Molecular mechanisms of neocortical malformation relevant to autism spectrum disorder
| Project/Area Number |
16H06729
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Kawaguchi Daichi 東京大学, 大学院薬学系研究科(薬学部), 助教 (70549518)
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|---|
| Project Period (FY) |
2016-08-26 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 脳・神経 / 発生・分化 / 自閉症 / 大脳新皮質 / 大脳領野 |
|---|
| Outline of Final Research Achievements |
The neocortex regulates complex cognitive tasks such as sensory perception and higher cognition. Defects in cortical development are believed to cause neurological disorders including autism spectrum disorder (ASD). ASD children often have an overgrowth of the frontal cortex, but the underlying molecular mechanisms responsible for this region-specific overgrowth as well as its pathological relevance remain elusive. In this study, we found that fibroblast growth factor signaling might have a causal role in brain morphological and behavioral alterations relevant to ASD.
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Report
(3 results)
Research Products
(4 results)
