Budget Amount *help |
¥181,870,000 (Direct Cost: ¥139,900,000、Indirect Cost: ¥41,970,000)
Fiscal Year 2020: ¥37,440,000 (Direct Cost: ¥28,800,000、Indirect Cost: ¥8,640,000)
Fiscal Year 2019: ¥39,650,000 (Direct Cost: ¥30,500,000、Indirect Cost: ¥9,150,000)
Fiscal Year 2018: ¥34,840,000 (Direct Cost: ¥26,800,000、Indirect Cost: ¥8,040,000)
Fiscal Year 2017: ¥31,720,000 (Direct Cost: ¥24,400,000、Indirect Cost: ¥7,320,000)
Fiscal Year 2016: ¥38,220,000 (Direct Cost: ¥29,400,000、Indirect Cost: ¥8,820,000)
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Outline of Final Research Achievements |
In this research project, to elucidate the molecular mechanism of articular cartilage homeostasis, we focused on the roles of the regulatory mechanism of gene expression and its intracellular signaling, and identified transcription factors and intracellular signaling pathways required for the formation of articular cartilage chondrocytes. We also found the mechanisms involved in the destruction of articular cartilage, which is observed in osteoarthritis and other joint diseases. Based on these findings, they succeeded in identifying target molecules and developing a screening system for drug discovery against osteoarthritis, contributing to the establishment of a foundation for therapeutic strategies for osteoarthritis.
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