵素がどのようにして細胞運命を決定するのかを解明し、新規治療標的の可能性を提示した。

Assessment Rating
Verification Result (Rating)

A

Assessment Rating
Result (Rating)

A: Progress in the research is steadily towards the initial goal. Expected research results are expected.

Report

(11 results)
  • 2022 Research Progress Assessment (Verification Result) ( PDF )
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report   Abstract(Research Progress Assessment) ( PDF )   Research Progress Assessment (Result) ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • 2016 Abstract ( PDF )   Comments on the Screening Results ( PDF )   Annual Research Report
  • Research Products

    (61 results)

All 2022 2021 2020 2019 2018 2017 2016 Other

All Journal Article (27 results) (of which Int'l Joint Research: 14 results,  Peer Reviewed: 27 results,  Open Access: 20 results,  Acknowledgement Compliant: 4 results) Presentation (31 results) (of which Int'l Joint Research: 7 results,  Invited: 21 results) Remarks (3 results)

  • [Journal Article] Epigenetic and environmental regulation of adipocytes.2022

    • Author(s)
      Matsumura Y, Osborne T.F, Sakai J.
    • Journal Title

      The Journal of Biochemistry (Review)

      Volume: -

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] β-Adrenergic signal and epigenomic regulatory process for adaptive thermogenesis.2022

    • Author(s)
      Matsumura Y, Osborne T.F, Ito R, Takahashi H, Sakai J.
    • Journal Title

      Thermal Biology

      Volume: -

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Selective PPARα Modulator Pemafibrate and Sodium-Glucose Cotransporter 2 Inhibitor Tofogliflozin Combination Treatment Improved Histopathology in Experimental Mice Model of Non-Alcoholic Steatohepatitis2022

    • Author(s)
      Murakami K, Sasaki Y, Asahiyama M, Yano W, Takizawa T, Kamiya W, Matsumura Y, Anai M, Osawa T, Fruchart JC, Fruchart-Najib J, Aburatani H, Sakai J, Kodama T, Tanaka T.
    • Journal Title

      Cells

      Volume: 11 Issue: 4 Pages: 720-720

    • DOI

      10.3390/cells11040720

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Spatiotemporal dynamics of SETD5-containing NCoR-HDAC3 complex determines enhancer activation for adipogenesis2021

    • Author(s)
      Matsumura Y, Ito R, Yajima A, Yamaguchi R, Tanaka T, Kawamura T, Magoori K, Abe Y, Uchida A, Yoneshiro T, Hirakawa H, Zhang J, Arai M, Yang C, Yang G, Takahashi H, Fujihashi H, Nakaki R, Yamamoto S, Ota S, Tsutsumi S, Inoue SI, Kimura H, Wada Y, Kodama T, Inagaki T, Osborne TF, Aburatani H, Node K, Sakai J.
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 7045-7045

    • DOI

      10.1038/s41467-021-27321-5

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function2021

    • Author(s)
      Sugiyama T, Murao N, Kadowaki H, Takao K, Miyakawa T, Matsushita Y, Katagiri T, Futatsugi A, Shinmyo Y, Kawasaki H, Sakai J, Shiomi K, Nakazato M, Takeda K, Mikoshiba K, Ploegh HL, Ichijo H, Nishitoh H
    • Journal Title

      iScience

      Volume: 24 Issue: 7 Pages: 102758-102758

    • DOI

      10.1016/j.isci.2021.102758

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ubiquitination-dependent and -independent repression of target genes by SETDB1 reveal a context-dependent role for its methyltransferase activity during adipogenesis2021

    • Author(s)
      Zhang J, Matsumura Y, Kano Y, Yoshida A, Kawamura T, Hirakawa H, Inagaki T, Tanaka T, Kimura H, Yanagi S, Fukami K, Doi T, Osborne TF, Kodama T, Aburatani H, Sakai J.
    • Journal Title

      Genes Cells

      Volume: 26 Issue: 7 Pages: 513-529

    • DOI

      10.1111/gtc.12868

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Measurement of the nuclear concentration of α-ketoglutarate during adipocyte differentiation by using a fluorescence resonance energy transfer-based biosensor with nuclear localization signals2021

    • Author(s)
      Suzuki Tomohiro、Hayashi Mayuko、Komatsu Tetsuro、Tanioka Akiko、Nagasawa Masahiro、Tanimura-Inagaki Kyoko、Rahman Mohammad Sharifur、Masuda Shinnosuke、Yusa Kosuke、Sakai Juro、Shibata Hiroshi、Inagaki Takeshi
    • Journal Title

      Endocrine Journal

      Volume: 68 Issue: 12 Pages: 1429-1438

    • DOI

      10.1507/endocrj.EJ21-0255

    • NAID

      130008136509

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever2021

    • Author(s)
      Yoneshiro T, Kataoka N, Walejko JM, Ikeda K, Brown Z, Yoneshiro M, Crown SB, Osawa T, Sakai J, McGarrah RW, White PJ, Nakamura K, Kajimura S.
    • Journal Title

      Elife

      Volume: 10

    • DOI

      10.7554/elife.66865

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Loss of Down syndrome critical region-1 leads to cholesterol metabolic dysfunction that exaggerates hypercholesterolemia in ApoE-null background2021

    • Author(s)
      Muramatsu Masashi、Osawa Tsuyoshi、Miyamura Yuri、Nakagawa Suguru、Tanaka Toshiya、Kodama Tatsuhiko、Aburatani Hiroyuki、Sakai Juro、Ryeom Sandra、Minami Takashi
    • Journal Title

      Journal of Biological Chemistry

      Volume: 296 Pages: 100697-100697

    • DOI

      10.1016/j.jbc.2021.100697

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] PPARα activation directly upregulates thrombomodulin in the diabetic retina.2020

    • Author(s)
      Shiono A, Sasaki H, Sekine R, Abe Y, Matsumura Y, Inagaki T, Tanaka T, Kodama T, Aburatani H, Sakai J, Takagi H.
    • Journal Title

      Sci Rep

      Volume: 10 Issue: 1 Pages: 10837-10837

    • DOI

      10.1038/s41598-020-67579-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content.2020

    • Author(s)
      Sasaki Y, Asahiyama M, Tanaka T, Yamamoto S, Murakami K, Kamiya W, Matsumura Y, Osawa T, Anai M, Fruchart JC, Aburatani H, Sakai J, Kodama T.
    • Journal Title

      Sci Rep

      Volume: 10 Issue: 1 Pages: 7817-7817

    • DOI

      10.1038/s41598-020-64902-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT22019

    • Author(s)
      Osawa T, Shimamura T, Saito K, Hasegawa Y, Ishii N, Nishida M, Ando R, Kondo A, Anwar M, Kato K, Endo K, Yamano S, Kanki Y, Matsumura Y, Minami T, Tanaka T, Anai M, Wada Y, Wanibuchi H, Hayashi M, Hamada A, Yoshida M, Yachida S, Nakao M, Sakai J, Aburatani H, Shibuya M, Hanada K, Miyano S, Soga T, Kodama T
    • Journal Title

      Cell Rep.

      Volume: 29(1) Issue: 1 Pages: 89-103

    • DOI

      10.1016/j.celrep.2019.08.087

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gene Expression Profiles Induced by a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα) Pemafibrate2019

    • Author(s)
      Sasaki Y, Raza-Iqbal S, Tanaka T, Murakami K, Anai M, Osawa T, Matsumura Y, Sakai J, Kodama T
    • Journal Title

      Int J Mol Sci

      Volume: 20(22) Issue: 22 Pages: 5682-5682

    • DOI

      10.3390/ijms20225682

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Downregulation of ERG and FLI1 expression in endothelial cells triggers endothelial-to-mesenchymal transition2018

    • Author(s)
      Nagai Nao、Ohguchi Hiroto、Nakaki Ryo、Matsumura Yoshihiro、Kanki Yasuharu、Sakai Juro、Aburatani Hiroyuki、Minami Takashi
    • Journal Title

      PLOS Genetics

      Volume: 14 Issue: 11 Pages: e1007826-e1007826

    • DOI

      10.1371/journal.pgen.1007826

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Discovery of peroxisome proliferator?activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line2018

    • Author(s)
      Tachibana Keisuke、Yuzuriha Tomohiro、Tabata Ryotaro、Fukuda Syohei、Maegawa Takashi、Takahashi Rika、Tanimoto Keiichi、Tsujino Hirofumi、Nunomura Kazuto、Lin Bangzhong、Matsuura Yoshiharu、Tanaka Toshiya、Hamakubo Takao、Sakai Juro、Kodama Tatsuhiko、Kobayashi Tadayuki、Ishimoto Kenji、Miyachi Hiroyuki、Doi Takefumi
    • Journal Title

      Journal of Biological Chemistry

      Volume: 293 Issue: 26 Pages: 10333-10343

    • DOI

      10.1074/jbc.ra118.002077

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch.2018

    • Author(s)
      Yohei Abe, Yosuke Fujiwara, Hiroki Takahashi, Yoshihiro Matsumura, Tomonobu Sawada, Shuying Jiang, Ryo Nakaki, Aoi Uchida, Noriko Nagao, Makoto Naito, Shingo Kajimura, Hiroshi Kimura, Timothy F. Osborne, Hiroyuki Aburatani, Tatsuhiko Kodama, Takeshi Inagaki, Juro Sakai
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 1566-1566

    • DOI

      10.1038/s41467-018-03868-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Overexpression of p54nrb/NONO induces differential EPHA6 splicing and contributes to castration-resistant prostate cancer growth2018

    • Author(s)
      Yamamoto R, Osawa T, Sasaki Y, Yamamoto S, Anai M, Izumi K, Matsumura Y, Sakai J, Aburatani H, Mizokami A, Kodama T, Tanaka T
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 12 Pages: 10510-10524

    • DOI

      10.18632/oncotarget.24063

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of histone demethylase KDM3A-dependent AP-1 transactivity on hepatotumorigenesis induced by PI3K activation2017

    • Author(s)
      Nakatsuka T, Tateishi K, Kudo Y, Yamamoto K, Nakagawa H, Fujiwara H, Takahashi R, Miyabayashi K, Asaoka Y, Tanaka Y, Ijichi H, Hirata Y, Otsuka M, Kato M, Sakai J, Tachibana M, Aburatani H, Shinkai Y, *Koike K.
    • Journal Title

      Oncogene

      Volume: 36 Issue: 45 Pages: 6262

    • DOI

      10.1038/onc.2017.222

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional and epigenetic control of brown and beige adipose cell fate and function.2017

    • Author(s)
      Inagaki T, Sakai J, Kajimura S.
    • Journal Title

      Nat Rev Mol Cell Biol.

      Volume: 18 Issue: 8 Pages: 527-527

    • DOI

      10.1038/nrm.2017.72

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin D metabolite, 25-Hydroxyvitamin D, regulates lipid metabolism by inducing degradation of SREBP/SCAP.2017

    • Author(s)
      Asano, L., Watanabe, M., Ryoden, Y., Usuda, K., Yamaguchi, T., Khambu, B., Takashima, M., Sato, S., Sakai, J., Nagasawa, K., Uesugi, M.
    • Journal Title

      Cell Chem Biol.

      Volume: 24 Issue: 2 Pages: 207-217

    • DOI

      10.1016/j.chembiol.2016.12.017

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Extracellular Acidic pH Activates the Sterol Regulatory Element-binding Protein 2 to Promote Tumor Progression2017

    • Author(s)
      Kondo A, Yamamoto S, Nakaki R, Shimamura T, Hamakubo T, Sakai J, Kodama T, Yoshida T, Aburatani H and Osawa T
    • Journal Title

      Cell Reports

      Volume: 18 Issue: 9 Pages: 2228-2242

    • DOI

      10.1016/j.celrep.2017.02.006

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability.2017

    • Author(s)
      Yeyati PL, Schiller R, Mali G, Kasioulis I, Kawamura A, Adams IR, Playfoot C, Gilbert N, van Heyningen V, Wills J, von Kriegsheim A, Finch A, Sakai J, Schofield CJ, Jackson IJ, Mill P.
    • Journal Title

      J Cell Biol.

      Volume: 216 Issue: 4 Pages: 999-1013

    • DOI

      10.1083/jcb.201607032

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase2017

    • Author(s)
      Ishimoto Kenji、Hayase Ayaka、Kumagai Fumiko、Kawai Megumi、Okuno Hiroko、Hino Nobumasa、Okada Yoshiaki、Kawamura Takeshi、Tanaka Toshiya、Hamakubo Takao、Sakai Juro、Kodama Tatsuhiko、Tachibana Keisuke、Doi Takefumi
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 488 Issue: 1 Pages: 159-164

    • DOI

      10.1016/j.bbrc.2017.04.159

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptional and epigenetic control of brown and beige adipose cell fate and function2016

    • Author(s)
      Inagaki T, Sakai J, Kajimura S.
    • Journal Title

      Nature Reviews Molecular Cell Biology

      Volume: 17 Issue: 8 Pages: 480-495

    • DOI

      10.1038/nrm.2016.62

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages.2016

    • Author(s)
      R. Hachiya, T. Shiihashi, I. Shirakawa, Y. Iwasaki, Y. Matsumura, Y. Oishi, Y. Nakayama, Y. Miyamoto, I. Manabe, K. Ochi, M. Tanaka, N. Goda, J. Sakai, T. Suganami, Y. Ogawa.
    • Journal Title

      Sci. Rep.

      Volume: 6 Issue: 1 Pages: 28845-28845

    • DOI

      10.1038/srep28845

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ubiquitination of Lysine 867 of the Human SETDB1 Protein Upregulates Its Histone H3 Lysine 9 (H3K9) Methyltransferase Activity.2016

    • Author(s)
      Ishimoto K, Kawamata N, Uchihara Y, Okubo M, Fujimoto R, Gotoh E, Kakinouchi K, Mizohata E, Hino N, Okada Y, Mochizuki Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Inoue T, Tachibana K, Doi T
    • Journal Title

      PLoS One

      Volume: 11 Issue: 10 Pages: e0165766-e0165766

    • DOI

      10.1371/journal.pone.0165766

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] QRFP-deficient mice are hypophagic, lean, hypoactive and exhibit increased anxiety-like behavior2016

    • Author(s)
      Okamoto K, Yamasaki M, Takao K, Soya S, Iwasaki M, Sasaki K, Magoori K, Sakakibara I, Miyakawa T, Mieda M, Watanabe M, Sakai J, Yanagisawa M, Sakurai T
    • Journal Title

      PLoS ONE

      Volume: 11 Issue: 11 Pages: e0164716-e0164716

    • DOI

      10.1371/journal.pone.0164716

    • NAID

      120007129233

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] エピゲノム変化とアクトミオシン緊張を制御する脱リン酸化酵素同定と同酵素によるベージュ化制御の解明2022

    • Author(s)
      酒井寿郎
    • Organizer
      第99回日本生理学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] A Phosphatase Protein Complex Orchestrates Uncoupled Respiration via a Histone Demethylase and YAP/TAZ Mediated Actomyosin Pathway in White Adipose Tissue2021

    • Author(s)
      Juro Sakai
    • Organizer
      The 19th International Symposium on Atherosclerosis
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A Concerted Thermogenic Response via A Phosphor-switch of An Epigenetic Modifier2021

    • Author(s)
      Juro Sakai
    • Organizer
      第1回健康長寿代謝制御研究センター国際シンポジウム
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生活習慣病におけるエピゲノムの役割2021

    • Author(s)
      酒井寿郎
    • Organizer
      日本スポーツ栄養学会第7回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 熱産生性脂肪のエピジェネティクス2021

    • Author(s)
      稲垣毅, 酒井寿郎
    • Organizer
      第64回日本糖尿病学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 肥満発症に関与するエピゲノム酵素のシグナル感知とヒストン脱メチル化機構の解明2021

    • Author(s)
      酒井寿郎
    • Organizer
      第41回日本肥満学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ヒストン脱メチル化酵素JMJD1Aによる2つの独立した機構による2つの異なる脂肪組織における熱産生遺伝子発現機構2021

    • Author(s)
      酒井寿郎
    • Organizer
      第43回日本分子生物学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 脂肪細胞分化を制御するヒストンメチル化・脱メチル化反応2020

    • Author(s)
      松村欣宏, Eko Fuji Ariyanto, 曽我朋義, 酒井寿郎
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] SETDB1 represses H3K4/H3K9me3 bivalent genes by ubiquitination-dependent and -independent mechanisms.2020

    • Author(s)
      張吉, 松村欣宏, 鹿野優佳, 吉田文乃, 川村猛, 平川弘幸, 油谷浩幸, 酒井 寿郎
    • Organizer
      第93回 日本生化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] “Histone demethylase-mediated adaptive thermogenesis”2019

    • Author(s)
      Juro Sakai
    • Organizer
      71th Annual Korean Physiological Society Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 内分泌機構におけるエピゲノム2019

    • Author(s)
      酒井寿郎
    • Organizer
      第92回日本内分泌学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 脂肪細胞の機能制御に関わるヒストン修飾とクロマチン構造の変化2019

    • Author(s)
      酒井寿郎
    • Organizer
      第42回日本分子生物学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] ヒストン脱メチル化酵素による寒冷環境への適応機構2018

    • Author(s)
      酒井寿郎
    • Organizer
      第91回日本内分泌学会
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Invited
  • [Presentation] Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phosphor-switch.2018

    • Author(s)
      酒井寿郎
    • Organizer
      第50回日本動脈硬化学会総会・学術集会
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Invited
  • [Presentation] Beta-Adrenergic Signaling Regulates a Concerted Thrmogenic Response in Brown Adipose Tissue and subcutaneous White Adipose Tissue2018

    • Author(s)
      Juro Sakai
    • Organizer
      American Diabetes Association 77th Scientific Sessions
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] JMJD1A Mediates Acute and Chronic Thermogenic Responses through Complementary Mechanisms2018

    • Author(s)
      Juro Sakai
    • Organizer
      The 5th Bandung International Biomoleculara Medicine Conference
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] JMJD1A Mediates Acute and Chronic Thermogenic Responses through Complementary Mechanisms2018

    • Author(s)
      Juro Sakai
    • Organizer
      THE 15TH NIKKO INTERNATIONAL SYMPOSIUM 2018 Genomic Approach for Non-communicable Diseases
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A histone demethylase JMJD1A mediates acute and chronic thermogenic responses through complementary Mechanisms2018

    • Author(s)
      Juro Sakai
    • Organizer
      The 4th IMCR Symposium on Endocrine and Metabolism: At the Cutting Edge of Metabolic Regulation Research
    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒストン脱メチル化酵素による脂肪細胞の熱産生機構と糖代謝制御機構2018

    • Author(s)
      酒井寿郎
    • Organizer
      第52回糖尿病学の進歩
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Invited
  • [Presentation] エピゲノムを介した白色脂肪細胞分化の制御機構2017

    • Author(s)
      松村欣宏, 仲木竜, 稲垣毅, 油谷浩幸, 酒井寿郎
    • Organizer
      第35回内分泌学代謝学サマーセミナー
    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Invited
  • [Presentation] 脂肪細胞における代謝産物とエピゲノムによるエネルギー代謝調節2017

    • Author(s)
      Eko F. Ariyanto, 松村欣宏, 曽我朋義, 稲垣毅, 酒井寿郎
    • Organizer
      日本がん分子標的治療学会 第12回トランスレーショナルリサーチワークショップ
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ヒストン脱メチル化酵素JMJD1Aの肥満、糖尿病における機能解析2017

    • Author(s)
      稲垣毅, 酒井寿郎
    • Organizer
      第31回日本糖尿病・肥満動物学会年次学術集会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ヒストン脱メチル化酵素のリン酸化と脱メチル化による白色脂肪細胞の褐色化機構2017

    • Author(s)
      酒井寿郎
    • Organizer
      第11回エピジェネティクス研究会年会
    • Related Report
      2016 Annual Research Report
  • [Presentation] ヒストン修飾酵素による脂肪細胞制御2016

    • Author(s)
      稲垣毅, 阿部陽平, Rozqie Royhan, 松村欣宏, 岩崎聡, 梶村真吾, 田中十志也, 児玉龍彦, 油谷浩幸, 酒井寿郎
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Related Report
      2016 Annual Research Report
  • [Presentation] 絶食でのケトン体産生のメカニズム2016

    • Author(s)
      酒井寿郎
    • Organizer
      第16回日本抗加齢医学会総会 シンポジウム
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Nuclear receptor PPARγ epigenomic modifier complexes that control adipocyte differentiation and metabolic phenotype2016

    • Author(s)
      Juro Sakai
    • Organizer
      第48回日本動脈硬化学会総会・学術総会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Metabolic Regulation of Histone Demethylase KDM4A and Glycolytic Gene Expression by Isocitrate Dehydrogenase 3β during Adipogenesis2016

    • Author(s)
      Eko F. Ariyanto, Yoshihiro Matsumura, Tomoyoshi Soga, Takeshi Inagaki, Juro Sakai
    • Organizer
      第89回日本生化学会
    • Related Report
      2016 Annual Research Report
  • [Presentation] Nutritin,metabolic state,and Epigenomic Regulation of Adipogenesis and Obesity2016

    • Author(s)
      Juro Sakai
    • Organizer
      第37回日本肥満学会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] JMJD1A複合体による熱産生のエピゲノム制御機構2016

    • Author(s)
      稲垣毅, 阿部陽平, Rozqie Royhan, 松村欣宏, 仲木竜, 川村猛, 梶村真吾, 児玉龍彦, 油谷浩幸, 酒井寿郎
    • Organizer
      第39回日本分子生物学会年会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 生活習慣病、遺伝子からエピゲノムへ2016

    • Author(s)
      酒井寿郎
    • Organizer
      第24回日本ステロイドホルモン学会学術集会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Environmental cues and Epigenetic Regulation of Adipogenesis and Obesity2016

    • Author(s)
      Juro Sakai
    • Organizer
      第24回血管生物医学会学術集会
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Remarks] 東北大学大学院医学系研究科細胞生物学講座分子代謝生理学分野/Publications

    • URL

      http://http://www.metab.med.tohoku.ac.jp/publications/

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Remarks] 東北大学大学院医学系研究科細胞生物学講座分子生理学分野/publications

    • URL

      http://www.metab.med.tohoku.ac.jp/publications/

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
  • [Remarks] 東京大学先端科学技術研究センター酒井研究室/原著論文

    • URL

      http://www.mm.rcast.u-tokyo.ac.jp/publications/pubs.html

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2016-06-01   Modified: 2023-10-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi