Molecular mechanisms of neocortical malformation relevant to autism spectrum disorder

Research Project

Project/Area Number	16H06729
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Neurochemistry/Neuropharmacology
Research Institution	The University of Tokyo
Principal Investigator	Kawaguchi Daichi 東京大学, 大学院薬学系研究科(薬学部), 助教 (70549518)
Project Period (FY)	2016-08-26 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	脳・神経 / 発生・分化 / 自閉症 / 大脳新皮質 / 大脳領野
Outline of Final Research Achievements	The neocortex regulates complex cognitive tasks such as sensory perception and higher cognition. Defects in cortical development are believed to cause neurological disorders including autism spectrum disorder (ASD). ASD children often have an overgrowth of the frontal cortex, but the underlying molecular mechanisms responsible for this region-specific overgrowth as well as its pathological relevance remain elusive. In this study, we found that fibroblast growth factor signaling might have a causal role in brain morphological and behavioral alterations relevant to ASD.

Report

(3 results)