| Project/Area Number |
16H06686
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 血管新生 / 三次元組織モデル / 足場材料 / 曲率 / 3次元in vitro微小血管モデル / 3次元in vitroモデル / 微小血管 / ゲル / 微小血管モデル / 血管曲率 / 生体材料 |
|---|
| Outline of Final Research Achievements |
This study aims to develop three-dimensional in vitro angiogenesis model on microdevice chip. The microvessels of several sizes (120, 200, and 300 micrometer in diameter) were successfully prepared and angiogenesis was induced by addition of vascular endothelial growth factor (VEGF). Angiogenesis induction was characterized by the sizes of the prepared microvasculatures. Longer and larger neovascular vessels formed from host microvasculature with smaller diameters, while only small sprouts were detected from large microvasculatures. By observation of the angiogenesis models, we visualized 3D features of the angiogenic sprouting process and provide information on the dynamics of luminal formation.
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