Identification of novel DAMP molecules involved in inflammatory diseases
Project/Area Number |
16H06747
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
Immunology
|
Research Institution | The University of Tokyo |
Principal Investigator |
Hangai Sho 東京大学, 生産技術研究所, 特任助教 (50785350)
|
Project Period (FY) |
2016-08-26 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 炎症 / 生体分子 / がん微小環境 |
Outline of Final Research Achievements |
This study aimed at discovering novel self-derived molecules, hereafter DAMPs, which could provoke inflammatory response. Combining biochemical and molecular biology methods, we obtained several candidate molecules of those DAMPs. Interestingly, when we made knock out cells of one candidate gene by CRISPR/Cas9, those cells grew slower than wild type cells in vivo but not in vitro. Since progression of cancer is closely connected with inflammation, the candidate molecule might augment tumor growth through modulating inflammatory response within tumor microenvironment. Colectively, we identified a DAMP molecule which enhanced inflammation, and tumor growth possibly through tumor microenvironment.
|
Report
(3 results)
Research Products
(4 results)
-
-
-
-
[Book] Oncoimmunology2018
Author(s)
Sho Hangai, Yoshitaka Kimura, Tadatsugu Taniguchi, Hideyuki Yanai
Total Pages
724
Publisher
Springer International Publishing
ISBN
9783319624303
Related Report