Development of LC-MS/MS methods to analyze lipid molecules that possess unique structures for the elucidation their functions
| Project/Area Number |
16H06637
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Yamagata University (2017)
Tohoku University (2016) |
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Principal Investigator |
ITO Junya 山形大学, 農学部, 研究支援者 (50781647)
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 食品科学 / 過酸化脂質 / 糖化脂質 / 質量分析 / 脂質分析 / 変性脂質 / 修飾脂質 |
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| Outline of Final Research Achievements |
In this study, we analyzed "lipid molecules that possess unique structures" (i.e., squalene hydroperoxide, glycated lipids and plasmalogen) by LC-MS/MS analysis in the presence of alkali metal ions, since such methods were previously proved to be effective for the analysis of lipid hydroperoxides (e.g., fatty acid hydroperoxide). Since the analysis of these "lipid molecules that possess unique structures" were previously difficult to perform, the developed analytical methods are expected to greatly contribute to the elucidation of further functions and activities of such lipids in foods as well as in animals and humans.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Mass Spectrometric Discrimination of Squalene Monohydroperoxide Isomers2017
Author(s)
Shimizu, N., Bersabe, H., Ito, J., Kato, S., Towada, R., Eitsuka, T., Kuwahara, S., Miyazawa, T., Nakagawa, K.
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Journal Title
Journal of Oleo Science
Volume: 66
Issue: 3
Pages: 227-234
DOI
NAID
ISSN
1345-8957, 1347-3352
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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