| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
This study aimed at discovering novel self-derived molecules, hereafter DAMPs, which could provoke inflammatory response. Combining biochemical and molecular biology methods, we obtained several candidate molecules of those DAMPs. Interestingly, when we made knock out cells of one candidate gene by CRISPR/Cas9, those cells grew slower than wild type cells in vivo but not in vitro. Since progression of cancer is closely connected with inflammation, the candidate molecule might augment tumor growth through modulating inflammatory response within tumor microenvironment. Colectively, we identified a DAMP molecule which enhanced inflammation, and tumor growth possibly through tumor microenvironment.
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