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Quantitative study for the natural history of norovirus infection

Research Project

Project/Area Number 16H06581
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Statistical science
Research InstitutionHokkaido University

Principal Investigator

Matsuyama Ryota  北海道大学, 医学研究院, 博士研究員 (00780008)

Project Period (FY) 2016-08-26 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords感染症疫学 / ノロウイルス感染症 / 理論疫学 / 感染性 / 感受性 / 不顕性感染 / 感染自然史 / 社会医学 / 数理モデル / ノロウイルス
Outline of Final Research Achievements

Although outbreaks of norovirus infection (NVI) are frequently observed, the natural history of NVI has not been sufficiently understood. The present study aimed to quantify the unknown parameters of NVI transmission, such as the basic reproduction number (R0: the average number of secondary infection from a initial infection) and the infectivity of asymptomatic infection. Those parameters in NVI were analyzed through the comprehensive analysis of multiple NVI outbreak data and the use of mathematical modeling.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • Research Products

    (14 results)

All 2018 2017 2016

All Journal Article (4 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Estimating the Asymptomatic Ratio of Norovirus Infection During Foodborne Outbreaks With Laboratory Testing in Japan2018

    • Author(s)
      Miura F, Matsuyama R, Nishiura H
    • Journal Title

      Journal of Epidemiology

      Volume: 28 Issue: 9 Pages: 382-387

    • DOI

      10.2188/jea.JE20170040

    • NAID

      130007481555

    • ISSN
      0917-5040, 1349-9092
    • Year and Date
      2018-09-05
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Uncertainty and sensitivity analysis of the basic reproduction number of diphtheria: a case study of a Rohingya refugee camp in Bangladesh, November-December 2017.2018

    • Author(s)
      Matsuyama R, Akhmetzhanov AR, Endo A, Lee H, Yamaguchi T, Tsuzuki S, Nishiura H
    • Journal Title

      PeerJ

      Volume: - Pages: e4583-e4583

    • DOI

      10.7717/peerj.4583

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The transmissibility of noroviruses: Statistical modeling of outbreak events with known route of transmission in Japan2017

    • Author(s)
      Matsuyama R, Miura F, Nishiura H
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 3 Pages: e0173996-e0173996

    • DOI

      10.1371/journal.pone.0173996

    • NAID

      120006219940

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Clinical determinants of the severity of Middle East respiratory syndrome (MERS): a systematic review and meta-analysis2016

    • Author(s)
      Matsuyama R, Nishiura H, Kutsuna S, Hayakawa K, Ohmagari N
    • Journal Title

      BMC Public Health

      Volume: 16 Issue: 1 Pages: 1203-1203

    • DOI

      10.1186/s12889-016-3881-4

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Household transmission of acute gastroenteritis with suspected norovirus infection (noro-like illness)2018

    • Author(s)
      Ryota Matsuyama, Fuminari Miura, Shinya Tsuzuki, Hiroshi Nishiura
    • Organizer
      18th International Congress on Infectious Diseases
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Estimating the transmissibility of norovirus infection using outbreak event data with known route of transmission in Japan2017

    • Author(s)
      Ryota Matsuyama, Fuminari Miura, Hiroshi Nishiura
    • Organizer
      The 21st International Epidemiological Association World Congress of Epidemiology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sample size consideration for influenza transmission experiments using ferret model2017

    • Author(s)
      Ryota Matsuyama, Yusuke Asai, Hiroshi Nishiura
    • Organizer
      Epidemics 6, Sixth International Conference ofInfectious Disease Dynamics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Exploration of the optimal design for transmission experiments within a fixed sample size2017

    • Author(s)
      Ryota Matsuyama, Yusuke Asai, Hiroshi Nishiura
    • Organizer
      Japan Innovative Mathematical Modeling for the Analysis of Infectious Disease Data: IMAID
    • Related Report
      2017 Annual Research Report
  • [Presentation] Exploring the cost effectiveness in transmission experiments using ferret model2017

    • Author(s)
      Ryota Matsuyama, Yusuke Asai, Hiroshi Nishiura
    • Organizer
      27th Annual Meeting of Japanese Society for Medical Biology
    • Related Report
      2017 Annual Research Report
  • [Presentation] Household transmission of acute viral gastroenteritis with suspected norovirus infection2017

    • Author(s)
      Ryota Matsuyama, Hiroshi Nishiura
    • Organizer
      第28回日本疫学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Assessment for the time-dependent variation of the transmissibility of norovirus infection in Japan2017

    • Author(s)
      Matsuyama R, Nishiura H
    • Organizer
      The 27th Annual Scientific Meeting of the Japan Epidemiological Association
    • Place of Presentation
      ベルクラシック甲府(山梨県甲府市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Statistical modeling for the analysis of the transmissibility of noroviruses using outbreak events data with known route of transmission in Japan2017

    • Author(s)
      Ryota Matsuyama, Hiroshi Nishiura
    • Organizer
      第二回北海道大学部局横断シンポジウム『免疫・癌・感染』
    • Place of Presentation
      北海道大学工学部鈴木章記念ホール(北海道札幌市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Time dependent increase in the transmissibility of norovirus infection: Statistical modeling of outbreak event data with known major route of transmission in Japan2016

    • Author(s)
      Matsuyama R, Nishiura H
    • Organizer
      Innovative Mathematical Modeling for the Analysis of Infectious Disease Data: IMAID 2016
    • Place of Presentation
      神戸大学滝川メモリアルホール(兵庫県神戸市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Meta-Analysis of Risk and Risk Factors related mortality of Middle East Respiratory syndrome2016

    • Author(s)
      Matsuyama R, Nishiura H
    • Organizer
      The annual meeting of the Japanese Society for Mathematical Biology 2016
    • Place of Presentation
      九州大学椎木講堂(福岡県福岡市)
    • Related Report
      2016 Annual Research Report

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Published: 2016-09-02   Modified: 2019-03-29  

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