Identification of probiotic derived bioactive molecule and clarification of its recognition system and activation mechanisms of cell signaling
| Project/Area Number |
16H06607
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 大腸癌 / プロバイオティクス / 腸内細菌 / 癌治療 / 抗腫瘍活性物質 / アポトーシス / 細胞シグナル / 癌 / 生理活性物質 |
|---|
| Outline of Final Research Achievements |
Ferrichrome was identified from culture supernatant of L. casei ATCC334 which exhibited the strong growth inhibition effect of colorectal cancer cells. The anti-tumor effect of ferrichrome was stronger than classical anti-tumor agents, including 5-FU and cisplatin, and the additional effect was observed when ferrichrome and these agents were treated to cancer cells simultaneously. Ferrichrome activated the endoplasmic reticulum stress pathway for its anti-tumor effects. The molecular simulation based on structure of ferrichrome showed the molecular targets of ferrichrome. Ferrichrome exhibited tumor suppressive effects in tumor model mice. The adverse events, including lethality, hepatic dysfunction and anemia, were not observed when tenfold of medicinal dose of ferrichrome was administrated daily for a week.
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Report
(3 results)
Research Products
(8 results)
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[Presentation] Ferrichrome, a tumor suppressive molecule derived from Lactobacillus casei, inhibits the progression of colorectal cancer via the endoplasmic reticulum stress pathway2017
Author(s)
Hiroaki Konishi, Mikihiro Fujiya, Masami Ijiri, Kazuyuki Tanaka, Shugo Fujibayashi, Takuma Goto, Shin Kashima, Katsuyoshi Ando, Keitaro Takahashi, Nobuhiro Ueno, Junpei Sasajima, Kentaro Moriichi, Hiroki Tanaka, Katsuya Ikuta, Katsutoshi Okumura
Organizer
Digestive Disease Week 2017
Place of Presentation
McCormick Place、米国、シカゴ
Year and Date
2017-05-06
Related Report
Int'l Joint Research
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[Presentation] Ferrichrome, a tumor suppressive molecule derived from Lactobacillus casei, inhibits the progression of colorectal cancer via the endoplasmic reticulum stress pathway2017
Author(s)
Konishi H, Fujiya M, Ijiri M, Tanaka K, Fujibayashi S, Goto T, Kashima S, Ando K, Takahashi K, Ueno N, Sasajima J, Moriichi K, Tanaka H, Ikuta K, Okumura T
Organizer
Digestive Disease Week 2017
Related Report
Int'l Joint Research
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