Elucidation of lifestyle-related diseases development due to environmental factors and epigenetic memory

• Project/Area Number: 16H06390
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: Tohoku University (2017-2021); The University of Tokyo (2016)
• Principal Investigator: SAKAI Juro 東北大学, 医学系研究科, 教授 (80323020)
• Co-Investigator(Kenkyū-buntansha): 松村 欣宏 東京大学, 先端科学技術研究センター, 准教授 (20375257) ; 川村 猛 東京大学, アイソトープ総合センター, 准教授 (70306835)
• Project Period (FY): 2016-05-31 – 2021-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥182,910,000 (Direct Cost: ¥140,700,000、Indirect Cost: ¥42,210,000); Fiscal Year 2020: ¥34,970,000 (Direct Cost: ¥26,900,000、Indirect Cost: ¥8,070,000); Fiscal Year 2019: ¥38,090,000 (Direct Cost: ¥29,300,000、Indirect Cost: ¥8,790,000); Fiscal Year 2018: ¥32,890,000 (Direct Cost: ¥25,300,000、Indirect Cost: ¥7,590,000); Fiscal Year 2017: ¥32,110,000 (Direct Cost: ¥24,700,000、Indirect Cost: ¥7,410,000); Fiscal Year 2016: ¥44,850,000 (Direct Cost: ¥34,500,000、Indirect Cost: ¥10,350,000)
• Keywords: 肥満 / 生活習慣病 / 脂肪細胞 / エピゲノム / 翻訳後修飾 / 適応熱産生 / メタボリックシンドローム / エビゲノム

Outline of Final Research Achievements

Adipose tissue plays an important role in the development of obesity and lifestyle-related diseases. Adipose tissue plays a major role in the adaptation of individuals to their living environment: white adipocytes store fat and become hypertrophied under nutritional surpluses, while they turn browning and develop heat-producing capacity in cold environments. Failure of this adaptation can lead to lifestyle-related diseases.
Epigenomics is a mechanism to control gene expression by chemical modification of histones and DNA. We have elucidated a stepwise mechanism by which epigenomic modification enzymes undergo post-translational modification in response to environmental stimuli to form specific protein complexes (1st step) and continuously induce heat-producing gene expression via histone demethylation (2nd step) to adapt to cold environment. We also demonstrated the possibility of targeting this mechanism for the treatment of lifestyle-related diseases.

Academic Significance and Societal Importance of the Research Achievements

2型糖尿病を始め、肥満に起因した生活習慣病の発症進展に脂肪組織は重要な役割を持つ。脂肪組織は個体がおかれた環境に応じて動的に量と質を変化させる。余剰な栄養環境下では白色脂肪細胞は脂肪として蓄え肥大化する一方、寒冷刺激下で脂肪を燃焼する熱を産生する脂肪細胞が脂肪組織に集簇してくるなど、個体の生活環境の適応に大きく関与する。この適応がうまくなされないと生活習慣病の原因となる。本研究では脂肪細胞の質を制御する環境を感知するエピゲノム酵素がどのようにして細胞運命を決定するのかを解明し、新規治療標的の可能性を提示した。

Assessment Rating

Verification Result (Rating)

A

Research Products

• [Journal Article] Epigenetic and environmental regulation of adipocytes. (2022)
  • Author(s): Matsumura Y, Osborne T.F, Sakai J.
  • Journal Title: The Journal of Biochemistry (Review) Volume: -
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] β-Adrenergic signal and epigenomic regulatory process for adaptive thermogenesis. (2022)
  • Author(s): Matsumura Y, Osborne T.F, Ito R, Takahashi H, Sakai J.
  • Journal Title: Thermal Biology Volume: -
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Selective PPARα Modulator Pemafibrate and Sodium-Glucose Cotransporter 2 Inhibitor Tofogliflozin Combination Treatment Improved Histopathology in Experimental Mice Model of Non-Alcoholic Steatohepatitis (2022)
  • Author(s): Murakami K, Sasaki Y, Asahiyama M, Yano W, Takizawa T, Kamiya W, Matsumura Y, Anai M, Osawa T, Fruchart JC, Fruchart-Najib J, Aburatani H, Sakai J, Kodama T, Tanaka T.
  • Journal Title: Cells Volume: 11 Issue: 4 Pages: 720-720
  • DOI: 10.3390/cells11040720
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Spatiotemporal dynamics of SETD5-containing NCoR-HDAC3 complex determines enhancer activation for adipogenesis (2021)
  • Author(s): Matsumura Y, Ito R, Yajima A, Yamaguchi R, Tanaka T, Kawamura T, Magoori K, Abe Y, Uchida A, Yoneshiro T, Hirakawa H, Zhang J, Arai M, Yang C, Yang G, Takahashi H, Fujihashi H, Nakaki R, Yamamoto S, Ota S, Tsutsumi S, Inoue SI, Kimura H, Wada Y, Kodama T, Inagaki T, Osborne TF, Aburatani H, Node K, Sakai J.
  • Journal Title: Nature Communications Volume: 12 Issue: 1 Pages: 7045-7045
  • DOI: 10.1038/s41467-021-27321-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function (2021)
  • Author(s): Sugiyama T, Murao N, Kadowaki H, Takao K, Miyakawa T, Matsushita Y, Katagiri T, Futatsugi A, Shinmyo Y, Kawasaki H, Sakai J, Shiomi K, Nakazato M, Takeda K, Mikoshiba K, Ploegh HL, Ichijo H, Nishitoh H
  • Journal Title: iScience Volume: 24 Issue: 7 Pages: 102758-102758
  • DOI: 10.1016/j.isci.2021.102758
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ubiquitination-dependent and -independent repression of target genes by SETDB1 reveal a context-dependent role for its methyltransferase activity during adipogenesis (2021)
  • Author(s): Zhang J, Matsumura Y, Kano Y, Yoshida A, Kawamura T, Hirakawa H, Inagaki T, Tanaka T, Kimura H, Yanagi S, Fukami K, Doi T, Osborne TF, Kodama T, Aburatani H, Sakai J.
  • Journal Title: Genes Cells Volume: 26 Issue: 7 Pages: 513-529
  • DOI: 10.1111/gtc.12868
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Measurement of the nuclear concentration of α-ketoglutarate during adipocyte differentiation by using a fluorescence resonance energy transfer-based biosensor with nuclear localization signals (2021)
  • Author(s): Suzuki Tomohiro、Hayashi Mayuko、Komatsu Tetsuro、Tanioka Akiko、Nagasawa Masahiro、Tanimura-Inagaki Kyoko、Rahman Mohammad Sharifur、Masuda Shinnosuke、Yusa Kosuke、Sakai Juro、Shibata Hiroshi、Inagaki Takeshi
  • Journal Title: Endocrine Journal Volume: 68 Issue: 12 Pages: 1429-1438
  • DOI: 10.1507/endocrj.EJ21-0255
  • NAID: 130008136509
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever (2021)
  • Author(s): Yoneshiro T, Kataoka N, Walejko JM, Ikeda K, Brown Z, Yoneshiro M, Crown SB, Osawa T, Sakai J, McGarrah RW, White PJ, Nakamura K, Kajimura S.
  • Journal Title: Elife Volume: 10
  • DOI: 10.7554/elife.66865
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Loss of Down syndrome critical region-1 leads to cholesterol metabolic dysfunction that exaggerates hypercholesterolemia in ApoE-null background (2021)
  • Author(s): Muramatsu Masashi、Osawa Tsuyoshi、Miyamura Yuri、Nakagawa Suguru、Tanaka Toshiya、Kodama Tatsuhiko、Aburatani Hiroyuki、Sakai Juro、Ryeom Sandra、Minami Takashi
  • Journal Title: Journal of Biological Chemistry Volume: 296 Pages: 100697-100697
  • DOI: 10.1016/j.jbc.2021.100697
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] PPARα activation directly upregulates thrombomodulin in the diabetic retina. (2020)
  • Author(s): Shiono A, Sasaki H, Sekine R, Abe Y, Matsumura Y, Inagaki T, Tanaka T, Kodama T, Aburatani H, Sakai J, Takagi H.
  • Journal Title: Sci Rep Volume: 10 Issue: 1 Pages: 10837-10837
  • DOI: 10.1038/s41598-020-67579-1
  • Peer Reviewed / Open Access
• [Journal Article] Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content. (2020)
  • Author(s): Sasaki Y, Asahiyama M, Tanaka T, Yamamoto S, Murakami K, Kamiya W, Matsumura Y, Osawa T, Anai M, Fruchart JC, Aburatani H, Sakai J, Kodama T.
  • Journal Title: Sci Rep Volume: 10 Issue: 1 Pages: 7817-7817
  • DOI: 10.1038/s41598-020-64902-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2 (2019)
  • Author(s): Osawa T, Shimamura T, Saito K, Hasegawa Y, Ishii N, Nishida M, Ando R, Kondo A, Anwar M, Kato K, Endo K, Yamano S, Kanki Y, Matsumura Y, Minami T, Tanaka T, Anai M, Wada Y, Wanibuchi H, Hayashi M, Hamada A, Yoshida M, Yachida S, Nakao M, Sakai J, Aburatani H, Shibuya M, Hanada K, Miyano S, Soga T, Kodama T
  • Journal Title: Cell Rep. Volume: 29(1) Issue: 1 Pages: 89-103
  • DOI: 10.1016/j.celrep.2019.08.087
  • Peer Reviewed / Open Access
• [Journal Article] Gene Expression Profiles Induced by a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα) Pemafibrate (2019)
  • Author(s): Sasaki Y, Raza-Iqbal S, Tanaka T, Murakami K, Anai M, Osawa T, Matsumura Y, Sakai J, Kodama T
  • Journal Title: Int J Mol Sci Volume: 20(22) Issue: 22 Pages: 5682-5682
  • DOI: 10.3390/ijms20225682
  • Peer Reviewed / Open Access
• [Journal Article] Downregulation of ERG and FLI1 expression in endothelial cells triggers endothelial-to-mesenchymal transition (2018)
  • Author(s): Nagai Nao、Ohguchi Hiroto、Nakaki Ryo、Matsumura Yoshihiro、Kanki Yasuharu、Sakai Juro、Aburatani Hiroyuki、Minami Takashi
  • Journal Title: PLOS Genetics Volume: 14 Issue: 11 Pages: e1007826-e1007826
  • DOI: 10.1371/journal.pgen.1007826
  • Peer Reviewed / Open Access
• [Journal Article] Discovery of peroxisome proliferator?activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line (2018)
  • Author(s): Tachibana Keisuke、Yuzuriha Tomohiro、Tabata Ryotaro、Fukuda Syohei、Maegawa Takashi、Takahashi Rika、Tanimoto Keiichi、Tsujino Hirofumi、Nunomura Kazuto、Lin Bangzhong、Matsuura Yoshiharu、Tanaka Toshiya、Hamakubo Takao、Sakai Juro、Kodama Tatsuhiko、Kobayashi Tadayuki、Ishimoto Kenji、Miyachi Hiroyuki、Doi Takefumi
  • Journal Title: Journal of Biological Chemistry Volume: 293 Issue: 26 Pages: 10333-10343
  • DOI: 10.1074/jbc.ra118.002077
  • Peer Reviewed
• [Journal Article] Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch. (2018)
  • Author(s): Yohei Abe, Yosuke Fujiwara, Hiroki Takahashi, Yoshihiro Matsumura, Tomonobu Sawada, Shuying Jiang, Ryo Nakaki, Aoi Uchida, Noriko Nagao, Makoto Naito, Shingo Kajimura, Hiroshi Kimura, Timothy F. Osborne, Hiroyuki Aburatani, Tatsuhiko Kodama, Takeshi Inagaki, Juro Sakai
  • Journal Title: Nature Communications Volume: 9 Issue: 1 Pages: 1566-1566
  • DOI: 10.1038/s41467-018-03868-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Overexpression of p54nrb/NONO induces differential EPHA6 splicing and contributes to castration-resistant prostate cancer growth (2018)
  • Author(s): Yamamoto R, Osawa T, Sasaki Y, Yamamoto S, Anai M, Izumi K, Matsumura Y, Sakai J, Aburatani H, Mizokami A, Kodama T, Tanaka T
  • Journal Title: Oncotarget Volume: 9 Issue: 12 Pages: 10510-10524
  • DOI: 10.18632/oncotarget.24063
  • Peer Reviewed
• [Journal Article] Impact of histone demethylase KDM3A-dependent AP-1 transactivity on hepatotumorigenesis induced by PI3K activation. (2017)
  • Author(s): Nakatsuka T, Tateishi K, Kudo Y, Yamamoto K, Nakagawa H, Fujiwara H, Takahashi R, Miyabayashi K, Asaoka Y, Tanaka Y, Ijichi H, Hirata Y, Otsuka M, Kato M, Sakai J, Tachibana M, Aburatani H, Shinkai Y, *Koike K.
  • Journal Title: Oncogene Volume: 印刷中 Issue: 45 Pages: 6262-6271
  • DOI: 10.1038/onc.2017.222
  • Peer Reviewed
• [Journal Article] Transcriptional and epigenetic control of brown and beige adipose cell fate and function. (2017)
  • Author(s): Inagaki T, Sakai J, Kajimura S.
  • Journal Title: Nat Rev Mol Cell Biol. Volume: 18 Issue: 8 Pages: 527-527
  • DOI: 10.1038/nrm.2017.72
  • Peer Reviewed
• [Journal Article] Vitamin D metabolite, 25-Hydroxyvitamin D, regulates lipid metabolism by inducing degradation of SREBP/SCAP. (2017)
  • Author(s): Asano, L., Watanabe, M., Ryoden, Y., Usuda, K., Yamaguchi, T., Khambu, B., Takashima, M., Sato, S., Sakai, J., Nagasawa, K., Uesugi, M.
  • Journal Title: Cell Chem Biol. Volume: 24 Issue: 2 Pages: 207-217
  • DOI: 10.1016/j.chembiol.2016.12.017
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Extracellular Acidic pH Activates the Sterol Regulatory Element-binding Protein 2 to Promote Tumor Progression (2017)
  • Author(s): Kondo A, Yamamoto S, Nakaki R, Shimamura T, Hamakubo T, Sakai J, Kodama T, Yoshida T, Aburatani H and Osawa T
  • Journal Title: Cell Reports Volume: 18 Issue: 9 Pages: 2228-2242
  • DOI: 10.1016/j.celrep.2017.02.006
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability. (2017)
  • Author(s): Yeyati PL, Schiller R, Mali G, Kasioulis I, Kawamura A, Adams IR, Playfoot C, Gilbert N, van Heyningen V, Wills J, von Kriegsheim A, Finch A, Sakai J, Schofield CJ, Jackson IJ, Mill P.
  • Journal Title: J Cell Biol. Volume: 216 Issue: 4 Pages: 999-1013
  • DOI: 10.1083/jcb.201607032
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Degradation of human Lipin-1 by BTRC E3 ubiquitin ligase (2017)
  • Author(s): Ishimoto Kenji、Hayase Ayaka、Kumagai Fumiko、Kawai Megumi、Okuno Hiroko、Hino Nobumasa、Okada Yoshiaki、Kawamura Takeshi、Tanaka Toshiya、Hamakubo Takao、Sakai Juro、Kodama Tatsuhiko、Tachibana Keisuke、Doi Takefumi
  • Journal Title: Biochem Biophys Res Commun. Volume: 488 Issue: 1 Pages: 159-164
  • DOI: 10.1016/j.bbrc.2017.04.159
  • Peer Reviewed
• [Journal Article] Transcriptional and epigenetic control of brown and beige adipose cell fate and function (2016)
  • Author(s): Inagaki T, Sakai J, Kajimura S.
  • Journal Title: Nature Reviews Molecular Cell Biology Volume: 17 Issue: 8 Pages: 480-495
  • DOI: 10.1038/nrm.2016.62
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages. (2016)
  • Author(s): R. Hachiya, T. Shiihashi, I. Shirakawa, Y. Iwasaki, Y. Matsumura, Y. Oishi, Y. Nakayama, Y. Miyamoto, I. Manabe, K. Ochi, M. Tanaka, N. Goda, J. Sakai, T. Suganami, Y. Ogawa.
  • Journal Title: Sci. Rep. Volume: 6 Issue: 1 Pages: 28845-28845
  • DOI: 10.1038/srep28845
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Ubiquitination of Lysine 867 of the Human SETDB1 Protein Upregulates Its Histone H3 Lysine 9 (H3K9) Methyltransferase Activity. (2016)
  • Author(s): Ishimoto K, Kawamata N, Uchihara Y, Okubo M, Fujimoto R, Gotoh E, Kakinouchi K, Mizohata E, Hino N, Okada Y, Mochizuki Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Inoue T, Tachibana K, Doi T
  • Journal Title: PLoS One Volume: 11 Issue: 10 Pages: e0165766-e0165766
  • DOI: 10.1371/journal.pone.0165766
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] QRFP-deficient mice are hypophagic, lean, hypoactive and exhibit increased anxiety-like behavior (2016)
  • Author(s): Okamoto K, Yamasaki M, Takao K, Soya S, Iwasaki M, Sasaki K, Magoori K, Sakakibara I, Miyakawa T, Mieda M, Watanabe M, Sakai J, Yanagisawa M, Sakurai T
  • Journal Title: PLoS ONE Volume: 11 Issue: 11 Pages: e0164716-e0164716
  • DOI: 10.1371/journal.pone.0164716
  • NAID: 120007129233
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] エピゲノム変化とアクトミオシン緊張を制御する脱リン酸化酵素同定と同酵素によるベージュ化制御の解明 (2022)
  • Author(s): 酒井寿郎
  • Organizer: 第99回日本生理学会大会
• [Presentation] A Phosphatase Protein Complex Orchestrates Uncoupled Respiration via a Histone Demethylase and YAP/TAZ Mediated Actomyosin Pathway in White Adipose Tissue (2021)
  • Author(s): Juro Sakai
  • Organizer: The 19th International Symposium on Atherosclerosis
  • Int'l Joint Research / Invited
• [Presentation] A Concerted Thermogenic Response via A Phosphor-switch of An Epigenetic Modifier (2021)
  • Author(s): Juro Sakai
  • Organizer: 第１回健康長寿代謝制御研究センター国際シンポジウム
  • Int'l Joint Research / Invited
• [Presentation] 生活習慣病におけるエピゲノムの役割 (2021)
  • Author(s): 酒井寿郎
  • Organizer: 日本スポーツ栄養学会第7回大会
• [Presentation] 熱産生性脂肪のエピジェネティクス (2021)
  • Author(s): 稲垣毅, 酒井寿郎
  • Organizer: 第64回日本糖尿病学会
• [Presentation] 肥満発症に関与するエピゲノム酵素のシグナル感知とヒストン脱メチル化機構の解明 (2021)
  • Author(s): 酒井寿郎
  • Organizer: 第41回日本肥満学会
• [Presentation] ヒストン脱メチル化酵素JMJD1Aによる2つの独立した機構による2つの異なる脂肪組織における熱産生遺伝子発現機構 (2021)
  • Author(s): 酒井寿郎
  • Organizer: 第43回日本分子生物学会
• [Presentation] 脂肪細胞分化を制御するヒストンメチル化・脱メチル化反応 (2020)
  • Author(s): 松村欣宏, Eko Fuji Ariyanto, 曽我朋義, 酒井寿郎
  • Organizer: 第93回日本生化学会大会
• [Presentation] SETDB1 represses H3K4/H3K9me3 bivalent genes by ubiquitination-dependent and -independent mechanisms. (2020)
  • Author(s): 張吉, 松村欣宏, 鹿野優佳, 吉田文乃, 川村猛, 平川弘幸, 油谷浩幸, 酒井 寿郎
  • Organizer: 第93回 日本生化学会大会
• [Presentation] “Histone demethylase-mediated adaptive thermogenesis” (2019)
  • Author(s): Juro Sakai
  • Organizer: 71th Annual Korean Physiological Society Meeting
  • Int'l Joint Research / Invited
• [Presentation] 内分泌機構におけるエピゲノム (2019)
  • Author(s): 酒井寿郎
  • Organizer: 第92回日本内分泌学会
  • Invited
• [Presentation] 脂肪細胞の機能制御に関わるヒストン修飾とクロマチン構造の変化 (2019)
  • Author(s): 酒井寿郎
  • Organizer: 第42回日本分子生物学会
  • Invited
• [Presentation] ヒストン脱メチル化酵素による寒冷環境への適応機構 (2018)
  • Author(s): 酒井寿郎
  • Organizer: 第91回日本内分泌学会
  • Invited
• [Presentation] Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phosphor-switch. (2018)
  • Author(s): 酒井寿郎
  • Organizer: 第50回日本動脈硬化学会総会・学術集会
  • Invited
• [Presentation] Beta-Adrenergic Signaling Regulates a Concerted Thrmogenic Response in Brown Adipose Tissue and subcutaneous White Adipose Tissue (2018)
  • Author(s): Juro Sakai
  • Organizer: American Diabetes Association 77th Scientific Sessions
  • Int'l Joint Research / Invited
• [Presentation] JMJD1A Mediates Acute and Chronic Thermogenic Responses through Complementary Mechanisms (2018)
  • Author(s): Juro Sakai
  • Organizer: The 5th Bandung International Biomoleculara Medicine Conference
  • Int'l Joint Research / Invited
• [Presentation] JMJD1A Mediates Acute and Chronic Thermogenic Responses through Complementary Mechanisms (2018)
  • Author(s): Juro Sakai
  • Organizer: THE 15TH NIKKO INTERNATIONAL SYMPOSIUM 2018 Genomic Approach for Non-communicable Diseases
  • Int'l Joint Research / Invited
• [Presentation] A histone demethylase JMJD1A mediates acute and chronic thermogenic responses through complementary Mechanisms (2018)
  • Author(s): Juro Sakai
  • Organizer: The 4th IMCR Symposium on Endocrine and Metabolism: At the Cutting Edge of Metabolic Regulation Research
  • Int'l Joint Research / Invited
• [Presentation] ヒストン脱メチル化酵素による脂肪細胞の熱産生機構と糖代謝制御機構 (2018)
  • Author(s): 酒井寿郎
  • Organizer: 第52回糖尿病学の進歩
  • Invited
• [Presentation] エピゲノムを介した白色脂肪細胞分化の制御機構 (2017)
  • Author(s): 松村欣宏, 仲木竜, 稲垣毅, 油谷浩幸, 酒井寿郎
  • Organizer: 第35回内分泌学代謝学サマーセミナー
  • Invited
• [Presentation] 脂肪細胞における代謝産物とエピゲノムによるエネルギー代謝調節 (2017)
  • Author(s): Eko F. Ariyanto, 松村欣宏, 曽我朋義, 稲垣毅, 酒井寿郎
  • Organizer: 日本がん分子標的治療学会 第12回トランスレーショナルリサーチワークショップ
  • Invited
• [Presentation] ヒストン脱メチル化酵素JMJD1Aの肥満、糖尿病における機能解析 (2017)
  • Author(s): 稲垣毅, 酒井寿郎
  • Organizer: 第31回日本糖尿病・肥満動物学会年次学術集会
  • Invited
• [Presentation] ヒストン脱メチル化酵素のリン酸化と脱メチル化による白色脂肪細胞の褐色化機構 (2017)
  • Author(s): 酒井寿郎
  • Organizer: 第11回エピジェネティクス研究会年会
• [Presentation] ヒストン修飾酵素による脂肪細胞制御 (2016)
  • Author(s): 稲垣毅, 阿部陽平, Rozqie Royhan, 松村欣宏, 岩崎聡, 梶村真吾, 田中十志也, 児玉龍彦, 油谷浩幸, 酒井寿郎
  • Organizer: 第59回日本糖尿病学会年次学術集会
• [Presentation] 絶食でのケトン体産生のメカニズム (2016)
  • Author(s): 酒井寿郎
  • Organizer: 第16回日本抗加齢医学会総会 シンポジウム
  • Invited
• [Presentation] Nuclear receptor PPARγ epigenomic modifier complexes that control adipocyte differentiation and metabolic phenotype (2016)
  • Author(s): Juro Sakai
  • Organizer: 第48回日本動脈硬化学会総会・学術総会
  • Invited
• [Presentation] Metabolic Regulation of Histone Demethylase KDM4A and Glycolytic Gene Expression by Isocitrate Dehydrogenase 3β during Adipogenesis (2016)
  • Author(s): Eko F. Ariyanto, Yoshihiro Matsumura, Tomoyoshi Soga, Takeshi Inagaki, Juro Sakai
  • Organizer: 第89回日本生化学会
• [Presentation] Nutritin,metabolic state,and Epigenomic Regulation of Adipogenesis and Obesity (2016)
  • Author(s): Juro Sakai
  • Organizer: 第37回日本肥満学会
  • Invited
• [Presentation] JMJD1A複合体による熱産生のエピゲノム制御機構 (2016)
  • Author(s): 稲垣毅, 阿部陽平, Rozqie Royhan, 松村欣宏, 仲木竜, 川村猛, 梶村真吾, 児玉龍彦, 油谷浩幸, 酒井寿郎
  • Organizer: 第39回日本分子生物学会年会
  • Invited
• [Presentation] 生活習慣病、遺伝子からエピゲノムへ (2016)
  • Author(s): 酒井寿郎
  • Organizer: 第24回日本ステロイドホルモン学会学術集会
  • Invited
• [Presentation] Environmental cues and Epigenetic Regulation of Adipogenesis and Obesity (2016)
  • Author(s): Juro Sakai
  • Organizer: 第24回血管生物医学会学術集会
  • Invited
• [Remarks] 東北大学大学院医学系研究科細胞生物学講座分子代謝生理学分野/Publications
  • URL: http://http://www.metab.med.tohoku.ac.jp/publications/
• [Remarks] 東北大学大学院医学系研究科細胞生物学講座分子生理学分野/publications
  • URL: http://www.metab.med.tohoku.ac.jp/publications/
• [Remarks] 東京大学先端科学技術研究センター酒井研究室/原著論文
  • URL: http://www.mm.rcast.u-tokyo.ac.jp/publications/pubs.html