Elucidation of the mechanism by which extracellular vesicles miRNA induces abnormalities in tumor endothelial cells and development of novel cancer diagnostics and therapy
Project/Area Number |
16H06603
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Surgical dentistry
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Research Institution | Hokkaido University |
Principal Investigator |
Torii Chisaho 北海道大学, 遺伝子病制御研究所, 客員研究員 (00780561)
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Project Period (FY) |
2016-08-26 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 腫瘍血管 / 細胞外小胞 / miRNA / 薬剤耐性 / 腫瘍 |
Outline of Final Research Achievements |
In this study, we investigated whether extracellular vesicles (EVs) involved in drug resistance in tumor endothelial cells. EVs were isolated from low and high metastatic tumor. We identified miRNA-X which was contained higher level in high metastatic tumor EVs than in low metastatic tumor EVs. miR-X was transported by EVs into endothelial cells and downregulated target gene Y expression. It induced drug resistance to 5-FU in endothelial cells. In the future, we will investigate whether miRNA-X relates to pathological factors and prognosis using clinical samples in order to develop novel cancer diagnostics and therapy.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Aneuploidy of murine immortalized endothelial cell line, MS1.2017
Author(s)
Hida K., Maishi N., Dorcas Akuba-Muhyia Annan, Kondoh M., Hojo T., Umma Habiba, Ohga N., Ishikawa K, Sato M., Torii C., Yanagiya M., Morimoto M., Hida Y., Shindoh M.
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Journal Title
J Oral Biosci
Volume: 59
Issue: 1
Pages: 50-54
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Vasohibin-1 as a novel prognostic factor for head and neck squamous cell carcinoma2017
Author(s)
Torii C., Hida Y., Shindoh M., Akiyama K., Ohga N., Maishi N., Ohiro Y., Ono M., Totsuka Y., Kitagawa Y., Tei K., Sato Y., *Hida K.
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Journal Title
Anticancer Res
Volume: 37(3)
Pages: 1219-1225
Related Report
Peer Reviewed
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[Journal Article] Vasohibin-1 as a novel prognostic factor for head and neck squamous cell carcinoma2017
Author(s)
Torii C., Hida Y., Shindoh M., Akiyama K., Ohga N., Maishi N., Ohiro Y., Ono M., Totsuka Y., Kitagawa Y., Tei K., Sato Y., Hida K.
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Journal Title
Anticancer Res
Volume: 37
Issue: 3
Pages: 1219-1225
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Aneuploidy of murine immortalized endothelial cell line, MS12017
Author(s)
Hida K., Maishi N., Dorcas Akuba-Muhyia Annan, Kondoh M., Hojo T., Umma Habiba, Ohga N., Ishikawa K, Sato M., Torii C., Yanagiya M., Morimoto M., Hida Y., Shindoh M
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Journal Title
J Oral Biosci
Volume: 59
Pages: 50-54
Related Report
Peer Reviewed
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[Journal Article] Tumor endothelial cells express high pentraxin 3 levels2016
Author(s)
Hida K., Maishi N., Kawamoto T., Akiyama K., Ohga N., Hida Y., Yamada K., Hojo T., Kikuchi H., Sato M., Torii C., Shinohara N., Shindoh M
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Journal Title
Pathol Int
Volume: 66
Issue: 12
Pages: 687-694
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 高転移性腫瘍miRによる血管内皮における薬剤耐性誘導2017
Author(s)
間石奈湖, 鳥居ちさほ, 川本泰輔, 森本真弘, 秋山廣輔, 吉岡祐亮, Alam Mohammad Towfik, 南 敬, 落谷孝広, 樋田泰浩, 樋田京子
Organizer
第26回日本がん転移学会学術集会
Related Report
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[Presentation] Correlation between endothelial CXCR7 expression and clinic pathological factors in oral squamous cell carcinoma (OSCC)2017
Author(s)
Randa Ibrahim Dawood, Yanagiya M., Maishi N., Hida Y., Torii C., Kikuchi H., Ohga N., Tei K., Kitakura T., Shindoh M., Hida K.
Organizer
第5回がんと代謝研究会
Related Report
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[Presentation] Tumor endothelial cells acquire drug resistance by exosomal-miR derived from high metastatic tumor2016
Author(s)
Hida K., Torii C., Maishi N., Morimoto M., Akiyama K., Kawamoto T., Minami T., Yoshioka Y., Mohammad Towfik Alam, Shindoh M., Hida Y., Ochiya T
Organizer
The 19th International Vascular Biology Meeting
Place of Presentation
Boston (America)
Year and Date
2016-11-02
Related Report
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[Presentation] 高転移性腫瘍エクソソームmiRNAは血管内皮のIL6を誘導し血管新生阻害療法への耐性を誘導する2016
Author(s)
森本真弘, 鳥居ちさほ, 川本泰輔, 秋山廣輔, 間石奈湖, 吉岡祐亮, 落谷孝広, 柳谷美沙, 菊地 央, 北川善政, 鄭漢 忠, 進藤正信, 樋田泰浩, 樋田京子
Organizer
第7回IGM研究交流会
Place of Presentation
北海道大学(北海道札幌市)
Year and Date
2016-10-18
Related Report
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