Research for molecular mechanism of cardiac fibrosis
| Project/Area Number |
16H06748
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2016-08-26 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 心臓線維化 / I型コラーゲン / 低酸素誘導因子 / 線維化 / 心筋線維芽細胞 |
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| Outline of Final Research Achievements |
We have succeeded in establishing cardiac fibroblast cell line from Col1a1-GFP transgenic mice, which express green fluorescent protein (GFP) under the control of Collagen1a1 promoter. Additionally we have found that lactic acid increases Collagen 1a1 transcription in mRNA level in the established cell line. There was an increase in nuclear transcription factor HIF1a protein level in Western blot analysis which suggest Col1a1 transcription level is controlled under HIF1a protein level.
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Report
(3 results)
Research Products
(1 results)
